Michele Carugno
Biographic Data
| ID | 1940420 |
|---|---|
| NAME | Michele Carugno |
| GIVEN NAMES | Michele |
| FAMILY NAME | Carugno |
| SIGNATURE | CARUGNO M |
| AFFILIATIONS | University of Milan |
| ORCID | 0000-0001-5212-2489 |
| VERIFIED | Yes |
| TOTAL WORKS | 8 |
| TOTAL CITATIONS | 0 |
| AUTHOR COUNT | 8 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2012 |
| LATEST PUBLICATION YEAR | 2023 |
| H-INDEX | 0 |
Metabolomic profiles in night shift workers: A cross-sectional study on hospital female nurses
Background and aim: Shift work, especially including night shifts, has been found associated with several diseases, including obesity, diabetes, cancers, and cardiovascular, mental, gastrointestinal and sleep disorders. Metabolomics (an omics-based methodology) may shed light on early biological alterations underlying these associations. We thus aimed to evaluate the effect of night shift work (NSW) on serum metabolites in a sample of hospital fe…
Association between night shift work and methylation of a subset of immune-related genes
Introduction Night shift (NS) work has been associated with an increased risk of different conditions characterized by altered inflammatory and immune responses, such as cardio-metabolic and infectious diseases, cancer, and obesity. Epigenetic modifications, such as DNA methylation, might mirror alterations in biological processes that are influenced by NS work. Methods The present study was conducted on 94 healthy female workers with different w…
Understanding the Interplay between Air Pollution, Biological Variables, and Major Depressive Disorder: Rationale and Study Protocol of the DeprAir Study
Major depressive disorder (MDD) is a serious and disabling condition, whose etiological mechanisms are not fully understood. The aim of the DeprAir study is to verify the hypothesis that air pollution exposure may exacerbate neuroinflammation with consequent alterations in DNA methylation of genes involved in circadian rhythms and hormonal dysregulation, resulting in the worsening of depressive symptoms. The study population consists of 420 depre…
Can Night Shift Work Affect Biological Age? Hints from a Cross-Sectional Study on Hospital Female Nurses
Disruption of age-related processes seems to play a relevant role in health effects related to night shift (NS) work. We aim to verify whether NS work can influence biological age (BA), estimated through Zbieć-Piekarska's epigenetic signature, based on methylation of five CpG sites in ELOVL2 , C1orf132 / MIR29B2C , TRIM59 , KLF14, and FHL2 . Forty-six female nurses working in NS were matched by age and length of employment with 51 female colleagu…
Nasal Microbiota Modifies the Effects of Particulate Air Pollution on Plasma Extracellular Vesicles
Air pollution exposure has been linked to modifications of both extracellular vesicle (EV) concentration and nasal microbiota structure (NMB), which might act as the respiratory health gatekeeper. This study aimed to assess whether an unbalanced NMB could modify the effect of particulate matter (PM) exposure on plasmatic EV levels. Due to two different NMB taxonomical profiles characterized by a widely different relative abundance of the Moraxell…
Night Shift Work, DNA Methylation and Telomere Length: An Investigation on Hospital Female Nurses
Increased breast cancer risk has been reported in some night shift (NS) workers but underlying biological mechanisms are still unclear. We assessed the association between NS work and DNA methylation of tumor suppressor ( TP53 , CDKN2A , BRCA1 , BRCA2 ) and estrogen receptor ( ESR1 , ESR2 ) genes, methylation of repetitive elements ( LINE-1 , Alu ), and telomere length (TL). Forty six female nurses employed in NS for at least two years were match…
Susceptibility to particle health effects, miRNA and exosomes: Rationale and study protocol of the SPHERE study
SPHERE is the first large study aimed to explore EVs as a novel potential mechanism of how air pollution exposure acts in a highly susceptible population. The rigorous study design, the availability of banked biological samples and the potential to integrate epidemiological, clinical and molecular data will also furnish a powerful base for investigating different complementary molecular mechanisms. Our findings, if confirmed, could lead to the id…
Physical and psychosocial risk factors for musculoskeletal disorders in Brazilian and Italian nurses
As part of the international CUPID investigation, we compared physical and psychosocial risk factors for musculoskeletal disorders among nurses in Brazil and Italy. Using questionnaires, we collected information on musculoskeletal disorders and potential risk factors from 751 nurses employed in public hospitals. By fitting countryspecific multiple logistic regression models, we investigated the association of stressful physical activities and psy…
