M J Goldacre
Biographic Data
| ID | 1868752 |
|---|---|
| NAME | M J Goldacre |
| GIVEN NAMES | M J |
| FAMILY NAME | Goldacre |
| SIGNATURE | GOLDACRE M J |
| AFFILIATIONS | University of Oxford |
| ORCID | 0000-0002-3895-1739 |
| VERIFIED | Yes |
| TOTAL WORKS | 37 |
| TOTAL CITATIONS | 75 |
| AUTHOR COUNT | 37 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1977 |
| LATEST PUBLICATION YEAR | 2022 |
| H-INDEX | 4 |
Long-term trends in population-based hospitalisation rates for myocardial infarction in England
AIM: To analyse the timing and scale of temporal changes in rates of hospitalised myocardial infarction (MI) in England by age and sex from 1968 to 2016. METHODS: MI admissions for adults aged 15-84 years were identified from electronic hospital data. We calculated age-standardised and age-specific rates, and examined trends using joinpoint. RESULTS: From 1968 to 2016, there were 3.5 million admissions for MI in England (68% men). Rates increased…
Risk of Schizophrenia and Bipolar Disorder in Patients With Multiple Sclerosis
Further research is needed to investigate the potential association between MS and schizophrenia and/or bipolar disorder as it may shed light on underlying pathophysiology and help identify potential shared risk factors
Associations between specific autoimmune diseases and subsequent dementia
OBJECTIVE: To determine whether hospital admission for autoimmune disease is associated with an elevated risk of future admission for dementia. METHODS: Retrospective, record-linkage cohort study using national hospital care and mortality administrative data, 1999-2012. Cohorts of people admitted to hospital with a range of autoimmune diseases were constructed, along with a control cohort, and followed forward in time to see if they developed dem…
Mortality from heart failure, acute myocardial infarction and other ischaemic heart disease in England and Oxford
BACKGROUND: Age-standardised death rates from acute myocardial infarction (AMI) and ischaemic heart disease (IHD) have been declining in most developed countries. However, the magnitude of such reductions and how they impact on death from heart failure are less certain. We sought to assess and compare temporal trends in mortality from heart failure, AMI and non-AMI IHD over a 30-year period in England. METHODS: We analysed death registration data…
OP28 Trends in Mortality from Stroke, and Stroke Subtypes, in the Oxford Region 1979-2011
Background A decline in mortality rates from stroke has been observed in many industrialised countries in recent decades. We were interested in whether any of the observed decline in stroke, and its subtypes, might be artefactual rather than real. In particular, we wanted to determine whether any of the trends over time might be attributable to shifts in death certification practice between underlying cause and contributory cause, and/or shifts o…
PS56 Risk Of Intentional Self-Harm In Young People With Selected Mental And Chronic Physical Conditions In England
Background Self-harm is a well recognised act of psychological distress in some young people. Children and young adults with chronic disease are known to have an increased risk of psychological distress, but their risk of intentional self-harm is not well documented in England. We aimed to determine the risk of intentional self-harm in an English population aged 10–24 years with a range of psychological disorders, namely schizophrenia, bipolar di…
Increased risk of tuberculosis disease in people with diabetes mellitus
BACKGROUND: The authors aimed to determine whether, and by how much, diabetes mellitus (DM) increases the risk of tuberculosis (TB) and conversely whether TB increases the risk of DM. METHODS: Retrospective cohort analyses using data from two Oxford Record Linkage Study (ORLS) datasets, containing information on hospital admissions and day-case care between 1963 and 1998 (ORLS1) and between 1999 and 2005 (ORLS2), were carried out. The rate ratio …
Risk of invasive pneumococcal disease in people admitted to hospital with selected immune-mediated diseases
BACKGROUND: Invasive pneumococcal disease is a serious infection, and it is an important cause of morbidity and mortality in certain groups of 'at-risk' people. Those considered 'at-risk' in the UK include very young children, people aged 65 years and older and people with certain serious chronic diseases, asplenia or immunosuppression. There is little evidence about whether people with immune-mediated diseases are at increased risk of pneumococc…
Quantifying Urbanization as a Risk Factor for Noncommunicable Disease
P2-333 Acute myocardial infarction
