Raffaella Ravinetto
Biographic Data
| ID | 2315345 |
|---|---|
| NAME | Raffaella Ravinetto |
| GIVEN NAMES | Raffaella |
| FAMILY NAME | Ravinetto |
| SIGNATURE | RAVINETTO R |
| AFFILIATIONS | Instituut voor Tropische Geneeskunde |
| ORCID | 0000-0001-7765-2443 |
| VERIFIED | Yes |
| TOTAL WORKS | 26 |
| TOTAL CITATIONS | 1 |
| AUTHOR COUNT | 26 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2015 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 1 |
Systemic challenges in the supply and distribution of medicines in conflict-affected areas of Mali
BACKGROUND: The conflicts that have been ongoing for over a decade in different Sahel countries, including Mali, have a negative impact on the supply and distribution of medicines. OBJECTIVE: This study aims to identify and analyze the key contextual challenges affecting the supply and distribution of medicines in conflict-affected areas in Mali. METHODS: This study adopts a qualitative study design. First, we conducted 28 interviews with key sta…
Can a code of professional ethics influence the supply of substandard and falsified medicines? Insights from Ethiopia
Substandard and falsified (SF) medicines are serious global health problems. Their high prevalence is a threat to public health in resource-limited settings. It is assumed that professionals will uphold specific standards of behaviour to protect the public interest and maintain trust. This study assesses whether a professional ethical code can serve as an effective way to prevent and respond to SF medicines by enhancing ethical behaviours in prac…
Inadequate last-mile pharmaceutical waste management is a neglected threat to environmental and public health
BOX Last-mile pharmaceutical waste is generated at the level of the community, healthcare facilities, pharmaceutical outlets and markets, and animal husbandry
Is global health security worth 0.01% of our gross domestic product
Contextual constraints and dilemmas influencing health providers’ prescription practices in a conflict-affected area
Armed conflicts present complex, multidimensional challenges that severely compromise both access to and the quality of healthcare, including the adequate prescription of essential medicines. This study aimed to identify and understand the factors underlying the irrational prescribing of medicine in areas affected by armed conflict in the Mopti region in Mali. An exploratory qualitative study was conducted using a semi-structured interview guide …
Access to essential medicines for noncommunicable diseases during conflicts
Access to essential medicines is a critical component of healthcare. Conflicts severely disrupt pharmaceutical supply chains. This study examines the availability and prices of essential noncommunicable diseases (NCDs) medicines in Northern Syria, and explores the underlying factors contributing to medicine shortages and price variability. We applied a mixed-methods approach, combining a cross-sectional quantitative survey based on the World Heal…
Assessing patterns of authorship of low- and middle-income countries in global commercial clinical trials in oncology
Poor authorship practices in global health research may be a sign of unequal partnerships. Previous studies have shown that authors from low- and middle-income countries (LMICs) are frequently underrepresented in publications from global research collaborations between LMICs and high-income countries (HICs). To the best of our knowledge, the patterns of authorship from LMICs in international industry-sponsored clinical research on breast, lung an…
Irrational medicine use and its associated factors in conflict-affected areas in Mali
BACKGROUND: Rational use of essential medicines is a critical step towards prevention and treatment of many illnesses. However, it represents a significant challenge worldwide, and particularly for under-resourced health systems in conflict-affected areas. OBJECTIVE: To assess barriers to rational use of essential medicines at primary healthcare level in conflict-affected areas of Mali. METHODS: We conducted a cross-sectional study in twenty rand…
Dispensing of medicines for asthma and chronic obstructive pulmonary disease through the government health insurance in Syria
BACKGROUND: Asthma and chronic obstructive pulmonary disease (COPD) are common noncommunicable diseases, exacerbated in conflict settings by the heightened environmental exposure to triggers, weakened health systems, and poor access to medicines and healthcare. However, accurate data on medicines dispensing in this context are generally scarce. OBJECTIVE: We examined the patterns and rates of medicines dispensing for asthma and COPD among the ben…
Can Systemic Corruption be Prevented by Legal Means? The Market for Pharmaceuticals in Southern Ethiopia
Some international and national regulatory and policy actors assume thatstrengthening domestic laws and tightening enforcement measures will besufficient to reduce the extra-legal supply of medicines, whether legal, sub-standard, or falsified, to patients in low- and middle-income countries. Thispaper uses a qualitative study of the pharmaceutical market in SouthernEthiopia to argue that this assumption is unjustified, given the commonlack of ins…
An ancillary care policy in a vaccine trial conducted in a resource-constrained setting
INTRODUCTION: Clear guidelines to implement ancillary care (AC) in clinical trials conducted in resource-constrained settings are lacking. Here, we evaluate an AC policy developed for a vaccine trial in the Democratic Republic of the Congo and formulate policy recommendations. METHODS: To evaluate the AC policy, we performed a longitudinal cohort study, nested in an open-label, single-centre, randomised Ebola vaccine trial conducted among healthc…
