A Clarke
Biographic Data
| ID | 12134 |
|---|---|
| NAME | A Clarke |
| GIVEN NAMES | A |
| FAMILY NAME | Clarke |
| SIGNATURE | CLARKE A |
| AFFILIATIONS | Cardiff University |
| ORCID | 0000-0002-1200-9286 |
| VERIFIED | Yes |
| TOTAL WORKS | 47 |
| TOTAL CITATIONS | 156 |
| AUTHOR COUNT | 47 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1970 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 7 |
Non‐Directiveness and Authenticity in the Predictive Genetic Clinic
The predictive genetic clinic is a space where counsellors use non‐directive counselling to facilitate asymptomatic patients at risk of carrying a dominantly inherited disease access a predictive genetic test. The social science literature has a history of examining practices within this clinic, but with little attention from the sociology of identity. In this paper, we highlight the importance of identity within these clinics by examining how cu…
Communicating Genetic Information in Families with Inherited Late-Onset Neurodegenerative Diseases: A Scoping Review
Communicating genetic information within families living with inherited genetic conditions (IGCs), especially incurable and progressive late-onset neurodegenerative diseases (LONDs), presents significant challenges. To date, no literature review has specifically addressed this issue in families with LONDs. To fill this gap, a scoping review was conducted following PRISMA and JBI guidelines. Four databases (Scopus, Web of Science, PubMed, and Psyc…
Delivering a Specialised Best Practice Service for People with Functional Neurological Disorder: An Australian Qualitative Descriptive Study
Specialised functional neurological disorder (FND) clinics are emerging as the preferred way of providing best practice care to people with FND. However, questions remain around optimal care pathways, service provision, and resources. This study aimed to identify (1) service characteristics of Australian FND models of care; (2) barriers and enablers to implementing a specialised FND service; and (3) enablers and barriers to providing best practic…
Taking after a parent: Phenotypic resemblance and the professional familialisation of genomics
This article draws on 2 years' worth of ethnographic observation of team meetings to explore decision-making in an NHS clinical genomics service. The focus of discussions was on ambiguous genomic results known as VUS or Variants of Uncertain Significance, which may be pathogenic but which also may turn out to be benign. In examining decision-making around such results, we note how, in contrast to much policy and promotional material in this area,…
Reflexive standardization and the resolution of uncertainty in the genomics clinic
In genomics, the clinical application of Next Generation Sequencing technologies (such as Whole Genome or Exome Sequencing) has attracted considerable attention from UK policymakers, interested in the benefits such technologies could bring the National Health Service. However, this boosterism plays little attention to the challenges raised by a kind of result known as a Variant of Uncertain Significance, or VUS, which require clinical geneticists…
The impact of the Covid-19 pandemic on UK medical education. A nationwide student survey
The COVID-19 pandemic had a significant impact on the delivery of medical education across the UK, with the majority of face-to-face teaching cancelled during the first wave, and medical schools consequently making varied adaptations to education delivery. To identify and share effective adaptations, we conducted a cross-sectional, online survey (COVID Med-Ed) between 20th May and 31st August 2020 which divided undergraduate teaching by GMC “Outc…
Can Genomics Remove Uncertainty from Adoption? Social Workers’ and Medical Advisors’ Accounts of Genetic Testing
Genetic testing is controversial in adoption with professionals taking different positions on whether children should be protected from genetic information or whether it can be used to assist adoption. In this article, we argue that advances in ‘genome-wide’ testing add further complications to these debates. Although next-generation sequencing (NGS) and microarray-based technologies can offer high-quality molecular diagnoses for a variety of con…
Genetic testing and family entanglements
The development of the 'new genetics' in the early 1990's opened up a new space which required some patients and families to understand and navigate genetic testing. The social science literature that has grown alongside the 'new genetics', now spanning more than thirty years, has continued to explore and question assumptions about attitudes and responses towards genetic technologies. In this article we highlight how individual experience of gene…
