Nicola Desmond
Dados Biográficos
| ID | 1731950 |
|---|---|
| NOME | Nicola Desmond |
| PRENOMES | Nicola |
| SOBRENOME | Desmond |
| ASSINATURA | DESMOND N |
| AFILIAÇÕES | University of Liverpool |
| ORCID | 0000-0002-2874-8569 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 41 |
| TOTAL DE CITAÇÕES | 28 |
| TOTAL COMO AUTOR | 41 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 2005 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2026 |
| ÍNDICE H | 2 |
How the multiple burdens of daily oral antiretroviral therapy shape the acceptability of long-acting injectable cabotegravir and rilpivirine among people living with HIV in Uganda and South Africa
Long-acting injectable antiretroviral therapy (LAI-ART) has the potential to improve adherence and treatment outcomes among people living with HIV (PLHIV) who experience challenges with adherence to oral medication. We explored how experiences with daily oral ART shaped LAI-ART acceptability within a clinical trial in Uganda and South Africa. A qualitative methods sub-study was nested within a phase 3b randomised clinical trial evaluating long-ac…
A context-responsive health systems intervention improves the uptake of early infant HIV diagnosis
Health system challenges limit uptake of early infant diagnosis of HIV (EID). Context-appropriate strategies are required to achieve global 95% six-week testing target. We evaluated a co-designed context-appropriate enhanced health system (EEHS) intervention to strengthen client identification, appointment booking systems, leadership, and facility-based training to improve enrolment of Infants Exposed to HIV (IEH) in HIV care and testing at six w…
Acceptability of Covid-19 self-testing among social and clinical vulnerable populations using a decentralized testing model in Abuja, Nigeria; A mixed methods analysis of an implementation study
Diagnostic testing is critical during infectious disease outbreaks, enabling timely patient management and isolation to reduce transmission and mortality. During the COVID-19 outbreak in Nigeria, testing rates remained low due to limited access to centralized RT-PCR sites. To expand access, the National COVID-19 Testing Strategy (January 2021) introduced decentralized self-testing models targeting vulnerable populations. This study assessed the u…
Expert stakeholders on the role of qualitative research in World Health Organisation guidelines
Qualitative research findings are sometimes used in guideline development, but usually in an ad hoc manner. We sought to explore how qualitative research could contribute to guideline development, identify examples of qualitative research being used to inform guideline development, and gather suggestions for how qualitative research might be incorporated more systematically in guideline development. Using a topic guide, in 2022–24, we interviewed…
Developing an intervention to improve early infant HIV diagnosis service uptake among postpartum women in Malawi’s primary healthcare using a co-designing approach with stakeholders
Low health service use by women and infants after birth limits early infant HIV diagnosis (EID). From August 2021 to December 2022, we collaborated with 44 healthcare workers (HCW), service users, and non-governmental organisation stakeholders from seven public facilities and five non-governmental organisations in Blantyre, building on a previous study. We analysed context-specific problems in EID services and co-designed a context-appropriate en…
Covid-19 diagnosis within five days of symptoms onset among healthcare workers in Malawi; Non-randomized control trial of self-testing using Ag-RDTs
Efficient and sustainable models of Corona Virus Disease of 2019 (COVID‐19) screening among healthcare workers (HCWs) such as self-testing are essential for averting transmission within and outside health care facilities. We compared the number of confirmed early COVID‐19 positive diagnoses (defined as COVID‐19 cases diagnosed within five days of symptoms onset) among HCW in self-testing arm using Antigen Rapid Diagnostic Test kits (Ag-RDT) and s…
Understanding the acceptability of Covid-19 antigen rapid diagnostic tests
Accessible and timely diagnostic testing was essential during the COVID-19 pandemic to control the virus’s spread and mitigate severe outcomes. However, real-time polymerase chain reaction tests, although sensitive incur high costs and prolonged turnaround times, and face implementation challenges in many resource-constrained settings. Antigen rapid diagnostic tests (Ag-RDT), which can be administered either by providers or as self-tests, are acc…
Self-management of chronic conditions including multimorbidity in sub-Saharan Africa
The increasing prevalence of multimorbidity in sub-Saharan Africa (SSA) is an urgent concern for health service delivery, yet little is known about how best to support self-management- the tasks patients and carers take to maintain physical and mental health in this context. This review synthesized qualitative evidence that describes self-management of four chronic conditions- HIV, diabetes, chronic kidney disease, and hypertension, including mul…
Exploring the Interplay of Social and Physical Factors in Risk Dynamics and Transitions Across the Life-Course of Female Sex Workers in Blantyre, Malawi
Sexual risk amongst female sex workers (FSW) varies across the life-course and is influenced by socio-economic and interpersonal factors that affect behavioural choices and engagement in HIV/STI care. We explored transitions in the life-course of FSW to understand the dynamics of sexual risk in Blantyre, Malawi. We implemented a nested longitudinal qualitative study as part of the AMETHIST Consortium, a study testing approaches to reduce HIV tran…
Improving care pathways for children with severe illness through implementation of the Aspire mHealth primary Etat package in Malawi
Providing emergency care in low resource settings relies on delivery by lower cadres of health workers (LCHW). We describe the development, implementation and mixed methods evaluation of a mobile health (mHealth) triage algorithm based on the WHO Emergency, Triage, Assessment, and Treatment (ETAT) for primary-level care. We conducted an observational study design of implementation research. Key stakeholders were engaged throughout implementation.…
‘Why would they spend all this money and give us these items for free?’