Access to medicines among asylum seekers, refugees and undocumented migrants across the migratory cycle in Europe
INTRODUCTION: Access to essential medicines is a critical element of health systems and an important measure of their performance. Migrants may face barriers in accessing healthcare, including essential medicines, throughout the migration cycle, which includes the stages of departure from home or residence countries, transit through non-European or European countries, reception and settlement in a country in Europe and deportation. We aim to prov…
Shaping the future of global access to safe, effective, appropriate and quality health products
status: Published
Researchers’ responsibilities in resource-constrained settings
In this paper, we discuss challenges associated with implementing a policy for Ancillary Care (AC) for related and unrelated (serious) adverse events during an Ebola vaccine trial conducted in a remote area of the Democratic Republic of the Congo. Conducting clinical trials in resourceconstrained settings can raise context-related challenges that have implications for study participants’ health and wellbeing. During the Ebola vaccine study, three…
Research ethics preparedness during outbreaks and public health emergencies
Research represents an essential component of the response to infectious disease outbreaks and to other public health emergencies, whether they are localised, of international concern, or global. Research conducted in such contexts also comes with particular ethics challenges, the awareness of which has significantly grown following the Ebola outbreak in West Africa, the Zika outbreak in Latin America and the COVID-19 pandemic. These challenges i…
Substandard and falsified medicines in African pharmaceutical markets
Uncertainties about the quality of medical products globally
How the concept of WHO-listed authorities will change international procurement policies for medicines
Facilitating access to medicines and continuity of care for Ukrainian refugees
Aljadeeah S, Michielsen J, Ravinetto R, et al. Facilitating access to medicines and continuity of care for Ukrainian refugees: exceptional response or the promise of more inclusive healthcare for all migrants? BMJ Global Health . 2022;7(8): e010327
Algorithm for the support of non-related (serious) adverse events in an Ebola vaccine trial in the Democratic Republic of the Congo
Implementing an Ebola vaccine trial in a remote area in the Democratic Republic of the Congo (DRC), and being confronted with a dysfunctional health care system and acute unmet health needs of participants, ethical considerations were made regarding the ancillary care obligations of the sponsor and researchers. Spurred by the occurrence of non-related (serious) adverse events (NR-SAEs), the Universities of Antwerp and Kinshasa jointly developed a…
Vaccinating children in high-endemic rabies regions
box On September 28 this year, the World Rabies Day came as a reminder that a fully preventable viral encephalitis still claims at least 59 000 victims per year in over 150 countries; and particularly in rural Africa and Asia, where over 40% of individuals bitten by a suspect rabid animal are children. Sadly, these figures are probably underestimated.1 Rabies is one of the Neglected Tropical Diseases (NTDs) announced by the WHO, that is, a divers…
Europe should lead in coordinated procurement of quality-assured medicines for programmes in low-income and middle-income countries
box A secured supply of quality-assured medicines and other medical products is an essential prerequisite for universal health coverage. Unfortunately, on average one in 10 medicines do not meet acceptable quality standards in low-income and middle-income countries (LMICs).1 2 The high prevalence of poor-quality medicines in LMICs greatly depends on the globalisation of pharmaceutical production and distribution, combined with the weakness of man…
Informed consent, community engagement, and study participation at a research site in Kigali, Rwanda
People enroll in medical research for many reasons ranging from decisions regarding their own or family members' health situation to broader considerations including access to health and financial resources. In socially vulnerable communities the choice to participate is often based on a risk‐benefit assessment that goes beyond the medical aspects of the research, and considers the benefits received. In this qualitative study, we examined the mot…
Community sensitization and decision‐making for trial participation
Community sensitization is effective in providing first-hand, reliable information to communities as the information is cascaded to those who could not attend the sessions. However, further research is needed to assess how the informal spread of information further shapes people's expectations, how the process engages with existing social relations and hierarchies (e.g. local political power structures; permissions of heads of households) and how…
The Challenges of Research Informed Consent in Socio‐Economically Vulnerable Populations
In medical research, the ethical principle of respect for persons is operationalized into the process of informed consent. The consent tools should be contextualized and adapted to the different socio‐cultural environment, especially when research crosses the traditional boundaries and reaches poor communities. We look at the challenges experienced in the malaria Quinact trial, conducted in the D emocratic R epublic of C ongo, and describe some l…
