L H Lumey
Biographic Data
| ID | 162892 |
|---|---|
| NAME | L H Lumey |
| GIVEN NAMES | L H |
| FAMILY NAME | Lumey |
| SIGNATURE | LUMEY L H |
| AFFILIATIONS | Columbia University |
| ORCID | 0000-0002-0957-5973 |
| VERIFIED | Yes |
| TOTAL WORKS | 23 |
| TOTAL CITATIONS | 78 |
| AUTHOR COUNT | 23 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1994 |
| LATEST PUBLICATION YEAR | 2024 |
| H-INDEX | 5 |
Famine mortality and contributions to later-life type 2 diabetes at the population level
Since the 1970s, influential literature has been using famines as natural experiments to examine the long-term health impact of prenatal famine exposure at the individual level. Although studies based on various famines have consistently shown that prenatal famine exposure is associated with an increased risk of type 2 diabetes (T2D), no studies have yet quantified the contribution of famines to later-life T2D at the population level. We, therefo…
Severe prenatal shocks and adolescent health
This paper investigates health impacts at the end of adolescence of prenatal exposure to multiple shocks, by exploiting the unique natural experiment of the Dutch Hunger Winter. At the end of World War II, a famine occurred abruptly in the Western Netherlands (November 1944-May 1945), pushing the previously and subsequently well-nourished Dutch population to the brink of starvation. We link high-quality military recruits data with objective healt…
Infant and child mortality in the Netherlands 1935-47 and changes related to the Dutch famine of 1944-45
Precise estimates of the impact of famine on infant and child mortality are rare due to lack of representative data. Using vital statistics reports on the Netherlands for 1935-47, we examine the impact of the Dutch famine (November 1944 to May 1945) on age-specific mortality risk and cause of death in four age groups (stillbirths, <1 year, 1-4, 5-14) in the three largest famine-affected cities and the remainder of the country. Mortality during th…
War- and famine-related excess mortality among civilians in the Netherlands, 1944–1945
National estimates exist for war- and famine-related deaths in the Netherlands during the last stages of World War II, but no such estimates are available at the local level. To fill this information gap, this article aims at mapping and visualizing the timing of war- and famine-related excess mortality by municipality among the civilian population within the Netherlands. We use mortality statistics at the level of municipalities because these ar…
Impact of disease screening on awareness and management of hypertension and diabetes between 2011 and 2015
Disease screening in CHARLS did not lead to significant improvements in awareness of hypertension and diabetes. Improvements should be made by the systematic feedback of screening results to survey participants and the monitoring of disease awareness over time. This will be essential to improve disease recognition and facilitate optimal management
War-related excess mortality in The Netherlands, 1944–45
Despite there being several estimates for famine-related deaths in the west of The Netherlands during the last stage of World War II, no such information exists for war-related excess mortality among the civilian population from other areas of the country. Previously unavailable data files from Statistics Netherlands allow researchers to estimate the number of war-related excess deaths during the last stage of the war in the whole country. This s…
Can resource dilution explain differences in height by birth order and family size? A study of 389,287 male recruits in twentieth-century Netherlands
Resource dilution' has been invoked as a possible mechanism to explain the inverse relation between sibship size and sibling heights in European populations (Öberg, 2015). Alternative explanations include confounding of the relation by other measured or unmeasured family characteristics including socio-economic position or birth order. It is difficult to quantify the contribution of any factor in isolation. To examine the question, we accessed da…
Differences in height by education among 371,105 Dutch military conscripts
Independent and additive association of prenatal famine exposure and intermediary life conditions with adult mortality between age 18-63 years
A re-analysis of the long-term effects on life expectancy of the Great Finnish Famine of 1866-68
The results of studies exploring the long-term consequences of famine during foetal or infant development are inconsistent. We tested the hypothesis that selection forces occurring during a famine change the distribution of frailty in the affected cohorts, possibly hiding negative long-term effects. Using mortality data for Finland, gathered from the Human Mortality Database, we explored the effect of being born during the Great Finnish Famine of…
Maternal Prenatal Nutrition and Health in Grandchildren and Subsequent Generations
This review focuses on how maternal prenatal nutritional states may affect the health of grandchildren and later generations. We first summarize the limited current data in human populations relating to the potential transmission of phenotypes across multiple generations that result from the nutritional experience of a pregnant woman. We then discuss findings from other species, especially mammals, that provide important clues as to whether, and …
Prenatal Famine and Adult Health