New Evidence for Upland Occupation in the Mesolithic of Scotland
This paper discusses the evidence for periodic human activity in the Cairngorm Mountains of Scotland from the late 9th millennium to the early 4th millennium cal bc . While contemporary paradigms for Mesolithic Europe acknowledge the significance of upland environments, the archaeological record for these areas is not yet as robust as that for the lowland zone. Results of excavation at Chest of Dee, along the headwaters of the River Dee, are set …
Co-creating a knowledge base in the “22q11.2 deletion syndrome” community
22q11.2 DS is characterised by its variability, rarity and variety of features ranging from congenital heart conditions to psychiatric and behavioural issues. As a result, health information-seeking behaviour is different from other more common conditions. An exploratory study was carried out to understand how parents access information and support, and how that information is shared. Qualitative interviews were carried out with families and supp…
Hidden in plain sight: Uncovering the emotional labor of Black women students at historically White colleges and universities
Dimensions of responsibility in medical genetics: Exploring the complexity of the “duty to recontact”
Discussion of a “duty to recontact” emerged as technological advances left professionals considering getting back in touch with patients they had seen in the past. While there has been much discussion of the duty to recontact as a matter of theory and ethics, there has been rather little empirically based analysis of what this “duty” consists of. Drawing on interviews with 34 professionals working in, or closely with, genetics services, this pape…
Discredited legacy: Stigma and familial amyloid polyneuropathy in Northwestern Portugal
Culture, Kinship and Genes: Towards Cross-Cultural Genetics
Anticipated stigma and blameless guilt: Mothers' evaluation of life with the sex-linked disorder, hypohidrotic ectodermal dysplasia (XHED)
Practical experience of a genetic disorder may influence how parents approach reproduction, if they know their child may be affected by an inherited condition. One important aspect of this practical experience is the stigmatisation which family members may experience or witness. We outline the concept of stigma and how it affects those in families with a condition that impacts upon physical appearance. We then consider the accounts given by femal…
Challenges for providing genetic counselling in Colombian genetic clinics: The viewpoint of the physicians providing genetic consultations
Genetics and ethics in Latin America
PP45 Developing Recommendations to Improve the Effectiveness of Multidisciplinary Team Meetings for Patients with Chronic Diseases
Background Multidisciplinary team meetings (MDMs) have been endorsed by the Department of Health as the core model for managing chronic diseases. It is believed that MDMs ensure higher quality decision making and improved outcomes. However, the evidence underpinning the development of MDMs is not strong and the degree to which MDMs have been absorbed into clinical practice varies widely across conditions and settings. We conducted a large mixed-m…
OP92 Improving the Effectiveness of Multidisciplinary Team Meetings for Patients with Chronic Diseases: Assessing the Predictors of Decision Implementation
Background Department of Health policy states that health care for chronic diseases should be delivered through multidisciplinary team meetings (MDMs). It is known that multidisciplinary teams should include certain features (for example commitment to leadership) to be effective. But additional factors need to be considered: e.g. the context in which MDMs operate, group decision processes, and patient related factors such as their preferences and…
Stigma, Self-esteem and Reproduction: Talking with Men about Life with Hypohidrotic Ectodermal Dysplasia
Interviews were conducted with members of 20 families, including affected males, to explore their experiences of life with hypohidrotic ectodermal dysplasia (HED), which impacts physical appearance. Stigmatisation is an important aspect of life for affected males; choosing how to respond becomes an important aspect of identity. Strategies include consolation, complaint, the rejection of complaint, humour and retaliation. Affected males suggest pa…
Voicing the lifeworld: Parental accounts of responsibility in genetic consultations for polycystic kidney disease
Implementation of a campus-wide Irish hospital smoking ban in 2009: Prevalence and attitudinal trends among staff and patients in lead up
