Vicki Marsh
Biographic Data
| ID | 1731369 |
|---|---|
| NAME | Vicki Marsh |
| GIVEN NAMES | Vicki |
| FAMILY NAME | Marsh |
| SIGNATURE | MARSH V |
| AFFILIATIONS | Kenya Medical Research Institute |
| ORCID | 0000-0002-5178-4250 |
| VERIFIED | Yes |
| TOTAL WORKS | 22 |
| TOTAL CITATIONS | 75 |
| AUTHOR COUNT | 22 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1996 |
| LATEST PUBLICATION YEAR | 2022 |
| H-INDEX | 4 |
Undertaking Community Engagement for a Controlled Human Malaria Infection Study in Kenya
Human infection studies (HIS) involve deliberately infecting healthy volunteers with disease-causing pathogens under controlled conditions. These studies are “controlled” by way of using specific types of pathogens, including dose, and the availability of emergency medical facilities to research volunteers. Most HIS involve diseases whose treatment is known and are done to accelerate the development of novel therapeutics such as vaccines, to addr…
Model for developing context-sensitive responses to vulnerability in research
Health research in low-resource settings often involves individuals and populations defined as ‘vulnerable’. There is growing attention in the literature to the ethical dilemmas that frontline research staff face while conducting such research. However, there is little documented as to how research staff might support one another in identifying and handling these dilemmas in different contexts. Over the course of conducting empirical ethics resea…
Towards an appropriate ethics framework for Health and Demographic Surveillance Systems (HDSS)
INTRODUCTION: Health and Demographic Surveillance Systems (HDSS) collect data on births, deaths and migration from relatively small, geographically defined populations primarily in Africa and Asia. HDSS occupy a grey area between research, healthcare and public health practice and it is unclear how ethics guidance that rely on a research-practice distinction apply to HDSS. This topic has received little attention in the literature. In this paper,…
Applying a gender lens to understand pathways through care for acutely ill young children in Kenyan urban informal settlements
Women in urban low-income settings are disproportionately impacted by acute child illness and the related treatment-seeking and recovery process. The range of interventions needed to support mothers as they navigate their way through children's illnesses and recovery include: deliberate engagement of men in child health to counteract the dominant perception of child health and care as a 'female-domain'; targeted economic strategies such as cash t…
Vulnerability, Agency, and the Research Encounter
Pediatric clinical research in low-resourced countries involves individuals defined as "vulnerable" in research ethics guidance. Insights from research participants can strengthen the design and oversight of studies. We share family members' perspectives and experiences of an observational clinical study conducted in one Kenyan hospital as part of an integrated empirical ethics study. Employing qualitative methods, we explored how research encoun…
Deliberately infecting healthy volunteers with malaria parasites
Controlled human malaria infection (CHMI) studies involve the deliberate infection of healthy volunteers with malaria parasites under controlled conditions to study immune responses and/or test drug or vaccine efficacy. An empirical ethics study was embedded in a CHMI study at a Kenyan research programme to explore stakeholders’ perceptions and experiences of deliberate infection and moral implications of these. Data for this qualitative study we…
Vulnerability and agency across treatment-seeking journeys for acutely ill children
To support children's care and recovery, health systems must be more responsive to the needs of families facing multiple and interacting vulnerabilities. Reducing incurred treatment costs, improving interpersonal quality of care, and strengthening continuity of care across facilities is essential. Promising interventions need to be co-designed with community representatives and health providers and carefully tested for unintended negative consequ…
Socio-ecological determinants of alcohol, tobacco, and drug use behavior of adolescents in Kilifi County at the Kenyan coast
Alcohol, tobacco, and other drug use form a risk factor for health and social problems during adolescence. From a socio-ecological model, perceptions of 85 young people and 10 stakeholders on the types of alcohol, tobacco, and other drugs used and the predisposing and protective factors were explored; among adolescents at the Kenyan Coast in the Kilifi County. We found that the consumption of home-brewed alcohol, tobacco and marijuana smoking, an…
Commentary 1
Young people's and stakeholders' perspectives of adolescent sexual risk behavior in Kilifi County, Kenya
A lack of research exists around the most common forms of sexual risk behaviors among adolescents, including their underlying factors, in Sub-Saharan Africa. Using an Ecological Model of Adolescent Behavior, we explore the perceptions of 85 young people and 10 stakeholders on sexual risk behavior of adolescents in Kilifi County on the coast of Kenya. Our findings show that transactional sex, early sexual debut, coerced sex, and multiple sexual pa…
