William R Lovallo

Biographic Data

ID1562525
NAMEWilliam R Lovallo
GIVEN NAMESWilliam R
FAMILY NAMELovallo
SIGNATURELOVALLO W R
AFFILIATIONSUniversity of Oklahoma Health Sciences Center
ORCID0000-0002-8489-3509
VERIFIEDYes
TOTAL WORKS27
TOTAL CITATIONS4
WORKS AS AUTHOR27
WORKS AS EDITOR0
FIRST PUBLICATION YEAR1980
LATEST PUBLICATION YEAR2021
H-INDEX1

  • Cardiovascular Stress Reactivity and Health

    Anna C Whittaker, Annie T Ginty et al.ARTICLEPsychosomatic Medicine2021

    OBJECTIVE: High cardiovascular reactions to psychological stress are associated with the development of hypertension, systemic atherosclerosis, and cardiovascular disease. However, it has become apparent that low biological stress reactivity also may have serious consequences for health, although less is known about the mechanisms of this. The objectives of this narrative review and opinion article are to summarize and consider where we are now i…

  • Joint Impact of Early Life Adversity and Comt Val158Met (rs4680) Genotypes on the Adult Cortisol Response to Psychological Stress

    William R Lovallo, Mary-Anne Enoch et al.ARTICLEPsychosomatic Medicine2017

    OBJECTIVE: Exposure to stress during critical periods of development can diminish stress reactivity by the hypothalamic-pituitary-adrenocortical axis. Genetic characteristics may further modify this effect of early adversity, leading to a gene by environment (G × E) interaction on stress reactivity in adulthood. Val-allele carriers of a common polymorphism of the COMT gene (Val158Met, rs4680) have rapid removal of catecholamines in the prefrontal…

  • Can Exaggerated Stress Reactivity and Prolonged Recovery Predict Negative Health Outcomes? The Case of Cardiovascular Disease

    William R LovalloARTICLEPsychosomatic Medicine2015

    Researchers and laypersons have long argued that stress is bad for health, particularly when responses are large, prolonged, and frequent. By extension, individuals who have the largest and the most prolonged responses are assumed to have worse outcomes than do less reactive persons. Research in animals has been supportive of the connection between stress and poor health, but evidence in humans has been slow to accumulate. The current issue of Ps…

  • The Rebirth of Neuroscience in Psychosomatic Medicine, Part I

    Richard D Lane, Shari R Waldstein et al.ARTICLEPsychosomatic Medicine2009

    Neuroscience was an integral part of psychosomatic medicine at its inception in the early 20th century. Since the mid-20th century, however, psychosomatic research has largely ignored the brain. The field of neuroscience has burgeoned in recent years largely because a variety of powerful new methods have become available. Many of these methods allow for the noninvasive study of the living human brain and thus are potentially available for integra…

  • The Rebirth of Neuroscience in Psychosomatic Medicine, Part II

    Richard D Lane, Shari R Waldstein et al.ARTICLEPsychosomatic Medicine2009

    During the second half of the last century, biopsychosocial research in psychosomatic medicine largely ignored the brain. Neuroscience has started to make a comeback in psychosomatic medicine research and promises to advance the field in important ways. In this paper we briefly review select brain imaging research findings in psychosomatic medicine in four key areas: cardiovascular regulation, visceral pain in the context of functional gastrointe…

  • Obituary

    William R Lovallo, Diane J Willis et al.ARTICLEAmerican Psychologist2007

  • Caffeine Stimulation of Cortisol Secretion Across the Waking Hours in Relation to Caffeine Intake Levels

    William R Lovallo, Thomas L Whitsett et al.ARTICLEPsychosomatic Medicine2005

    OBJECTIVE: Caffeine increases cortisol secretion in people at rest or undergoing mental stress. It is not known whether tolerance develops in this response with daily intake of caffeine in the diet. We therefore tested the cortisol response to caffeine challenge after controlled levels of caffeine intake. METHODS: Men (N = 48) and women (N = 48) completed a double-blind, crossover trial conducted over 4 weeks. On each week, subjects abstained for…