Introduction There are several population-based English studies of AMI, but they are local rather than national, do not necessarily distinguish first events and re-infarctions, and are out of date. Our objective was to study AMI incidence and 30-day case fatality rates (CFRs) for first and recurrent events in England in 2007 (population 51.8 million). Methods Analysis of linked routine national hospital and mortality data, with an 8-year washout …
An index of unhealthy lifestyle is associated with coronary heart disease mortality rates for small areas in England after adjustment for deprivation
Indices of socio-economic deprivation are often used as a proxy for differences in the health behaviours of populations within small areas, but these indices are a measure of the economic environment rather than the health environment. Sets of synthetic estimates of the ward-level prevalence of low fruit and vegetable consumption, obesity, raised blood pressure, raised cholesterol and smoking were combined to develop an index of unhealthy lifesty…
Validation of model-based estimates (synthetic estimates) of the prevalence of risk factors for coronary heart disease for wards in England
Elective surgery for aortic abdominal aneurysm
Introduction: The aim of this study was to quantify mortality after elective repair of abdominal aortic aneurysm (AAA) in England, and to compare English case fatality rates (CFRs) with those reported in the literature. Patients and methods: English Hospital Episode Statistics (HES) for the financial years 1998/9 to 2001/2, linked to death data, were analysed. A systematic literature search was undertaken to identify studies reporting CFRs after …
Mortality from heart failure in an English population, 1979–2003
Objective: It is widely held that there will be an epidemic of heart failure in Europe and North America as a result of increased survival from myocardial infarction and other coronary heart disease. The study objective was to discover if the decline in mortality from coronary heart disease has been accompanied by a rise in mortality from heart failure in the study population. Design: Analysis of database of mortality records including all certif…
The association between smoking during pregnancy and hospital inpatient costs in childhood
Multiple sclerosis after infectious mononucleosis
Objective: To ascertain if infectious mononucleosis is a risk factor for the development of multiple sclerosis (MS); and, if it is, whether its effect is close to or remote in time from the onset of MS. Design: Analysis of database of linked abstracts of records of hospital admission and death. Setting: Health region in central southern England. Main outcome measure: Ratio of rate of MS in a cohort of people admitted to hospital with infectious m…
Skin cancer in people with multiple sclerosis
Objective: The prevalence of multiple sclerosis (MS) varies with latitude: it increases with distance from the equator in both hemispheres. To seek evidence on whether solar radiation is a protective factor for MS, this study investigated whether skin cancer, as an indicator of solar radiation, is less common in people with MS than in others. Design: Analysis of a database of linked hospital records and death certificates. Setting: The Oxford Reg…
Crohn’s disease, ulcerative colitis, and measles vaccine in an English population, 1979–1998
Study objectives: To study the hospitalised incidence of Crohn’s disease (CD) and ulcerative colitis (UC) from 1979 to 1998; and to determine whether the introduction of the measles vaccination programme was associated with an increase in the young. Design: Analysis of linked data on hospital admissions; a cohort analysis of the effect of the measles vaccination programme on the incidence of hospitalised CD and UC; and a comparison of these resul…
Appendicectomy, tonsillectomy, and inflammatory bowel disease
Study objective: To determine whether appendicectomy and tonsillectomy are associated with ulcerative colitis (UC) or Crohn's disease (CD); and, if so, whether the associations are related to age at operation. Design: Nested case-control studies using a longitudinal database of linked hospital and death record abstracts. Setting: Southern England. Patients: Statistical records of people diagnosed with UC, CD, or a control condition admitted to ho…
Abortion and breast cancer
There is controversy about whether interruption of pregnancy, particularly if it is induced rather than spontaneous, increases the risk of breast cancer. Individual studies, and reviews summarising them, have given conflicting results.1 2 Recent guidelines from the UK Royal College of Obstetricians and Gynaecologists (http://www.rcog.org.uk) state that the evidence is inconclusive but that, when only those studies least susceptible to bias are co…
