Junichi Takagi
Biographic Data
| ID | 10675408 |
|---|---|
| NAME | Junichi Takagi |
| GIVEN NAMES | Junichi |
| FAMILY NAME | Takagi |
| SIGNATURE | TAKAGI J |
| VERIFIED | No |
| TOTAL WORKS | 1 |
| TOTAL CITATIONS | 0 |
| WORKS AS AUTHOR | 1 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 2004 |
| LATEST PUBLICATION YEAR | 2004 |
| H-INDEX | 0 |
Locking the β3 Integrin I-like Domain into High and Low Affinity Conformations with Disulfides
Although integrin alpha subunit I domains exist in multiple conformations, it is controversial whether integrin beta subunit I-like domains undergo structurally analogous movements of the alpha7-helix that are linked to affinity for ligand. Disulfide bonds were introduced into the beta(3) integrin I-like domain to lock its beta6-alpha7 loop and alpha7-helix in two distinct conformations. Soluble ligand binding, ligand mimetic mAb binding and cell…
No prominent works on this page.
Locking the β3 Integrin I-like Domain into High and Low Affinity Conformations with Disulfides
Although integrin alpha subunit I domains exist in multiple conformations, it is controversial whether integrin beta subunit I-like domains undergo structurally analogous movements of the alpha7-helix that are linked to affinity for ligand. Disulfide bonds were introduced into the beta(3) integrin I-like domain to lock its beta6-alpha7 loop and alpha7-helix in two distinct conformations. Soluble ligand binding, ligand mimetic mAb binding and cell…
Computer Science (1 work) · Public Policy and Governance (1 work) · Social Sciences and Policies (1 work)