Perminder S Sachdev

Biographic Data

ID	189168
NAME	Perminder S Sachdev
GIVEN NAMES	Perminder S
FAMILY NAME	Sachdev
SIGNATURE	SACHDEV P S
AFFILIATIONS	UNSW Sydney
ORCID	0000-0002-9595-3220
VERIFIED	Yes
TOTAL WORKS	47
TOTAL CITATIONS	17
AUTHOR COUNT	47
EDITOR COUNT	0
FIRST PUBLICATION YEAR	1983
LATEST PUBLICATION YEAR	2026
H-INDEX	2

Moderating effects of educational inequality on education polygenic scores, attained education and dementia-risk relationships
Open AccessBrian Karl Finch, Sneha Nimmagadda et al.ARTICLESSM - Population Health2026
While education is among the most consistent predictors of cognitive health and dementia risk, it is unclear whether this reflects the benefits of schooling itself or other factors such as underlying genetic predispositions or family-based inequality. Further, the benefits of education to cognitive health may be dependent on larger structures of inequality. Using data from the IGEMS Consortium of over 4,500 twins from seven cohorts in the USA, Sw…
Levels and changes in cognitive, mental, and physical health as correlates of attitudes to aging in very old age
Open AccessSerena Sabatini, Katya Numbers et al.ARTICLEFrontiers in Psychiatry2025
Self-perceptions of aging in different domains are cross-sectionally associated with different health indicators. However, among cognitive, mental, and physical health indicators, changes in depressive symptoms are the most correlated with perceived psychosocial loss in very old age
How well do social frailty indices predict incident dementia in older adults
Open AccessAnnabel P Matison, Suraj Samtani et al.ARTICLEThe Journals of Gerontology…2025References: 4
Objectives Few studies have examined the association between social frailty and dementia. We aim to assess if social frailty indices predict dementia and evaluate causality. Methods Data from 851 community-dwelling participants aged 70 years and older without dementia from the Sydney Memory and Ageing Study were used. Social frailty was assessed using five published indices that incorporated a range of psychosocial factors. Incident dementia was …
Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes
Open AccessElham Assary, Jonathan R I Coleman et al.ARTICLENature Human Behaviour2025References: 48
Individual sensitivity to environmental exposures may be genetically influenced. This genotype-by-environment interplay implies differences in phenotypic variance across genotypes, but these variants have proven challenging to detect. Genome-wide association studies of monozygotic twin differences are conducted through family-based variance analyses, which are more robust to the systemic biases that impact population-based methods. We combined da…
Burden of disease scenarios for 204 countries and territories, 2022–2050: A forecasting analysis for the Global Burden of Disease Study 2021
Open AccessStein Emil Vollset, Hazim S Ababneh et al.ARTICLEThe Lancet2024
BACKGROUND: Future trends in disease burden and drivers of health are of great interest to policy makers and the public at large. This information can be used for policy and long-term health investment, planning, and prioritisation. We have expanded and improved upon previous forecasts produced as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) and provide a reference forecast (the most likely future), and alternativ…
Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: A systematic analysis for the Global Burden of Disease Study 2021
Open AccessMichael Brauer, Gregory A Roth et al.ARTICLEThe Lancet2024
BACKGROUND: Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to specific health outcomes, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 aims to provide comprehensive estimates of exposure levels, relative health risks, and attributable burden of disease for 88 ri…
Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: A systematic analysis for the Global Burden of Disease…
Open AccessMohsen Naghavi, Kanyin Liane Ong et al.ARTICLEThe Lancet2024
BACKGROUND: Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mort…
Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (Dalys), and healthy life expectancy (Hale) for 371 diseases and injuries in 204 countries and territor…
Open AccessAlize J Ferrari, Damian Francesco Santomauro et al.ARTICLEThe Lancet2024
BACKGROUND: Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury burden over time and across age groups, sexes, and locations. The availability of disease burden estimates can promote evidence-based interventions that enable public health researchers, policy makers, and other professionals to im…
Patterns in health care use and intensity for diagnosed and undiagnosed cognitive impairment in the older australian community: Implications for primary care management
Open AccessAkeel Bilgrami, Mona Aghdaee et al.ARTICLESSM - Population Health2024
Diagnosis and symptom management in primary care may enable individuals with MCI to improve their quality of life and prevent more costly future health care use. However, our study found potential gaps in medical service use for people with undiagnosed MCI in the community, especially when they had less support or did not have memory symptoms. Primary care services may need to better diagnose and target these individuals
Case report: Down syndrome regression disorder, catatonia, and psychiatric and immunomodulatory interventions
Open AccessMichael H Connors, Perminder S Sachdev et al.ARTICLEFrontiers in Psychiatry2024
Down syndrome regression disorder (DSRD) is a rare condition involving subacute cognitive decline, loss of previously acquired developmental skills, and prominent neuropsychiatric symptoms, particularly catatonia, in people with Down syndrome. It is thought to involve both autoimmune and neuropsychiatric mechanisms. Research, however, is largely restricted to case studies and retrospective case series and is particularly limited in terms of prosp…
Age and Sex Differences in the Genetic Architecture of Measures of Subjective Health: Relationships With Physical Health, Depressive Symptoms, and Episodic Memory
Open AccessD Finkel, Margaret Gatz et al.ARTICLEThe Journals of Gerontology…2024References: 5
The predictive value of SH has been amply demonstrated. The higher genetic contributions to associations between SH and its components in older adults support the increasing conceptualization with age of SH as an intuitive summation of one's vital reserve
Prospective Memory Function Predicts Future Cognitive Decline and Incident Dementia
Open AccessCatherine A Browning, Claire Thompson et al.ARTICLEThe Journals of Gerontology…2023Cited by: 1References: 1
