Marco Antonio Zago
Biographic Data
| ID | 107431 |
|---|---|
| NAME | Marco Antonio Zago |
| GIVEN NAMES | Marco Antonio |
| FAMILY NAME | Zago |
| SIGNATURE | ZAGO M A |
| AFFILIATIONS | Universidade de São Paulo |
| ORCID | 0000-0002-2840-0650 |
| VERIFIED | Yes |
| TOTAL WORKS | 18 |
| TOTAL CITATIONS | 32 |
| AUTHOR COUNT | 18 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1992 |
| LATEST PUBLICATION YEAR | 2022 |
| H-INDEX | 3 |
Anos de Fapesp
A Fapesp é hoje a mais sólida agência de apoio a pesquisa do país. Foi forjada ao longo de quase oito décadas, com forte inspiração do positivismo em suas origens. Seu modelo jurídico influenciou todas as demais fundações estaduais similares do país, associando a garantia constitucional de estabilidade orçamentária e a gestão autônoma que destina 95% de seus recursos orçamentários à pesquisa, em todas as áreas do conhecimento. Em 60 anos, a agênc…
Estimates of interethnic admixture in the Brazilian population using a panel of 24 X‐linked insertion/deletion markers
Objectives. In this study, we aimed to identify ancestry informative haplotypes and make interethnic admixture estimates using X‐chromosome markers. Methods. A significant sample (461 individuals) of European, African, and Native American populations was analyzed, and four linkage groups were identified. The data obtained were used to describe the ancestral contribution of populations from four different geographical regions of Brazil (745 indivi…
Assessing interethnic admixture using an X‐linked insertion‐deletion multiplex
In this study, a PCR multiplex was optimized, allowing the simultaneous analysis of 13 X‐chromosome Insertion/deletion polymorphisms (INDELs). Genetic variation observed in Africans, Europeans, and Native Americans reveals high inter‐population variability. The estimated proportions of X‐chromosomes in an admixed population from the Brazilian Amazon region show a predominant Amerindian contribution (≅41%), followed by European (≅32%) and African …
Mitochondrial Population Genomics Supports a Single Pre-Clovis Origin with a Coastal Route for the Peopling of the Americas
MtDNA Haplogroup Analysis of Black Brazilian and Sub-Saharan Populations
Seventy individuals from two African and four black Brazilian populations were studied for the first hypervariable segment of mtDNA. To delineate a more complete phylogeographic scenario of the African mtDNA haplogroups in Brazil and to provide additional information on the nature of the Atlantic slave trade, we analyzed our data together with previously published data. The results indicate different sources of African slaves for the four major B…
Modern cancer epidemiological research
Individual cancer susceptibility seems to be related to factors such as changes in oncogenes and tumor suppressor genes expression, and differences in the action of metabolic enzymes and DNA repair regulated by specific genes. Epidemiological studies on genetic polymorphisms of human xenobiotics metabolizing enzymes and cancer have revealed low relative risks. Research considering genetic polymorphisms prevalence jointly with environmental exposu…
A pesquisa clínica no Brasil
O fortalecimento da pesquisa clínica no Brasil implica a criação, expansão ou consolidação de novos centros, em especial na recuperação dos hospitais universitários e do fortalecimento do vínculo entre ensino e pesquisa. A interação entre pesquisa biomédica e básica é indispensável para geração de conhecimento nacional em questões específicas e para estruturar o setor produtivo de tecnologia ligada à saúde. As mudanças do perfil demográfico e epi…
Heterogeneity of the Y Chromosome in Afro-Brazilian Populations
Sixteen biallelic markers (SRY10831a, SRY10831b, SRY4064, SRY2627, 92R7, P2, P3, M34, M9, M3, M2, YAP, M60, M89, M213, M216) located in the nonrecombinant region of the Y chromosome were analyzed in 209 individuals belonging to six Brazilian populations: four Afro-Brazilian populations, one population of white European descendants, and one population of Japanese descendants. The results showed that most of the Y chromosomes of the Afro-Brazilians…
African-derived South American populations
Estimates of African, European, and Amerindian contributions to the gene pool of 11 predominantly African-derived South American populations were obtained using five autosomal and one Y chromosome hypervariable loci, as well as mitochondrial DNA (sequences of the first hypervariable segment of the control region, plus two restriction sites and the presence or absence of the CoII/tRNA(Lys) intergenic 9-bp deletion). The three latter characteristic…
Heterogeneity of Y chromosome markers among Brazilian Amerindians
The allele frequency distribution of DYS19 and DYS199 loci were analyzed in 59 Brazilian Amerindians from five tribes from the Amazon region (Zoé, Awá-Guajá, Urubú-Kaapór, Katuena, and Kayapó, Xikrin of Bacajá village). Three different alleles of the DYS19 microsatellite (182-bp, 186-bp, and 190-bp) were found at average frequencies of 0.08, 0.85, and 0.07, respectively. The DYS199-T allele was identified in 78% of the Amerindians studied (43/55)…
