Potential Drug–Drug Interactions in the Outpatient Setting
Datos Bibliográficos
| ID | 9101445 |
|---|---|
| Autores | Jennifer Elston Lafata (0000-0002-8550-6195, Brigham and Women's Hospital, autor de correspondencia), Lonni Schultz (Kaiser Permanente, autor de correspondencia), Jan Simpkins (Kaiser Permanente, autor de correspondencia), K Arnold Chan (0000-0001-8161-1986, Brigham and Women's Hospital), John R Horn (0000-0003-4525-4250, University of Washington), Scott Kaatz (0000-0002-3080-3328, Kaiser Permanente, autor de correspondencia), Charron Long (0000-0002-7535-5821, Science Wares (United States)), Richard Platt (0000-0002-3248-3583, Harvard University), Marsha A Raebel (0000-0002-8485-7161, Brigham and Women's Hospital, autor de correspondencia), David H Smith (0000-0001-7184-8947, Harvard University), Huago Xi (Kaiser Permanente, autor de correspondencia), Marianne Ulcickas Yood (0000-0003-4204-0871, Kaiser Permanente, autor de correspondencia) |
| Año | 2006 |
| Volumen | 44 |
| Número | 6 |
| Páginas | 534-541 |
| Fecha de publicación | 2006-06-01 |
| Peer Reviewed | Sí |
| Open Access | No |
| Tipo | ARTICLE |
| Revista | Medical Care (JOURNAL) |
| Identificadores de la revista | ISSN: 0025-7079 • E-ISSN: 1537-1948 |
| Editorial | Ovid Technologies (Wolters Kluwer Health) (PUBLISHER) |
| DOI | 10.1097/01.mlr.0000215807.91798.25 |
| PMID | 16708002 |
| OpenAlex | W2094060955 |
| Idioma | EN |
| Citas recibidas | 2 |
| Referencias citadas | 40 |
BACKGROUND: Although medication safety research has tended to focus on inpatients, the safety of drug use among outpatients is also a concern. OBJECTIVE: We estimate the frequency of potentially interacting concomitant medication dispensing among outpatients. RESEARCH DESIGN: We report the number and percent of patients annually dispensed an object drug of interest (ie, warfarin, digoxin, cyclosporine, or lovastatin/simvastatin) with a potentially interacting drug among a random sample of insured adults receiving care from 10 integrated delivery systems. We use 2 definitions of concomitant dispensing: medications dispensed: 1) during the time period for which the patient had the other medication available ('days supply') and 2) on the same day. We also estimate the number of insured U.S. population codispensed these medication pairs. RESULTS: Among patients dispensed a drug of interest, between 17.8% (95% confidence interval [CI]=17.1-18.6%) and 28.0% (95% CI=24.0-32.1%) were concomitantly dispensed a potentially interacting drug using the "days supply" definition, and between 7.1% (95% CI=6.6-7.7%) and 17.7% (95% CI=14.4-21.1%) using the "same day" definition. Extrapolating to the insured U.S. population, between 1.29 (95% CI=1.25-1.33; same day) and 2.67 (95% CI=2.62-2.72; days supply) million insured adults are dispensed 1 of these 4 potentially interacting pairs. CONCLUSIONS: We found evidence of potentially interacting concomitant medication dispensing among outpatients. An opportunity exists to better understand how such dispensing translates into adverse events and ultimately to improved medication safety
Adverse effect · Ambulatory care · Atrial fibrillation · Concomitant · Confidence interval · Drug · Health care · Intensive care medicine · Odds ratio · Population · Warfarin · Emergency Medicine · Internal Medicine · Medication Adherence and Compliance · Medicine · Pharmaceutical Practices and Patient Outcomes · Pharmacology · Pharmacovigilance and Adverse Drug Reactions
| Obras citantes distintas | 2 |
|---|---|
| Citas por año | 0,11 |
| Intervalo de citas | 2007 - 2017 (11) |
| Velocidad de citación | historical |
| Altamente citado | No |
| Tipos de cita | Neutras: 2 |