We report the evidence base that supported the decision to implement the first campus-wide hospital smoking ban in the Republic of Ireland with effect from 1 January 2009. Three separate data sources are utilized; surveillance data collected from patients and staff in 8 surveys between 1997 and 2006, a 1-week observational study to assess smoker behaviour in designated smoking shelters and an attitudinal interview with 28 smoker patients and 30 s…
Managing self-responsibility through other-oriented blame: Family accounts of genetic testing
The micropolitics of responsibility vis-à-vis autonomy: Parental Accounts of Childhood Genetic Testing and (Non)disclosure
Genetic testing and (non)disclosure of genetic information present ethical and moral dilemmas for the management of parental responsibility vis-à-vis the child's autonomy. Ethical guidelines aimed at professionals currently seek to defer childhood testing where there is no clear medical or psychosocial benefit. This version of autonomy is derived from a bioethical paradigm which brackets the individual rights and capacities of the child. In this …
Rebirthing the Clinic: The Interaction of Clinical Judgment and Genetic Technology in the Production of Medical Science
The article reconsiders the nature and location of science in the development of genetic classification. Drawing on field studies of medical genetics, we explore how patient categorization is accomplished in between the clinic and laboratory. We focus on dysmorphology, a specialism concerned with complex syndromes that impair physical development. We show that dys-morphology is about more than fitting patients into prefixed diagnostic categories …
Rebirthing the Clinic: The Interaction of Clinical Judgment and Genetic Technology in the Production of Medical Science
The article reconsiders the nature and location of science in the development of genetic classification. Drawing on field studies of medical genetics, we explore how patient categorization is accomplished in between the clinic and laboratory. We focus on dysmorphology, a specialism concerned with complex syndromes that impair physical development. We show that dys-morphology is about more than fitting patients into prefixed diagnostic categories …
Dysmorphology and the spectacle of the clinic
Dysmorphology is the medical study of abnormal forms in the human and is concerned with the identification and classification of a variety of congenital malformations. Such diagnostic work rests on the inspection of images of affected individuals. Based on physical appearance individuals are classified in terms of a wide range of conditions, often with 'exotic' nomenclatures. This paper will describe the features of clinical dysmorphology and the…
Zones of Expertise and the Management of Uncertainty in Genetics Risk Communication
In the context of risk communication in genetic counseling, there appears to be a tension between clients seeking an authoritative, definitive risk assessment and the geneticist-expert actively defining the boundaries of his or her (in)expertise through formulation of uncertainty that is such a feature of genetic disorders. In the process of demarcating his or her zone of expertise, he or she defers to the judgment of other medical colleagues wit…
Managing self-responsibility through other-oriented blame: Family accounts of genetic testing
Constructing an account by contrast in counselling for childhood genetic testing
Genetic testing and family entanglements
The development of the 'new genetics' in the early 1990's opened up a new space which required some patients and families to understand and navigate genetic testing. The social science literature that has grown alongside the 'new genetics', now spanning more than thirty years, has continued to explore and question assumptions about attitudes and responses towards genetic technologies. In this article we highlight how individual experience of gene…
Excavation of Neolithic enclosures at Cowie Road, Bannockburn, Stirling, 1984-85
Excavations undertaken in 1984 and 1985 on cropmark sites identified as pit and post alignments revealed a bow-ended pit-defined enclosure dated to late-fifth to mid-fourth millennium BC, a post-defined enclosure dated to the mid-fourth to early-third millennium BC, and possible domestic activity. The pits of the enclosure showed up to three phases of use with deposits containing Carinated Bowl-type pottery in the later phases. Medieval or post m…
Hidden in plain sight: Uncovering the emotional labor of Black women students at historically White colleges and universities
