Andrea A Baccarelli
Biographic Data
| ID | 190212 |
|---|---|
| NAME | Andrea A Baccarelli |
| GIVEN NAMES | Andrea A |
| FAMILY NAME | Baccarelli |
| SIGNATURE | BACCARELLI A A |
| AFFILIATIONS | Laboratory of Environmental Epigenetics, Department of Environmental Health Sciences Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA |
| VERIFIED | No |
| TOTAL WORKS | 14 |
| TOTAL CITATIONS | 1 |
| WORKS AS AUTHOR | 14 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 2014 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 1 |
Social determinants of vulnerability to nitrogen oxide- and sulfur dioxide-related bone damage among postmenopausal women in the United States
Background Studying social determinants of health (SDOH) in air pollutant-related bone loss among aging women may help identify bone health disparities, design preventive strategies, and inform policy. Prolonged exposure to air pollution is associated with decreased bone mineral density (BMD) and increased fracture risk in later life. However, the extent to which socioeconomic status (SES) contributes to pollution-related bone damage remains uncl…
Threats and humiliation at the workplace and mental health among environmental scientists - a cross-sectional study
Violence at the workplace (e.g., threats, humiliation) is an increasing area of concern in many countries around the world. This study aimed to quantify the prevalence of mental health conditions associated with workplace violence among environmental health professionals. We conducted a cross-sectional survey between January and February 2022 among scientists who are members and former members of the International Society for Environmental Epidem…
Developing intensive, short-term courses for public health—Creation and outcome evaluation of the Skills for Health and Research Professionals (SHARP) program at the Columbia University Mailman School…
Short, intensive education programs provide an under-utilized avenue for public health professionals to learn and apply the latest methods and technologies. We report on the creation and implementation of the Skills for Health and Research Professionals (SHARP) program at the Columbia University Mailman School of Public Health. The self-sustaining, concise, intense educational format equips participants with concrete skills, better enabling them …
Cumulative Stress Across the Life Course and Biological Aging in Adulthood
OBJECTIVE: Psychosocial stressors have been linked with accelerated biological aging in adults; however, few studies have examined stressors across the life course in relation to biological aging. METHODS: In 359 individuals (57% White, 34% Black) from the Child Health and Development Studies Disparities study, economic (income, education, financial strain), social (parent-child relations, caretaker responsibilities) and traumatic (death of a sib…
Maternal age at birth and child attention‐deficit hyperactivity disorder
BACKGROUND: Causal explanations for the association of young motherhood with increased risk for child attention-deficit hyperactivity disorder (ADHD) remain unclear. METHODS: The ABCD Study recruited 11,878 youth from 22 sites across the United States between June 1, 2016 and October 15, 2018. This cross-sectional analysis of 8,514 children aged 8-11 years excluded 2,260 twins/triplets, 265 adopted children, and 839 younger siblings. We examined …
Epigenome-Wide Analysis of DNA Methylation and Optimism in Women and Men
OBJECTIVE: Higher optimism is associated with reduced mortality and a lower risk of age-related chronic diseases. DNA methylation (DNAm) may provide insight into mechanisms underlying these relationships. We hypothesized that DNAm would differ among older individuals who are more versus less optimistic. METHODS: Using cross-sectional data from two population-based cohorts of women with diverse races/ethnicities ( n = 3816) and men (only White, n …
In Utero Exposure to Caffeine and Acetaminophen, the Gut Microbiome, and Neurodevelopmental Outcomes
Pregnant individuals are exposed to acetaminophen and caffeine, but it is unknown how these exposures interact with the developing gut microbiome. We aimed to determine whether acetaminophen and/or caffeine relate to the childhood gut microbiome and whether features of the gut microbiome alter the relationship between acetaminophen/caffeine and neurodevelopment. Forty-nine and 85 participants provided meconium and stool samples at 6-7, respective…
Predictors of patterns of weight change 1 year after delivery in a cohort of Mexican women
Objective: To evaluate the associations of pregestational BMI, gestational weight gain (GWG) and breast-feeding at 1 month postpartum with four patterns of weight change during the first year after delivery: postpartum weight retention (PPWR), postpartum weight gain (PPWG), postpartum weight retention + gain (PPWR + WG) and return to pregestational weight. Design: In this secondary analysis of a prospective study, we categorised postpartum weight…