Depression and anxiety in people with inflammatory bowel disease
STUDY OBJECTIVE: To determine whether depression or anxiety co-occurs with ulcerative colitis (UC) or Crohn's disease (CD) more often than expected by chance, and, if so, whether the mental disorders generally precede or follow the inflammatory bowel diseases (IBD). DESIGN: Nested case-control studies using a database of linked hospital record abstracts. SETTING: Southern England. MAIN RESULTS: Both depression and anxiety preceded UC significantl…
Hospitalization for Ambulatory Care-Sensitive Conditions
Secular trends in proximal femoral fracture, Oxford record linkage study area and England 1968-86
OBJECTIVE: To study hospital admission rates for fractures of the proximal femur over a period when incidence is reported to have increased, compensating for known lack of precision in coding, excluding nonemergency admissions and transfers, and modelling for age, period, and cohort effects. DESIGN: Validation of coding of a sample of hospital admissions followed by study of two sets of routinely collected statistical abstracts of hospital record…
Comparing measures of variation
late 1970s and is now rising.After allowing for the proportion of births to mothers over 35 years, the trend with year remains significant at the 5% level, OR=0-9996, (95%CI: 0 9995, 0 9997).Over the period there has also been a steady increase in the proportion of single mothers.As single mothers are more likely to have boys,4 it is likely that the decline in the sex ratio of children born to other women is even greater.This decline in the sex r…
Geographical variation in hospital admission rates
OBJECTIVE--To measure variation in hospital admission rates between health districts in part of the English NHS, comparing a wide range of medical and surgical conditions. DESIGN--Retrospective analysis of interdistrict variation using linked routine hospital admission data. Comparisons were also made with levels of variation reported from the USA. SETTING--Oxford Regional Health Authority, 1979-86. SUBJECTS--Six district health authorities--tota…
Hospitalization for Ambulatory Care-Sensitive Conditions
Cause-specific mortality
STUDY OBJECTIVE--To determine the extent to which individual diseases, when recorded as being present shortly before death, were certified as causes of death. DESIGN--Retrospective cohort study in which the "subjects" were computerised linked records. SETTING--Six districts in the Oxford Regional Health Authority area (covering a population of 1.9 million people). SUBJECTS--Linked abstracts of hospital records and death certificates for people wh…
Quantifying Urbanization as a Risk Factor for Noncommunicable Disease
Reliability of routine hospital data on poisoning as measures of deliberate self poisoning in adolescents
STUDY OBJECTIVE--The aim was to assess the extent to which routinely collected data on poisoning in adolescents reflected deliberate self poisoning and, in doing, so to assess the accuracy of the diagnostic information on poisoning in the routine hospital abstracts which form the joint data base of Hospital Activity Analysis and the Oxford Record Linkage Study (ORLS). DESIGN--A comparison was made (a) of all eligible ORLS records during the study…
Depression and anxiety in people with inflammatory bowel disease
STUDY OBJECTIVE: To determine whether depression or anxiety co-occurs with ulcerative colitis (UC) or Crohn's disease (CD) more often than expected by chance, and, if so, whether the mental disorders generally precede or follow the inflammatory bowel diseases (IBD). DESIGN: Nested case-control studies using a database of linked hospital record abstracts. SETTING: Southern England. MAIN RESULTS: Both depression and anxiety preceded UC significantl…
Computerised linking of medical records
OBJECTIVES--To report on the development of computer assisted methods for linking medical records and record abstracts. DESIGN--The methods include file blocking, to put records in an order which makes searching efficient; matching, which is the process of comparing records to determine whether they do or do not relate to the same person; linkage, which is the process of assembling correctly matched records into a time sequenced composite record …
Validation of model-based estimates (synthetic estimates) of the prevalence of risk factors for coronary heart disease for wards in England
Skin cancer in people with multiple sclerosis
