Daniel S Pine
Biographic Data
| ID | 1914737 |
|---|---|
| NAME | Daniel S Pine |
| GIVEN NAMES | Daniel S |
| FAMILY NAME | Pine |
| SIGNATURE | PINE D S |
| AFFILIATIONS | National Institute of Mental Health |
| ORCID | 0000-0002-4301-9516 |
| VERIFIED | Yes |
| TOTAL WORKS | 45 |
| TOTAL CITATIONS | 32 |
| WORKS AS AUTHOR | 44 |
| WORKS AS EDITOR | 1 |
| FIRST PUBLICATION YEAR | 1996 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 4 |
Adolescence under fire
BACKGROUND: Given the long-term negative impact of exposure to military conflict, identifying its immediate psychological effects is crucial to develop prevention and intervention approaches, especially in adolescents, a group particularly vulnerable to mental health challenges. METHODS: = 16.35 years; 131 females, 65 males), 1-3 months into the Israel-Hamas war (2023), using a multi-method approach combining mental health questionnaires with wee…
Reward‐network connectivity in childhood predicts multi‐domain dysregulation in adolescence
Background Multi‐domain dysregulation in adolescence, indexed by co‐occurring affective, cognitive, and behavioural difficulties, is a robust transdiagnostic risk factor. However, its developmental course and neural antecedents are poorly understood. Given heightened emotional reactivity and impulsivity in adolescence, alterations in reward‐network connectivity may represent an early neural marker of risk. Methods Adolescents completed four asses…
An Investigation of Inhibitory Control as a Mechanism Differentiating Tonic and Phasic Irritability
Attention Focusing Moderates the Association Between Parent Anxiety and Attention Bias to Threat in Youth with Social Anxiety Disorder
The roles of parental verbal communication and child characteristics in the transmission and maintenance of social fears
BACKGROUND: Although social anxiety runs in families, little is known about how parents and children contribute to the intergenerational transmission of social fears. We examined whether mothers transfer social fear beliefs to their children through verbal communication and how children's behavioral inhibition and social anxiety contribute to this transmission. The associations of children's social fear beliefs with peer avoidance and interpretat…
Infants’ resting-state functional connectivity and event-related potentials
Individual differences in how the brain responds to novelty are present from infancy. A common method of studying novelty processing is through event-related potentials (ERPs). While ERPs possess millisecond precision, spatial resolution remains poor, especially in infancy. This study aimed to balance spatial and temporal precision by combining ERP data with functional magnetic resonance imaging (fMRI) data. Twenty-nine infants (15 female) underw…
Sleepless nights, sour moods
BACKGROUND: Sleep, or a lack thereof, is strongly related to mood dysregulation. Although considerable research uses symptom scales to examine this relation, few studies use longitudinal, real-time methods focused on pediatric irritability. This study leveraged an ecological momentary assessment (EMA) protocol, assessing bidirectional associations between momentary irritability symptoms and daily sleep duration in a transdiagnostic pediatric samp…
Enhanced late positive potential to conditioned threat cue during delayed extinction in anxious youth
BACKGROUND: Deficits in threat learning relate to anxiety symptoms. Since several anxiety disorders arise in adolescence, impaired adolescent threat learning could contribute to adolescent changes in risk for anxiety. This study compared threat learning among anxious and non-anxious youth using self-reports, peripheral psychophysiology measures, and event-related potentials. Because exposure therapy, the first-line treatment for anxiety disorders…
Neonatal neural responses to novelty related to behavioral inhibition at 1 year
Behavioral inhibition (BI), an early-life temperament characterized by vigilant responses to novelty, is a risk factor for anxiety disorders. In this study, we investigated whether differences in neonatal brain responses to infrequent auditory stimuli relate to children's BI at 1 year of age. Using functional magnetic resonance imaging (fMRI), we collected blood-oxygen-level-dependent (BOLD) data from N = 45 full-term, sleeping neonates during an…
Longitudinal relations among temperament, cognitive control, and anxiety
Children with a history of behaviorally inhibited (BI) temperament face a heightened risk for anxiety disorders and often use control strategies that are less planful. Although these relations have been observed concurrently in early childhood, middle childhood, and adolescence, few studies leverage longitudinal data to examine long-term prospective relations between cognitive control and anxiety. Using longitudinal data from 149 adolescents (55%…
Network analysis of ecological momentary assessment identifies frustration as a central node in irritability
BACKGROUND: Irritability presents transdiagnostically, commonly occurring with anxiety and other mood symptoms. However, little is known about the temporal and dynamic interplay among irritability-related clinical phenomena. Using a novel network analytic approach with smartphone-based ecological momentary assessment (EMA), we examined how irritability and other anxiety and mood symptoms were connected. METHODS: Sample included 152 youth ages 8-1…
