Annette Rid
Datos Biográficos
| ID | 231096 |
|---|---|
| NOMBRE | Annette Rid |
| NOMBRES | Annette |
| APELLIDO | Rid |
| FIRMA | RID A |
| AFILIACIONES | National Institutes of Health Clinical Center |
| ORCID | 0000-0003-1117-1975 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 15 |
| TOTAL DE CITAS | 4 |
| TOTAL COMO AUTOR | 14 |
| TOTAL COMO EDITOR | 1 |
| PRIMER AÑO DE PUBLICACIÓN | 2015 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2025 |
| ÍNDICE H | 1 |
Observational research in epidemic settings
Observational studies are critical tools in clinical research and public health response, but challenges arise in ensuring the data produced by these studies are scientifically robust and socially valuable. Resolving these challenges requires careful attention to prioritising the most valuable research questions, ensuring robust study design, strong data management practices, expansive community engagement, and access and benefit sharing of resul…
Respecting formerly autonomous persons
Views from patients, students, and preceptors about the ethics of student-run free clinics
At roughly three-quarters of U.S. medical schools, health professional students run student-run free clinics (SRFCs) to provide free or reduced-cost care—including, for example, primary care services, medications, and social services—to their local communities [ 1 , 2 ]. Typically, student volunteers engage with patients, then consult with licensed preceptor volunteers to design treatment plans [ 3 ]. Patients at SRFCs often face one or multiple …
Ethical preparedness of data monitoring committees (DMCs) to oversee international clinical trials
INTRODUCTION: A data monitoring committee (DMC) is an independent group of experts who assess the ongoing scientific and ethical integrity of a study through periodic analyses of study data. The objective of this study was to explore the extent to which the structure, membership and deliberations of DMCs enable them to address ethical issues. METHODS: We conducted qualitative individual interviews (n=22) with DMC members from countries across Afr…
Global health reciprocal innovation
Global health reciprocal innovation (GHRI) is a recent and more formalised approach to conducting research that recognises and develops innovations (eg, medicines, devices, methodologies) from low- and middle-income countries (LMICs). At present, studies using GHRI most commonly adapt innovations from LMICs for use in high-income countries (HICs), although some develop innovations in LMICs and HICs. In this paper, we propose that GHRI implicitly …
Ethical considerations for referral partnerships in clinical research
Recruitment challenges in clinical research are widespread, particularly for traditionally under-represented groups. Referral relationships—in which research partners and clinical partners agree to collaborate on selected research studies or programmes, with the expectation that the clinical partners refer appropriate patients as potential participants—may help alleviate these challenges. Referral relationships allow research partners access to e…
Regulating international clinical research
The global distribution of clinical trials is shifting to low-income and middle-income countries (LMICs), and adequate regulations are essential for protecting the rights and interests of research participants in these countries. However, policy-makers in LMICs can face an ethical trade-off: stringent regulatory protections for participants can lead researchers or sponsors to conduct their research elsewhere, potentially depriving the local popul…
Informed consent for controlled human infection studies in low‐ and middle‐income countries
In controlled human infection studies (CHIs), participants are deliberately exposed to infectious agents in order to better understand the mechanism of infection or disease and test therapies or vaccines. While most CHIs have been conducted in high‐income countries, CHIs have recently been expanding into low‐ and middle‐income countries (LMICs). One potential ethical concern about this expansion is the challenge of obtaining the voluntary informe…
Ethics of controlled human infection studies
Judging the social value of controlled human infection studies
In controlled human infection (CHI) studies, investigators deliberately infect healthy individuals with pathogens in order to study mechanisms of disease or obtain preliminary efficacy data on investigational vaccines and medicines. CHI studies offer a fast and cost‐effective way of generating new scientific insights, prioritizing investigational products for clinical testing, and reducing the risk that large numbers of people are exposed to inef…
Innovation as a value in healthcare priority-setting
All healthcare systems operate with limited resources and therefore need to set priorities for allocating resources across a population. Trade-offs between maximising health and promoting health equity are inevitable in this process. In this paper, we use the UK's National Institute for Health and Care Excellence (NICE) as an example to examine how efforts to promote healthcare innovation in the priority-setting process can complicate these trade…
The Next Wave in Health Care Priority Setting
A new problem in health care priority‐setting is currently emerging for wealthy countries: what should be done when a new drug is considered cost effective but implementing it would still be unaffordable? The standard approach to setting priorities in health care rests on cost effectiveness. This approach is now being tested by new drugs that are highly effective but very costly. Because they are so effective, these drugs deliver “value for money…
What Is Enough?
Ethical Rationale for the Ebola “Ring Vaccination” Trial Design
The 2014 Ebola virus epidemic is the largest and most severe ever recorded. With no approved vaccines or specific treatments for Ebola, clinical trials were launched within months of the epidemic in an unprecedented show of global partnership. One of these trials used a highly innovative “ring vaccination” design. The design was chosen for operational, scientific, and ethical reasons—in particular, it was regarded as ethically superior to individ…
Placebo-Controlled Trials, Ethics of
Ethical Rationale for the Ebola “Ring Vaccination” Trial Design
The 2014 Ebola virus epidemic is the largest and most severe ever recorded. With no approved vaccines or specific treatments for Ebola, clinical trials were launched within months of the epidemic in an unprecedented show of global partnership. One of these trials used a highly innovative “ring vaccination” design. The design was chosen for operational, scientific, and ethical reasons—in particular, it was regarded as ethically superior to individ…
Innovation as a value in healthcare priority-setting
All healthcare systems operate with limited resources and therefore need to set priorities for allocating resources across a population. Trade-offs between maximising health and promoting health equity are inevitable in this process. In this paper, we use the UK's National Institute for Health and Care Excellence (NICE) as an example to examine how efforts to promote healthcare innovation in the priority-setting process can complicate these trade…
Placebo-Controlled Trials, Ethics of
What Is Enough?