Genetic diversity of two African and sixteen South American populations determined on the basis of six hypervariable loci
A total of 582 individuals (1,164 chromosomes) from two African, eight African-derived South American, five South American Amerindian, and three Brazilian urban populations were studied at four variable number of tandem repeat (VNTR) and two short tandem repeat (STR) hypervariable loci. These two sets of loci did not show distinct allele profiles, which might be expected if different processes promoted their molecular differentiation. The two Afr…
Genetic diversity of two African and sixteen South American populations determined on the basis of six hypervariable loci
A total of 582 individuals (1,164 chromosomes) from two African, eight African-derived South American, five South American Amerindian, and three Brazilian urban populations were studied at four variable number of tandem repeat (VNTR) and two short tandem repeat (STR) hypervariable loci. These two sets of loci did not show distinct allele profiles, which might be expected if different processes promoted their molecular differentiation. The two Afr…
Differential contribution of indigenous men and women to the formation of an urban population in the Amazon region as revealed by mtDNA and Y‐dNA
The human populations of the Brazilian Amazon were formed by interethnic crosses between Europeans, Africans, and Amerindians. The relative contribution of men and women of different ethnic groups was not homogeneous, since the social policies of the first three centuries of Brazilian colonization encouraged mating between European men and indigenous women and, later on, African women. In order to test this model based on historical data, we comp…
MtDNA and the indigenous ocupation ot the Amazon
Diversas abordagens têm sido empregadas na tentativa de responder questões sobre a origem e a dispersão do homem nas Américas. Do ponto de vista da biologia, a investigação da variabilidade presente no DNA mitocondrial (mtDNA) tem se revelado um excelente instrumento para este fim. Os dados acumulados a partir da investigação de populações indígenas contemporâneas indicam: i) a existência de um estrangulamento populacional dramático durante a mig…
Genetic variability in two Brazilian ethnic groups
Sequence data from the first hypervariable segment of the mitochondrial DNA control region of 124 subjects belonging to three African-Brazilian and three Brazilian Indian populations were compared with information related to 12 protein genetic loci from 601 persons living in the same localities. There is high diversity among the mtDNA sites, and the most variable in one ethnic group are not the most variable in the other. No differences in gene d…
Heterogeneity of mitochondrial DNA haplotypes in Pre‐Columbian natives of the Amazon region
We report the first study of mitochondrial DNA (mtDNA) sequencing from ancestral Amerindian populations of the South American continent. Sequencing of the D-loop region of mtDNA was carried out for bone fragments from 18 skeletons of Pre-Columbian Amerinidians. The skeletons were excavated in different archeological sites of the Brazilian Amazon region, with dating estimated at 500–4,000 years before the present. The sequencing of at least 354 ba…
Heterogeneity of mitochondrial DNA haplotypes in Pre-Columbian natives of the Amazon region
We report the first study of mitochondrial DNA (mtDNA) sequencing from ancestral Amerindian populations of the South American continent. Sequencing of the D-loop region of mtDNA was carried out for bone fragments from 18 skeletons of Pre-Columbian Amerinidians. The skeletons were excavated in different archeological sites of the Brazilian Amazon region, with dating estimated at 500-4,000 years before the present. The sequencing of at least 354 ba…
Bantu β s cluster haplotype predominates among Brazilian Blacks
We describe the combination of polymorphic restriction‐enzyme sites in the β globin gene cluster (haplotypes) for 74 chromosomes from Brazilian Blacks bearing the sickle hemoglobin gene (β s ). The three most common African β s haplotypes account for 67 chromosomes: 49/74 (66.2%) were identified as Central African Republic (CAR or Bantu) type, 17 (23.0%) as Benin, and one as Senegal; seven chromosomes (9.5%) had minor atypical haplotypes. This di…
Heterogeneity of the Y Chromosome in Afro-Brazilian Populations
Sixteen biallelic markers (SRY10831a, SRY10831b, SRY4064, SRY2627, 92R7, P2, P3, M34, M9, M3, M2, YAP, M60, M89, M213, M216) located in the nonrecombinant region of the Y chromosome were analyzed in 209 individuals belonging to six Brazilian populations: four Afro-Brazilian populations, one population of white European descendants, and one population of Japanese descendants. The results showed that most of the Y chromosomes of the Afro-Brazilians…
Bantu β s cluster haplotype predominates among Brazilian Blacks