Neural underpinnings of threat bias in relation to loss-of-control eating behaviors among adolescent girls with high weight
These findings suggest that girls with overweight or obesity may fail to adaptively engage neural regions implicated in higher-order executive processes. This difficulty may relate to disinhibited eating patterns that could lead to excess weight gain
A highly replicable decline in mood during rest and simple tasks
Pathways from maternal shyness to adolescent social anxiety
BACKGROUND: Social anxiety is amongst the most prevalent adolescent mental health problems; however, it is often unrecognized due to its comorbidity with other anxiety problems such as generalized anxiety. Thus, understanding the unique developmental pathways to social anxiety is critical for improving its prevention. We examined the pathway from maternal shyness, when children were 4 years old, to adolescents' social anxiety at age 15 through so…
Emotional distractors and attentional control in anxious youth
Attentional control theory suggests that high cognitive demands impair the flexible deployment of attention control in anxious adults, particularly when paired with external threats. Extending this work to pediatric anxiety, we report two studies utilising eye tracking (Study 1) and functional magnetic resonance imaging (Study 2). Both studies use a visual search paradigm to examine anxiety-related differences in the impact of threat on attention…
Developmental Changes in the Association Between Cognitive Control and Anxiety
Anxiety has been associated with reliance on reactive (stimulus-driven/reflexive) control strategies in response to conflict. However, this conclusion rests primarily on indirect evidence. Few studies utilize tasks that dissociate the use of reactive ('just in time') vs. proactive (anticipatory/preparatory) cognitive control strategies in response to conflict, and none examine children diagnosed with anxiety. The current study utilizes the AX-CPT…
Intimate Partner Violence Exposure and Childhood Psychopathology
Anticipatory Effects on Perceived Pain
OBJECTIVE: Naturalistic studies suggest that expectation of adverse experiences such as pain exerts particularly strong effects on anxious youth. In healthy adults, expectation influences the experience of pain. The current study uses experimental methods to compare the effects of expectation on pain among adults, healthy youth, and youth with an anxiety disorder. METHODS: Twenty-three healthy adults, 20 healthy youth, and 20 youth with an anxiet…
A systematic review of attentional biases in disorders involving binge eating
The Screen for Child Anxiety Related Emotional Disorders (SCARED)
Using Neuroscience to Help Understand Fear and Anxiety
Tremendous progress has been made in basic neuroscience in recent decades. One area that has been especially successful is research on how the brain detects and responds to threats. Such studies have demonstrated comparable patterns of brain-behavior relationships underlying threat processing across a range of mammalian species, including humans. This would seem to be an ideal body of information for advancing our understanding of disorders in wh…
Rutter's Child and Adolescent Psychiatry
Attentional bias to food cues in youth with loss of control eating
Effect of Mother's Dominance Rank on Offspring Temperament in Infant Rhesus Monkeys ( M acaca mulatta)
In humans, temperament plays an important role in socialization and personality. Some temperaments, such as behavioral inhibition are associated with an increased risk for psychopathology. Nonhuman primates can serve as a model for neurobiological and developmental contributions to emotional development and several recent studies have begun to investigate temperament in nonhuman primates. In rhesus monkeys, dominance rank is inherited from the mo…
Depression in adolescence
Rejection sensitivity and disruption of attention by social threat cues
Psychiatric symptoms in adolescence as predictors of obesity in early adulthood
OBJECTIVES: This study examined the longitudinal relationship between psychopathology and obesity in young adulthood. METHODS: More than 700 youth in a population-based sample were psychiatrically assessed in 1983 (mean age = 14 years) and 1992 (mean age = 22 years). Self-reported body mass index (BMI) in 1992 was regressed on measures of depression and conduct disorder as well as a set of covariates including indices of physical health, social c…
Attentional bias to food cues in youth with loss of control eating
Patterns of sustained attention in infancy shape the developmental trajectory of social behavior from toddlerhood through adolescence
The current study examined the relations between individual differences in sustained attention in infancy, the temperamental trait behavioral inhibition in childhood, and social behavior in adolescence. The authors assessed 9-month-old infants using an interrupted-stimulus attention paradigm. Behavioral inhibition was subsequently assessed in the laboratory at 14 months, 24 months, 4 years, and 7 years. At age 14 years, adolescents acted out soci…
Cardiac Profile and Disruptive Behavior in Boys at Risk for Delinquency