Debating Ethics in HIV Research
HIV prevention is a critical health issue in N igeria; a country that has one of the worst HIV epidemic profiles in the world. With 270,000 new infections in 2012, N igeria is a prime site for HIV prevention research. One effect of the HIV epidemic has been to revolutionalise ethical norms for the conduct of research: it is now considered unethical to design and implement HIV related studies without community engagement. Unfortunately, there is v…
Best Practices for Ethical Sharing of Individual-Level Health Research Data From Low- and Middle-Income Settings
Sharing individual-level data from clinical and public health research is increasingly being seen as a core requirement for effective and efficient biomedical research. This article discusses the results of a systematic review and multisite qualitative study of key stakeholders’ perspectives on best practices in ethical data sharing in low- and middle-income settings. Our research suggests that for data sharing to be effective and sustainable, mu…
Involving Research Stakeholders in Developing Policy on Sharing Public Health Research Data in Kenya
Increased global sharing of public health research data has potential to advance scientific progress but may present challenges to the interests of research stakeholders, particularly in low-to-middle income countries. Policies for data sharing should be responsive to public views, but there is little evidence of the systematic study of these from low-income countries. This qualitative study explored views on fair data-sharing processes among 60 …
Feedback of Research Findings for Vaccine Trials
Internationally, calls for feedback of findings to be made an ‘ethical imperative’ or mandatory have been met with both strong support and opposition. Challenges include differences in issues by type of study and context, disentangling between aggregate and individual study results, and inadequate empirical evidence on which to draw. In this paper we present data from observations and interviews with key stakeholders involved in feeding back aggr…
Working with C ommunity H ealth W orkers as ‘ V olunteers’ in a Vaccine Trial
C ommunity engagement is increasingly emphasized in biomedical research, as a right in itself, and to strengthen ethical practice. We draw on interviews and observations to consider the practical and ethical implications of involving C ommunity H ealth W orkers ( CHWs ) as part of a community engagement strategy for a vaccine trial on the K enyan C oast. CHWs were initially engaged as an important network to be informed about the trial. However o…
Engaging Communities to Strengthen Research Ethics in Low‐Income Settings
There is wide agreement that community engagement is important for many research types and settings, often including interaction with ‘representatives’ of communities. There is relatively little published experience of community engagement in international research settings, with available information focusing on Community Advisory Boards or Groups ( CAB / CAGs ), or variants of these, where CAB / G members often advise researchers on behalf of t…
Managing misaligned paternity findings in research including sickle cell disease screening in Kenya
All her children are born that way’
Mothers of children with SCD were particularly vulnerable to stigmatisation within families, with underlying structural influences that suggest these findings may apply to other similar settings in Africa, and have relevance for other genetic conditions. The potential, nature and form of stigmatisation point to the role of effective communication and SCD management in addressing for blame and discriminative effects of having a child with SCD. The…
Factors influencing implementation of the Ministry of Health-led private medicine retailer programmes on malaria in Kenya
Understanding the context and implementation processes of PMR programmes and the perspectives of key actors are critical to identifying measures to support their effective implementation. Financial barriers underlie many described challenges, with important implications for policies on subsidies in this sector. In spite of barriers to implementation, increased exposure to programme activities promoted trust and improved relationships between PMRs…
Beginning community engagement at a busy biomedical research programme
Recent debates have described theoretical approaches to identifying situations where this is most critical and potential mechanisms to achieve it. However, there is relatively little published experience of community engagement in practice. A major component of the Kenya Medical Research Institute (KEMRI) Wellcome Trust Research Programme is centred on Kilifi District General Hospital and surrounding community of 240,000 local residents. Document…
Taking social relationships seriously
