Chromosome painting reveals that galagos have highly derived karyotypes

Datos Bibliográficos

ID8317115
AutoresRoscoe Stanyon (0000-0002-7229-1092, Frederick National Laboratory for Cancer Research, autor de correspondencia), Udo Koehler (Medical Genetics Center), Stefania Consigliere (University of Genoa)
Año2002
Volumen117
Número4
Páginas319-326
Fecha de publicación2002-04-01
Peer ReviewedSí
Open AccessSí
TipoARTICLE
RevistaAmerican Journal of Physical Anthropology (JOURNAL)
Identificadores de la revistaISSN: 0002-9483 • E-ISSN: 1096-8644
EditorialWiley (PUBLISHER • GB)
DOI10.1002/ajpa.10047
PMID11920367
OpenAlexW2010782796
IdiomaEN
Citas recibidas3
Referencias citadas37

The differences in chromosome number between Otolemur crassicaudatus (2n = 62) and Galago moholi (2n = 38) are dramatic. However, the total number of signals given by hybridizing human chromosome paints to galago metaphases is similar: 42 in O. crassicaudatus and 38 G. moholi . Many human chromosome homologs are found fragmented in each species, and numerous translocations have resulted in chromosomal syntenies or hybridization associations which differ from those found in humans. Only 7 human autosomes showed conserved synteny in O. crassicaudatus , and 9 in G. moholi . Both galago species have numerous associations or syntenies not found in humans: O. crassicaudatus has 11, and G. moholi has 21. The phylogenetic line leading to the last common ancestor of the two galago species accumulated 6 synapomorphic fissions and 5 synapomorphic fusions. Since the divergence of the two galago species, 10 Robertsonian translocations have further transformed the G. moholi karyotype, and 2 fissions have been incorporated into the O. crassicaudatus karyotype. Comparison with other primates, tree shrews, and other mammals shows that both galagos have karyotypes which are a mixture of derived and conserved chromosomes, and neither has a karyotype close to that of the proposed ancestor of all primates. Am J Phys Anthropol 117:319–326, 2002. Published 2002 Wiley‐Liss, Inc

Autosome · Biology · Chromosome · Clade · Evolutionary biology · Galago · Gene · Hylobates · Karyotype · Phylogenetic tree · Primate · Prosimian · Synapomorphy · Zoology · Anatomy · Chromosomal and Genetic Variations · Ecology · Genetics · Genomic variations and chromosomal abnormalities · Genomics and Chromatin Dynamics

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