We review human studies on the relation between acute exposures to prenatal famine and adult physical and mental health. These studies are observational and include exposures to a famine environment by natural or man-made causes or, more commonly, from the interplay between natural and human factors. These natural experiments provide an opportunity to examine long-term outcomes after famine exposures by comparing exposed and nonexposed individual…
P1-33 Adult DNA methylation in relation to prenatal nutrition and risk factors for cardio-vascular disease
Epigenetic changes may play an important role in the development of adult disease. Exposure to a prenatal famine environment has been associated with a persistent decrease in DNA methylation of the IGF2 gene, and other early life factors like birthweight with adult genomic DNA methylation. We evaluated genomic DNA methylation in relation to prenatal nutrition and CVD risk factors. Our study includes 353 births from three clinics with prenatal exp…
P1-34 Can associations between prenatal nutrition and body mass index be explained by common genetic variants? Findings from the Dutch hunger winter families study
Genome wide association (GWAS) studies have identified single nucleotide polymorphisms (SNPs) related to body mass index (BMI: kg/m 2 ). Associations have also been reported between fetal malnutrition and BMI. We use the circumstances of the Dutch Hunger Winter of 1944–1945 to further examine these relations. We studied 348 adult men and women born in affected cities in the western Netherlands who had been exposed to famine during pregnancy, 294 …
P2-163 Mortality after prenatal exposure to the Dutch famine of 1944–1945
Introduction Some studies have examined long term health effects of famine exposure during pregnancy but little is known about possible effects on adult survival. Methods We selected men with prenatal exposure to the Dutch famine of 1944–1945 from military examinations records (n=408 015) for births 1944–1946 in the Netherlands. We included men exposed in the immediate post-natal period (n=8225) and in the third (n=8197), the second (n=6809), and…
The 2D
Objectives: Digit lengths, and in particular the ratio of the 2nd (2D) to 4th (4D) digit (2D:4D), are stable in adulthood and have been linked to characteristics thought to have developmental origins, but little research has focused on early life determinants of these measures. We examined whether exposure to acute famine during specific periods of gestation was associated with 2D, 4D or the 2D:4D ratio. Methods: We studied men and women (1) born…
Maternal Preconception Diet and the Sex Ratio
Temporal variations in the sex ratio, or the ratio of boys to girls at birth, have been widely studied and variously attributed to social changes, conditions of war, and environmental changes. Recently, Mathews et al. ["You are what your mother eats: Evidence for maternal preconception diet influencing fetal sex in humans," Proc. R. Soc. bond. B 275:1661-1668 (2008)] studied the direct evidence of individual pregnancies and established an associa…
Persistent epigenetic differences associated with prenatal exposure to famine in humans
Extensive epidemiologic studies have suggested that adult disease risk is associated with adverse environmental conditions early in development. Although the mechanisms behind these relationships are unclear, an involvement of epigenetic dysregulation has been hypothesized. Here we show that individuals who were prenatally exposed to famine during the Dutch Hunger Winter in 1944–45 had, 6 decades later, less DNA methylation of the imprinted IGF2 …
A fingerprint characteristic associated with the early prenatal environment
Fingerprints and fingertip ridge counts (RCs) have a significant genetic component. However, they also reflect the nongenetic environment of early pregnancy, an important time window for tissue differentiation and organogenesis. Fingerprints are permanently configured before the 20th week of gestation, and each fingertip's RC is related to the growth and regression of its early fetal volar pads. Rostral and caudal aspects of the embryonic limb bu…
In utero exposure to famine and subsequent fertility
OBJECTIVES: We hypothesized that if prenatal caloric restriction due to nutritional deprivation had affected development of the organs responsible for producing and regulating female reproductive hormones, a woman's fertility would be impaired. METHODS: Women born in Amsterdam from August 1, 1944, through April 15, 1946, a period encompassing a severe 5-month famine, were identified (n = 700; 85% response rate). Date of birth and vital status of …
Perinatal mortality in a first generation immigrant population and its relation to unemployment in The Netherlands
late 1970s and is now rising.After allowing for the proportion of births to mothers over 35 years, the trend with year remains significant at the 5% level, OR=0-9996, (95%CI: 0 9995, 0 9997).Over the period there has also been a steady increase in the proportion of single mothers.As single mothers are more likely to have boys,4 it is likely that the decline in the sex ratio of children born to other women is even greater.This decline in the sex r…
Perinatal mortality in a first generation immigrant population and its relation to unemployment in The Netherlands
STUDY OBJECTIVE--To consider the association between biological and social risk factors and perinatal mortality in an ethnically mixed population in Amsterdam, The Netherlands. DESIGN--This was a matched case-control study. Cases included all registered stillborn infants and all registered liveborn infants who died within seven days of birth. Controls were selected from infants remaining alive. Each case was matched with two controls by date of r…