  • Psychophysiological Reactivity

    William R Lovallo, William GerinARTICLEPsychosomatic Medicine2003

    OBJECTIVE: This article examines possible sources of heightened psychophysiological reactivity in relation to risk for hypertension and coronary artery disease. The idea that exaggerated reactions to psychological stress may predict greater risk for future disease has some support in the psychosomatic and behavioral medicine literature. However, the pathways by which exaggerated reactivity could arise in a given person and the implications of dif…

  • Cardiovascular Reactivity to Psychological Challenge

    Thomas W Kamarck, William R LovalloARTICLEPsychosomatic Medicine2003

    OBJECTIVE AND METHODS: This article is a selective review of recent findings bearing on the conceptualization and measurement of cardiovascular reactivity to psychological challenge, with a focus on several issues relevant to the reliability, content validity, construct validity, and criterion validity of these measures. RESULTS AND CONCLUSIONS: With respect to reliability, use of standardized task demands and aggregated scores are associated wit…

  • Physiologic Markers of Chronic Stress in Premenopausal, Middle-Aged Women

    Lynda H Powell, William R Lovallo et al.ARTICLEPsychosomatic Medicine2002

    OBJECTIVE: The purpose of this study was to identify physiological markers of chronic stress in middle-aged women that can be assessed simply and are thus feasible for introduction into large-scale, epidemiologic studies of aging. METHODS: Subjects were 40 nonsmoking, premenopausal women between the ages of 42 and 52 years, 20 of whom were chronically stressed because of undergoing a divorce or separation and 20 of whom were nonstressed because o…

  • Bridging psychology and biology

    Stephen M Kosslyn, John T Cacioppo et al.ARTICLEAmerican Psychologist2002

    Biological systems are particularly prone to variation, and the authors argue that such variation must be regarded as important data in its own right. The authors describe a method in which individual differences are studied within the framework of a general theory of the population as a whole and illustrate how this method can be used to address three types of issues: the nature of the mechanisms that give rise to a specific ability, such as men…

  • Bridging psychology and biology

    Stephen M Kosslyn, John T Cacioppo et al.ARTICLEAmerican Psychologist2002

  • Psychological and Physiological Responses to Postprandial Mental Stress in Women With the Irritable Bowel Syndrome

    Sigrid Elsenbruch, William R Lovallo et al.ARTICLEPsychosomatic Medicine2001

    OBJECTIVE: To investigate the psychological (affective and symptomatic) and physiological (autonomic and cortisol) responses to postprandial mental stress in women with irritable bowel syndrome (IBS). It was hypothesized that patients with IBS would show exaggerated autonomic and cortisol responses to the psychological stressor and that the stressor would enhance gastrointestinal symptoms. METHOD: Twenty-four women with IBS and 20 healthy women p…

  • Sex Differences in Pain Perception and Cardiovascular Responses in Persons With Parental History for Hypertension

    Mustafa Al’Absi, Tony W Buchanan et al.ARTICLEPsychosomatic Medicine1999

  • Effects of Caffeine and Stress on Men at Increased Risk for Hypertension

    T L Thomas, William R Lovallo et al.ARTICLEPsychosomatic Medicine1999

  • Symposium Synopsis

    M H Antoni, Mike Antoni et al.ARTICLEPsychosomatic Medicine1999

    s of Papers for 1999 Annual Meeting: Symposium: The Psychoneuroendocrinology of HIV Infection

  • Caffeine Affects Blood Pressure at Rest, During Task and Recovery

    T R Hartley, T Hartley et al.ARTICLEPsychosomatic Medicine1999

  • Hypothalamic-Pituitary-Adrenocortical Responses to Psychological Stress and Caffeine in Men at High and Low Risk for Hypertension

    Mustafa Al’Absi, William R Lovallo et al.ARTICLEPsychosomatic Medicine1998

    OBJECTIVE: This study examined pituitary-adrenocortical responses to dietary doses of caffeine (3.3 mg/kg, equivalent to 2 to 3 cups of coffee), alone and combined with behavioral stress, in men at high risk versus low risk for hypertension. A randomized, double-blind, caffeine-placebo crossover design was used. METHOD: Adrenocorticotropic hormone (ACTH) and cortisol levels in plasma were assessed at rest and in response to 60-minutes of continuo…