We describe the combination of polymorphic restriction‐enzyme sites in the β globin gene cluster (haplotypes) for 74 chromosomes from Brazilian Blacks bearing the sickle hemoglobin gene (β s ). The three most common African β s haplotypes account for 67 chromosomes: 49/74 (66.2%) were identified as Central African Republic (CAR or Bantu) type, 17 (23.0%) as Benin, and one as Senegal; seven chromosomes (9.5%) had minor atypical haplotypes. This di…
MtDNA Haplogroup Analysis of Black Brazilian and Sub-Saharan Populations
Seventy individuals from two African and four black Brazilian populations were studied for the first hypervariable segment of mtDNA. To delineate a more complete phylogeographic scenario of the African mtDNA haplogroups in Brazil and to provide additional information on the nature of the Atlantic slave trade, we analyzed our data together with previously published data. The results indicate different sources of African slaves for the four major B…
Bantu β s cluster haplotype predominates among Brazilian Blacks
We describe the combination of polymorphic restriction‐enzyme sites in the β globin gene cluster (haplotypes) for 74 chromosomes from Brazilian Blacks bearing the sickle hemoglobin gene (β s ). The three most common African β s haplotypes account for 67 chromosomes: 49/74 (66.2%) were identified as Central African Republic (CAR or Bantu) type, 17 (23.0%) as Benin, and one as Senegal; seven chromosomes (9.5%) had minor atypical haplotypes. This di…
Heterogeneity of mitochondrial DNA haplotypes in Pre‐Columbian natives of the Amazon region
We report the first study of mitochondrial DNA (mtDNA) sequencing from ancestral Amerindian populations of the South American continent. Sequencing of the D-loop region of mtDNA was carried out for bone fragments from 18 skeletons of Pre-Columbian Amerinidians. The skeletons were excavated in different archeological sites of the Brazilian Amazon region, with dating estimated at 500–4,000 years before the present. The sequencing of at least 354 ba…
Heterogeneity of mitochondrial DNA haplotypes in Pre-Columbian natives of the Amazon region
We report the first study of mitochondrial DNA (mtDNA) sequencing from ancestral Amerindian populations of the South American continent. Sequencing of the D-loop region of mtDNA was carried out for bone fragments from 18 skeletons of Pre-Columbian Amerinidians. The skeletons were excavated in different archeological sites of the Brazilian Amazon region, with dating estimated at 500-4,000 years before the present. The sequencing of at least 354 ba…
MtDNA and the indigenous ocupation ot the Amazon
Diversas abordagens têm sido empregadas na tentativa de responder questões sobre a origem e a dispersão do homem nas Américas. Do ponto de vista da biologia, a investigação da variabilidade presente no DNA mitocondrial (mtDNA) tem se revelado um excelente instrumento para este fim. Os dados acumulados a partir da investigação de populações indígenas contemporâneas indicam: i) a existência de um estrangulamento populacional dramático durante a mig…
Genetic variability in two Brazilian ethnic groups
Sequence data from the first hypervariable segment of the mitochondrial DNA control region of 124 subjects belonging to three African-Brazilian and three Brazilian Indian populations were compared with information related to 12 protein genetic loci from 601 persons living in the same localities. There is high diversity among the mtDNA sites, and the most variable in one ethnic group are not the most variable in the other. No differences in gene d…
African-derived South American populations
Estimates of African, European, and Amerindian contributions to the gene pool of 11 predominantly African-derived South American populations were obtained using five autosomal and one Y chromosome hypervariable loci, as well as mitochondrial DNA (sequences of the first hypervariable segment of the control region, plus two restriction sites and the presence or absence of the CoII/tRNA(Lys) intergenic 9-bp deletion). The three latter characteristic…
Heterogeneity of Y chromosome markers among Brazilian Amerindians
The allele frequency distribution of DYS19 and DYS199 loci were analyzed in 59 Brazilian Amerindians from five tribes from the Amazon region (Zoé, Awá-Guajá, Urubú-Kaapór, Katuena, and Kayapó, Xikrin of Bacajá village). Three different alleles of the DYS19 microsatellite (182-bp, 186-bp, and 190-bp) were found at average frequencies of 0.08, 0.85, and 0.07, respectively. The DYS199-T allele was identified in 78% of the Amerindians studied (43/55)…
Genetic diversity of two African and sixteen South American populations determined on the basis of six hypervariable loci
A total of 582 individuals (1,164 chromosomes) from two African, eight African-derived South American, five South American Amerindian, and three Brazilian urban populations were studied at four variable number of tandem repeat (VNTR) and two short tandem repeat (STR) hypervariable loci. These two sets of loci did not show distinct allele profiles, which might be expected if different processes promoted their molecular differentiation. The two Afr…
