Oral microbiome diversity among Cheyenne and Arapaho individuals from Oklahoma

Datos Bibliográficos

ID8315685
AutoresAndrew T Ozga (0000-0003-4540-7106, Department of Anthropology University of Oklahoma Norman Oklahoma 73019), Krithivasan Sankaranarayanan (0000-0002-4767-311X, Department of Anthropology University of Oklahoma Norman Oklahoma 73019), Raúl Y Tito (0000-0001-9660-7621, Department of Anthropology University of Oklahoma Norman Oklahoma 73019), Alexandra J Obregon‐Tito (Department of Anthropology University of Oklahoma Norman Oklahoma 73019), Alexandra J Obregón-Tito (0000-0003-2508-7176, University of Oklahoma), Morris W Foster (0000-0003-3008-4447, Old Dominion University Norfolk Virginia 23529), Gloria Tallbull (Center for Applied Social Research, University of Oklahoma Norman Oklahoma 73019), Paul Spicer (Department of Anthropology University of Oklahoma Norman Oklahoma 73019), Christina Warinner (0000-0002-4528-5877, Department of Anthropology University of Oklahoma Norman Oklahoma 73019), Christina G Warinner, Cecil M Lewis (0000-0002-2198-3427, Department of Anthropology University of Oklahoma Norman Oklahoma 73019, autor de correspondencia)
Año2016
Volumen161
Número2
Páginas321-327
Fecha de publicación2016-10-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaAmerican Journal of Physical Anthropology (JOURNAL)
Identificadores de la revistaISSN: 0002-9483 • E-ISSN: 1096-8644
EditorialWiley (PUBLISHER • GB)
DOI10.1002/ajpa.23033
PMID27357925
OpenAlexW2469872498
IdiomaEN
Citas recibidas1
Referencias citadas37

OBJECTIVES: There is a major ascertainment bias in microbiome research, with individuals of predominately European ancestry living within metropolitan areas dominating most studies. Here we present a study of the salivary microbiome within a North American Indian community. This research is the culmination of four years of collaboration and community engagement with Cheyenne & Arapaho (C&A) tribal members from western Oklahoma. MATERIALS AND METHODS: Using 16S rRNA gene amplification and next-generation sequencing, we generated microbial taxonomic inventories for 37 individuals representing five towns within the C&A tribes. For comparison, we performed the same laboratory techniques on saliva samples from 20 non-native individuals (NNI) from Norman, Oklahoma. RESULTS: The C&A participants differ from the NNI in having reduced within-individual species richness and higher between-individual variation. Unsupervised clustering analyses reveal that three ecological groupings best fit the data, and while C&A individuals include assignments to all three groups, the NNI individuals are assigned to only one group. One of the ecological groups found exclusively among C&A participants was characterized by high abundance of the oral bacterial genus Prevotella. DISCUSSION: The C&A and NNI participants from Oklahoma have notable differences in their microbiome diversity, with a wider range of variation observed among the C&A individuals, including a higher frequency of bacteria implicated in systemic disorders. Overall, this study highlights the importance of engagement with indigenous communities, and the need for an improved understanding of human microbiome diversity among underrepresented groups and those individuals living outside of metropolitan areas

Alpha diversity · Biology · Diversity (politics) · Geography · Indigenous · Microbiome · Sociology · Species richness · Zoology · Anthropology · Demography · Ecology · Genetics · Gut microbiota and health · Oral microbiology and periodontitis research · Salivary Gland Disorders and Functions