M J Devlin
Biographic Data
| ID | 14776 |
|---|---|
| NAME | M J Devlin |
| GIVEN NAMES | M J |
| FAMILY NAME | Devlin |
| SIGNATURE | DEVLIN M J |
| AFFILIATIONS | University of Michigan |
| ORCID | 0000-0003-0845-3090 |
| VERIFIED | Yes |
| TOTAL WORKS | 14 |
| TOTAL CITATIONS | 159 |
| AUTHOR COUNT | 14 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2001 |
| LATEST PUBLICATION YEAR | 2024 |
| H-INDEX | 3 |
Des souris et des Hommes: Plasticité Phénotypique Du Squelette Crâniofacial en Lien Avec La Température Et l'Alimentation
susceptibles d'tre soumis des autorisations d'usage spcifiques
The utility of dried blood spot measurement of bone turnover markers in biological anthropology
Validation of an enzyme‐linked immunoassay assay for osteocalcin, a marker of bone formation, in dried blood spots
OBJECTIVES: Investigating factors that contribute to bone loss and accretion across populations in remote settings is challenging, particularly where diagnostic tools are scarce. To mitigate this challenge, we describe validation of a commercial ELISA assay to measure osteocalcin, a biomarker of bone formation, from dried blood spots (DBS). METHODS: We validated the Osteocalcin Human SimpleStep ELISA kit from Abcam (ab1951214) using 158 matched p…
Development and validation of an Elisa for a biomarker of thyroid dysfunction, thyroid peroxidase autoantibodies (TPO-Ab), in dried blood spots
Background The prevalence of allergic and autoimmune conditions has been steadily increasing in wealthy nations over the past century. One hypothesis put forward to explain this is the Old Friends Hypothesis, which posits that increased hygiene, urbanization, and lifestyle changes have reduced our exposure to parasites and microbes that we co-evolved with, resulting in immune dysregulation. However, research in traditionally living populations, w…
A dried blood spot‐based method to measure levels of tartrate‐resistant acid phosphatase 5b (TRACP‐5b), a marker of bone resorption
OBJECTIVES: A number of basic questions about bone biology have not been answered, including population differences in bone turnover. In part, this stems from the lack of validated minimally invasive biomarker techniques to measure bone formation and resorption in field-based population-level research. The present study addresses this gap by validating a fingerprick dried blood spot (fDBS) assay for tartrate-resistant acid phosphatase 5b (TRACP-5…
Low temperature decreases bone mass in mice: Implications for humans
OBJECTIVES: Humans exhibit significant ecogeographic variation in bone size and shape. However, it is unclear how significantly environmental temperature influences cortical and trabecular bone, making it difficult to recognize adaptation versus acclimatization in past populations. There is some evidence that cold-induced bone loss results from sympathetic nervous system activation and can be reduced by nonshivering thermogenesis (NST) via uncoup…
The “Skinny” on brown fat, obesity, and bone
The discovery that metabolically active brown fat is present in humans throughout ontogeny raises new questions about the interactions between thermoregulatory, metabolic, and skeletal homeostasis. Brown adipose tissue (BAT) is distinct from white adipose tissue (WAT) for its ability to burn, rather than store, energy. BAT uniquely expresses uncoupling protein‐1 (abbreviated as UCP1), which diverts the energy produced by cellular respiration to g…
A comparative study of the trabecular bony architecture of the talus in humans, non-human primates, and Australopithecus
Why does starvation make bones fat
Body fat, or adipose tissue, is a crucial energetic buffer against starvation in humans and other mammals, and reserves of white adipose tissue (WAT) rise and fall in parallel with food intake. Much less is known about the function of bone marrow adipose tissue (BMAT), which are fat cells found in bone marrow. BMAT mass actually increases during starvation, even as other fat depots are being mobilized for energy. This review considers several pos…
Estrogen, exercise, and the skeleton
Patterns of variation in bone size and shape provide crucial data for reconstructing hominin paleobiology, including ecogeographic adaptation, life history, and functional morphology. Measures of bone strength, including robusticity (diaphyseal thickness relative to length) and cross-sectional geometric properties such as moments of area, are particularly useful for inferring behavior because bone tissue adapts to its mechanical environment. Part…
Trabecular bone in the bird knee responds with high sensitivity to changes in load orientation
Wolff's law of trajectorial orientation proposes that trabecular struts align with the orientation of dominant compressive loads within a joint. Although widely considered in skeletal biology, Wolff's law has never been experimentally tested while controlling for ontogenetic stage, activity level,and species differences, all factors that may affect trabecular bone growth. Here we report an experimental test of Wolff's law using a within-species d…
