Estella S Poloni
Biographic Data
| ID | 168419 |
|---|---|
| NAME | Estella S Poloni |
| GIVEN NAMES | Estella S |
| FAMILY NAME | Poloni |
| SIGNATURE | POLONI E S |
| AFFILIATIONS | University of Geneva |
| ORCID | 0000-0002-8465-003X |
| VERIFIED | Yes |
| TOTAL WORKS | 8 |
| TOTAL CITATIONS | 13 |
| WORKS AS AUTHOR | 8 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 2002 |
| LATEST PUBLICATION YEAR | 2017 |
| H-INDEX | 2 |
The historical spread of A rabian P astoralists to the eastern A frican S ahel evidenced by the lactase persistence −13,915*G allele and mitochondrial DNA
OBJECTIVES: Thanks to the ability to digest lactose, Arabian nomads had become less dependent upon their sedentary neighbors and some of these populations spread to Africa. When and by which route they migrated to their current locations have previously been addressed only by historical and archaeological data. METHODS: To address the question of Arab expansion into Africa, we collected samples from several Arabic populations, especially the Bagg…
Comprehensive view of the population history of A rabia as inferred by mt DNA variation
OBJECTIVES: Genetic and archaeological research supports the theory that Arabia was the first region traversed by modern humans as they left Africa and dispersed throughout Eurasia. However, the role of Arabia from the initial migration out of Africa until more recent times is still unclear. MATERIALS AND METHODS: We have generated 379 new hypervariable segment 1 (HVS-1) sequences from a range of geographic locations throughout Yemen. We compare …
The place of Slovakian paternal diversity in the clinal European landscape
The highly significant correlation between the results based on fast evolving STRs on one hand and slow evolving SNPs on the other hand suggests a recent timeframe for the settlement of the area
A Homogenizing Process of Selection Has Maintained an “Ultra-Slow” Acetylation NAT2 Variant in Humans
N-Acetyltransferase 2 (NAT2) is an important enzyme involved in the metabolism of a wide spectrum of naturally occurring xenobiotics, including therapeutic drugs and common environmental carcinogens. Extensive polymorphism in NAT2 gives rise to a wide interindividual variation in acetylation capacity, which influences individual susceptibility to various drug-induced adverse reactions and cancers. Striking patterns of geographic differentiation h…
Hla Genetic Diversity and Linguistic Variation in East Asia
INTRODUCTION Molecular anthropology - the study of human genetic polymorphisms - is now often used to investigate the accuracy of archaeological and/or linguistic hypotheses. One of the classic examples is the use of genetics in an attempt to discriminate between two alternative models for the spread of agriculture in Europe - the demic and the cultural diffusion models - which finally led to a general approval of the former by geneticists, who r…
Haplotype tagging efficiency and tagSNP sets portability in worldwide populations in NAT2 gene
Genetic polymorphism in the NAT2 gene is responsible for pronounced interindividual differences in the acetylation activity of the N-acetyltransferase 2 (NAT2) enzyme, which plays a crucial role in the metabolism of many clinically useful drugs and exogenous chemicals. Up to now, most association studies that have attempted to relate the acetylation phenotype in NAT2 to a variety of complex human disorders have led to contradictory results in dif…
Genetic structure of Mediterranean populations revealed by Y‐chromosome haplotype analysis
The allelic variability at six Y‐chromosome‐specific polymorphisms (YAP, DYS19, DYS389‐I, DYS390, DYS391, and DYS392) was used to generate male‐specific haplotypes in 333 males representing 12 population samples from the region around the Mediterranean sea. Extreme interindividual variation was observed, as more than 160 distinct Y‐chromosome variants could be defined as six‐locus haplotypes. Concomitant with this high variability, low levels of …
Génétique, linguistique et histoire des peuplements humains
Recent and independent progresses achieved in population genetics and historical linguistics led to the comparison of their results on the origins and migrations of modern humans. Here we present and discuss several studies that show evidence for a strong link between genetic and linguistic differentiation among human populations at the continental scale. We further present the first results of our "boundaries" method, a new interdisciplinary app…
Comprehensive view of the population history of A rabia as inferred by mt DNA variation
OBJECTIVES: Genetic and archaeological research supports the theory that Arabia was the first region traversed by modern humans as they left Africa and dispersed throughout Eurasia. However, the role of Arabia from the initial migration out of Africa until more recent times is still unclear. MATERIALS AND METHODS: We have generated 379 new hypervariable segment 1 (HVS-1) sequences from a range of geographic locations throughout Yemen. We compare …
Genetic structure of Mediterranean populations revealed by Y‐chromosome haplotype analysis