Objective: The prevalence of multiple sclerosis (MS) varies with latitude: it increases with distance from the equator in both hemispheres. To seek evidence on whether solar radiation is a protective factor for MS, this study investigated whether skin cancer, as an indicator of solar radiation, is less common in people with MS than in others. Design: Analysis of a database of linked hospital records and death certificates. Setting: The Oxford Reg…
Mortality from heart failure, acute myocardial infarction and other ischaemic heart disease in England and Oxford
BACKGROUND: Age-standardised death rates from acute myocardial infarction (AMI) and ischaemic heart disease (IHD) have been declining in most developed countries. However, the magnitude of such reductions and how they impact on death from heart failure are less certain. We sought to assess and compare temporal trends in mortality from heart failure, AMI and non-AMI IHD over a 30-year period in England. METHODS: We analysed death registration data…
An index of unhealthy lifestyle is associated with coronary heart disease mortality rates for small areas in England after adjustment for deprivation
Indices of socio-economic deprivation are often used as a proxy for differences in the health behaviours of populations within small areas, but these indices are a measure of the economic environment rather than the health environment. Sets of synthetic estimates of the ward-level prevalence of low fruit and vegetable consumption, obesity, raised blood pressure, raised cholesterol and smoking were combined to develop an index of unhealthy lifesty…
Mortality from heart failure in an English population, 1979–2003
Objective: It is widely held that there will be an epidemic of heart failure in Europe and North America as a result of increased survival from myocardial infarction and other coronary heart disease. The study objective was to discover if the decline in mortality from coronary heart disease has been accompanied by a rise in mortality from heart failure in the study population. Design: Analysis of database of mortality records including all certif…
The association between smoking during pregnancy and hospital inpatient costs in childhood
Abortion and breast cancer
There is controversy about whether interruption of pregnancy, particularly if it is induced rather than spontaneous, increases the risk of breast cancer. Individual studies, and reviews summarising them, have given conflicting results.1 2 Recent guidelines from the UK Royal College of Obstetricians and Gynaecologists (http://www.rcog.org.uk) state that the evidence is inconclusive but that, when only those studies least susceptible to bias are co…
Geographical variation in hospital admission rates
OBJECTIVE--To measure variation in hospital admission rates between health districts in part of the English NHS, comparing a wide range of medical and surgical conditions. DESIGN--Retrospective analysis of interdistrict variation using linked routine hospital admission data. Comparisons were also made with levels of variation reported from the USA. SETTING--Oxford Regional Health Authority, 1979-86. SUBJECTS--Six district health authorities--tota…
Increased risk of tuberculosis disease in people with diabetes mellitus
BACKGROUND: The authors aimed to determine whether, and by how much, diabetes mellitus (DM) increases the risk of tuberculosis (TB) and conversely whether TB increases the risk of DM. METHODS: Retrospective cohort analyses using data from two Oxford Record Linkage Study (ORLS) datasets, containing information on hospital admissions and day-case care between 1963 and 1998 (ORLS1) and between 1999 and 2005 (ORLS2), were carried out. The rate ratio …
Risk of invasive pneumococcal disease in people admitted to hospital with selected immune-mediated diseases
BACKGROUND: Invasive pneumococcal disease is a serious infection, and it is an important cause of morbidity and mortality in certain groups of 'at-risk' people. Those considered 'at-risk' in the UK include very young children, people aged 65 years and older and people with certain serious chronic diseases, asplenia or immunosuppression. There is little evidence about whether people with immune-mediated diseases are at increased risk of pneumococc…
Multiple sclerosis after infectious mononucleosis
Objective: To ascertain if infectious mononucleosis is a risk factor for the development of multiple sclerosis (MS); and, if it is, whether its effect is close to or remote in time from the onset of MS. Design: Analysis of database of linked abstracts of records of hospital admission and death. Setting: Health region in central southern England. Main outcome measure: Ratio of rate of MS in a cohort of people admitted to hospital with infectious m…