We carried out a qualitative study to gain a deeper understanding of the social context of the Cooking and Pneumonia Study (CAPS) and implications for implementation of clean cooking and similar interventions. Such initiatives are recognised as complex, power-laden processes, which has consequences for outcomes and uptake. However, understanding of how precarious livelihoods and unequal power differentials impact on trials of technology is limite…
Power and Powerlessness in a Group Based Digital Story Telling Project-An Exploration of Community Perceptions of Health Concerns in Urban Malawi
Digital Story Telling (DST) is an art-based research method used to explore embodied experience of health and initiate dialogue with under-represented groups on issues affecting them. It involves engaging participants to create and share their stories using photos, drawings, and audio recordings in short videos. Benefits of DST include enhancing co-creation of knowledge, empowering participants to confront dominant narratives and revise inaccurat…
A critical examination of research narratives ‘rumours’ and passive community resistance in medical research
Several studies in Africa have reported effects of ‘rumours, misconceptions or misinformation’ on medical research participation and uptake of health interventions. As such, community engagement has sometimes been used for instrumental purposes to enhance acceptability of research or interventions and prevent ‘rumours’. This paper seeks to highlight the value of ongoing engagement with communities to understand research narratives ‘rumours’ repro…
Resource availability and barriers to delivering quality care for newborns in hospitals in the southern region of Malawi
Facility-based births have increased in low and middle-income countries, but babies still die due to poor care. Improving care leads to better newborn outcomes. However, data are lacking on how well facilities are prepared to support. We assessed the availability of human and material resources and barriers to delivering quality care for newborns and barriers to delivering quality care for newborns. We adapted the WHO Service Availability and Rea…
Effect of door-to-door distribution of HIV self-testing kits on HIV testing and antiretroviral therapy initiation
INTRODUCTION: Reaching high coverage of HIV testing remains essential for HIV diagnosis, treatment and prevention. We evaluated the effectiveness and safety of door-to-door distribution of HIV self-testing (HIVST) kits in rural Malawi. METHODS: This cluster randomised trial, conducted between September 2016 and January 2018, used restricted 1:1 randomisation to allocate 22 health facilities and their defined areas to door-to-door HIVST alongside …
Paediatric Emergency Triage, Assessment and Treatment (Etat) – preparedness for implementation at primary care facilities in Malawi
BACKGROUND: The majority of deaths amongst children under 5 years are still due to preventable infectious causes. Emergency care has been identified as a key health system weakness, and referrals are often challenging. OBJECTIVE: We aimed to establish how prepared frontline facilities in Malawi are to implement WHO Emergency Triage Assessment and Treatment (ETAT) guidelines, to support policy and planning decisions. METHODS: We conducted a concur…
‘Cooking is for everyone?’
BACKGROUND: Household air pollution (HAP) resulting from cooking on open fires has been linked to considerable ill-health in women and girls, including chronic respiratory diseases, and has been identified as a contributor to climate change. It has been suggested that cleaner burning cookstoves can mitigate these risks, and that time saved through speedier cooking can lead to the economic empowerment of women. Despite these and other potential ad…
Too old to test?’