The allelic variability at six Y‐chromosome‐specific polymorphisms (YAP, DYS19, DYS389‐I, DYS390, DYS391, and DYS392) was used to generate male‐specific haplotypes in 333 males representing 12 population samples from the region around the Mediterranean sea. Extreme interindividual variation was observed, as more than 160 distinct Y‐chromosome variants could be defined as six‐locus haplotypes. Concomitant with this high variability, low levels of …
A Homogenizing Process of Selection Has Maintained an “Ultra-Slow” Acetylation NAT2 Variant in Humans
N-Acetyltransferase 2 (NAT2) is an important enzyme involved in the metabolism of a wide spectrum of naturally occurring xenobiotics, including therapeutic drugs and common environmental carcinogens. Extensive polymorphism in NAT2 gives rise to a wide interindividual variation in acetylation capacity, which influences individual susceptibility to various drug-induced adverse reactions and cancers. Striking patterns of geographic differentiation h…
Génétique, linguistique et histoire des peuplements humains
Recent and independent progresses achieved in population genetics and historical linguistics led to the comparison of their results on the origins and migrations of modern humans. Here we present and discuss several studies that show evidence for a strong link between genetic and linguistic differentiation among human populations at the continental scale. We further present the first results of our "boundaries" method, a new interdisciplinary app…
Genetic structure of Mediterranean populations revealed by Y‐chromosome haplotype analysis
The allelic variability at six Y‐chromosome‐specific polymorphisms (YAP, DYS19, DYS389‐I, DYS390, DYS391, and DYS392) was used to generate male‐specific haplotypes in 333 males representing 12 population samples from the region around the Mediterranean sea. Extreme interindividual variation was observed, as more than 160 distinct Y‐chromosome variants could be defined as six‐locus haplotypes. Concomitant with this high variability, low levels of …
Haplotype tagging efficiency and tagSNP sets portability in worldwide populations in NAT2 gene
Genetic polymorphism in the NAT2 gene is responsible for pronounced interindividual differences in the acetylation activity of the N-acetyltransferase 2 (NAT2) enzyme, which plays a crucial role in the metabolism of many clinically useful drugs and exogenous chemicals. Up to now, most association studies that have attempted to relate the acetylation phenotype in NAT2 to a variety of complex human disorders have led to contradictory results in dif…
Hla Genetic Diversity and Linguistic Variation in East Asia
INTRODUCTION Molecular anthropology - the study of human genetic polymorphisms - is now often used to investigate the accuracy of archaeological and/or linguistic hypotheses. One of the classic examples is the use of genetics in an attempt to discriminate between two alternative models for the spread of agriculture in Europe - the demic and the cultural diffusion models - which finally led to a general approval of the former by geneticists, who r…
The place of Slovakian paternal diversity in the clinal European landscape
The highly significant correlation between the results based on fast evolving STRs on one hand and slow evolving SNPs on the other hand suggests a recent timeframe for the settlement of the area
A Homogenizing Process of Selection Has Maintained an “Ultra-Slow” Acetylation NAT2 Variant in Humans
N-Acetyltransferase 2 (NAT2) is an important enzyme involved in the metabolism of a wide spectrum of naturally occurring xenobiotics, including therapeutic drugs and common environmental carcinogens. Extensive polymorphism in NAT2 gives rise to a wide interindividual variation in acetylation capacity, which influences individual susceptibility to various drug-induced adverse reactions and cancers. Striking patterns of geographic differentiation h…
Comprehensive view of the population history of A rabia as inferred by mt DNA variation
OBJECTIVES: Genetic and archaeological research supports the theory that Arabia was the first region traversed by modern humans as they left Africa and dispersed throughout Eurasia. However, the role of Arabia from the initial migration out of Africa until more recent times is still unclear. MATERIALS AND METHODS: We have generated 379 new hypervariable segment 1 (HVS-1) sequences from a range of geographic locations throughout Yemen. We compare …
The historical spread of A rabian P astoralists to the eastern A frican S ahel evidenced by the lactase persistence −13,915*G allele and mitochondrial DNA
OBJECTIVES: Thanks to the ability to digest lactose, Arabian nomads had become less dependent upon their sedentary neighbors and some of these populations spread to Africa. When and by which route they migrated to their current locations have previously been addressed only by historical and archaeological data. METHODS: To address the question of Arab expansion into Africa, we collected samples from several Arabic populations, especially the Bagg…
Biology (7 works) · Demography (6 works) · Evolutionary biology (6 works) · Genetics (6 works) · Population (6 works) · Allele (5 works) · Geography (5 works) · Haplotype (5 works) · Forensic and Genetic Research (4 works) · Gene (4 works)