Locomotor activity, growth hormones, and systemic robusticity

An investigation of cranial vault thickness in mouse lines bred for high endurance running

Datos Bibliográficos

ID8311481
AutoresLynn E Copes (0000-0002-4337-4016, Department of Medical Sciences, Frank H. Netter MD School of Medicine Quinnipiac University Hamden Connecticut 06518, autor de correspondencia), H Schutz (0000-0002-1019-9514, Department of Biology Pacific Lutheran University Tacoma Washington, DC 98447), Elizabeth M Dlugsoz (University of California, Riverside), Stefan Judex (0000-0002-4511-1535, Stony Brook University), T Garland (0000-0002-7916-3552, Department of Biology University of California Riverside, Riverside California 92521)
Año2018
Volumen166
Número2
Páginas442-458
Fecha de publicación2018-06-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaAmerican Journal of Physical Anthropology (JOURNAL)
Identificadores de la revistaISSN: 0002-9483 • E-ISSN: 1096-8644
EditorialWiley (PUBLISHER • GB)
DOI10.1002/ajpa.23446
PMID29473645
OpenAlexW2790467157
IdiomaEN
Citas recibidas6
Referencias citadas96

OBJECTIVES: To use a mouse model to investigate the relationships among the components of the systemic robusticity hypothesis (SRH): voluntary exercise on wheels, spontaneous physical activity (SPA) in cages, growth hormones, and skeletal robusticity, especially cranial vault thickness (CVT). MATERIALS AND METHODS: Fifty female mice from lines artificially selected for high running (HR) and 50 from nonselected control (C) lines were housed in cages with (Active) or without wheels (Sedentary). Wheel running and SPA were monitored daily. The experiment began at 24-27 days of age and lasted 12 weeks. Food consumption was measured weekly. Mice were skeletonized and their interparietal, parietal, humerus, and femur were μCT scanned. Mean total thickness of the parietal and interparietal bones was determined, along with thickness of the cortical and diploe layers individually. Geometric cross-sectional indicators of strength were calculated for the long bones. Blood samples were assayed for IGF-1 and IGFBP-3. RESULTS: Physical activity differed significantly among groups, based both on linetype (C vs. HR) and activity (A vs. S). However, contrary to our predictions, the ratio of IGF-1 to IGFBP-3 was higher in C mice than in HR mice. Neither CVT nor postcranial robusticity was affected by linetype or activity, nor were most measures of CVT and postcranial robusticity significantly associated with one another. DISCUSSION: Our results fail to provide support for the systemic robusticity hypothesis, suggesting it is important to rethink the long-standing theory that increased CVT in Homo erectus reflects increased physical activity compared other hominin species

Biology · Cranial vault · Postcrania · Skeleton (computer programming) · Skull · Anatomy · Ecology · Genetics and Physical Performance · Hemispheric Asymmetry in Neuroscience · Sports Performance and Training