Brian Mcguinne
Biographic Data
| ID | 1027952 |
|---|---|
| NAME | Brian Mcguinne |
| GIVEN NAMES | Brian |
| FAMILY NAME | Mcguinne |
| SIGNATURE | MCGUINNE B |
| AFFILIATIONS | Queen's University Belfast |
| ORCID | 0000-0002-7028-5633 |
| VERIFIED | Yes |
| TOTAL WORKS | 10 |
| TOTAL CITATIONS | 1 |
| AUTHOR COUNT | 10 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1978 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 1 |
Post-traumatic stress disorder and memory function in older adults exposed to civilian conflict
Research with veterans, refugees and other trauma-exposed groups has identified a link between post-traumatic stress disorder (PTSD) and deficits in memory. This study sought to determine whether similar associations can be observed in a large, population-representative sample of older adults with high levels of exposure to conflict amongst older adults in Northern Ireland (NI). Using data from the Northern Ireland COhort for the Longitudinal stu…
Relationship between long-term exposure to sources of particulate matter, ambient air pollution and cognitive function in older adults
Long-term exposure to particulate matter with a diameter of less than 2.5 μm (PM 2.5 ) is associated with cognitive decline, but it is not clear whether the potential effects of PM 2.5 from different emission sources vary. This study aims to assess the association between PM 2.5 from different emission sources and cognitive function in older adults in Northern Ireland. Using data of the Northern Ireland Cohort of Longitudinal Ageing from wave 1 (…
Green space, life-course socioeconomic disparities and cognitive function in later life
There is evidence that green space may reduce socioeconomic disparities in health (‘equigenesis’). However, it is still unclear whether such a finding is also valid for cognitive function in older adults. Therefore, using data from the Northern Ireland Cohort for the Longitudinal Study of Ageing, this study examines whether exposure to green spaces reduces the effect of socioeconomic disparities in cognitive function in later life. It uses the No…
Awareness, facilitators, barriers, and behaviours surrounding brain health
Understanding of brain health and dementia risk reduction was variable in this large sample of UK and Irish citizens. There were identified gaps in awareness of risk factors relating to cardiometabolic health, hearing loss, and air pollution. These findings highlight the need for credible sources of accessible and relevant information to improve awareness and behaviours surrounding brain health
Remarkable concordance in associations between epigenetic clocks and health behaviors across three countries
Carers' experiences and perspectives of the use of anticholinergic medications in people living with dementia
INTRODUCTION: There is concern about the use of anticholinergic medications in people living with dementia (PLWD). Such medicines may increase cognitive decline and may be associated with higher mortality in PLWD who take these medicines. The aim of this study was to analyse data from an online dementia discussion forum to explore the experiences and perspectives of PLWD and carers about the use of anticholinergic medicines in this population. ME…
Differential methylation in CD44 and SEC23A is associated with time preference in older individuals
Time preference is a measure used to ascertain the level of which individuals prefer smaller, immediate rewards over larger, delayed rewards. We explored how an individual's time preference associates with their epigenetic profile. Time preferences were ascertained by asking participants of the Northern Ireland COhort for the Longitudinal study of Ageing to make a series of choices between two hypothetical income scenarios. From these, eight 'tim…
Northern Ireland Cohort for the Longitudinal Study of Ageing (Nicola)
This manuscript can help inform design considerations for other population based studies of ageing and facilitate cross-country comparative analysis of key life-course factors affecting healthy ageing such as educational attainment, diet, the accumulation of chronic conditions (including Alzheimer's disease, dementia and cardiovascular disease) as well as welfare and retirement policies
Feasibility of Repeated Assessment of Cognitive Function in Older Adults Using a Wireless, Mobile, Dry-EEG Headset and Tablet-Based Games
Access to affordable, objective and scalable biomarkers of brain function is needed to transform the healthcare burden of neuropsychiatric and neurodegenerative disease. Electroencephalography (EEG) recordings, both resting and in combination with targeted cognitive tasks, have demonstrated utility in tracking disease state and therapy response in a range of conditions from schizophrenia to Alzheimer's disease. But conventional methods of recordi…
Psychoneurotic profiles in the adult population
Self‐reported psychoneurotic characteristics and aspects of affective status have been examined within the adult population of a market town and the surrounding rural community using a standardized instrument. Features of anxiety in particular are more common amongst females than males, peaking in the third, fourth (phobic avoidance behaviour being also especially evident at this time) and fifth decades of life. Many of the characteristics are al…
Psychoneurotic profiles in the adult population