  • Denial of Depression as an Independent Correlate of Coronary Artery Disease

    Open AccessMark W Ketterer, Lori Kenyon et al.ARTICLEJournal of Health Psychology1996Cited by: 4References: 53

    A number of psychosocial measures were tested as correlates of coronary artery disease (CAD) in 122 males with positive coronary angiograms and 56 males with no manifest history of atherosclerotic disease who were selected to approximate the patients' age and socio economic status. Only denial of depression as indexed by spouse/friend-minus-self scores on the Ketterer Stress Symptom Frequency Checklist and number of unprovoked nocturnal awakening…

  • Borderline hypertensives produce exaggerated adrenocortical responses to mental stress

    Mustafa Al’Absi, William R Lovallo et al.ARTICLEPsychosomatic Medicine1994

    Serum cortisol concentrations were compared in 18 borderline hypertensive (BH) and 20 normotensive (NT) men before and after mental stress. Two levels of demand, intermittent reaction time with brief rests and reaction time alternating continuously with mental arithmetic, were used in two consecutive protocols on different days in the laboratory. Continuous, but not intermittent, mental stress produced significant elevations in cortisol levels on…

  • Cardiovascular differentiation of emotions

    Rajita Sinha, William R Lovallo et al.ARTICLEPsychosomatic Medicine1992

    This study examined the cardiovascular mechanisms governing differential blood pressure changes during the emotions of joy, sadness, fear, and anger. Heart rate, blood pressure, stroke volume, peripheral vascular resistance, cardiac output, and indices of myocardial contractility were measured during fear, anger, joy, sadness, physical action, and neutral imagery conditions in 27 right-handed male volunteers screened for imagery ability, alexithy…

  • Methodological Guidelines for Impedance Cardiography

    Open AccessAndrew Sherwood, Michael T Allen et al.ARTICLEPsychophysiology1990

    Impedance cardiography was introduced over 20 years ago as a noninvasive and unobtrusive technique for measuring systolic time intervals and cardiac output. Although our understanding of the physiological events reflected in the impedance cardiogram has become more refined, the technique's theoretical basis remains somewhat controversial and acceptance of its validity has relied heavily upon empirical validation. Largely as a consequence of this …

  • Heart rate reactivity as a predictor of neuroendocrine responses to aversive and appetitive challenges

    William R Lovallo, G A Pincomb et al.ARTICLEPsychosomatic Medicine1990

    The present paper examines the neuroendocrine influences of aversive and reward incentives (noise and shock versus monetary bonuses) presented during reaction time tasks administered to 71 healthy men (ages 21 to 35) classified as being high (N = 30) or low (N = 41) in heart rate reactivity. High heart rate reactivity was defined as a peak heart rate increase or greater than 19 bpm to a cold pressor test administered on a different day. Independe…

  • Mechanisms of myocardial ischemia induced by epinephrine

    Bong Hyun Sung, Michael F Wilson et al.ARTICLEPsychosomatic Medicine1988

    The role of epinephrine in eliciting myocardial ischemia was examined in patients with coronary artery disease. Objective signs of ischemia and factors increasing myocardial oxygen consumption were compared during epinephrine infusion and supine bicycle exercise. Both epinephrine and exercise produced myocardial ischemia as evidenced by ST segment depression and angina. However, the mechanisms of myocardial ischemia induced by epinephrine were si…

  • Work pressure and the type A behavior pattern exam stress in male medical students

    William R Lovallo, G A Pincomb et al.ARTICLEPsychosomatic Medicine1986

    The psychologic and physiologic effects of variations in occupational stress on Type A (coronary-prone) and Type B men have not previously been examined. Accordingly, 58 male medical students in two successive first-year classes (32 As, 26 Bs defined by interview) were tested for mood states, perception of work pressure, and for pituitary-adrenal and cardiovascular function during a period of minimal work pressure (no exams for 1 week) and during…