PM is a sensitive early marker of future cognitive decline and risk of incident dementia. PM tasks supported by spontaneous retrieval (event-based) and those with lower retrospective memory demands (regular tasks) function as particularly sensitive predictors. In other words, deficits in performing less effortful PM tasks best predicted cognitive decline. These findings may encourage clinicians to incorporate PM tasks in clinical assessments
Recognition of social health: A conceptual framework in the context of dementia research
Open AccessMyrra Vernooij-Dassen, Myrra Vernooij‐dassen et al.ARTICLEFrontiers in Psychiatry2022
The conceptual framework provides guidance for future research and facilitates identification of modifiable risk and protective factors, which may in turn shape new avenues for preventive interventions. We highlight the paradigm of social health in dementia as a priority for dementia research
Aging Is Associated With Multidirectional Changes in Social Cognition: Findings From an Adult Life-Span Sample Ranging From 18 to 101 Years
Open AccessSarah A Grainger, John D Crawford et al.ARTICLEThe Journals of Gerontology…2022Cited by: 2References: 2
These findings provide novel and important evidence that normative aging is associated with both gains and losses in social cognition that occur at distinct points of the adult life-span, and that are at least partially independent of general age-related cognitive decline
Five insights from the Global Burden of Disease Study 2019
Open AccessChristopher J L Murray, Cristiana Abbafati et al.ARTICLEThe Lancet2020
Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study…
Open AccessR Lozano, Nancy Fullman et al.ARTICLEThe Lancet2020
BACKGROUND: Achieving universal health coverage (UHC) involves all people receiving the health services they need, of high quality, without experiencing financial hardship. Making progress towards UHC is a policy priority for both countries and global institutions, as highlighted by the agenda of the UN Sustainable Development Goals (SDGs) and WHO's Thirteenth General Programme of Work (GPW13). Measuring effective coverage at the health-system le…
Global burden of 87 risk factors in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019
Open AccessChristopher J L Murray, Aleksandr Y Aravkin et al.ARTICLEThe Lancet2020
BACKGROUND: Rigorous analysis of levels and trends in exposure to leading risk factors and quantification of their effect on human health are important to identify where public health is making progress and in which cases current efforts are inadequate. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a standardised and comprehensive assessment of the magnitude of risk factor exposure, relative risk, and attribu…
Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019
Open AccessTheo Vos, Stephen S Lim et al.ARTICLEThe Lancet2020
BACKGROUND: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive…
Age-Related Changes of Peak Width Skeletonized Mean Diffusivity (PSMD) Across the Adult Lifespan: A Multi-Cohort Study
Open AccessGrégory Beaudet, Ami Tsuchida et al.ARTICLEFrontiers in Psychiatry2020
Parameters of water diffusion in white matter derived from diffusion-weighted imaging (DWI), such as fractional anisotropy (FA), mean, axial, and radial diffusivity (MD, AD, and RD), and more recently, peak width of skeletonized mean diffusivity (PSMD), have been proposed as potential markers of normal and pathological brain ageing. However, their relative evolution over the entire adult lifespan in healthy individuals remains partly unknown duri…
Cross-Lagged Modeling of Cognition and Social Network Size in the Sydney Memory and Ageing Study
Open AccessAnne‐Nicole Casey, Zhixin Liu et al.ARTICLEThe Journals of Gerontology…2020References: 7
Findings support a co-constitutive view of cognitive function and social relationships in older age. Although both cognition and network size declined over time, slower than expected decline in language ability predicted less than expected contraction in social networks. A similar influence of network size on executive functioning indicated that relationships with friends and family outside of the home contributed significantly to the maintenance…
Global, regional, and national burden of neurological disorders, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016
Open AccessValery L Feigin, Emma Nichols et al.ARTICLEThe Lancet Neurology2019
BACKGROUND: Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most comprehensive and up-to-date estimates of the global, regional, and national burden from neurological disorders. METHODS: We estimated prevalence, incidence, deaths, and disability-adjusted life-years (DALYs;…
Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016
Open AccessEmma Nichols, Cassandra Szoeke et al.ARTICLEThe Lancet Neurology2019
BACKGROUND: The number of individuals living with dementia is increasing, negatively affecting families, communities, and health-care systems around the world. A successful response to these challenges requires an accurate understanding of the dementia disease burden. We aimed to present the first detailed analysis of the global prevalence, mortality, and overall burden of dementia as captured by the Global Burden of Diseases, Injuries, and Risk …
Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: A systematic analysis for the Global Burden of Disease Study 2017
Open AccessDaniel Dicker, Grant Nguyen et al.ARTICLEThe Lancet2018
BACKGROUND: Assessments of age-specific mortality and life expectancy have been done by the UN Population Division, Department of Economics and Social Affairs (UNPOP), the United States Census Bureau, WHO, and as part of previous iterations of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD). Previous iterations of the GBD used population estimates from UNPOP, which were not derived in a way that was internally consistent wit…
Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: A systematic analysis for the Global Burden of Disease Study 2017
Open AccessGregory A Roth, D Abate et al.ARTICLEThe Lancet2018
BACKGROUND: Global development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated global, regional, national, and, for selected locations, subnational cause-specific mortality beginning in the year 1980. Here we report an update to that study, making use of newly available data and improved methods. GBD …
Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: A s…
Open AccessJeffrey D Stanaway, Ashkan Afshin et al.ARTICLEThe Lancet2018
BackgroundThe Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk–outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk–outcome pairs, and new data on risk exposure levels and risk–outcome associatio…