The objective of this study was to examine associations in youth between antisocial behavior and cardiovascular profile. Younger brothers of adjudicated delinquents (N = 120) received a standardized psychiatric assessment and an assessment of three factors often studied in behavioral cardiology research: family history of hypertension, resting blood pressure, and obesity. As a group, relative to population norms, these youth exhibited signs of ob…
Psychiatric symptoms in adolescence as predictors of obesity in early adulthood
OBJECTIVES: This study examined the longitudinal relationship between psychopathology and obesity in young adulthood. METHODS: More than 700 youth in a population-based sample were psychiatrically assessed in 1983 (mean age = 14 years) and 1992 (mean age = 22 years). Self-reported body mass index (BMI) in 1992 was regressed on measures of depression and conduct disorder as well as a set of covariates including indices of physical health, social c…
The Risk for Early-Adulthood Anxiety and Depressive Disorders in Adolescents With Anxiety and Depressive Disorders
BACKGROUND: Various studies find relationships among anxiety and depressive disorders of adolescence and adulthood. This study prospectively examines the magnitude of longitudinal associations between adolescent and adult anxiety or depressive disorders. METHODS: An epidemiologically selected sample of 776 young people living in upstate New York received DSM-based psychiatric assessments in 1983, 1985, and 1992 using structured interviews. The ma…
Adolescent Depressive Symptoms as Predictors of Adult Depression
OBJECTIVE: The authors' goal was to examine the relationship between subclinical depressive symptoms in adolescence and major depressive episodes in adulthood. METHOD: An epidemiologic sample of 776 young people received psychiatric assessments in 1983, 1985, and 1992. Among adolescents not meeting criteria for major depression, the authors estimated the magnitude of the association between subclinical adolescent depressive symptoms and adult maj…
Cortical brain regions engaged by masked emotional faces in adolescents and adults
Cortical brain regions engaged by masked emotional faces in adolescents and adults
Face-emotion processing has shown signs of developmental change during adolescence. Functional magnetic resonance imaging (fMRI) was used on 10 adolescents and 10 adults to contrast brain regions engaged by a masked emotional-face task (viewing a fixation cross and a series of masked happy and masked fearful faces), while blood oxygen level dependent signal was monitored by a 1.5-T MRI scanner. Brain regions differentially engaged in the 2 age gr…
Neurological Soft Signs and Disruptive Behavior Among Children of Opiate Dependent Parents
The social re-orientation of adolescence
Background. Many changes in social behavior take place during adolescence. Sexuality and romantic interests emerge during this time, and adolescents spend more time with peers and less time with parents and family. While such changes in social behavior have been well documented in the literature, relatively few neurophysiological explanations for these behavioral changes have been presented. Method. In this article we selectively review studies d…
Sensation Seeking and the Aversive Motivational System
Sensation seeking (SS) has traditionally been viewed as a phenomenon of the appetitive motivational system. The limited SS research exploring contributions from the aversive motivational system reveals greater anxious reactivity to dangerous activities among low sensation seekers. The present study extends this line of work by comparing levels of fear and anxiety during anticipation of predictable and unpredictable aversive stimuli across high- a…
Onset of Spontaneous Panic Attacks
OBJECTIVE: Earlier analyses have shown that, among currently well individuals with no history of panic attacks, a family history of panic disorder is associated with a greater likelihood of panic symptoms after exposure to 35% CO2 and of ventilatory-response abnormalities during inhalation of 5% CO2. An association of those features with a subsequent onset of panic attacks would compose additional evidence that they are trait markers for panic di…
Incidence of Social Anxiety Disorder and the Consistent Risk for Secondary Depression in the First Three Decades of Life
CONTEXT: Epidemiological findings demonstrating an increased risk for individuals with social anxiety disorder (SAD) to develop depression have been challenged by discrepant findings from prospective longitudinal examinations in childhood and early adolescence. OBJECTIVES: To examine patterns of SAD incidence, the consistency of associations of SAD with subsequent depression, and distal and proximal predictors for subsequent depression. DESIGN: F…
Anxiety and Anxiety Disorders in Children and Adolescents
Stable Early Maternal Report of Behavioral Inhibition Predicts Lifetime Social Anxiety Disorder in Adolescence
Impact of Behavioral Inhibition and Parenting Style on Internalizing and Externalizing Problems from Early Childhood through Adolescence
Rejection sensitivity and disruption of attention by social threat cues
Research Domain Criteria (RDoC)
Self-archived author copy of a scholarly work originally published in American Journal of Psychiatry (2010), made available through Wesleyan University's digital collections.