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Physical and psychosocial risk factors for musculoskeletal disorders in Brazilian and Italian nurses
As part of the international CUPID investigation, we compared physical and psychosocial risk factors for musculoskeletal disorders among nurses in Brazil and Italy. Using questionnaires, we collected information on musculoskeletal disorders and potential risk factors from 751 nurses employed in public hospitals. By fitting countryspecific multiple logistic regression models, we investigated the association of stressful physical activities and psy…
Susceptibility to particle health effects, miRNA and exosomes: Rationale and study protocol of the SPHERE study
SPHERE is the first large study aimed to explore EVs as a novel potential mechanism of how air pollution exposure acts in a highly susceptible population. The rigorous study design, the availability of banked biological samples and the potential to integrate epidemiological, clinical and molecular data will also furnish a powerful base for investigating different complementary molecular mechanisms. Our findings, if confirmed, could lead to the id…
Night Shift Work, DNA Methylation and Telomere Length: An Investigation on Hospital Female Nurses
Increased breast cancer risk has been reported in some night shift (NS) workers but underlying biological mechanisms are still unclear. We assessed the association between NS work and DNA methylation of tumor suppressor ( TP53 , CDKN2A , BRCA1 , BRCA2 ) and estrogen receptor ( ESR1 , ESR2 ) genes, methylation of repetitive elements ( LINE-1 , Alu ), and telomere length (TL). Forty six female nurses employed in NS for at least two years were match…
Nasal Microbiota Modifies the Effects of Particulate Air Pollution on Plasma Extracellular Vesicles
Air pollution exposure has been linked to modifications of both extracellular vesicle (EV) concentration and nasal microbiota structure (NMB), which might act as the respiratory health gatekeeper. This study aimed to assess whether an unbalanced NMB could modify the effect of particulate matter (PM) exposure on plasmatic EV levels. Due to two different NMB taxonomical profiles characterized by a widely different relative abundance of the Moraxell…
Can Night Shift Work Affect Biological Age? Hints from a Cross-Sectional Study on Hospital Female Nurses
Disruption of age-related processes seems to play a relevant role in health effects related to night shift (NS) work. We aim to verify whether NS work can influence biological age (BA), estimated through Zbieć-Piekarska's epigenetic signature, based on methylation of five CpG sites in ELOVL2 , C1orf132 / MIR29B2C , TRIM59 , KLF14, and FHL2 . Forty-six female nurses working in NS were matched by age and length of employment with 51 female colleagu…
Metabolomic profiles in night shift workers: A cross-sectional study on hospital female nurses
Background and aim: Shift work, especially including night shifts, has been found associated with several diseases, including obesity, diabetes, cancers, and cardiovascular, mental, gastrointestinal and sleep disorders. Metabolomics (an omics-based methodology) may shed light on early biological alterations underlying these associations. We thus aimed to evaluate the effect of night shift work (NSW) on serum metabolites in a sample of hospital fe…
Association between night shift work and methylation of a subset of immune-related genes
Introduction Night shift (NS) work has been associated with an increased risk of different conditions characterized by altered inflammatory and immune responses, such as cardio-metabolic and infectious diseases, cancer, and obesity. Epigenetic modifications, such as DNA methylation, might mirror alterations in biological processes that are influenced by NS work. Methods The present study was conducted on 94 healthy female workers with different w…
Understanding the Interplay between Air Pollution, Biological Variables, and Major Depressive Disorder: Rationale and Study Protocol of the DeprAir Study
Major depressive disorder (MDD) is a serious and disabling condition, whose etiological mechanisms are not fully understood. The aim of the DeprAir study is to verify the hypothesis that air pollution exposure may exacerbate neuroinflammation with consequent alterations in DNA methylation of genes involved in circadian rhythms and hormonal dysregulation, resulting in the worsening of depressive symptoms. The study population consists of 420 depre…
Medicine (8 works) · Biology (6 works) · Internal Medicine (5 works) · Environmental health (4 works) · Pathology (4 works) · Air Quality and Health Impacts (3 works) · Epigenetics and DNA Methylation (3 works) · Genetics (3 works) · Methylation (3 works) · Population (3 works)