Effects of food processing on masticatory strain and craniofacial growth in a retrognathic face
Abstracts of AAPA poster and podium presentations
The human face differs from most other primates in that it lacks a rostrum and is oriented primarily in the coronal plane. These differences may influence biomechanical resistance to torsional, shearing, and bending forces generated during mastication that are known to affect the growth of the maxillary and mandibular arches. We tested the effects of facial retraction on facial strain patterns using in vivo strain data collected from rock hyraxes…
Articular area responses to mechanical loading: Effects of exercise, age, and skeletal location
How reliable are reconstructions of body mass and joint function based on articular surface areas? While the dynamic relationship between mechanical loading and cross‐sectional geometry in long bones is well‐established, the effect of loading on the subchondral articular surface area of epiphyses (hereafter, articular surface area, or ASA) has not been experimentally tested. The degree to which ASA can change in size and shape is important, becau…
Articular area responses to mechanical loading: Effects of exercise, age, and skeletal location
How reliable are reconstructions of body mass and joint function based on articular surface areas? While the dynamic relationship between mechanical loading and cross‐sectional geometry in long bones is well‐established, the effect of loading on the subchondral articular surface area of epiphyses (hereafter, articular surface area, or ASA) has not been experimentally tested. The degree to which ASA can change in size and shape is important, becau…
A comparative study of the trabecular bony architecture of the talus in humans, non-human primates, and Australopithecus
The “Skinny” on brown fat, obesity, and bone
The discovery that metabolically active brown fat is present in humans throughout ontogeny raises new questions about the interactions between thermoregulatory, metabolic, and skeletal homeostasis. Brown adipose tissue (BAT) is distinct from white adipose tissue (WAT) for its ability to burn, rather than store, energy. BAT uniquely expresses uncoupling protein‐1 (abbreviated as UCP1), which diverts the energy produced by cellular respiration to g…
Development and validation of an Elisa for a biomarker of thyroid dysfunction, thyroid peroxidase autoantibodies (TPO-Ab), in dried blood spots
Background The prevalence of allergic and autoimmune conditions has been steadily increasing in wealthy nations over the past century. One hypothesis put forward to explain this is the Old Friends Hypothesis, which posits that increased hygiene, urbanization, and lifestyle changes have reduced our exposure to parasites and microbes that we co-evolved with, resulting in immune dysregulation. However, research in traditionally living populations, w…
Low temperature decreases bone mass in mice: Implications for humans
OBJECTIVES: Humans exhibit significant ecogeographic variation in bone size and shape. However, it is unclear how significantly environmental temperature influences cortical and trabecular bone, making it difficult to recognize adaptation versus acclimatization in past populations. There is some evidence that cold-induced bone loss results from sympathetic nervous system activation and can be reduced by nonshivering thermogenesis (NST) via uncoup…
Abstracts of AAPA poster and podium presentations
The human face differs from most other primates in that it lacks a rostrum and is oriented primarily in the coronal plane. These differences may influence biomechanical resistance to torsional, shearing, and bending forces generated during mastication that are known to affect the growth of the maxillary and mandibular arches. We tested the effects of facial retraction on facial strain patterns using in vivo strain data collected from rock hyraxes…
Articular area responses to mechanical loading: Effects of exercise, age, and skeletal location
How reliable are reconstructions of body mass and joint function based on articular surface areas? While the dynamic relationship between mechanical loading and cross‐sectional geometry in long bones is well‐established, the effect of loading on the subchondral articular surface area of epiphyses (hereafter, articular surface area, or ASA) has not been experimentally tested. The degree to which ASA can change in size and shape is important, becau…
Abstracts of AAPA poster and podium presentations
The human face differs from most other primates in that it lacks a rostrum and is oriented primarily in the coronal plane. These differences may influence biomechanical resistance to torsional, shearing, and bending forces generated during mastication that are known to affect the growth of the maxillary and mandibular arches. We tested the effects of facial retraction on facial strain patterns using in vivo strain data collected from rock hyraxes…