Characteristics associated with age-gender norms and social position encourage self-testing but drive poor HIV-risk perception and unacceptability of conventional HIV testing in midlife-older adults. There is an urgent need to provide targeted messages and services more appropriate to midlife-older adults in sub-Saharan Africa. HIVST which has often been highlighted as a tool for reaching young people, may be a valuable tool for engaging midlife-…
“I wanted evidence that my status had changed, so that is why I tested”
HIV testing among female sex workers (FSWs) is an established global health priority. HIV self-testing (HIVST) seems to have the potential to address issues of confidentiality, privacy and convenience among this key population. HIVST, however, may result in unintended consequences as its implementation unfolds in a complex sex work context characterised by unequal power relations, stigma and high HIV prevalence. We aimed to explore the experience…
Sex, power, marginalisation and HIV amongst young fishermen in Malawi
Through scale-up of effective treatment and prevention, HIV incidence rates are falling across Southern and Eastern Africa. However, key population groups, including people living in fishing communities, continue to face an elevated risk of infection and have high rates of undiagnosed disease. We set out to investigate how intersecting inequalities make young fishermen working on the southern shores of Lake Malawi particularly vulnerable to HIV-i…
Public engagement in Malawi through a health-talk radio programme ‘ Umoyo nkukambirana ’
Radio is an effective source of health information in many resource poor countries. In Malawi, 53% of households own radios however few radio programmes in Malawi focus on health issues in the context of medical research. An interactive health-talk radio programme ‘ Umoyo nkukambirana’ was introduced by Malawi-Liverpool-Wellcome Trust Clinical Research Programme on a national radio station. The aim was to increase awareness of health and medical …
‘We are the eyes and ears of researchers and community’
Community engagement to protect and empower participating individuals and communities is an ethical requirement in research. There is however limited evidence on effectiveness or relevance of some of the approaches used to improve ethical practice. We conducted a study to understand the rationale, relevance and benefits of community engagement in health research. This paper draws from this wider study and focuses on factors that shaped Community …
The effectiveness and cost-effectiveness of community-based lay distribution of HIV self-tests in increasing uptake of HIV testing among adults in rural Malawi and rural and peri-urban Zambia
Clinicaltrials.gov, Malawi: NCT02718274 , 18 March 2016; Zambia: NCT02793804 , 3 June 2016. Protocol date: 21 February 2018
Measuring sexual behaviour in Malawi
Diaries may therefore have higher validity for sensitive behaviour reporting and thus be the preferred method in similar African contexts in measuring sexual behaviours
A qualitative evaluation of hospital versus community-based management of patients on injectable treatments for tuberculosis
Guardian administered intramuscular injections were safe and well received. Community-based care offered many advantages over hospital-based care for patients receiving long-term injectable treatment for TB and their families
A typology of groups at risk of HIV/STI in a gold mining town in north-western Tanzania
Exploring the complexity of microfinance and HIV in fishing communities on the shores of Lake Malawi
This study utilised qualitative research methodology to explore female fish traders’ experiences of accessing microfinance in fishing communities in southern Malawi. Microfinance is a tool that has been used to alleviate poverty. People living in fishing communities in the Global South are at an increased risk of HIV and, equally, microfinance has been identified as a tool to prevent HIV. The authors' research found consistent testimonies of over…
Sex, power, marginalisation and HIV amongst young fishermen in Malawi
Through scale-up of effective treatment and prevention, HIV incidence rates are falling across Southern and Eastern Africa. However, key population groups, including people living in fishing communities, continue to face an elevated risk of infection and have high rates of undiagnosed disease. We set out to investigate how intersecting inequalities make young fishermen working on the southern shores of Lake Malawi particularly vulnerable to HIV-i…
Whose failure counts?' A critical reflection on definitions of failure for community health volunteers providing HIV self-testing in a community-based HIV/TB intervention study in urban Malawi
The category of community health worker applied within the context of health intervention trials has been promoted as a cost-effective approach to meeting study objectives across large populations, relying on the promotion of the concept of 'community belonging' to encourage altruistic volunteerism from community members to promote health. This community-based category of individuals is recruited to facilitate externally driven priorities defined…
A typology of groups at risk of HIV/STI in a gold mining town in north-western Tanzania
The benefits of participatory methodologies to develop effective community dialogue in the context of a microbicide trial feasibility study in Mwanza, Tanzania
Participatory techniques were instrumental in promoting meaningful dialogue between the research team, study participants and community representatives in Mwanza, allowing researchers and community representatives to gain a shared understanding of project-related priority areas for intervention