Sponsorship in non-commercial clinical trials
BACKGROUND: Non-commercial clinical research plays an increasingly essential role for global health. Multiple partners join in international consortia that operate under the limited timeframe of a specific funding period. One organisation (the sponsor) designs and carries out the trial in collaboration with research partners, and is ultimately responsible for the trial's scientific, ethical, regulatory and legal aspects, while another organizatio…
The Challenges of Research Informed Consent in Socio‐Economically Vulnerable Populations
In medical research, the ethical principle of respect for persons is operationalized into the process of informed consent. The consent tools should be contextualized and adapted to the different socio‐cultural environment, especially when research crosses the traditional boundaries and reaches poor communities. We look at the challenges experienced in the malaria Quinact trial, conducted in the D emocratic R epublic of C ongo, and describe some l…
Informed consent, community engagement, and study participation at a research site in Kigali, Rwanda
People enroll in medical research for many reasons ranging from decisions regarding their own or family members' health situation to broader considerations including access to health and financial resources. In socially vulnerable communities the choice to participate is often based on a risk‐benefit assessment that goes beyond the medical aspects of the research, and considers the benefits received. In this qualitative study, we examined the mot…
Community sensitization and decision‐making for trial participation
Community sensitization is effective in providing first-hand, reliable information to communities as the information is cascaded to those who could not attend the sessions. However, further research is needed to assess how the informal spread of information further shapes people's expectations, how the process engages with existing social relations and hierarchies (e.g. local political power structures; permissions of heads of households) and how…
Europe should lead in coordinated procurement of quality-assured medicines for programmes in low-income and middle-income countries
box A secured supply of quality-assured medicines and other medical products is an essential prerequisite for universal health coverage. Unfortunately, on average one in 10 medicines do not meet acceptable quality standards in low-income and middle-income countries (LMICs).1 2 The high prevalence of poor-quality medicines in LMICs greatly depends on the globalisation of pharmaceutical production and distribution, combined with the weakness of man…
Algorithm for the support of non-related (serious) adverse events in an Ebola vaccine trial in the Democratic Republic of the Congo
Implementing an Ebola vaccine trial in a remote area in the Democratic Republic of the Congo (DRC), and being confronted with a dysfunctional health care system and acute unmet health needs of participants, ethical considerations were made regarding the ancillary care obligations of the sponsor and researchers. Spurred by the occurrence of non-related (serious) adverse events (NR-SAEs), the Universities of Antwerp and Kinshasa jointly developed a…
Vaccinating children in high-endemic rabies regions
box On September 28 this year, the World Rabies Day came as a reminder that a fully preventable viral encephalitis still claims at least 59 000 victims per year in over 150 countries; and particularly in rural Africa and Asia, where over 40% of individuals bitten by a suspect rabid animal are children. Sadly, these figures are probably underestimated.1 Rabies is one of the Neglected Tropical Diseases (NTDs) announced by the WHO, that is, a divers…
How the concept of WHO-listed authorities will change international procurement policies for medicines
Facilitating access to medicines and continuity of care for Ukrainian refugees
Aljadeeah S, Michielsen J, Ravinetto R, et al. Facilitating access to medicines and continuity of care for Ukrainian refugees: exceptional response or the promise of more inclusive healthcare for all migrants? BMJ Global Health . 2022;7(8): e010327
Uncertainties about the quality of medical products globally
An ancillary care policy in a vaccine trial conducted in a resource-constrained setting
INTRODUCTION: Clear guidelines to implement ancillary care (AC) in clinical trials conducted in resource-constrained settings are lacking. Here, we evaluate an AC policy developed for a vaccine trial in the Democratic Republic of the Congo and formulate policy recommendations. METHODS: To evaluate the AC policy, we performed a longitudinal cohort study, nested in an open-label, single-centre, randomised Ebola vaccine trial conducted among healthc…
Access to medicines among asylum seekers, refugees and undocumented migrants across the migratory cycle in Europe
INTRODUCTION: Access to essential medicines is a critical element of health systems and an important measure of their performance. Migrants may face barriers in accessing healthcare, including essential medicines, throughout the migration cycle, which includes the stages of departure from home or residence countries, transit through non-European or European countries, reception and settlement in a country in Europe and deportation. We aim to prov…
Shaping the future of global access to safe, effective, appropriate and quality health products
status: Published