Secular trends in proximal femoral fracture, Oxford record linkage study area and England 1968-86
OBJECTIVE: To study hospital admission rates for fractures of the proximal femur over a period when incidence is reported to have increased, compensating for known lack of precision in coding, excluding nonemergency admissions and transfers, and modelling for age, period, and cohort effects. DESIGN: Validation of coding of a sample of hospital admissions followed by study of two sets of routinely collected statistical abstracts of hospital record…
Estimating incidence and prevalence of treated psychiatric disorders from routine statistics
STUDY OBJECTIVE--To use routine statistical records to estimate the incidence and prevalence of treated schizophrenia. DESIGN AND SETTING--Analysis of linked records in Oxfordshire (population 540,000) for all people in contact with specialist psychiatric services from 1975-86. SUBJECTS--Records of 685 people with a diagnosis of schizophrenia as an inpatient and a further 294 people who received specialist psychiatric care for schizophrenia outsi…
Day case surgery
Data from the Oxford Record Linkage Study were analysed to determine the amount of work undertaken in day case surgery for 12 surgical conditions in five districts in the Oxford Region during the years 1976 to 1985. Record linkage was used to study readmission rates, comparing day surgery with inpatient care. The use of day surgery gradually increased in some conditions (eg, termination of pregnancy, female sterilisation) but did not increase fro…
Community hospitals in Oxfordshire
About one-third of the general practices in the Oxfordshire Health District have access to beds in community hospitals as well as district general hospitals. Hospital Activity Analysis data were used to calculate the average number of hospital beds occupied daily by patients registered with each general practice in the district. Practices with and without access to community hospitals were compared to determine whether such access was associated …
Peripheral outpatient clinics
A census was taken of outpatient bookings at all hospitals and health centres in Oxfordshire for the main medical and surgical specialities. Nine per cent of all bookings were to peripheral clinics (that is, those outsie the two main medical centres at Oxford and Banbury). About half of all bookings in the area were made to clinics within three of four miles of the patients' homes. The work load at peripheral clinics was mainly local: 75% of all …
Cardiovascular Disease and Vasectomy
We performed two epidemiologic studies using routine abstracts of medical records to test the hypothesis that vasectomy may predispose men to cardiovascular disease. In a case-control study 1512 men who were under 55 years of age and had a history of myocardial infarction, stroke, or hypertension were matched with 3024 controls with other conditions; 2.4 per cent of the cases and 2.7 per cent of the controls were identified as having undergone va…
Repetition of accidents in young children
Data from the Oxford Record Linkage Study have been used to describe rates of accident repetition for children aged under 5 years. As reflected by hospital admissions, accident rates for children who have already had one accident were approximately twice those of children of the same age and sex who had previously been accident free
Community hospitals in Oxfordshire
About one-third of the general practices in the Oxfordshire Health District have access to beds in community hospitals as well as district general hospitals. Hospital Activity Analysis data were used to calculate the average number of hospital beds occupied daily by patients registered with each general practice in the district. Practices with and without access to community hospitals were compared to determine whether such access was associated …
Day case surgery
Data from the Oxford Record Linkage Study were analysed to determine the amount of work undertaken in day case surgery for 12 surgical conditions in five districts in the Oxford Region during the years 1976 to 1985. Record linkage was used to study readmission rates, comparing day surgery with inpatient care. The use of day surgery gradually increased in some conditions (eg, termination of pregnancy, female sterilisation) but did not increase fro…
Reliability of routine hospital data on poisoning as measures of deliberate self poisoning in adolescents