The Dutch Famine of 1944-45
During the last months of the Second World War the Western Netherlands was affected by an acute famine, known as the Hunger Winter. Food intake from all sources was reduced to extremely low levels. The effect on mortality at all ages was very large and immediate. By making use of unpublished data from the Dutch Central Bureau of Statistics, estimates could be made of the changes in mortality by cause of death and age for both sexes. Mortality due…
The Dutch Famine of 1944-45
During the last months of the Second World War the Western Netherlands was affected by an acute famine, known as the Hunger Winter. Food intake from all sources was reduced to extremely low levels. The effect on mortality at all ages was very large and immediate. By making use of unpublished data from the Dutch Central Bureau of Statistics, estimates could be made of the changes in mortality by cause of death and age for both sexes. Mortality due…
Independent and additive association of prenatal famine exposure and intermediary life conditions with adult mortality between age 18-63 years
A re-analysis of the long-term effects on life expectancy of the Great Finnish Famine of 1866-68
The results of studies exploring the long-term consequences of famine during foetal or infant development are inconsistent. We tested the hypothesis that selection forces occurring during a famine change the distribution of frailty in the affected cohorts, possibly hiding negative long-term effects. Using mortality data for Finland, gathered from the Human Mortality Database, we explored the effect of being born during the Great Finnish Famine of…
In utero exposure to famine and subsequent fertility
OBJECTIVES: We hypothesized that if prenatal caloric restriction due to nutritional deprivation had affected development of the organs responsible for producing and regulating female reproductive hormones, a woman's fertility would be impaired. METHODS: Women born in Amsterdam from August 1, 1944, through April 15, 1946, a period encompassing a severe 5-month famine, were identified (n = 700; 85% response rate). Date of birth and vital status of …
Can resource dilution explain differences in height by birth order and family size? A study of 389,287 male recruits in twentieth-century Netherlands
Resource dilution' has been invoked as a possible mechanism to explain the inverse relation between sibship size and sibling heights in European populations (Öberg, 2015). Alternative explanations include confounding of the relation by other measured or unmeasured family characteristics including socio-economic position or birth order. It is difficult to quantify the contribution of any factor in isolation. To examine the question, we accessed da…
War-related excess mortality in The Netherlands, 1944–45
Despite there being several estimates for famine-related deaths in the west of The Netherlands during the last stage of World War II, no such information exists for war-related excess mortality among the civilian population from other areas of the country. Previously unavailable data files from Statistics Netherlands allow researchers to estimate the number of war-related excess deaths during the last stage of the war in the whole country. This s…
Maternal Preconception Diet and the Sex Ratio
Temporal variations in the sex ratio, or the ratio of boys to girls at birth, have been widely studied and variously attributed to social changes, conditions of war, and environmental changes. Recently, Mathews et al. ["You are what your mother eats: Evidence for maternal preconception diet influencing fetal sex in humans," Proc. R. Soc. bond. B 275:1661-1668 (2008)] studied the direct evidence of individual pregnancies and established an associa…
Perinatal mortality in a first generation immigrant population and its relation to unemployment in The Netherlands
late 1970s and is now rising.After allowing for the proportion of births to mothers over 35 years, the trend with year remains significant at the 5% level, OR=0-9996, (95%CI: 0 9995, 0 9997).Over the period there has also been a steady increase in the proportion of single mothers.As single mothers are more likely to have boys,4 it is likely that the decline in the sex ratio of children born to other women is even greater.This decline in the sex r…
Perinatal mortality in a first generation immigrant population and its relation to unemployment in The Netherlands
STUDY OBJECTIVE--To consider the association between biological and social risk factors and perinatal mortality in an ethnically mixed population in Amsterdam, The Netherlands. DESIGN--This was a matched case-control study. Cases included all registered stillborn infants and all registered liveborn infants who died within seven days of birth. Controls were selected from infants remaining alive. Each case was matched with two controls by date of r…
The Dutch Famine of 1944-45
During the last months of the Second World War the Western Netherlands was affected by an acute famine, known as the Hunger Winter. Food intake from all sources was reduced to extremely low levels. The effect on mortality at all ages was very large and immediate. By making use of unpublished data from the Dutch Central Bureau of Statistics, estimates could be made of the changes in mortality by cause of death and age for both sexes. Mortality due…
