Stress-responsive biomarkers and sexual behaviors among young women in rural South Africa
Datos Bibliográficos
| ID | 7146752 |
|---|---|
| Autores | Nicole K Kelly (0000-0003-1061-2767, University of North Carolina at Chapel Hill), Marie C D Stoner (0000-0002-7189-8669, RTI International), Sumaya Mall (0000-0001-8430-368X, University of the Witwatersrand), Kirsten Rowe (0000-0002-2005-3666, Western Cape Department of Health), Francesc Xavier Gómez-Olivé (0000-0002-4876-0848, University of the Witwatersrand), Laura Danielle Wagner (0000-0002-3417-491X, RTI International), A E Aiello (0000-0001-7029-2537, Columbia University), Kathleen Kahn (0000-0003-3339-3931, University of the Witwatersrand), Audrey Pettifor (0000-0002-3387-0817, University of North Carolina at Chapel Hill), Audrey E Pettifor |
| Año | 2025 |
| Volumen | 59 |
| Número | 1 |
| Fecha de publicación | 2025-01-04 |
| Peer Reviewed | Sí |
| Open Access | Sí |
| Tipo | ARTICLE |
| Revista | Annals of Behavioral Medicine (JOURNAL) |
| Identificadores de la revista | ISSN: 0883-6612 • E-ISSN: 1532-4796 |
| Editorial | Oxford University Press (PUBLISHER • GB) |
| DOI | 10.1093/abm/kaaf060 |
| PMID | 40815085 |
| OpenAlex | W4413141243 |
| Idioma | EN |
| Referencias citadas | 65 |
BACKGROUND: Adolescence is a critical period when youth develop their decision-making skills and may engage in their first sexual encounters. Stress during this time can affect decision making; however, limited research has examined the relationship between biological stress correlates and sexual behavior among adolescent girls and young women (AGYW) in high-HIV incidence areas. PURPOSE: To examine whether stress-responsive biomarkers are longitudinally associated with sexual behaviors that are predictive of HIV. METHODS: We used data from a cohort of 897 AGYW nested within the HIV Prevention Trials 068 study in rural South Africa. Stress-responsive biomarkers were tested retrospectively from enrollment: C-reactive protein (CRP), herpes simplex virus type-1 (HSV-1) antibody titers, and cytomegalovirus (CMV) antibody titers. We estimated the longitudinal associations between each biomarker (2011-2012) and each behavior throughout follow-up (2011-2019; transactional sex, age-disparate partnerships, multiple partners, and condomless sex). RESULTS: At enrollment, 25.4% (n = 228) had ever had sex, 7.0% (n = 63) had >1 partner, 7.9% (n = 71) had recent condomless sex, and 3.0% (n = 27) reported transactional sex. Compared to low CRP levels, medium and high CRP levels were associated with having an older partner (RR: 1.41 [95% CI, 1.08-1.84]; RR: 1.33 [95% CI, 1.02-1.74], respectively) and with condomless sex (RR: 1.40 [95% CI, 1.10-1.77]; RR: 1.42 [95% CI, 1.12-1.80], respectively). CONCLUSIONS: Higher CRP levels were longitudinally associated with age-disparate relationships and condomless sex. Inflammation may increase AGYW's engagement in these behaviors; however, future studies should examine whether there is a stress-inflammation-sexual behavior pathway, and if so, evaluate stress-reduction interventions to promote sexual well-being.
Developmental psychology · Environmental health · Health psychology · Public health · Sexual behavior · Stress (linguistics) · Adolescent Sexual and Reproductive Health · Clinical Psychology · Medicine · Psychology · Stress Responses and Cortisol · Tryptophan and brain disorders
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| Velocidad de citación | historical |
|---|---|
| Altamente citado | No |