Individual informed consent is a key ethical obligation for clinical studies, but empirical studies show that key requirements are often not met. Common recommendations to strengthen consent in low income settings include seeking permission from community members through existing structures before approaching individuals, considering informed consent as a process rather than a single event, and assessing participant understanding using questionna…
Evaluating the community education programme of an insecticide-treated bed net trial on the Kenyan coast
Increased interest in the potential contribution of insecticide-impregnated bed nets (ITBN) to malaria control has led to research efforts to determine the impact and sustainability of ITBN programmes in differing environments. There is a need to develop effective, feasible educational strategies that will both inform and motivate community members, and thus maximize the correct usage of ITBN. This is especially true in communities where indigeno…
Taking social relationships seriously
Individual informed consent is a key ethical obligation for clinical studies, but empirical studies show that key requirements are often not met. Common recommendations to strengthen consent in low income settings include seeking permission from community members through existing structures before approaching individuals, considering informed consent as a process rather than a single event, and assessing participant understanding using questionna…
Beginning community engagement at a busy biomedical research programme
Recent debates have described theoretical approaches to identifying situations where this is most critical and potential mechanisms to achieve it. However, there is relatively little published experience of community engagement in practice. A major component of the Kenya Medical Research Institute (KEMRI) Wellcome Trust Research Programme is centred on Kilifi District General Hospital and surrounding community of 240,000 local residents. Document…
All her children are born that way’
Mothers of children with SCD were particularly vulnerable to stigmatisation within families, with underlying structural influences that suggest these findings may apply to other similar settings in Africa, and have relevance for other genetic conditions. The potential, nature and form of stigmatisation point to the role of effective communication and SCD management in addressing for blame and discriminative effects of having a child with SCD. The…
Involving Research Stakeholders in Developing Policy on Sharing Public Health Research Data in Kenya
Increased global sharing of public health research data has potential to advance scientific progress but may present challenges to the interests of research stakeholders, particularly in low-to-middle income countries. Policies for data sharing should be responsive to public views, but there is little evidence of the systematic study of these from low-income countries. This qualitative study explored views on fair data-sharing processes among 60 …
Young people's and stakeholders' perspectives of adolescent sexual risk behavior in Kilifi County, Kenya
A lack of research exists around the most common forms of sexual risk behaviors among adolescents, including their underlying factors, in Sub-Saharan Africa. Using an Ecological Model of Adolescent Behavior, we explore the perceptions of 85 young people and 10 stakeholders on sexual risk behavior of adolescents in Kilifi County on the coast of Kenya. Our findings show that transactional sex, early sexual debut, coerced sex, and multiple sexual pa…
Managing misaligned paternity findings in research including sickle cell disease screening in Kenya
Socio-ecological determinants of alcohol, tobacco, and drug use behavior of adolescents in Kilifi County at the Kenyan coast
Alcohol, tobacco, and other drug use form a risk factor for health and social problems during adolescence. From a socio-ecological model, perceptions of 85 young people and 10 stakeholders on the types of alcohol, tobacco, and other drugs used and the predisposing and protective factors were explored; among adolescents at the Kenyan Coast in the Kilifi County. We found that the consumption of home-brewed alcohol, tobacco and marijuana smoking, an…
Evaluating the community education programme of an insecticide-treated bed net trial on the Kenyan coast
Increased interest in the potential contribution of insecticide-impregnated bed nets (ITBN) to malaria control has led to research efforts to determine the impact and sustainability of ITBN programmes in differing environments. There is a need to develop effective, feasible educational strategies that will both inform and motivate community members, and thus maximize the correct usage of ITBN. This is especially true in communities where indigeno…
Beginning community engagement at a busy biomedical research programme