DNA methylation GrimAge strongly predicts lifespan and healthspan
Using large scale validation data from thousands of individuals, we demonstrate that DNAm GrimAge stands out among existing epigenetic clocks in terms of its predictive ability for time-to-death (Cox regression P=2.0E-75), time-to-coronary heart disease (Cox P=6.2E-24), time-to-cancer (P= 1.3E-12), its strong relationship with computed tomography data for fatty liver/excess visceral fat, and age-at-menopause (P=1.6E-12). AgeAccelGrim is strongly …
Smoking-Related DNA Methylation is Associated with DNA Methylation Phenotypic Age Acceleration
DNA methylation may play a critical role in aging and age-related diseases. DNA methylation phenotypic age (DNAmPhenoAge) is a new aging biomarker and predictor of chronic disease risk. While smoking is a strong risk factor for chronic diseases and influences methylation, its influence on DNAmPhenoAge is unknown. We investigated associations of self-reported and epigenetic smoking indicators with DNAmPhenoAge acceleration in a longitudinal aging …
Fried and Baccarelli Comment
An epigenetic biomarker of aging for lifespan and healthspan
Identifying reliable biomarkers of aging is a major goal in geroscience. While the first generation of epigenetic biomarkers of aging were developed using chronological age as a surrogate for biological age, we hypothesized that incorporation of composite clinical measures of phenotypic age that capture differences in lifespan and healthspan may identify novel CpGs and facilitate the development of a more powerful epigenetic biomarker of aging. U…
Prenatal Stress, Methylation in Inflammation-Related Genes, and Adiposity Measures in Early Childhood
OBJECTIVE: Maternal stress during pregnancy may influence childhood growth and adiposity, possibly through immune/inflammatory programming. We investigated whether exposure to prenatal stress and methylation in inflammation-related genes were associated with childhood adiposity in 424 mother-child pairs in Mexico City, Mexico. METHODS: A stress index was created based on four prenatally administered stress-related scales (Exposure to Violence, Cr…
Heart rate variability and DNA methylation levels are altered after short-term metal fume exposure among occupational welders
Acute decline of HRV was observed following exposure to welding PM2.5 and evidence for an epigenetic response of transposable elements to short-term exposure to high-level metal-rich particulates was reported
Heart rate variability and DNA methylation levels are altered after short-term metal fume exposure among occupational welders
Acute decline of HRV was observed following exposure to welding PM2.5 and evidence for an epigenetic response of transposable elements to short-term exposure to high-level metal-rich particulates was reported
An epigenetic biomarker of aging for lifespan and healthspan
Identifying reliable biomarkers of aging is a major goal in geroscience. While the first generation of epigenetic biomarkers of aging were developed using chronological age as a surrogate for biological age, we hypothesized that incorporation of composite clinical measures of phenotypic age that capture differences in lifespan and healthspan may identify novel CpGs and facilitate the development of a more powerful epigenetic biomarker of aging. U…
Prenatal Stress, Methylation in Inflammation-Related Genes, and Adiposity Measures in Early Childhood
OBJECTIVE: Maternal stress during pregnancy may influence childhood growth and adiposity, possibly through immune/inflammatory programming. We investigated whether exposure to prenatal stress and methylation in inflammation-related genes were associated with childhood adiposity in 424 mother-child pairs in Mexico City, Mexico. METHODS: A stress index was created based on four prenatally administered stress-related scales (Exposure to Violence, Cr…
DNA methylation GrimAge strongly predicts lifespan and healthspan
Using large scale validation data from thousands of individuals, we demonstrate that DNAm GrimAge stands out among existing epigenetic clocks in terms of its predictive ability for time-to-death (Cox regression P=2.0E-75), time-to-coronary heart disease (Cox P=6.2E-24), time-to-cancer (P= 1.3E-12), its strong relationship with computed tomography data for fatty liver/excess visceral fat, and age-at-menopause (P=1.6E-12). AgeAccelGrim is strongly …
Smoking-Related DNA Methylation is Associated with DNA Methylation Phenotypic Age Acceleration
DNA methylation may play a critical role in aging and age-related diseases. DNA methylation phenotypic age (DNAmPhenoAge) is a new aging biomarker and predictor of chronic disease risk. While smoking is a strong risk factor for chronic diseases and influences methylation, its influence on DNAmPhenoAge is unknown. We investigated associations of self-reported and epigenetic smoking indicators with DNAmPhenoAge acceleration in a longitudinal aging …