The micropolitics of responsibility vis-à-vis autonomy: Parental Accounts of Childhood Genetic Testing and (Non)disclosure
Genetic testing and (non)disclosure of genetic information present ethical and moral dilemmas for the management of parental responsibility vis-à-vis the child's autonomy. Ethical guidelines aimed at professionals currently seek to defer childhood testing where there is no clear medical or psychosocial benefit. This version of autonomy is derived from a bioethical paradigm which brackets the individual rights and capacities of the child. In this …
New Evidence for Upland Occupation in the Mesolithic of Scotland
This paper discusses the evidence for periodic human activity in the Cairngorm Mountains of Scotland from the late 9th millennium to the early 4th millennium cal bc . While contemporary paradigms for Mesolithic Europe acknowledge the significance of upland environments, the archaeological record for these areas is not yet as robust as that for the lowland zone. Results of excavation at Chest of Dee, along the headwaters of the River Dee, are set …
Stigma, Self-esteem and Reproduction: Talking with Men about Life with Hypohidrotic Ectodermal Dysplasia
Interviews were conducted with members of 20 families, including affected males, to explore their experiences of life with hypohidrotic ectodermal dysplasia (HED), which impacts physical appearance. Stigmatisation is an important aspect of life for affected males; choosing how to respond becomes an important aspect of identity. Strategies include consolation, complaint, the rejection of complaint, humour and retaliation. Affected males suggest pa…
Excavation of a timber round-house and broch at the Fairy Knowe, Buchlyvie, Stirlingshire, 1975-8
Reports on work that revealed evidence of occupation of what was essentially a fortified farmhouse by a native elite group practising a mixed-farming economy. There are a number of specialist sections on: `Wooden posts' by John Barber (301--2); `Palaeobotanical remains' by W E Boyd (310--16); `Animal bone' by Catherine Smith & Archie Young (316--20); `Iron Age and Roman pottery' (321--31), `Objects of fired clay' (332--5) and `Industrial fired cl…
Anticipated stigma and blameless guilt: Mothers' evaluation of life with the sex-linked disorder, hypohidrotic ectodermal dysplasia (XHED)
Practical experience of a genetic disorder may influence how parents approach reproduction, if they know their child may be affected by an inherited condition. One important aspect of this practical experience is the stigmatisation which family members may experience or witness. We outline the concept of stigma and how it affects those in families with a condition that impacts upon physical appearance. We then consider the accounts given by femal…
Voicing the lifeworld: Parental accounts of responsibility in genetic consultations for polycystic kidney disease
Excavations at Kaimes Hill, Ratho, City of Edinburgh, 1964 -72
Kaimes Hill, City of Edinburgh, has been the focus for both antiquarian and modern archaeological research since at least the mid-nineteenth century and has produced evidence for activity dating from the Mesolithic through to the medieval period. The paper assimilates this evidence, provides a complete account of the excavations undertaken over the ramparts, `hut circles', prehistoric ritual and funerary monuments by D D A Simpson between 1964--7…
An early metal assemblage from Dail na Caraidh, Inverness-shire, and its context
Between 1980 and 1984 a number of finds of EBA metalwork were recovered via metal-detecting from an area of rough ground at the head of a small disused quarry. This report considers the character of the metalwork and the context in which that material was deposited. It concludes that the entire assemblage could have resulted from more than one period of votive deposition, and that these activities focused upon a prominent, but natural, long mound…
Carronbridge, Dumfries and Galloway: The excavation of Bronze Age cremations, Iron Age settlements and a Roman camp
Cropmarks of a square, double-ditched Iron Age/Romano-British enclosure, a Roman temporary camp and another sub-rectangular enclosure were excavated in advance of road building. All the monuments were plough damaged. The square enclosure had three main enclosure phases. It contained six intersecting circular buildings, one of which was surrounded by a large ditch and three large sunken features with complex, charcoal-rich fills. A cobbled surface…
Short Notices
Journal Article Short Notices Get access AIDAN CLARKE AIDAN CLARKE Trinity CollegeDublin Search for other works by this author on: Oxford Academic Google Scholar The English Historical Review, Volume LXXXV, Issue 336, July 1970, Pages 613-b–614, https://doi.org/10.1093/ehr/LXXXV.336.613-b Published: 01 July 1970