Recent debates have described theoretical approaches to identifying situations where this is most critical and potential mechanisms to achieve it. However, there is relatively little published experience of community engagement in practice. A major component of the Kenya Medical Research Institute (KEMRI) Wellcome Trust Research Programme is centred on Kilifi District General Hospital and surrounding community of 240,000 local residents. Document…
Taking social relationships seriously
Individual informed consent is a key ethical obligation for clinical studies, but empirical studies show that key requirements are often not met. Common recommendations to strengthen consent in low income settings include seeking permission from community members through existing structures before approaching individuals, considering informed consent as a process rather than a single event, and assessing participant understanding using questionna…
Factors influencing implementation of the Ministry of Health-led private medicine retailer programmes on malaria in Kenya
Understanding the context and implementation processes of PMR programmes and the perspectives of key actors are critical to identifying measures to support their effective implementation. Financial barriers underlie many described challenges, with important implications for policies on subsidies in this sector. In spite of barriers to implementation, increased exposure to programme activities promoted trust and improved relationships between PMRs…
All her children are born that way’
Mothers of children with SCD were particularly vulnerable to stigmatisation within families, with underlying structural influences that suggest these findings may apply to other similar settings in Africa, and have relevance for other genetic conditions. The potential, nature and form of stigmatisation point to the role of effective communication and SCD management in addressing for blame and discriminative effects of having a child with SCD. The…
Feedback of Research Findings for Vaccine Trials
Internationally, calls for feedback of findings to be made an ‘ethical imperative’ or mandatory have been met with both strong support and opposition. Challenges include differences in issues by type of study and context, disentangling between aggregate and individual study results, and inadequate empirical evidence on which to draw. In this paper we present data from observations and interviews with key stakeholders involved in feeding back aggr…
Working with C ommunity H ealth W orkers as ‘ V olunteers’ in a Vaccine Trial
C ommunity engagement is increasingly emphasized in biomedical research, as a right in itself, and to strengthen ethical practice. We draw on interviews and observations to consider the practical and ethical implications of involving C ommunity H ealth W orkers ( CHWs ) as part of a community engagement strategy for a vaccine trial on the K enyan C oast. CHWs were initially engaged as an important network to be informed about the trial. However o…
Engaging Communities to Strengthen Research Ethics in Low‐Income Settings
There is wide agreement that community engagement is important for many research types and settings, often including interaction with ‘representatives’ of communities. There is relatively little published experience of community engagement in international research settings, with available information focusing on Community Advisory Boards or Groups ( CAB / CAGs ), or variants of these, where CAB / G members often advise researchers on behalf of t…
Managing misaligned paternity findings in research including sickle cell disease screening in Kenya
Debating Ethics in HIV Research
HIV prevention is a critical health issue in N igeria; a country that has one of the worst HIV epidemic profiles in the world. With 270,000 new infections in 2012, N igeria is a prime site for HIV prevention research. One effect of the HIV epidemic has been to revolutionalise ethical norms for the conduct of research: it is now considered unethical to design and implement HIV related studies without community engagement. Unfortunately, there is v…
Best Practices for Ethical Sharing of Individual-Level Health Research Data From Low- and Middle-Income Settings
Sharing individual-level data from clinical and public health research is increasingly being seen as a core requirement for effective and efficient biomedical research. This article discusses the results of a systematic review and multisite qualitative study of key stakeholders’ perspectives on best practices in ethical data sharing in low- and middle-income settings. Our research suggests that for data sharing to be effective and sustainable, mu…
Involving Research Stakeholders in Developing Policy on Sharing Public Health Research Data in Kenya
Increased global sharing of public health research data has potential to advance scientific progress but may present challenges to the interests of research stakeholders, particularly in low-to-middle income countries. Policies for data sharing should be responsive to public views, but there is little evidence of the systematic study of these from low-income countries. This qualitative study explored views on fair data-sharing processes among 60 …
Young people's and stakeholders' perspectives of adolescent sexual risk behavior in Kilifi County, Kenya