Attention biases to threat and behavioral inhibition in early childhood shape adolescent social withdrawal
Behavioral inhibition (BI) is a temperament characterized in young children by a heightened sensitivity to novelty, social withdrawal, and anxious behaviors. For many children, these social difficulties dissipate over time. For others, patterns of social withdrawal continue into adolescence. Over time, attention biases to threat may influence the stability of BI and its association with social withdrawal, ultimately modulating the risk for anxiet…
Patterns of sustained attention in infancy shape the developmental trajectory of social behavior from toddlerhood through adolescence
The current study examined the relations between individual differences in sustained attention in infancy, the temperamental trait behavioral inhibition in childhood, and social behavior in adolescence. The authors assessed 9-month-old infants using an interrupted-stimulus attention paradigm. Behavioral inhibition was subsequently assessed in the laboratory at 14 months, 24 months, 4 years, and 7 years. At age 14 years, adolescents acted out soci…
Depression in adolescence
Flexible attention deployment in threatening contexts
Factors leading humans to shift attention away from danger cues remain poorly understood. Two laboratory experiments reported here show that context interacts with learning experiences to shape attention avoidance of mild danger cues. The first experiment exposed 18 participants to contextual threat of electric shock. Attention allocation to mild danger cues was then assessed with the dot-probe task. Results showed that contextual threat caused s…
Approach–withdrawal and the role of the striatum in the temperament of behavioral inhibition
Behavioral inhibition is a temperament characterized in infancy and early childhood by a tendency to withdraw from novel or unfamiliar stimuli. Children exhibiting this disposition, relative to children with other dispositions, are more socially reticent, less likely to initiate interaction with peers, and more likely to develop anxiety over time. Until recently, a dominant model attributed this disposition to reductions in the threshold for enga…
Effect of Mother's Dominance Rank on Offspring Temperament in Infant Rhesus Monkeys ( M acaca mulatta)
In humans, temperament plays an important role in socialization and personality. Some temperaments, such as behavioral inhibition are associated with an increased risk for psychopathology. Nonhuman primates can serve as a model for neurobiological and developmental contributions to emotional development and several recent studies have begun to investigate temperament in nonhuman primates. In rhesus monkeys, dominance rank is inherited from the mo…
Rutter's Child and Adolescent Psychiatry
Attentional bias to food cues in youth with loss of control eating
Using Neuroscience to Help Understand Fear and Anxiety
Tremendous progress has been made in basic neuroscience in recent decades. One area that has been especially successful is research on how the brain detects and responds to threats. Such studies have demonstrated comparable patterns of brain-behavior relationships underlying threat processing across a range of mammalian species, including humans. This would seem to be an ideal body of information for advancing our understanding of disorders in wh…
Psychology (39 works) · Developmental psychology (27 works) · Psychiatry (27 works) · Anxiety (24 works) · Clinical Psychology (21 works) · Medicine (19 works) · Child and Adolescent Psychosocial and Emotional Development (18 works) · Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes (17 works) · Cognition (13 works) · Social Psychology (12 works)