Sleeper effects? in development: Fact or artifact
Intervention and sleeper effects: A reply to Victoria Seitz
American Society of Primatologists Membership List
Burials of possible Romano-British date from Inveresk, East Lothian
Five graves of Romano--British date, possibly associated with the fort or vicus at Inveresk, were revealed during building. The remains of one individual were recovered. There are specialist reports (317 & microfiche) on `Pottery' by Dennis Gallagher, `Human Bone' by Margaret Bruce, and `Animal bone' by Andrew Barlow
Forthcoming in American journal of primatology
Carronbridge, Dumfries and Galloway: The excavation of Bronze Age cremations, Iron Age settlements and a Roman camp
Cropmarks of a square, double-ditched Iron Age/Romano-British enclosure, a Roman temporary camp and another sub-rectangular enclosure were excavated in advance of road building. All the monuments were plough damaged. The square enclosure had three main enclosure phases. It contained six intersecting circular buildings, one of which was surrounded by a large ditch and three large sunken features with complex, charcoal-rich fills. A cobbled surface…
Culture, Kinship and Genes: Towards Cross-Cultural Genetics
The genetic revolution and medicine in the 21st century
We are currently in the midst of a revolution in our understanding of human disease. The greater understanding that has been achieved of many inherited diseases is giving insights into many more common conditions not previously regarded as ‘inherited’. An individual can be identified from a DNA fingerprint obtained from the analysis of a very small DNA sample in a hair root, mouth wash or a blood spot. By the turn of the century, we will know the…
Excavation of a promontory fort and a palisaded homestead at Lower Greenyards, Bannockburn, Stirling, 1982–5
Excavations undertaken in 1982,1984 and 1985 on cropmark sites of a promontory fort and nearby palisaded homestead revealed structural remains mainly of the Iron Age and evidence of occupation or other activity from the Mesolithic to the present day. The palisaded homestead was paralleled by a similar homestead phase of the occupation of the promontory, later replaced by a fort with three periods of defence construction. The project was organized…
Excavation of Neolithic enclosures at Cowie Road, Bannockburn, Stirling, 1984-85
Excavations undertaken in 1984 and 1985 on cropmark sites identified as pit and post alignments revealed a bow-ended pit-defined enclosure dated to late-fifth to mid-fourth millennium BC, a post-defined enclosure dated to the mid-fourth to early-third millennium BC, and possible domestic activity. The pits of the enclosure showed up to three phases of use with deposits containing Carinated Bowl-type pottery in the later phases. Medieval or post m…
Quality of Life in Sle During Active and Inactive Disease States: Differential Contributors to Mental and Physical Health
Dobkin, P. L.; Da Costa, D.; Dritsa, M.; Fortin, P. R.; Senecal, J.; Goulet, J. R.; Choquette, D.; Esdaile, J. M.; Beaulieu, A.; Cividino, A.; Edworthy, S.; Barr, S.; Ensworth, S.; Gladman, D.; Smith, D.; Zummer, M.; Rich, E.; Clarke, A. E. Author Information
Excavation of a timber round-house and broch at the Fairy Knowe, Buchlyvie, Stirlingshire, 1975-8
Reports on work that revealed evidence of occupation of what was essentially a fortified farmhouse by a native elite group practising a mixed-farming economy. There are a number of specialist sections on: `Wooden posts' by John Barber (301--2); `Palaeobotanical remains' by W E Boyd (310--16); `Animal bone' by Catherine Smith & Archie Young (316--20); `Iron Age and Roman pottery' (321--31), `Objects of fired clay' (332--5) and `Industrial fired cl…
An early metal assemblage from Dail na Caraidh, Inverness-shire, and its context
Between 1980 and 1984 a number of finds of EBA metalwork were recovered via metal-detecting from an area of rough ground at the head of a small disused quarry. This report considers the character of the metalwork and the context in which that material was deposited. It concludes that the entire assemblage could have resulted from more than one period of votive deposition, and that these activities focused upon a prominent, but natural, long mound…
Zones of Expertise and the Management of Uncertainty in Genetics Risk Communication