A lack of research exists around the most common forms of sexual risk behaviors among adolescents, including their underlying factors, in Sub-Saharan Africa. Using an Ecological Model of Adolescent Behavior, we explore the perceptions of 85 young people and 10 stakeholders on sexual risk behavior of adolescents in Kilifi County on the coast of Kenya. Our findings show that transactional sex, early sexual debut, coerced sex, and multiple sexual pa…
Commentary 1
Deliberately infecting healthy volunteers with malaria parasites
Controlled human malaria infection (CHMI) studies involve the deliberate infection of healthy volunteers with malaria parasites under controlled conditions to study immune responses and/or test drug or vaccine efficacy. An empirical ethics study was embedded in a CHMI study at a Kenyan research programme to explore stakeholders’ perceptions and experiences of deliberate infection and moral implications of these. Data for this qualitative study we…
Vulnerability and agency across treatment-seeking journeys for acutely ill children
To support children's care and recovery, health systems must be more responsive to the needs of families facing multiple and interacting vulnerabilities. Reducing incurred treatment costs, improving interpersonal quality of care, and strengthening continuity of care across facilities is essential. Promising interventions need to be co-designed with community representatives and health providers and carefully tested for unintended negative consequ…
Socio-ecological determinants of alcohol, tobacco, and drug use behavior of adolescents in Kilifi County at the Kenyan coast
Alcohol, tobacco, and other drug use form a risk factor for health and social problems during adolescence. From a socio-ecological model, perceptions of 85 young people and 10 stakeholders on the types of alcohol, tobacco, and other drugs used and the predisposing and protective factors were explored; among adolescents at the Kenyan Coast in the Kilifi County. We found that the consumption of home-brewed alcohol, tobacco and marijuana smoking, an…
Model for developing context-sensitive responses to vulnerability in research
Health research in low-resource settings often involves individuals and populations defined as ‘vulnerable’. There is growing attention in the literature to the ethical dilemmas that frontline research staff face while conducting such research. However, there is little documented as to how research staff might support one another in identifying and handling these dilemmas in different contexts. Over the course of conducting empirical ethics resea…
Towards an appropriate ethics framework for Health and Demographic Surveillance Systems (HDSS)
INTRODUCTION: Health and Demographic Surveillance Systems (HDSS) collect data on births, deaths and migration from relatively small, geographically defined populations primarily in Africa and Asia. HDSS occupy a grey area between research, healthcare and public health practice and it is unclear how ethics guidance that rely on a research-practice distinction apply to HDSS. This topic has received little attention in the literature. In this paper,…
Applying a gender lens to understand pathways through care for acutely ill young children in Kenyan urban informal settlements
Women in urban low-income settings are disproportionately impacted by acute child illness and the related treatment-seeking and recovery process. The range of interventions needed to support mothers as they navigate their way through children's illnesses and recovery include: deliberate engagement of men in child health to counteract the dominant perception of child health and care as a 'female-domain'; targeted economic strategies such as cash t…
Vulnerability, Agency, and the Research Encounter
Pediatric clinical research in low-resourced countries involves individuals defined as "vulnerable" in research ethics guidance. Insights from research participants can strengthen the design and oversight of studies. We share family members' perspectives and experiences of an observational clinical study conducted in one Kenyan hospital as part of an integrated empirical ethics study. Employing qualitative methods, we explored how research encoun…
Undertaking Community Engagement for a Controlled Human Malaria Infection Study in Kenya
Human infection studies (HIS) involve deliberately infecting healthy volunteers with disease-causing pathogens under controlled conditions. These studies are “controlled” by way of using specific types of pathogens, including dose, and the availability of emergency medical facilities to research volunteers. Most HIS involve diseases whose treatment is known and are done to accelerate the development of novel therapeutics such as vaccines, to addr…
Medicine (19 works) · Political science (19 works) · Public relations (15 works) · Psychology (13 works) · Ethics in Clinical Research (12 works) · Sociology (12 works) · Qualitative research (9 works) · Kenya (6 works) · Nursing (6 works) · Research ethics (6 works)