Ethical Rationale for the Ebola “Ring Vaccination” Trial Design
The 2014 Ebola virus epidemic is the largest and most severe ever recorded. With no approved vaccines or specific treatments for Ebola, clinical trials were launched within months of the epidemic in an unprecedented show of global partnership. One of these trials used a highly innovative “ring vaccination” design. The design was chosen for operational, scientific, and ethical reasons—in particular, it was regarded as ethically superior to individ…
The Next Wave in Health Care Priority Setting
A new problem in health care priority‐setting is currently emerging for wealthy countries: what should be done when a new drug is considered cost effective but implementing it would still be unaffordable? The standard approach to setting priorities in health care rests on cost effectiveness. This approach is now being tested by new drugs that are highly effective but very costly. Because they are so effective, these drugs deliver “value for money…
Innovation as a value in healthcare priority-setting
All healthcare systems operate with limited resources and therefore need to set priorities for allocating resources across a population. Trade-offs between maximising health and promoting health equity are inevitable in this process. In this paper, we use the UK's National Institute for Health and Care Excellence (NICE) as an example to examine how efforts to promote healthcare innovation in the priority-setting process can complicate these trade…
Regulating international clinical research
The global distribution of clinical trials is shifting to low-income and middle-income countries (LMICs), and adequate regulations are essential for protecting the rights and interests of research participants in these countries. However, policy-makers in LMICs can face an ethical trade-off: stringent regulatory protections for participants can lead researchers or sponsors to conduct their research elsewhere, potentially depriving the local popul…
Informed consent for controlled human infection studies in low‐ and middle‐income countries
In controlled human infection studies (CHIs), participants are deliberately exposed to infectious agents in order to better understand the mechanism of infection or disease and test therapies or vaccines. While most CHIs have been conducted in high‐income countries, CHIs have recently been expanding into low‐ and middle‐income countries (LMICs). One potential ethical concern about this expansion is the challenge of obtaining the voluntary informe…
Ethics of controlled human infection studies
Judging the social value of controlled human infection studies
In controlled human infection (CHI) studies, investigators deliberately infect healthy individuals with pathogens in order to study mechanisms of disease or obtain preliminary efficacy data on investigational vaccines and medicines. CHI studies offer a fast and cost‐effective way of generating new scientific insights, prioritizing investigational products for clinical testing, and reducing the risk that large numbers of people are exposed to inef…
Ethical preparedness of data monitoring committees (DMCs) to oversee international clinical trials
INTRODUCTION: A data monitoring committee (DMC) is an independent group of experts who assess the ongoing scientific and ethical integrity of a study through periodic analyses of study data. The objective of this study was to explore the extent to which the structure, membership and deliberations of DMCs enable them to address ethical issues. METHODS: We conducted qualitative individual interviews (n=22) with DMC members from countries across Afr…
Global health reciprocal innovation
Global health reciprocal innovation (GHRI) is a recent and more formalised approach to conducting research that recognises and develops innovations (eg, medicines, devices, methodologies) from low- and middle-income countries (LMICs). At present, studies using GHRI most commonly adapt innovations from LMICs for use in high-income countries (HICs), although some develop innovations in LMICs and HICs. In this paper, we propose that GHRI implicitly …
Ethical considerations for referral partnerships in clinical research
Recruitment challenges in clinical research are widespread, particularly for traditionally under-represented groups. Referral relationships—in which research partners and clinical partners agree to collaborate on selected research studies or programmes, with the expectation that the clinical partners refer appropriate patients as potential participants—may help alleviate these challenges. Referral relationships allow research partners access to e…
Observational research in epidemic settings
Observational studies are critical tools in clinical research and public health response, but challenges arise in ensuring the data produced by these studies are scientifically robust and socially valuable. Resolving these challenges requires careful attention to prioritising the most valuable research questions, ensuring robust study design, strong data management practices, expansive community engagement, and access and benefit sharing of resul…
Respecting formerly autonomous persons
Views from patients, students, and preceptors about the ethics of student-run free clinics
At roughly three-quarters of U.S. medical schools, health professional students run student-run free clinics (SRFCs) to provide free or reduced-cost care—including, for example, primary care services, medications, and social services—to their local communities [ 1 , 2 ]. Typically, student volunteers engage with patients, then consult with licensed preceptor volunteers to design treatment plans [ 3 ]. Patients at SRFCs often face one or multiple …
Medicine (14 obras) · Political science (10 obras) · Psychology (8 obras) · Computer Science (7 obras) · Ethics in Clinical Research (7 obras) · Nursing (7 obras) · Public relations (7 obras) · Law (6 obras) · Biomedical Ethics and Regulation (4 obras) · Family medicine (4 obras)