In the context of risk communication in genetic counseling, there appears to be a tension between clients seeking an authoritative, definitive risk assessment and the geneticist-expert actively defining the boundaries of his or her (in)expertise through formulation of uncertainty that is such a feature of genetic disorders. In the process of demarcating his or her zone of expertise, he or she defers to the judgment of other medical colleagues wit…
Artificial platforms of possible Iron Age or Dark Age date on Dùn Mór, Dornie, Skye & Lochalsh
Report a topographical survey and trial excavations that were conducted on a tree-covered ridge near Dornie. A number of artificially enhanced platforms were discovered at different levels on the ridge; these had been created by connecting bedrock outcrops with retaining walls. Walls delimit access to the ridge from the south-east, where there is an isolated platform. A well defined pathway, enhanced in two places by retaining walls, dog-legs up …
Constructing an account by contrast in counselling for childhood genetic testing
On Being an Object of Research: Reflections from a Professional Perspective
1Department of Medical Genetics, University of Wales College of Medicine, Cardiff
'Relatively speaking': Relativisation of genetic risk in counselling for predictive testing
The activity of risk communication in the healthcare setting is contingent upon the associated notions of uncertainty, normality and decision making. Focusing on the context of counselling for predictive genetic testing, we point out that because there is `medical' uncertainty surrounding such testing, the discourse of risk assessment concerning an unwanted event is articulated in terms of the likelihood (in objective, probabilistic language) and…
Excavations of Neolithic and Bronze Age sites near Peterhead, Aberdeenshire, 1998
Several archaeological sites were located and excavated by the Centre for Field Archaeology, University of Edinburgh (CFA) during a watching brief associated with the construction of a c 13km gas pipeline from St Fergus to Peterhead, Aberdeenshire, in the summer of 1998. The discoveries comprised two Neolithic artefact scatters, Bronze Age structures and an enclosure, and two features akin to burnt mounds. Penspen Limited commissioned the work on…
Excavations at Kaimes Hill, Ratho, City of Edinburgh, 1964 -72
Kaimes Hill, City of Edinburgh, has been the focus for both antiquarian and modern archaeological research since at least the mid-nineteenth century and has produced evidence for activity dating from the Mesolithic through to the medieval period. The paper assimilates this evidence, provides a complete account of the excavations undertaken over the ramparts, `hut circles', prehistoric ritual and funerary monuments by D D A Simpson between 1964--7…
Dysmorphology and the spectacle of the clinic
Dysmorphology is the medical study of abnormal forms in the human and is concerned with the identification and classification of a variety of congenital malformations. Such diagnostic work rests on the inspection of images of affected individuals. Based on physical appearance individuals are classified in terms of a wide range of conditions, often with 'exotic' nomenclatures. This paper will describe the features of clinical dysmorphology and the…
Rebirthing the Clinic: The Interaction of Clinical Judgment and Genetic Technology in the Production of Medical Science
The article reconsiders the nature and location of science in the development of genetic classification. Drawing on field studies of medical genetics, we explore how patient categorization is accomplished in between the clinic and laboratory. We focus on dysmorphology, a specialism concerned with complex syndromes that impair physical development. We show that dys-morphology is about more than fitting patients into prefixed diagnostic categories …
Managing self-responsibility through other-oriented blame: Family accounts of genetic testing
The micropolitics of responsibility vis-à-vis autonomy: Parental Accounts of Childhood Genetic Testing and (Non)disclosure
Genetic testing and (non)disclosure of genetic information present ethical and moral dilemmas for the management of parental responsibility vis-à-vis the child's autonomy. Ethical guidelines aimed at professionals currently seek to defer childhood testing where there is no clear medical or psychosocial benefit. This version of autonomy is derived from a bioethical paradigm which brackets the individual rights and capacities of the child. In this …
Psychology (23 works) · Medicine (19 works) · BRCA gene mutations in cancer (12 works) · Computer Science (12 works) · Social Psychology (12 works) · Sociology (12 works) · Biology (11 works) · Archaeology (10 works) · Archaeology and ancient environmental studies (10 works) · Geography (10 works)