Dinorah Castro De Guerra
Biographic Data
| ID | 107428 |
|---|---|
| NAME | Dinorah Castro De Guerra |
| GIVEN NAMES | Dinorah Castro |
| FAMILY NAME | De Guerra |
| SIGNATURE | DE GUERRA D C |
| AFFILIATIONS | Instituto Venezolano de Investigaciones Científicas |
| ORCID | 0000-0002-5308-0361 |
| VERIFIED | Yes |
| TOTAL WORKS | 12 |
| TOTAL CITATIONS | 8 |
| AUTHOR COUNT | 12 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1997 |
| LATEST PUBLICATION YEAR | 2021 |
| H-INDEX | 2 |
Estimación de mestizaje en dos poblaciones venezolanas usando marcadores informativos de ancestralidad y haplogrupos de ADN mitocondrial
Los marcadores informativos de ancestralidad (AIM) autosómicos y los del ADN mitocondrial (ADNmt) son muy útiles para identificar el origen y los patrones de migración de las poblaciones. En este trabajo se estimó el mestizaje a partir de siete AIM en 188 individuos venezolanos, 84 del estado Guárico y 104 de la región centro occidental de Venezuela (RCO), se estimó la ancestralidad mitocondrial en el estado Guárico y se compararon ambas poblacio…
Implicaciones antropológicas de la presencia del polimorfismo rs9282541 en los warao del delta del Orinoco, Venezuela
El gen ABCA1 juega un importante papel en la extracción del colesterol intracelular para la formación de la molécula de colesterol HDL. Una variante funcional de este gen, la ABCA1*230Cys (polimorfismo rs9282541), ha sido asociada con diversas alteraciones en los niveles de lípidos en sangre. Se le considera un marcador genético de origen amerindio ya que está presente solamente en nativos americanos y en poblaciones mestizas descendientes de ést…
Gender Differences in Ancestral Contribution and Admixture in Venezuelan Populations
The origin of the contribution of uniparental heritage were analyzed in 615 samples of individuals proceeding from 13 towns classified according to historic differences in their emergence and development as African-derived, European-derived, and admixed/urban. Mitochondrial and Y-chromosome haplogroups were identified by PCR-restriction fragment length polymorphism. The results were compared with previous estimates of admixture made with autosoma…
Admixture Estimates for Caracas, Venezuela, Based on Autosomal, Y-Chromosome, and mtDNA Markers
The present Venezuelan population is the product of admixture of Amerindians, Europeans, and Africans, a process that was not homogeneous throughout the country. Blood groups, short tandem repeats (STRs), mtDNA, and Y-chromosome markers have been used successfully in admixture studies, but few such studies have been conducted in Venezuela. In this study we aim to estimate the admixture components of samples from two different socioeconomic levels…
Admixture estimates for Churuguara, a Venezuelan town in the State of Falcón
Results of the admixture analysis are consistent with those obtained with two dendrograms and principal component analyses, suggesting that the strong initial Amerindian component of 500 years ago has been diluted by the continuous flow of European genes, mainly Spanish, to this region
Beta‐globin gene cluster haplotypes as evidence of African gene flow to the northeastern coast of Venezuela
In order to study the origin of mutation HBB*S in Sucre and Anzoátegui states and the genetic affinities of these Venezuelan populations with other human groups, the β‐globin gene cluster haplotypes were determined for 28 sickle cell and/or S‐beta thalassemia patients and for 37 individuals with normal hematological parameters. Bantu, Benin, Senegal, and atypical haplotypes were identified in 50%, 36%, 2%, and 12% of the HBB*S chromosomes, respec…
African-derived South American populations: A history of symmetrical and asymmetrical matings according to sex revealed by bi- and uni-parental genetic markers
Estimates of African, European, and Amerindian contributions to the gene pool of 11 predominantly African-derived South American populations were obtained using five autosomal and one Y chromosome hypervariable loci, as well as mitochondrial DNA (sequences of the first hypervariable segment of the control region, plus two restriction sites and the presence or absence of the CoII/tRNA(Lys) intergenic 9-bp deletion). The three latter characteristic…
Genetic diversity of two African and sixteen South American populations determined on the basis of six hypervariable loci
A total of 582 individuals (1,164 chromosomes) from two African, eight African-derived South American, five South American Amerindian, and three Brazilian urban populations were studied at four variable number of tandem repeat (VNTR) and two short tandem repeat (STR) hypervariable loci. These two sets of loci did not show distinct allele profiles, which might be expected if different processes promoted their molecular differentiation. The two Afr…
Genetic diversity of two African and sixteen South American populations determined on the basis of six hypervariable loci
