Emerging Methods in Comparative Effectiveness and Safety
Symposium Overview and Summary
Datos Bibliográficos
| ID | 9100746 |
|---|---|
| Autores | Kathleen N Lohr (0000-0002-3825-0713, RTI International, autor de correspondencia) |
| Año | 2007 |
| Volumen | 45 |
| Número | 10 |
| Páginas | S5-S8 |
| Fecha de publicación | 2007-10-01 |
| Peer Reviewed | Sí |
| Open Access | No |
| Tipo | ARTICLE |
| Revista | Medical Care (JOURNAL) |
| Identificadores de la revista | ISSN: 0025-7079 • E-ISSN: 1537-1948 |
| Editorial | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/mlr.0b013e31812714b6 |
| PMID | 17909383 |
| OpenAlex | W2092699823 |
| Idioma | EN |
| Referencias citadas | 27 |
BACKGROUND: Interest in new methods for comparative effectiveness, drug and patient safety, and related studies is burgeoning. The advent of Medicare Part D for outpatient prescription drugs has drawn significant attention to the need for efficient ways to monitor the potential benefits and harms of pharmaceuticals. These trends prompted the Effective Health Care program at the Agency for Healthcare Research and Quality and its DEcIDE (Developing Evidence to Inform Decisions about Effectiveness) network to examine innovative approaches for such investigations through an invitational symposium in June 2006. RESULTS: Conference papers covered numerous points about ways to structure both interventional and database-oriented studies, particularly those concerned with adverse drug events, to avoid bias in those studies, and to apply advanced statistical tools to exploit the information from these studies to their fullest. Of particular importance are: (1) using new types of experimental designs, including cluster randomization, delayed designs, pragmatic trials, and practice-based investigations that incorporate the natural variation of data from routine clinical practice; (2) finding efficient ways to use different types of databases-eg, Department of Veterans Affairs files, Centers for Disease Control and Prevention surveillance files, Medicaid claims data, and state hospital data-for examining initiation, persistence, and adherence, and the benefits and adverse events of pharmaceutical use; and (3) inventing or refining ways to decrease the threats to validity of analyses relying on administrative or other observational data, particularly through propensity scoring, inverse probability weighting, risk adjustment, and direct or indirect methods for synthesizing comparative effectiveness information
Agency (philosophy) · Alternative medicine · Comparative effectiveness research · Data science · Health care · Inverse probability weighting · Medicaid · Observational study · Propensity score matching · Veterans Affairs · Advanced Causal Inference Techniques · Computer Science · Health Systems, Economic Evaluations, Quality of Life · Medicine · Pharmacovigilance and Adverse Drug Reactions
Medicare Part D Data
Designed Delays Versus Rigorous Pragmatic Trials
Comparison of Meta-Analytic Results of Indirect, Direct, and Combined Comparisons of Drugs for Chronic Insomnia in Adults
Using Propensity Scores Subclassification to Estimate Effects of Longitudinal Treatments
A Simulation-Based Evaluation of Methods to Estimate the Impact of an Adverse Event on Hospital Length of Stay
Practice-Based Evidence Study Design for Comparative Effectiveness Research
Design of Cluster-Randomized Trials of Quality Improvement Interventions Aimed at Medical Care Providers
Developing Indicators of Inpatient Adverse Drug Events Through Nonlinear Analysis Using Administrative Data
Evaluation and Overview of the National Electronic Injury Surveillance System-Cooperative Adverse Drug Event Surveillance Project (Neiss-Cades)
Cluster Randomized Trials
Out-of-Pocket Pharmacy Expenditures for Veterans Under Medicare Part D
Use of Propensity Score Technique to Account for Exposure-Related Covariates
Creating and Synthesizing Evidence With Decision Makers in Mind
Using Inverse Probability-Weighted Estimators in Comparative Effectiveness Analyses With Observational Databases
The Medical License Number Accurately Identifies the Prescribing Physician in a Large Pharmacy Claims Database
Assessment of Adherence to and Persistence on Disease-Modifying Antirheumatic Drugs (DMARDs) in Patients With Rheumatoid Arthritis
Studying Prescription Drug Use and Outcomes With Medicaid Claims Data
The Utility of Administrative Data for Measuring Adherence to Cancer Surveillance Care Guidelines
Did the Medicare Inpatient Rehabilitation Facility Prospective Payment System Result in Changes in Relative Patient Severity and Relative Resource Use
Evaluating the Validity of an Instrumental Variable Study of Neuroleptics
Increasing Levels of Restriction in Pharmacoepidemiologic Database Studies of Elderly and Comparison With Randomized Trial Results
Adjustments for Unmeasured Confounders in Pharmacoepidemiologic Database Studies Using External Information
Methodologic Challenges to Studying Patient Safety and Comparative Effectiveness
Improving Depiction of Benefits and Harms
Heterogeneity and the Interpretation of Treatment Effect Estimates From Risk Adjustment and Instrumental Variable Methods
Real-Time Vaccine Safety Surveillance for the Early Detection of Adverse Events
Does the Patient's Payer Matter in Hospital Patient Safety
| Velocidad de citación | historical |
|---|---|
| Altamente citado | No |