Peter J Uhlhaas
Biographic Data
| ID | 1662915 |
|---|---|
| NAME | Peter J Uhlhaas |
| GIVEN NAMES | Peter J |
| FAMILY NAME | Uhlhaas |
| SIGNATURE | UHLHAAS P J |
| AFFILIATIONS | Charité - Universitätsmedizin Berlin |
| ORCID | 0000-0002-0892-2224 |
| VERIFIED | Yes |
| TOTAL WORKS | 10 |
| TOTAL CITATIONS | 2 |
| AUTHOR COUNT | 10 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2005 |
| LATEST PUBLICATION YEAR | 2025 |
| H-INDEX | 1 |
The Enter study (E-DetectioN Tool for Emerging Mental DisoRders): General population recruitment and data integrity in online screening for psychosis risk
The proportion of participants scoring ≥6 on the PQ-16 is consistent with the findings from other European studies in the general population and in outpatient mental health settings. The procedures and sample characteristics reported here provide context for further analyses using the ENTER tool. In addition, the findings highlight the considerable challenge of fraudulent and inauthentic responses in online research-an issue that may have been am…
Exploring global and local processes underlying alterations in resting-state functional connectivity and dynamics in schizophrenia
The current study suggests that large-scale alterations in ScZ are more likely the result of global rather than local network changes
MR-Spectroscopy of Gaba and Glutamate/Glutamine Concentrations in Auditory Cortex in Clinical High-Risk for Psychosis Individuals
Psychosis involves changes in GABAergic and glutamatergic neurotransmission in auditory cortex that could be important for understanding sensory deficits and symptoms of psychosis. However, it is currently unclear whether such deficits are present in participants at clinical high-risk for psychosis (CHR-P) and whether they are associated with clinical outcomes. Magnetic Resonance Spectroscopy (MEGAPRESS, 1H-MRS at 3 Tesla) was used to estimate GA…
Dissociation and Brain Rhythms: Pitfalls and Promises
Recently, Vesuna et al. proposed a novel circuit mechanism underlying dissociative states using optogenetics and pharmacology in mice in combination with intracranial recordings and electrical stimulation in an epilepsy patient. Specifically, the authors identified a posteromedial cortical delta-rhythm that underlies states of dissociation. In the following, we would like to critically review these findings in the context of the human literature …
Altered Autonomic Function in Individuals at Clinical High Risk for Psychosis
Introduction: Alterations in autonomic functioning in individuals diagnosed with schizophrenia are well-documented. Yet, it is currently unclear whether these dysfunctions extend into the clinical high-risk state. Thus, we investigated resting heart rate (RHR) and heart rate variability (HRV) indices in individuals at clinical high-risk for psychosis (CHR-P). Methods: We recruited 117 CHR-P participants, 38 participants with affective disorders a…
A MEG Study of Visual Repetition Priming in Schizophrenia: Evidence for Impaired High-Frequency Oscillations and Event-Related Fields in Thalamo-Occipital Cortices
Background: Cognitive dysfunctions represent a core feature of schizophrenia and a predictor for clinical outcomes. One possible mechanism for cognitive impairments could involve an impairment in the experience-dependent modifications of cortical networks. Methods: To address this issue, we employed magnetoencephalography (MEG) during a visual priming paradigm in a sample of chronic patients with schizophrenia ( n = 14), and in a group of healthy…
The Predictive Coding Account of Psychosis
Fueled by developments in computational neuroscience, there has been increasing interest in the underlying neurocomputational mechanisms of psychosis. One successful approach involves predictive coding and Bayesian inference. Here, inferences regarding the current state of the world are made by combining prior beliefs with incoming sensory signals. Mismatches between prior beliefs and incoming signals constitute prediction errors that drive new l…
Abnormal Connectional Fingerprint in Schizophrenia: A Novel Network Analysis of Diffusion Tensor Imaging Data
The graph theoretical analysis of structural magnetic resonance imaging (MRI) data has received a great deal of interest in recent years to characterize the organizational principles of brain networks and their alterations in psychiatric disorders, such as schizophrenia. However, the characterization of networks in clinical populations can be challenging, since the comparison of connectivity between groups is influenced by several factors, such a…
Techniques pour améliorer l’attention et l’engagement dans le traitement des patients souffrant de schizophrénie avec de graves déficits cognitifs (troisième partie)
Malgré l’existence de plusieurs interventions psychiatriques de groupe efficaces, beaucoup de patients gravement atteints sont incapables d’en bénéficier en raison de leur incapacité à maintenir leur attention lors des sessions de groupe. L’inattention pourrait être due à un ou plusieurs facteurs, dont un déficit d’attention, une faible motivation, aux effets sédatifs de la médication, et aux hallucinations et pensées troublantes dont l’effet int…
Perceptual Organization in Schizophrenia Spectrum Disorders: Empirical Research and Theoretical Implications
The research into perceptual organization in schizophrenia spectrum disorders has found evidence for and against a perceptual organization deficit and has interpreted the data from within several different theoretical frameworks. A synthesis of this evidence, however, reveals that this body of work has produced reliable evidence for deficits in schizophrenia, as well as for the clinical, stimulus, and task parameters associated with normal and ab…
Perceptual Organization in Schizophrenia Spectrum Disorders: Empirical Research and Theoretical Implications