Researchers’ responsibilities in resource-constrained settings
In this paper, we discuss challenges associated with implementing a policy for Ancillary Care (AC) for related and unrelated (serious) adverse events during an Ebola vaccine trial conducted in a remote area of the Democratic Republic of the Congo. Conducting clinical trials in resourceconstrained settings can raise context-related challenges that have implications for study participants’ health and wellbeing. During the Ebola vaccine study, three…
Research ethics preparedness during outbreaks and public health emergencies
Research represents an essential component of the response to infectious disease outbreaks and to other public health emergencies, whether they are localised, of international concern, or global. Research conducted in such contexts also comes with particular ethics challenges, the awareness of which has significantly grown following the Ebola outbreak in West Africa, the Zika outbreak in Latin America and the COVID-19 pandemic. These challenges i…
Substandard and falsified medicines in African pharmaceutical markets
Inadequate last-mile pharmaceutical waste management is a neglected threat to environmental and public health
BOX Last-mile pharmaceutical waste is generated at the level of the community, healthcare facilities, pharmaceutical outlets and markets, and animal husbandry
Is global health security worth 0.01% of our gross domestic product
Contextual constraints and dilemmas influencing health providers’ prescription practices in a conflict-affected area
Armed conflicts present complex, multidimensional challenges that severely compromise both access to and the quality of healthcare, including the adequate prescription of essential medicines. This study aimed to identify and understand the factors underlying the irrational prescribing of medicine in areas affected by armed conflict in the Mopti region in Mali. An exploratory qualitative study was conducted using a semi-structured interview guide …
Access to essential medicines for noncommunicable diseases during conflicts
Access to essential medicines is a critical component of healthcare. Conflicts severely disrupt pharmaceutical supply chains. This study examines the availability and prices of essential noncommunicable diseases (NCDs) medicines in Northern Syria, and explores the underlying factors contributing to medicine shortages and price variability. We applied a mixed-methods approach, combining a cross-sectional quantitative survey based on the World Heal…
Assessing patterns of authorship of low- and middle-income countries in global commercial clinical trials in oncology
Poor authorship practices in global health research may be a sign of unequal partnerships. Previous studies have shown that authors from low- and middle-income countries (LMICs) are frequently underrepresented in publications from global research collaborations between LMICs and high-income countries (HICs). To the best of our knowledge, the patterns of authorship from LMICs in international industry-sponsored clinical research on breast, lung an…
Irrational medicine use and its associated factors in conflict-affected areas in Mali
BACKGROUND: Rational use of essential medicines is a critical step towards prevention and treatment of many illnesses. However, it represents a significant challenge worldwide, and particularly for under-resourced health systems in conflict-affected areas. OBJECTIVE: To assess barriers to rational use of essential medicines at primary healthcare level in conflict-affected areas of Mali. METHODS: We conducted a cross-sectional study in twenty rand…
Dispensing of medicines for asthma and chronic obstructive pulmonary disease through the government health insurance in Syria
BACKGROUND: Asthma and chronic obstructive pulmonary disease (COPD) are common noncommunicable diseases, exacerbated in conflict settings by the heightened environmental exposure to triggers, weakened health systems, and poor access to medicines and healthcare. However, accurate data on medicines dispensing in this context are generally scarce. OBJECTIVE: We examined the patterns and rates of medicines dispensing for asthma and COPD among the ben…
Can Systemic Corruption be Prevented by Legal Means? The Market for Pharmaceuticals in Southern Ethiopia
Some international and national regulatory and policy actors assume thatstrengthening domestic laws and tightening enforcement measures will besufficient to reduce the extra-legal supply of medicines, whether legal, sub-standard, or falsified, to patients in low- and middle-income countries. Thispaper uses a qualitative study of the pharmaceutical market in SouthernEthiopia to argue that this assumption is unjustified, given the commonlack of ins…
Systemic challenges in the supply and distribution of medicines in conflict-affected areas of Mali
BACKGROUND: The conflicts that have been ongoing for over a decade in different Sahel countries, including Mali, have a negative impact on the supply and distribution of medicines. OBJECTIVE: This study aims to identify and analyze the key contextual challenges affecting the supply and distribution of medicines in conflict-affected areas in Mali. METHODS: This study adopts a qualitative study design. First, we conducted 28 interviews with key sta…
Medicine (17 works) · Business (11 works) · Pharmaceutical Economics and Policy (11 works) · Political science (11 works) · Pharmaceutical Quality and Counterfeiting (10 works) · Public health (9 works) · Ethics in Clinical Research (7 works) · Nursing (7 works) · Environmental health (6 works) · Health care (6 works)