Self‐reported psychoneurotic characteristics and aspects of affective status have been examined within the adult population of a market town and the surrounding rural community using a standardized instrument. Features of anxiety in particular are more common amongst females than males, peaking in the third, fourth (phobic avoidance behaviour being also especially evident at this time) and fifth decades of life. Many of the characteristics are al…
Psychoneurotic profiles in the adult population
Self‐reported psychoneurotic characteristics and aspects of affective status have been examined within the adult population of a market town and the surrounding rural community using a standardized instrument. Features of anxiety in particular are more common amongst females than males, peaking in the third, fourth (phobic avoidance behaviour being also especially evident at this time) and fifth decades of life. Many of the characteristics are al…
Feasibility of Repeated Assessment of Cognitive Function in Older Adults Using a Wireless, Mobile, Dry-EEG Headset and Tablet-Based Games
Access to affordable, objective and scalable biomarkers of brain function is needed to transform the healthcare burden of neuropsychiatric and neurodegenerative disease. Electroencephalography (EEG) recordings, both resting and in combination with targeted cognitive tasks, have demonstrated utility in tracking disease state and therapy response in a range of conditions from schizophrenia to Alzheimer's disease. But conventional methods of recordi…
Differential methylation in CD44 and SEC23A is associated with time preference in older individuals
Time preference is a measure used to ascertain the level of which individuals prefer smaller, immediate rewards over larger, delayed rewards. We explored how an individual's time preference associates with their epigenetic profile. Time preferences were ascertained by asking participants of the Northern Ireland COhort for the Longitudinal study of Ageing to make a series of choices between two hypothetical income scenarios. From these, eight 'tim…
Northern Ireland Cohort for the Longitudinal Study of Ageing (Nicola)
This manuscript can help inform design considerations for other population based studies of ageing and facilitate cross-country comparative analysis of key life-course factors affecting healthy ageing such as educational attainment, diet, the accumulation of chronic conditions (including Alzheimer's disease, dementia and cardiovascular disease) as well as welfare and retirement policies
Carers' experiences and perspectives of the use of anticholinergic medications in people living with dementia
INTRODUCTION: There is concern about the use of anticholinergic medications in people living with dementia (PLWD). Such medicines may increase cognitive decline and may be associated with higher mortality in PLWD who take these medicines. The aim of this study was to analyse data from an online dementia discussion forum to explore the experiences and perspectives of PLWD and carers about the use of anticholinergic medicines in this population. ME…
Awareness, facilitators, barriers, and behaviours surrounding brain health
Understanding of brain health and dementia risk reduction was variable in this large sample of UK and Irish citizens. There were identified gaps in awareness of risk factors relating to cardiometabolic health, hearing loss, and air pollution. These findings highlight the need for credible sources of accessible and relevant information to improve awareness and behaviours surrounding brain health
Remarkable concordance in associations between epigenetic clocks and health behaviors across three countries
Post-traumatic stress disorder and memory function in older adults exposed to civilian conflict
Research with veterans, refugees and other trauma-exposed groups has identified a link between post-traumatic stress disorder (PTSD) and deficits in memory. This study sought to determine whether similar associations can be observed in a large, population-representative sample of older adults with high levels of exposure to conflict amongst older adults in Northern Ireland (NI). Using data from the Northern Ireland COhort for the Longitudinal stu…
Relationship between long-term exposure to sources of particulate matter, ambient air pollution and cognitive function in older adults
Long-term exposure to particulate matter with a diameter of less than 2.5 μm (PM 2.5 ) is associated with cognitive decline, but it is not clear whether the potential effects of PM 2.5 from different emission sources vary. This study aims to assess the association between PM 2.5 from different emission sources and cognitive function in older adults in Northern Ireland. Using data of the Northern Ireland Cohort of Longitudinal Ageing from wave 1 (…
Green space, life-course socioeconomic disparities and cognitive function in later life
There is evidence that green space may reduce socioeconomic disparities in health (‘equigenesis’). However, it is still unclear whether such a finding is also valid for cognitive function in older adults. Therefore, using data from the Northern Ireland Cohort for the Longitudinal Study of Ageing, this study examines whether exposure to green spaces reduces the effect of socioeconomic disparities in cognitive function in later life. It uses the No…
Medicine (5 works) · Population (5 works) · Cognition (4 works) · Health disparities and outcomes (4 works) · Psychology (4 works) · Cohort (3 works) · Dementia and Cognitive Impairment Research (3 works) · Demography (3 works) · Longitudinal study (3 works) · Public health (3 works)