Effects of food processing on masticatory strain and craniofacial growth in a retrognathic face
Trabecular bone in the bird knee responds with high sensitivity to changes in load orientation
Wolff's law of trajectorial orientation proposes that trabecular struts align with the orientation of dominant compressive loads within a joint. Although widely considered in skeletal biology, Wolff's law has never been experimentally tested while controlling for ontogenetic stage, activity level,and species differences, all factors that may affect trabecular bone growth. Here we report an experimental test of Wolff's law using a within-species d…
Why does starvation make bones fat
Body fat, or adipose tissue, is a crucial energetic buffer against starvation in humans and other mammals, and reserves of white adipose tissue (WAT) rise and fall in parallel with food intake. Much less is known about the function of bone marrow adipose tissue (BMAT), which are fat cells found in bone marrow. BMAT mass actually increases during starvation, even as other fat depots are being mobilized for energy. This review considers several pos…
Estrogen, exercise, and the skeleton
Patterns of variation in bone size and shape provide crucial data for reconstructing hominin paleobiology, including ecogeographic adaptation, life history, and functional morphology. Measures of bone strength, including robusticity (diaphyseal thickness relative to length) and cross-sectional geometric properties such as moments of area, are particularly useful for inferring behavior because bone tissue adapts to its mechanical environment. Part…
A comparative study of the trabecular bony architecture of the talus in humans, non-human primates, and Australopithecus
The “Skinny” on brown fat, obesity, and bone
The discovery that metabolically active brown fat is present in humans throughout ontogeny raises new questions about the interactions between thermoregulatory, metabolic, and skeletal homeostasis. Brown adipose tissue (BAT) is distinct from white adipose tissue (WAT) for its ability to burn, rather than store, energy. BAT uniquely expresses uncoupling protein‐1 (abbreviated as UCP1), which diverts the energy produced by cellular respiration to g…
Low temperature decreases bone mass in mice: Implications for humans
OBJECTIVES: Humans exhibit significant ecogeographic variation in bone size and shape. However, it is unclear how significantly environmental temperature influences cortical and trabecular bone, making it difficult to recognize adaptation versus acclimatization in past populations. There is some evidence that cold-induced bone loss results from sympathetic nervous system activation and can be reduced by nonshivering thermogenesis (NST) via uncoup…
A dried blood spot‐based method to measure levels of tartrate‐resistant acid phosphatase 5b (TRACP‐5b), a marker of bone resorption
OBJECTIVES: A number of basic questions about bone biology have not been answered, including population differences in bone turnover. In part, this stems from the lack of validated minimally invasive biomarker techniques to measure bone formation and resorption in field-based population-level research. The present study addresses this gap by validating a fingerprick dried blood spot (fDBS) assay for tartrate-resistant acid phosphatase 5b (TRACP-5…
Validation of an enzyme‐linked immunoassay assay for osteocalcin, a marker of bone formation, in dried blood spots
OBJECTIVES: Investigating factors that contribute to bone loss and accretion across populations in remote settings is challenging, particularly where diagnostic tools are scarce. To mitigate this challenge, we describe validation of a commercial ELISA assay to measure osteocalcin, a biomarker of bone formation, from dried blood spots (DBS). METHODS: We validated the Osteocalcin Human SimpleStep ELISA kit from Abcam (ab1951214) using 158 matched p…
Development and validation of an Elisa for a biomarker of thyroid dysfunction, thyroid peroxidase autoantibodies (TPO-Ab), in dried blood spots
Background The prevalence of allergic and autoimmune conditions has been steadily increasing in wealthy nations over the past century. One hypothesis put forward to explain this is the Old Friends Hypothesis, which posits that increased hygiene, urbanization, and lifestyle changes have reduced our exposure to parasites and microbes that we co-evolved with, resulting in immune dysregulation. However, research in traditionally living populations, w…
The utility of dried blood spot measurement of bone turnover markers in biological anthropology
Des souris et des Hommes: Plasticité Phénotypique Du Squelette Crâniofacial en Lien Avec La Température Et l'Alimentation
susceptibles d'tre soumis des autorisations d'usage spcifiques
Biology (10 works) · Medicine (10 works) · Internal Medicine (7 works) · Anatomy (6 works) · Anatomy (4 works) · Endocrinology (4 works) · Forensic Anthropology and Bioarchaeology Studies (4 works) · Internal Medicine (4 works) · Adipose Tissue and Metabolism (3 works) · Biomarker (3 works)