Fried and Baccarelli Comment
Predictors of patterns of weight change 1 year after delivery in a cohort of Mexican women
Objective: To evaluate the associations of pregestational BMI, gestational weight gain (GWG) and breast-feeding at 1 month postpartum with four patterns of weight change during the first year after delivery: postpartum weight retention (PPWR), postpartum weight gain (PPWG), postpartum weight retention + gain (PPWR + WG) and return to pregestational weight. Design: In this secondary analysis of a prospective study, we categorised postpartum weight…
In Utero Exposure to Caffeine and Acetaminophen, the Gut Microbiome, and Neurodevelopmental Outcomes
Pregnant individuals are exposed to acetaminophen and caffeine, but it is unknown how these exposures interact with the developing gut microbiome. We aimed to determine whether acetaminophen and/or caffeine relate to the childhood gut microbiome and whether features of the gut microbiome alter the relationship between acetaminophen/caffeine and neurodevelopment. Forty-nine and 85 participants provided meconium and stool samples at 6-7, respective…
Maternal age at birth and child attention‐deficit hyperactivity disorder
BACKGROUND: Causal explanations for the association of young motherhood with increased risk for child attention-deficit hyperactivity disorder (ADHD) remain unclear. METHODS: The ABCD Study recruited 11,878 youth from 22 sites across the United States between June 1, 2016 and October 15, 2018. This cross-sectional analysis of 8,514 children aged 8-11 years excluded 2,260 twins/triplets, 265 adopted children, and 839 younger siblings. We examined …
Epigenome-Wide Analysis of DNA Methylation and Optimism in Women and Men
OBJECTIVE: Higher optimism is associated with reduced mortality and a lower risk of age-related chronic diseases. DNA methylation (DNAm) may provide insight into mechanisms underlying these relationships. We hypothesized that DNAm would differ among older individuals who are more versus less optimistic. METHODS: Using cross-sectional data from two population-based cohorts of women with diverse races/ethnicities ( n = 3816) and men (only White, n …
Developing intensive, short-term courses for public health—Creation and outcome evaluation of the Skills for Health and Research Professionals (SHARP) program at the Columbia University Mailman School…
Short, intensive education programs provide an under-utilized avenue for public health professionals to learn and apply the latest methods and technologies. We report on the creation and implementation of the Skills for Health and Research Professionals (SHARP) program at the Columbia University Mailman School of Public Health. The self-sustaining, concise, intense educational format equips participants with concrete skills, better enabling them …
Cumulative Stress Across the Life Course and Biological Aging in Adulthood
OBJECTIVE: Psychosocial stressors have been linked with accelerated biological aging in adults; however, few studies have examined stressors across the life course in relation to biological aging. METHODS: In 359 individuals (57% White, 34% Black) from the Child Health and Development Studies Disparities study, economic (income, education, financial strain), social (parent-child relations, caretaker responsibilities) and traumatic (death of a sib…
Social determinants of vulnerability to nitrogen oxide- and sulfur dioxide-related bone damage among postmenopausal women in the United States
Background Studying social determinants of health (SDOH) in air pollutant-related bone loss among aging women may help identify bone health disparities, design preventive strategies, and inform policy. Prolonged exposure to air pollution is associated with decreased bone mineral density (BMD) and increased fracture risk in later life. However, the extent to which socioeconomic status (SES) contributes to pollution-related bone damage remains uncl…
Threats and humiliation at the workplace and mental health among environmental scientists - a cross-sectional study
Violence at the workplace (e.g., threats, humiliation) is an increasing area of concern in many countries around the world. This study aimed to quantify the prevalence of mental health conditions associated with workplace violence among environmental health professionals. We conducted a cross-sectional survey between January and February 2022 among scientists who are members and former members of the International Society for Environmental Epidem…
Medicine (11 works) · Biology (8 works) · Genetics (6 works) · Internal Medicine (6 works) · DNA methylation (5 works) · Epigenetics and DNA Methylation (5 works) · Gene (5 works) · Genetics (5 works) · Bioinformatics (4 works) · Birth, Development, and Health (4 works)