STUDY OBJECTIVE--The aim was to assess the extent to which routinely collected data on poisoning in adolescents reflected deliberate self poisoning and, in doing, so to assess the accuracy of the diagnostic information on poisoning in the routine hospital abstracts which form the joint data base of Hospital Activity Analysis and the Oxford Record Linkage Study (ORLS). DESIGN--A comparison was made (a) of all eligible ORLS records during the study…
Some epidemiological observations on medicinal and non-medicinal poisoning in preschool children
STUDY OBJECTIVE--The aim was to identify and compare rates of admission to hospital of preschool children for medicinal and non-medicinal poisoning in a defined population. DESIGN--The study was an analysis of computerised abstracts of hospital inpatient records for poisoning. SETTING--Six districts in southern England covered by the Oxford record linkage study. SUBJECTS--The subjects were children under six years of age residing in the six distr…
Recording of deaths in hospital information systems
STUDY OBJECTIVE--The aim was to report on the extent to which death certificates which specify that death occurred in hospital can be matched and linked with routine hospital inpatient information systems. DESIGN--The study involved linkage of hospital records which specified that death occurred in hospital to corresponding death certificates; and linkage of death certificates which specified that death occurred in hospital to corresponding hospi…
Computerised linking of medical records
OBJECTIVES--To report on the development of computer assisted methods for linking medical records and record abstracts. DESIGN--The methods include file blocking, to put records in an order which makes searching efficient; matching, which is the process of comparing records to determine whether they do or do not relate to the same person; linkage, which is the process of assembling correctly matched records into a time sequenced composite record …
Ovarian cancer and ABO blood groups
OBJECTIVE--To determine whether the distribution of ABO blood groups in women with ovarian cancer differs from that in the general population in a large, defined English region. DESIGN--Analysis of record abstracts of hospital care held in the Oxford record linkage study supplemented with data from the Oxford cancer registry. SETTING--Oxford Regional Health Authority area. SUBJECTS--A total of 1261 women who had ovarian cancer between 1968 and 19…
Cause-specific mortality
STUDY OBJECTIVE--To determine the extent to which individual diseases, when recorded as being present shortly before death, were certified as causes of death. DESIGN--Retrospective cohort study in which the "subjects" were computerised linked records. SETTING--Six districts in the Oxford Regional Health Authority area (covering a population of 1.9 million people). SUBJECTS--Linked abstracts of hospital records and death certificates for people wh…
Geographical variation in hospital admission rates
OBJECTIVE--To measure variation in hospital admission rates between health districts in part of the English NHS, comparing a wide range of medical and surgical conditions. DESIGN--Retrospective analysis of interdistrict variation using linked routine hospital admission data. Comparisons were also made with levels of variation reported from the USA. SETTING--Oxford Regional Health Authority, 1979-86. SUBJECTS--Six district health authorities--tota…
Estimating incidence and prevalence of treated psychiatric disorders from routine statistics
STUDY OBJECTIVE--To use routine statistical records to estimate the incidence and prevalence of treated schizophrenia. DESIGN AND SETTING--Analysis of linked records in Oxfordshire (population 540,000) for all people in contact with specialist psychiatric services from 1975-86. SUBJECTS--Records of 685 people with a diagnosis of schizophrenia as an inpatient and a further 294 people who received specialist psychiatric care for schizophrenia outsi…
Comparing measures of variation
late 1970s and is now rising.After allowing for the proportion of births to mothers over 35 years, the trend with year remains significant at the 5% level, OR=0-9996, (95%CI: 0 9995, 0 9997).Over the period there has also been a steady increase in the proportion of single mothers.As single mothers are more likely to have boys,4 it is likely that the decline in the sex ratio of children born to other women is even greater.This decline in the sex r…
Secular trends in proximal femoral fracture, Oxford record linkage study area and England 1968-86
OBJECTIVE: To study hospital admission rates for fractures of the proximal femur over a period when incidence is reported to have increased, compensating for known lack of precision in coding, excluding nonemergency admissions and transfers, and modelling for age, period, and cohort effects. DESIGN: Validation of coding of a sample of hospital admissions followed by study of two sets of routinely collected statistical abstracts of hospital record…
