Rationale for the study of the human sex ratio in population studies of polluted environments

Datos Bibliográficos

ID5223046
AutoresJohn Jarrell (0000-0002-8985-8657, University of Calgary, autor de correspondencia)
Año2002
Volumen18
Número2
Páginas429-434
Fecha de publicación2002-04-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaCadernos de Saude Publica (JOURNAL)
Identificadores de la revistaISSN: 0102-311X • E-ISSN: 1678-4464
EditorialFapUNIFESP (SciELO) (PUBLISHER)
DOI10.1590/s0102-311x2002000200007
PMID11923884
OpenAlexW2096206987
SCIELO_PIDS0102-311X2002000200007
IdiomaEN
Citas recibidas6
Referencias citadas25

The human secondary sex ratio remains a subject of substantial interest. The possibility has been raised that environmental chemical exposures have played a role in the changes associated with the sex ratio in a number of countries. The possibility that such an effect may be present is supported at least theoretically by the observation that clomiphene citrate, a drug used in the treatment of infertility with powerful estrogenic and anti-estrogenic properties, has profound effects on the sex ratio resulting in significantly fewer males at birth. Using a model of causality based on the clinical identification of adverse drug effect methodology one may improve the objectivity of the assessment of significant environmental exposures on this human reproductive outcome

Biology · Causality (physics) · Environmental health · Identification (biology) · Infertility · Population · Pregnancy · Sex ratio · Demographic Trends and Gender Preferences · Demography · Ecology · Global Maternal and Child Health · Medicine · Migration and Labor Dynamics