Audrey Sabbagh
Biographic Data
| ID | 1887168 |
|---|---|
| NAME | Audrey Sabbagh |
| GIVEN NAMES | Audrey |
| FAMILY NAME | Sabbagh |
| SIGNATURE | SABBAGH A |
| AFFILIATIONS | Université Paris-Sud |
| ORCID | 0000-0003-0283-8803 |
| VERIFIED | Yes |
| TOTAL WORKS | 4 |
| TOTAL CITATIONS | 7 |
| WORKS AS AUTHOR | 4 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 2005 |
| LATEST PUBLICATION YEAR | 2024 |
| H-INDEX | 1 |
From carbon to meaning
A Homogenizing Process of Selection Has Maintained an “Ultra-Slow” Acetylation NAT2 Variant in Humans
N-Acetyltransferase 2 (NAT2) is an important enzyme involved in the metabolism of a wide spectrum of naturally occurring xenobiotics, including therapeutic drugs and common environmental carcinogens. Extensive polymorphism in NAT2 gives rise to a wide interindividual variation in acetylation capacity, which influences individual susceptibility to various drug-induced adverse reactions and cancers. Striking patterns of geographic differentiation h…
Haplotype tagging efficiency and tagSNP sets portability in worldwide populations in NAT2 gene
Genetic polymorphism in the NAT2 gene is responsible for pronounced interindividual differences in the acetylation activity of the N-acetyltransferase 2 (NAT2) enzyme, which plays a crucial role in the metabolism of many clinically useful drugs and exogenous chemicals. Up to now, most association studies that have attempted to relate the acetylation phenotype in NAT2 to a variety of complex human disorders have led to contradictory results in dif…
New method for surname studies of ancient patrilineal population structures, and possible application to improvement of Y‐chromosome sampling
Several studies showed that surnames are good markers to infer patrilineal genetic structures of populations, both on regional and microregional scales. As a case study, the spatial patterns of the 9,929 most common surnames of the Netherlands were analyzed by a clustering method called self‐organizing maps (SOMs). The resulting clusters grouped surnames with a similar geographic distribution and origin. The analysis was shown to be in agreement …
New method for surname studies of ancient patrilineal population structures, and possible application to improvement of Y‐chromosome sampling
Several studies showed that surnames are good markers to infer patrilineal genetic structures of populations, both on regional and microregional scales. As a case study, the spatial patterns of the 9,929 most common surnames of the Netherlands were analyzed by a clustering method called self‐organizing maps (SOMs). The resulting clusters grouped surnames with a similar geographic distribution and origin. The analysis was shown to be in agreement …
A Homogenizing Process of Selection Has Maintained an “Ultra-Slow” Acetylation NAT2 Variant in Humans
N-Acetyltransferase 2 (NAT2) is an important enzyme involved in the metabolism of a wide spectrum of naturally occurring xenobiotics, including therapeutic drugs and common environmental carcinogens. Extensive polymorphism in NAT2 gives rise to a wide interindividual variation in acetylation capacity, which influences individual susceptibility to various drug-induced adverse reactions and cancers. Striking patterns of geographic differentiation h…
New method for surname studies of ancient patrilineal population structures, and possible application to improvement of Y‐chromosome sampling
Several studies showed that surnames are good markers to infer patrilineal genetic structures of populations, both on regional and microregional scales. As a case study, the spatial patterns of the 9,929 most common surnames of the Netherlands were analyzed by a clustering method called self‐organizing maps (SOMs). The resulting clusters grouped surnames with a similar geographic distribution and origin. The analysis was shown to be in agreement …
Haplotype tagging efficiency and tagSNP sets portability in worldwide populations in NAT2 gene
Genetic polymorphism in the NAT2 gene is responsible for pronounced interindividual differences in the acetylation activity of the N-acetyltransferase 2 (NAT2) enzyme, which plays a crucial role in the metabolism of many clinically useful drugs and exogenous chemicals. Up to now, most association studies that have attempted to relate the acetylation phenotype in NAT2 to a variety of complex human disorders have led to contradictory results in dif…
A Homogenizing Process of Selection Has Maintained an “Ultra-Slow” Acetylation NAT2 Variant in Humans
N-Acetyltransferase 2 (NAT2) is an important enzyme involved in the metabolism of a wide spectrum of naturally occurring xenobiotics, including therapeutic drugs and common environmental carcinogens. Extensive polymorphism in NAT2 gives rise to a wide interindividual variation in acetylation capacity, which influences individual susceptibility to various drug-induced adverse reactions and cancers. Striking patterns of geographic differentiation h…
From carbon to meaning
Biology (3 works) · Population (3 works) · Allele (2 works) · Epigenetics and DNA Methylation (2 works) · Evolutionary biology (2 works) · Gene (2 works) · Genetics (2 works) · Genetics (2 works) · Haplotype (2 works) · Sociology (2 works)