Abortion and breast cancer
There is controversy about whether interruption of pregnancy, particularly if it is induced rather than spontaneous, increases the risk of breast cancer. Individual studies, and reviews summarising them, have given conflicting results.1 2 Recent guidelines from the UK Royal College of Obstetricians and Gynaecologists (http://www.rcog.org.uk) state that the evidence is inconclusive but that, when only those studies least susceptible to bias are co…
Depression and anxiety in people with inflammatory bowel disease
STUDY OBJECTIVE: To determine whether depression or anxiety co-occurs with ulcerative colitis (UC) or Crohn's disease (CD) more often than expected by chance, and, if so, whether the mental disorders generally precede or follow the inflammatory bowel diseases (IBD). DESIGN: Nested case-control studies using a database of linked hospital record abstracts. SETTING: Southern England. MAIN RESULTS: Both depression and anxiety preceded UC significantl…
Hospitalization for Ambulatory Care-Sensitive Conditions
Appendicectomy, tonsillectomy, and inflammatory bowel disease
Study objective: To determine whether appendicectomy and tonsillectomy are associated with ulcerative colitis (UC) or Crohn's disease (CD); and, if so, whether the associations are related to age at operation. Design: Nested case-control studies using a longitudinal database of linked hospital and death record abstracts. Setting: Southern England. Patients: Statistical records of people diagnosed with UC, CD, or a control condition admitted to ho…
Crohn’s disease, ulcerative colitis, and measles vaccine in an English population, 1979–1998
Study objectives: To study the hospitalised incidence of Crohn’s disease (CD) and ulcerative colitis (UC) from 1979 to 1998; and to determine whether the introduction of the measles vaccination programme was associated with an increase in the young. Design: Analysis of linked data on hospital admissions; a cohort analysis of the effect of the measles vaccination programme on the incidence of hospitalised CD and UC; and a comparison of these resul…
Multiple sclerosis after infectious mononucleosis
Objective: To ascertain if infectious mononucleosis is a risk factor for the development of multiple sclerosis (MS); and, if it is, whether its effect is close to or remote in time from the onset of MS. Design: Analysis of database of linked abstracts of records of hospital admission and death. Setting: Health region in central southern England. Main outcome measure: Ratio of rate of MS in a cohort of people admitted to hospital with infectious m…
Skin cancer in people with multiple sclerosis
Objective: The prevalence of multiple sclerosis (MS) varies with latitude: it increases with distance from the equator in both hemispheres. To seek evidence on whether solar radiation is a protective factor for MS, this study investigated whether skin cancer, as an indicator of solar radiation, is less common in people with MS than in others. Design: Analysis of a database of linked hospital records and death certificates. Setting: The Oxford Reg…
Mortality from heart failure in an English population, 1979–2003
Objective: It is widely held that there will be an epidemic of heart failure in Europe and North America as a result of increased survival from myocardial infarction and other coronary heart disease. The study objective was to discover if the decline in mortality from coronary heart disease has been accompanied by a rise in mortality from heart failure in the study population. Design: Analysis of database of mortality records including all certif…
The association between smoking during pregnancy and hospital inpatient costs in childhood
Elective surgery for aortic abdominal aneurysm
Introduction: The aim of this study was to quantify mortality after elective repair of abdominal aortic aneurysm (AAA) in England, and to compare English case fatality rates (CFRs) with those reported in the literature. Patients and methods: English Hospital Episode Statistics (HES) for the financial years 1998/9 to 2001/2, linked to death data, were analysed. A systematic literature search was undertaken to identify studies reporting CFRs after …
Medicine (37 works) · Internal Medicine (27 works) · Environmental health (23 works) · Internal Medicine (23 works) · Population (22 works) · Pediatrics (15 works) · Demography (13 works) · Pediatrics (13 works) · Disease (12 works) · Record linkage (11 works)