Perinatal mortality in a first generation immigrant population and its relation to unemployment in The Netherlands
STUDY OBJECTIVE--To consider the association between biological and social risk factors and perinatal mortality in an ethnically mixed population in Amsterdam, The Netherlands. DESIGN--This was a matched case-control study. Cases included all registered stillborn infants and all registered liveborn infants who died within seven days of birth. Controls were selected from infants remaining alive. Each case was matched with two controls by date of r…
Perinatal mortality in a first generation immigrant population and its relation to unemployment in The Netherlands
late 1970s and is now rising.After allowing for the proportion of births to mothers over 35 years, the trend with year remains significant at the 5% level, OR=0-9996, (95%CI: 0 9995, 0 9997).Over the period there has also been a steady increase in the proportion of single mothers.As single mothers are more likely to have boys,4 it is likely that the decline in the sex ratio of children born to other women is even greater.This decline in the sex r…
In utero exposure to famine and subsequent fertility
OBJECTIVES: We hypothesized that if prenatal caloric restriction due to nutritional deprivation had affected development of the organs responsible for producing and regulating female reproductive hormones, a woman's fertility would be impaired. METHODS: Women born in Amsterdam from August 1, 1944, through April 15, 1946, a period encompassing a severe 5-month famine, were identified (n = 700; 85% response rate). Date of birth and vital status of …
Persistent epigenetic differences associated with prenatal exposure to famine in humans
Extensive epidemiologic studies have suggested that adult disease risk is associated with adverse environmental conditions early in development. Although the mechanisms behind these relationships are unclear, an involvement of epigenetic dysregulation has been hypothesized. Here we show that individuals who were prenatally exposed to famine during the Dutch Hunger Winter in 1944–45 had, 6 decades later, less DNA methylation of the imprinted IGF2 …
A fingerprint characteristic associated with the early prenatal environment
Fingerprints and fingertip ridge counts (RCs) have a significant genetic component. However, they also reflect the nongenetic environment of early pregnancy, an important time window for tissue differentiation and organogenesis. Fingerprints are permanently configured before the 20th week of gestation, and each fingertip's RC is related to the growth and regression of its early fetal volar pads. Rostral and caudal aspects of the embryonic limb bu…
The 2D
Objectives: Digit lengths, and in particular the ratio of the 2nd (2D) to 4th (4D) digit (2D:4D), are stable in adulthood and have been linked to characteristics thought to have developmental origins, but little research has focused on early life determinants of these measures. We examined whether exposure to acute famine during specific periods of gestation was associated with 2D, 4D or the 2D:4D ratio. Methods: We studied men and women (1) born…
Maternal Preconception Diet and the Sex Ratio
Temporal variations in the sex ratio, or the ratio of boys to girls at birth, have been widely studied and variously attributed to social changes, conditions of war, and environmental changes. Recently, Mathews et al. ["You are what your mother eats: Evidence for maternal preconception diet influencing fetal sex in humans," Proc. R. Soc. bond. B 275:1661-1668 (2008)] studied the direct evidence of individual pregnancies and established an associa…
Prenatal Famine and Adult Health
We review human studies on the relation between acute exposures to prenatal famine and adult physical and mental health. These studies are observational and include exposures to a famine environment by natural or man-made causes or, more commonly, from the interplay between natural and human factors. These natural experiments provide an opportunity to examine long-term outcomes after famine exposures by comparing exposed and nonexposed individual…
P1-33 Adult DNA methylation in relation to prenatal nutrition and risk factors for cardio-vascular disease
Epigenetic changes may play an important role in the development of adult disease. Exposure to a prenatal famine environment has been associated with a persistent decrease in DNA methylation of the IGF2 gene, and other early life factors like birthweight with adult genomic DNA methylation. We evaluated genomic DNA methylation in relation to prenatal nutrition and CVD risk factors. Our study includes 353 births from three clinics with prenatal exp…
P1-34 Can associations between prenatal nutrition and body mass index be explained by common genetic variants? Findings from the Dutch hunger winter families study
Genome wide association (GWAS) studies have identified single nucleotide polymorphisms (SNPs) related to body mass index (BMI: kg/m 2 ). Associations have also been reported between fetal malnutrition and BMI. We use the circumstances of the Dutch Hunger Winter of 1944–1945 to further examine these relations. We studied 348 adult men and women born in affected cities in the western Netherlands who had been exposed to famine during pregnancy, 294 …
P2-163 Mortality after prenatal exposure to the Dutch famine of 1944–1945