A model for community representation and participation in HIV prevention trials among women who engage in transactional sex in Africa
Actively engaging communities in effective partnerships for the design and implementation of HIV prevention research is vital to the successful conduct of ethically robust, locally-appropriate clinical trials in developing countries. This is especially true in vulnerable at-risk sub-populations, where definitions of "community", "participation" and "representation" can be difficult to apply. This study was conducted to investigate the feasibility…
Sexual risk behaviour for women working in recreational venues in Mwanza, Tanzania
Qualitative research was conducted to explore the social context of sexual-risk behaviour among women working in recreational occupations, during a feasibility study in preparation for the Phase III clinical trial of vaginal microbicides in Mwanza, Tanzania. Participant observation was conducted in 68 recreational venues. Six focus group discussions were conducted with women working in recreational occupations and two with male customers at these…
Intravaginal and Menstrual Practices among Women Working in Food and Recreational Facilities in Mwanza, Tanzania
Intravaginal and menstrual practices may potentially influence results of trials of microbicides for HIV prevention through effects on the vaginal environment and on adherence to microbicide and placebo products. As part of the feasibility study for the Microbicides Development Programme Phase 3 trial of a vaginal microbicide in Mwanza, a variety of quantitative and qualitative methods were used to describe these practices, associations with beha…
The Uptake and Accuracy of Oral Kits for HIV Self-Testing in High HIV Prevalence Setting
BACKGROUND: Although HIV testing and counseling (HTC) uptake has increased dramatically in Africa, facility-based services are unlikely to ever meet ongoing need to the full. A major constraint in scaling up community and home-based HTC services is the unacceptability of receiving HTC from a provider known personally to prospective clients. We investigated the potential of supervised oral HIV self-testing from this perspective. METHODS AND FINDIN…
Managing risk through treatment-seeking in rural north-western Tanzania
This paper examines how risk is perceived by lay populations in response to two aetiologically connected but conceptually divided diseases – malaria and nzoka . Using case study data from an ethnographic study of risk perceptions in north-western Tanzania, we explore the relevance of risk as a concept within a community exposed to traditional and modern value systems, a pluralistic health care system and syncretic treatment-seeking behaviour. We …
Control, struggle, and emergent masculinities
Facilitating men to seek care early is an urgent public health imperative, given the contexts of high HIV/AIDS prevalence but increasingly available treatment, and the role of care-seeking delay in TB transmission. Men's struggles trying to achieve ideal images seem to influence their engagement with their health. Ambiguous views regarding some key masculinity representations and the embrace of less harmful masculinities raise questions about som…
Factors Shaping Initial Decision-Making to Self-test Amongst Cohabiting Couples in Urban Blantyre, Malawi
In sub-Saharan Africa, most new HIV infections occur in stable relationships, making couples testing an important intervention for HIV prevention. We explored factors shaping the decision-making of cohabiting couples who opted to self-test in Blantyre, Malawi. Thirty-four self-tested participants (17 couples) were interviewed. Motivators for HIV self-testing (HIVST) emerged at three main levels. Individual motivations included perceived benefits …
Uptake, Accuracy, Safety, and Linkage into Care over Two Years of Promoting Annual Self-Testing for HIV in Blantyre, Malawi
BACKGROUND: Home-based HIV testing and counselling (HTC) achieves high uptake, but is difficult and expensive to implement and sustain. We investigated a novel alternative based on HIV self-testing (HIVST). The aim was to evaluate the uptake of testing, accuracy, linkage into care, and health outcomes when highly convenient and flexible but supported access to HIVST kits was provided to a well-defined and closely monitored population. METHODS AND…
Considerations for a Human Rights Impact Assessment of a Population Wide Treatment for HIV Prevention Intervention
Increasing attention is being paid to the potential of anti‐retroviral treatment ( ART ) for HIV prevention. The possibility of eliminating HIV from a population through a universal test and treat intervention, where all people within a population are tested for HIV and all positive people immediately initiated on ART , as part of a wider prevention intervention, was first proposed in 2009. Several clinical trials testing this idea are now in inc…
Towards a gender perspective in qualitative research on voluntary medical male circumcision in east and southern Africa
The World Health Organization endorsed voluntary medical male circumcision (VMMC) in 2007 as an effective method to provide partial protection against heterosexual female-to-male transmission of HIV in regions with high rates of such transmission, and where uptake of VMMC is low. Qualitative research conducted in east and southern Africa has focused on assessing acceptability, barriers to uptake of VMMC and the likelihood of VMMC increasing men's…
Exploring the complexity of microfinance and HIV in fishing communities on the shores of Lake Malawi
This study utilised qualitative research methodology to explore female fish traders’ experiences of accessing microfinance in fishing communities in southern Malawi. Microfinance is a tool that has been used to alleviate poverty. People living in fishing communities in the Global South are at an increased risk of HIV and, equally, microfinance has been identified as a tool to prevent HIV. The authors' research found consistent testimonies of over…