A total of 582 individuals (1,164 chromosomes) from two African, eight African-derived South American, five South American Amerindian, and three Brazilian urban populations were studied at four variable number of tandem repeat (VNTR) and two short tandem repeat (STR) hypervariable loci. These two sets of loci did not show distinct allele profiles, which might be expected if different processes promoted their molecular differentiation. The two Afr…
Population structure of two black Venezuelan populations studied through their mating structure and other related variables
In order to obtain information about the population structure of two black Venezuelan populations with historical differences both in their origins and development, a variety of variables were utilized, especially on marital structure, including: frequency of surnames, isonymy, population genealogical consanguinity, multiple unions, and marital distances, all of which provided information and isolation, migration, endogamy, consanguinity, and pat…
Beta-globin gene cluster haplotypes in an admixed Venezuelan population
Haplotype frequencies for the beta-globin gene cluster were determined in 96 chromosomes from a Venezuelan mixed population. Twelve haplotypes were observed, the most frequent of which were 2, 3, and 4; all others showed prevalences below 10%. When the results were compared with those of 13 other groups using a phylogenetic tree, they clustered in an intermediate position somewhat nearer to those of four sub-Saharan African populations. This is i…
Coeficient of relationship (RI) within and between four black venezuelan populations
The coefficient of relationship by isonymy Ri was obteined using paternal and maternal surnames of individuals in four black Venezuelan populations. The analysis of eight Ri values obtained from different combinations of surnames within each population and between population in two periods of time (1900–1920 and 1944–1967) show that: 1) Higher values of Ri are those that include combinations of maternal surnames, 2) Ri values of the second period…
Admixture Estimates for Caracas, Venezuela, Based on Autosomal, Y-Chromosome, and mtDNA Markers
The present Venezuelan population is the product of admixture of Amerindians, Europeans, and Africans, a process that was not homogeneous throughout the country. Blood groups, short tandem repeats (STRs), mtDNA, and Y-chromosome markers have been used successfully in admixture studies, but few such studies have been conducted in Venezuela. In this study we aim to estimate the admixture components of samples from two different socioeconomic levels…
Gender Differences in Ancestral Contribution and Admixture in Venezuelan Populations
The origin of the contribution of uniparental heritage were analyzed in 615 samples of individuals proceeding from 13 towns classified according to historic differences in their emergence and development as African-derived, European-derived, and admixed/urban. Mitochondrial and Y-chromosome haplogroups were identified by PCR-restriction fragment length polymorphism. The results were compared with previous estimates of admixture made with autosoma…
Beta-globin gene cluster haplotypes in an admixed Venezuelan population
Haplotype frequencies for the beta-globin gene cluster were determined in 96 chromosomes from a Venezuelan mixed population. Twelve haplotypes were observed, the most frequent of which were 2, 3, and 4; all others showed prevalences below 10%. When the results were compared with those of 13 other groups using a phylogenetic tree, they clustered in an intermediate position somewhat nearer to those of four sub-Saharan African populations. This is i…
Coeficient of relationship (RI) within and between four black venezuelan populations
The coefficient of relationship by isonymy Ri was obteined using paternal and maternal surnames of individuals in four black Venezuelan populations. The analysis of eight Ri values obtained from different combinations of surnames within each population and between population in two periods of time (1900–1920 and 1944–1967) show that: 1) Higher values of Ri are those that include combinations of maternal surnames, 2) Ri values of the second period…
African-derived South American populations: A history of symmetrical and asymmetrical matings according to sex revealed by bi- and uni-parental genetic markers
Estimates of African, European, and Amerindian contributions to the gene pool of 11 predominantly African-derived South American populations were obtained using five autosomal and one Y chromosome hypervariable loci, as well as mitochondrial DNA (sequences of the first hypervariable segment of the control region, plus two restriction sites and the presence or absence of the CoII/tRNA(Lys) intergenic 9-bp deletion). The three latter characteristic…
Genetic diversity of two African and sixteen South American populations determined on the basis of six hypervariable loci