Introduction Some studies have examined long term health effects of famine exposure during pregnancy but little is known about possible effects on adult survival. Methods We selected men with prenatal exposure to the Dutch famine of 1944–1945 from military examinations records (n=408 015) for births 1944–1946 in the Netherlands. We included men exposed in the immediate post-natal period (n=8225) and in the third (n=8197), the second (n=6809), and…
Maternal Prenatal Nutrition and Health in Grandchildren and Subsequent Generations
This review focuses on how maternal prenatal nutritional states may affect the health of grandchildren and later generations. We first summarize the limited current data in human populations relating to the potential transmission of phenotypes across multiple generations that result from the nutritional experience of a pregnant woman. We then discuss findings from other species, especially mammals, that provide important clues as to whether, and …
A re-analysis of the long-term effects on life expectancy of the Great Finnish Famine of 1866-68
The results of studies exploring the long-term consequences of famine during foetal or infant development are inconsistent. We tested the hypothesis that selection forces occurring during a famine change the distribution of frailty in the affected cohorts, possibly hiding negative long-term effects. Using mortality data for Finland, gathered from the Human Mortality Database, we explored the effect of being born during the Great Finnish Famine of…
Differences in height by education among 371,105 Dutch military conscripts
Independent and additive association of prenatal famine exposure and intermediary life conditions with adult mortality between age 18-63 years
Can resource dilution explain differences in height by birth order and family size? A study of 389,287 male recruits in twentieth-century Netherlands
Resource dilution' has been invoked as a possible mechanism to explain the inverse relation between sibship size and sibling heights in European populations (Öberg, 2015). Alternative explanations include confounding of the relation by other measured or unmeasured family characteristics including socio-economic position or birth order. It is difficult to quantify the contribution of any factor in isolation. To examine the question, we accessed da…
War-related excess mortality in The Netherlands, 1944–45
Despite there being several estimates for famine-related deaths in the west of The Netherlands during the last stage of World War II, no such information exists for war-related excess mortality among the civilian population from other areas of the country. Previously unavailable data files from Statistics Netherlands allow researchers to estimate the number of war-related excess deaths during the last stage of the war in the whole country. This s…
Impact of disease screening on awareness and management of hypertension and diabetes between 2011 and 2015
Disease screening in CHARLS did not lead to significant improvements in awareness of hypertension and diabetes. Improvements should be made by the systematic feedback of screening results to survey participants and the monitoring of disease awareness over time. This will be essential to improve disease recognition and facilitate optimal management
War- and famine-related excess mortality among civilians in the Netherlands, 1944–1945
National estimates exist for war- and famine-related deaths in the Netherlands during the last stages of World War II, but no such estimates are available at the local level. To fill this information gap, this article aims at mapping and visualizing the timing of war- and famine-related excess mortality by municipality among the civilian population within the Netherlands. We use mortality statistics at the level of municipalities because these ar…
Famine mortality and contributions to later-life type 2 diabetes at the population level
Since the 1970s, influential literature has been using famines as natural experiments to examine the long-term health impact of prenatal famine exposure at the individual level. Although studies based on various famines have consistently shown that prenatal famine exposure is associated with an increased risk of type 2 diabetes (T2D), no studies have yet quantified the contribution of famines to later-life T2D at the population level. We, therefo…
Severe prenatal shocks and adolescent health
This paper investigates health impacts at the end of adolescence of prenatal exposure to multiple shocks, by exploiting the unique natural experiment of the Dutch Hunger Winter. At the end of World War II, a famine occurred abruptly in the Western Netherlands (November 1944-May 1945), pushing the previously and subsequently well-nourished Dutch population to the brink of starvation. We link high-quality military recruits data with objective healt…
Infant and child mortality in the Netherlands 1935-47 and changes related to the Dutch famine of 1944-45
Precise estimates of the impact of famine on infant and child mortality are rare due to lack of representative data. Using vital statistics reports on the Netherlands for 1935-47, we examine the impact of the Dutch famine (November 1944 to May 1945) on age-specific mortality risk and cause of death in four age groups (stillbirths, <1 year, 1-4, 5-14) in the three largest famine-affected cities and the remainder of the country. Mortality during th…
Medicine (19 works) · Birth, Development, and Health (16 works) · Famine (15 works) · Geography (13 works) · Population (13 works) · Demography (12 works) · Biology (9 works) · Environmental health (9 works) · Pregnancy (7 works) · Climate Change and Health Impacts (6 works)