Whose failure counts?' A critical reflection on definitions of failure for community health volunteers providing HIV self-testing in a community-based HIV/TB intervention study in urban Malawi
The category of community health worker applied within the context of health intervention trials has been promoted as a cost-effective approach to meeting study objectives across large populations, relying on the promotion of the concept of 'community belonging' to encourage altruistic volunteerism from community members to promote health. This community-based category of individuals is recruited to facilitate externally driven priorities defined…
Public engagement in Malawi through a health-talk radio programme ‘ Umoyo nkukambirana ’
Radio is an effective source of health information in many resource poor countries. In Malawi, 53% of households own radios however few radio programmes in Malawi focus on health issues in the context of medical research. An interactive health-talk radio programme ‘ Umoyo nkukambirana’ was introduced by Malawi-Liverpool-Wellcome Trust Clinical Research Programme on a national radio station. The aim was to increase awareness of health and medical …
‘We are the eyes and ears of researchers and community’
Community engagement to protect and empower participating individuals and communities is an ethical requirement in research. There is however limited evidence on effectiveness or relevance of some of the approaches used to improve ethical practice. We conducted a study to understand the rationale, relevance and benefits of community engagement in health research. This paper draws from this wider study and focuses on factors that shaped Community …
The effectiveness and cost-effectiveness of community-based lay distribution of HIV self-tests in increasing uptake of HIV testing among adults in rural Malawi and rural and peri-urban Zambia
Clinicaltrials.gov, Malawi: NCT02718274 , 18 March 2016; Zambia: NCT02793804 , 3 June 2016. Protocol date: 21 February 2018
Measuring sexual behaviour in Malawi
Diaries may therefore have higher validity for sensitive behaviour reporting and thus be the preferred method in similar African contexts in measuring sexual behaviours
A qualitative evaluation of hospital versus community-based management of patients on injectable treatments for tuberculosis
Guardian administered intramuscular injections were safe and well received. Community-based care offered many advantages over hospital-based care for patients receiving long-term injectable treatment for TB and their families
Discordance, Disclosure and Normative Gender Roles
A community-based HIV self-testing study in Blantyre, Malawi demonstrated that not all individuals living in couples tested with their partner. We describe factors dissuading individuals in couples from self-testing with their partner. Data were drawn from qualitative study exploring consequences of HIV self-testing within couples. In-depth interviews were conducted with 33 individuals living in couples who tested alone. Participants expressed fe…
Six dimensions of research trial acceptability
“I wanted evidence that my status had changed, so that is why I tested”
HIV testing among female sex workers (FSWs) is an established global health priority. HIV self-testing (HIVST) seems to have the potential to address issues of confidentiality, privacy and convenience among this key population. HIVST, however, may result in unintended consequences as its implementation unfolds in a complex sex work context characterised by unequal power relations, stigma and high HIV prevalence. We aimed to explore the experience…
Sex, power, marginalisation and HIV amongst young fishermen in Malawi
Through scale-up of effective treatment and prevention, HIV incidence rates are falling across Southern and Eastern Africa. However, key population groups, including people living in fishing communities, continue to face an elevated risk of infection and have high rates of undiagnosed disease. We set out to investigate how intersecting inequalities make young fishermen working on the southern shores of Lake Malawi particularly vulnerable to HIV-i…
Effect of door-to-door distribution of HIV self-testing kits on HIV testing and antiretroviral therapy initiation
INTRODUCTION: Reaching high coverage of HIV testing remains essential for HIV diagnosis, treatment and prevention. We evaluated the effectiveness and safety of door-to-door distribution of HIV self-testing (HIVST) kits in rural Malawi. METHODS: This cluster randomised trial, conducted between September 2016 and January 2018, used restricted 1:1 randomisation to allocate 22 health facilities and their defined areas to door-to-door HIVST alongside …
Paediatric Emergency Triage, Assessment and Treatment (Etat) – preparedness for implementation at primary care facilities in Malawi
BACKGROUND: The majority of deaths amongst children under 5 years are still due to preventable infectious causes. Emergency care has been identified as a key health system weakness, and referrals are often challenging. OBJECTIVE: We aimed to establish how prepared frontline facilities in Malawi are to implement WHO Emergency Triage Assessment and Treatment (ETAT) guidelines, to support policy and planning decisions. METHODS: We conducted a concur…
Medicine (32 obras) · HIV/AIDS Research and Interventions (20 obras) · Family medicine (17 obras) · Nursing (17 obras) · Sociology (17 obras) · Political science (16 obras) · Qualitative research (16 obras) · Population (13 obras) · Psychology (13 obras) · Environmental health (12 obras)