A total of 582 individuals (1,164 chromosomes) from two African, eight African-derived South American, five South American Amerindian, and three Brazilian urban populations were studied at four variable number of tandem repeat (VNTR) and two short tandem repeat (STR) hypervariable loci. These two sets of loci did not show distinct allele profiles, which might be expected if different processes promoted their molecular differentiation. The two Afr…
Genetic diversity of two African and sixteen South American populations determined on the basis of six hypervariable loci
A total of 582 individuals (1,164 chromosomes) from two African, eight African-derived South American, five South American Amerindian, and three Brazilian urban populations were studied at four variable number of tandem repeat (VNTR) and two short tandem repeat (STR) hypervariable loci. These two sets of loci did not show distinct allele profiles, which might be expected if different processes promoted their molecular differentiation. The two Afr…
Population structure of two black Venezuelan populations studied through their mating structure and other related variables
In order to obtain information about the population structure of two black Venezuelan populations with historical differences both in their origins and development, a variety of variables were utilized, especially on marital structure, including: frequency of surnames, isonymy, population genealogical consanguinity, multiple unions, and marital distances, all of which provided information and isolation, migration, endogamy, consanguinity, and pat…
Beta‐globin gene cluster haplotypes as evidence of African gene flow to the northeastern coast of Venezuela
In order to study the origin of mutation HBB*S in Sucre and Anzoátegui states and the genetic affinities of these Venezuelan populations with other human groups, the β‐globin gene cluster haplotypes were determined for 28 sickle cell and/or S‐beta thalassemia patients and for 37 individuals with normal hematological parameters. Bantu, Benin, Senegal, and atypical haplotypes were identified in 50%, 36%, 2%, and 12% of the HBB*S chromosomes, respec…
Admixture estimates for Churuguara, a Venezuelan town in the State of Falcón
Results of the admixture analysis are consistent with those obtained with two dendrograms and principal component analyses, suggesting that the strong initial Amerindian component of 500 years ago has been diluted by the continuous flow of European genes, mainly Spanish, to this region
Admixture Estimates for Caracas, Venezuela, Based on Autosomal, Y-Chromosome, and mtDNA Markers
The present Venezuelan population is the product of admixture of Amerindians, Europeans, and Africans, a process that was not homogeneous throughout the country. Blood groups, short tandem repeats (STRs), mtDNA, and Y-chromosome markers have been used successfully in admixture studies, but few such studies have been conducted in Venezuela. In this study we aim to estimate the admixture components of samples from two different socioeconomic levels…
Gender Differences in Ancestral Contribution and Admixture in Venezuelan Populations
The origin of the contribution of uniparental heritage were analyzed in 615 samples of individuals proceeding from 13 towns classified according to historic differences in their emergence and development as African-derived, European-derived, and admixed/urban. Mitochondrial and Y-chromosome haplogroups were identified by PCR-restriction fragment length polymorphism. The results were compared with previous estimates of admixture made with autosoma…
Implicaciones antropológicas de la presencia del polimorfismo rs9282541 en los warao del delta del Orinoco, Venezuela
El gen ABCA1 juega un importante papel en la extracción del colesterol intracelular para la formación de la molécula de colesterol HDL. Una variante funcional de este gen, la ABCA1*230Cys (polimorfismo rs9282541), ha sido asociada con diversas alteraciones en los niveles de lípidos en sangre. Se le considera un marcador genético de origen amerindio ya que está presente solamente en nativos americanos y en poblaciones mestizas descendientes de ést…
Estimación de mestizaje en dos poblaciones venezolanas usando marcadores informativos de ancestralidad y haplogrupos de ADN mitocondrial
Los marcadores informativos de ancestralidad (AIM) autosómicos y los del ADN mitocondrial (ADNmt) son muy útiles para identificar el origen y los patrones de migración de las poblaciones. En este trabajo se estimó el mestizaje a partir de siete AIM en 188 individuos venezolanos, 84 del estado Guárico y 104 de la región centro occidental de Venezuela (RCO), se estimó la ancestralidad mitocondrial en el estado Guárico y se compararon ambas poblacio…
Biology (10 works) · Forensic and Genetic Research (10 works) · Demography (9 works) · Gene (9 works) · Population (9 works) · Genetics (8 works) · Evolutionary biology (7 works) · Genetic diversity and population structure (7 works) · Genetic diversity (6 works) · Genetics (6 works)