The research into perceptual organization in schizophrenia spectrum disorders has found evidence for and against a perceptual organization deficit and has interpreted the data from within several different theoretical frameworks. A synthesis of this evidence, however, reveals that this body of work has produced reliable evidence for deficits in schizophrenia, as well as for the clinical, stimulus, and task parameters associated with normal and ab…
Techniques pour améliorer l’attention et l’engagement dans le traitement des patients souffrant de schizophrénie avec de graves déficits cognitifs (troisième partie)
Malgré l’existence de plusieurs interventions psychiatriques de groupe efficaces, beaucoup de patients gravement atteints sont incapables d’en bénéficier en raison de leur incapacité à maintenir leur attention lors des sessions de groupe. L’inattention pourrait être due à un ou plusieurs facteurs, dont un déficit d’attention, une faible motivation, aux effets sédatifs de la médication, et aux hallucinations et pensées troublantes dont l’effet int…
Perceptual Organization in Schizophrenia Spectrum Disorders: Empirical Research and Theoretical Implications
The research into perceptual organization in schizophrenia spectrum disorders has found evidence for and against a perceptual organization deficit and has interpreted the data from within several different theoretical frameworks. A synthesis of this evidence, however, reveals that this body of work has produced reliable evidence for deficits in schizophrenia, as well as for the clinical, stimulus, and task parameters associated with normal and ab…
Abnormal Connectional Fingerprint in Schizophrenia: A Novel Network Analysis of Diffusion Tensor Imaging Data
The graph theoretical analysis of structural magnetic resonance imaging (MRI) data has received a great deal of interest in recent years to characterize the organizational principles of brain networks and their alterations in psychiatric disorders, such as schizophrenia. However, the characterization of networks in clinical populations can be challenging, since the comparison of connectivity between groups is influenced by several factors, such a…
The Predictive Coding Account of Psychosis
Fueled by developments in computational neuroscience, there has been increasing interest in the underlying neurocomputational mechanisms of psychosis. One successful approach involves predictive coding and Bayesian inference. Here, inferences regarding the current state of the world are made by combining prior beliefs with incoming sensory signals. Mismatches between prior beliefs and incoming signals constitute prediction errors that drive new l…
Altered Autonomic Function in Individuals at Clinical High Risk for Psychosis
Introduction: Alterations in autonomic functioning in individuals diagnosed with schizophrenia are well-documented. Yet, it is currently unclear whether these dysfunctions extend into the clinical high-risk state. Thus, we investigated resting heart rate (RHR) and heart rate variability (HRV) indices in individuals at clinical high-risk for psychosis (CHR-P). Methods: We recruited 117 CHR-P participants, 38 participants with affective disorders a…
A MEG Study of Visual Repetition Priming in Schizophrenia: Evidence for Impaired High-Frequency Oscillations and Event-Related Fields in Thalamo-Occipital Cortices
Background: Cognitive dysfunctions represent a core feature of schizophrenia and a predictor for clinical outcomes. One possible mechanism for cognitive impairments could involve an impairment in the experience-dependent modifications of cortical networks. Methods: To address this issue, we employed magnetoencephalography (MEG) during a visual priming paradigm in a sample of chronic patients with schizophrenia ( n = 14), and in a group of healthy…
Dissociation and Brain Rhythms: Pitfalls and Promises
Recently, Vesuna et al. proposed a novel circuit mechanism underlying dissociative states using optogenetics and pharmacology in mice in combination with intracranial recordings and electrical stimulation in an epilepsy patient. Specifically, the authors identified a posteromedial cortical delta-rhythm that underlies states of dissociation. In the following, we would like to critically review these findings in the context of the human literature …
MR-Spectroscopy of Gaba and Glutamate/Glutamine Concentrations in Auditory Cortex in Clinical High-Risk for Psychosis Individuals
Psychosis involves changes in GABAergic and glutamatergic neurotransmission in auditory cortex that could be important for understanding sensory deficits and symptoms of psychosis. However, it is currently unclear whether such deficits are present in participants at clinical high-risk for psychosis (CHR-P) and whether they are associated with clinical outcomes. Magnetic Resonance Spectroscopy (MEGAPRESS, 1H-MRS at 3 Tesla) was used to estimate GA…
Exploring global and local processes underlying alterations in resting-state functional connectivity and dynamics in schizophrenia
The current study suggests that large-scale alterations in ScZ are more likely the result of global rather than local network changes
The Enter study (E-DetectioN Tool for Emerging Mental DisoRders): General population recruitment and data integrity in online screening for psychosis risk
The proportion of participants scoring ≥6 on the PQ-16 is consistent with the findings from other European studies in the general population and in outpatient mental health settings. The procedures and sample characteristics reported here provide context for further analyses using the ENTER tool. In addition, the findings highlight the considerable challenge of fraudulent and inauthentic responses in online research-an issue that may have been am…
Psychology (9 works) · Psychiatry (8 works) · Medicine (6 works) · Neuroscience (6 works) · Functional Brain Connectivity Studies (5 works) · Psychosis (5 works) · Neural dynamics and brain function (4 works) · Schizophrenia (object-oriented programming (4 works) · Advanced MRI Techniques and Applications (3 works) · Advanced Neuroimaging Techniques and Applications (3 works)