Genetic diversity of two African and sixteen South American populations determined on the basis of six hypervariable loci
A total of 582 individuals (1,164 chromosomes) from two African, eight African-derived South American, five South American Amerindian, and three Brazilian urban populations were studied at four variable number of tandem repeat (VNTR) and two short tandem repeat (STR) hypervariable loci. These two sets of loci did not show distinct allele profiles, which might be expected if different processes promoted their molecular differentiation. The two Afr…
Differential contribution of indigenous men and women to the formation of an urban population in the Amazon region as revealed by mtDNA and Y‐dNA
The human populations of the Brazilian Amazon were formed by interethnic crosses between Europeans, Africans, and Amerindians. The relative contribution of men and women of different ethnic groups was not homogeneous, since the social policies of the first three centuries of Brazilian colonization encouraged mating between European men and indigenous women and, later on, African women. In order to test this model based on historical data, we comp…
A pesquisa clínica no Brasil
O fortalecimento da pesquisa clínica no Brasil implica a criação, expansão ou consolidação de novos centros, em especial na recuperação dos hospitais universitários e do fortalecimento do vínculo entre ensino e pesquisa. A interação entre pesquisa biomédica e básica é indispensável para geração de conhecimento nacional em questões específicas e para estruturar o setor produtivo de tecnologia ligada à saúde. As mudanças do perfil demográfico e epi…
Heterogeneity of the Y Chromosome in Afro-Brazilian Populations
Sixteen biallelic markers (SRY10831a, SRY10831b, SRY4064, SRY2627, 92R7, P2, P3, M34, M9, M3, M2, YAP, M60, M89, M213, M216) located in the nonrecombinant region of the Y chromosome were analyzed in 209 individuals belonging to six Brazilian populations: four Afro-Brazilian populations, one population of white European descendants, and one population of Japanese descendants. The results showed that most of the Y chromosomes of the Afro-Brazilians…
Modern cancer epidemiological research
Individual cancer susceptibility seems to be related to factors such as changes in oncogenes and tumor suppressor genes expression, and differences in the action of metabolic enzymes and DNA repair regulated by specific genes. Epidemiological studies on genetic polymorphisms of human xenobiotics metabolizing enzymes and cancer have revealed low relative risks. Research considering genetic polymorphisms prevalence jointly with environmental exposu…
MtDNA Haplogroup Analysis of Black Brazilian and Sub-Saharan Populations
Seventy individuals from two African and four black Brazilian populations were studied for the first hypervariable segment of mtDNA. To delineate a more complete phylogeographic scenario of the African mtDNA haplogroups in Brazil and to provide additional information on the nature of the Atlantic slave trade, we analyzed our data together with previously published data. The results indicate different sources of African slaves for the four major B…
Mitochondrial Population Genomics Supports a Single Pre-Clovis Origin with a Coastal Route for the Peopling of the Americas
Assessing interethnic admixture using an X‐linked insertion‐deletion multiplex
In this study, a PCR multiplex was optimized, allowing the simultaneous analysis of 13 X‐chromosome Insertion/deletion polymorphisms (INDELs). Genetic variation observed in Africans, Europeans, and Native Americans reveals high inter‐population variability. The estimated proportions of X‐chromosomes in an admixed population from the Brazilian Amazon region show a predominant Amerindian contribution (≅41%), followed by European (≅32%) and African …
Estimates of interethnic admixture in the Brazilian population using a panel of 24 X‐linked insertion/deletion markers
Objectives. In this study, we aimed to identify ancestry informative haplotypes and make interethnic admixture estimates using X‐chromosome markers. Methods. A significant sample (461 individuals) of European, African, and Native American populations was analyzed, and four linkage groups were identified. The data obtained were used to describe the ancestral contribution of populations from four different geographical regions of Brazil (745 indivi…
Anos de Fapesp
A Fapesp é hoje a mais sólida agência de apoio a pesquisa do país. Foi forjada ao longo de quase oito décadas, com forte inspiração do positivismo em suas origens. Seu modelo jurídico influenciou todas as demais fundações estaduais similares do país, associando a garantia constitucional de estabilidade orçamentária e a gestão autônoma que destina 95% de seus recursos orçamentários à pesquisa, em todas as áreas do conhecimento. Em 60 anos, a agênc…
Biology (16 works) · Forensic and Genetic Research (14 works) · Gene (14 works) · Genetics (13 works) · Genetics (11 works) · Demography (10 works) · Evolutionary biology (10 works) · Geography (9 works) · Allele (8 works) · Haplotype (8 works)