G Owen Schaefer
Biographic Data
| ID | 2744254 |
|---|---|
| NAME | G Owen Schaefer |
| GIVEN NAMES | G Owen |
| FAMILY NAME | Schaefer |
| SIGNATURE | SCHAEFER G O |
| AFFILIATIONS | National University of Singapore |
| ORCID | 0000-0002-6915-6148 |
| VERIFIED | Yes |
| TOTAL WORKS | 29 |
| TOTAL CITATIONS | 7 |
| AUTHOR COUNT | 29 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2013 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 2 |
Assessing Risk Thresholds in Controlled Human Infection Models (CHIM)
Controlled Human Infection Models (CHIMs) are a type of clinical trial involving deliberately exposing human volunteers to an infectious agent. Compared to studies of natural infection, CHIMs offers distinctive benefits, from the ability to study presymptomatic infection to a direct assessment of the efficacy of vaccines and therapeutics in a shorter time and involving fewer participants. Although the CHIMs do not fundamentally differ from other …
Public Justification and Normatively Meaningful Bias
In a number of policy, institutional, activist and advocacy contexts, attributing bias to an algorithm does not just describe the algorithm but also imposes a particular, normatively laden conception of bias on others. Given the normative content of such bias attributions, this would involve making moral demands on others to rectify the algorithm, compensate the victims of such bias and/or not unselectively deploy the algorithm. It is also the ca…
Critical Engagement
Why is transparency important for the use of AI in healthcare? Responses to this question typically claim that transparency is something owed to the patient – because it is a condition for informed consent, legitimacy, accountability to the patient, etc. In this paper, we draw attention to why transparency can be valuable for medical practitioners. We claim that transparent AI models facilitate critical engagement by medical practitioners with AI…
Augmenting research consent
The integration of artificial intelligence (AI), particularly large language models (LLMs) like OpenAI’s ChatGPT, into clinical research could significantly enhance the informed consent process. This paper critically examines the ethical implications of employing LLMs to facilitate consent in clinical research. LLMs could offer considerable benefits, such as improving participant understanding and engagement, broadening participants’ access to th…
Polygenic risk scores and embryonic screening
Polygenic risk scores (PRSs) have recently been used to inform reproductive decision-making in the context of embryonic screening. While this is yet to be widespread, it is contested and raises several challenges. This article provides an overview of some of the ethical considerations that arise with using PRSs for embryo screening and offers a series of regulatory considerations for jurisdictions that may wish to permit this in the future. These…
Why de-identified data sharing for research should be in the public interest
‘Advancing the public interest’ is a criterion for de-identified data use for research via several national data platforms and biobanks. This may be referred to via cognate terms such as public benefit, public good or social value. The criterion is often adopted without it being a legal requirement. It is a legal requirement in some jurisdictions for sharing identifiable data without consent, which does not apply to de-identified data. We argue t…
Justifying emergent personhood
Singaporean attitudes to cognitive enhancement
Recent developments in genetic technologies have provided prospective parents with increasing opportunities to influence their future child’s phenotype. This study aimed to understand public attitudes towards gene-based technologies and services, with a particular focus on improving educational outcomes. We conducted a cross-sectional survey among a Singaporean population (n=1438), adapting a survey instrument previously used in the US context. O…
Sustainability in the pandemic accord
Careful consideration of ethical principles and their ramifications continues to be central to pandemic prevention, preparedness and response, as reflected in the latest iteration of the pandemic accord
AI and the need for justification (to the patient)
This paper argues that one problem that besets black-box AI is that it lacks algorithmic justifiability. We argue that the norm of shared decision making in medical care presupposes that treatment decisions ought to be justifiable to the patient. Medical decisions are justifiable to the patient only if they are compatible with the patient’s values and preferences and the patient is able to see that this is so. Patient-directed justifiability is t…
If it walks like a duck
Monitored Emergency Use of Unregistered and Experimental Interventions (MEURI) is an ethical framework developed by the WHO for using unproven interventions in public health emergencies outside the context of medical research. It is mainly intended for use when medical research would be impracticable, but there is still a need to systematically gather data about unproven interventions. As such, it is designed as something of a middle ground betwe…
Institutional Review Boards and Public Justification
Risk stratification
10.1136/jme-2022-108527
Ethics of digital contact tracing wearables
The success of digital COVID-19 contact tracing requires a strategy that successfully addresses the digital divide—inequitable access to technology such as smartphones. Lack of access both undermines the degree of social benefit achieved by the use of tracing apps, and exacerbates existing social and health inequities because those who lack access are likely to already be disadvantaged. Recently, Singapore has introduced portable tracing wearable…
Zero Covid and health inequities
Funder priority for vaccines
The development of some COVID‐19 vaccines by private companies like Moderna and Sanofi‐GSK has been substantially funded by various governments. While the Sanofi CEO has previously suggested that countries that fund this development ought to be given some priority, this suggestion has not been taken seriously in the literature. Considerations of nationalism, sustainability, need, and equitability have been more extensively discussed with respect …
Necessity, Rights, and Rationing in Compulsory Research
In “Compulsory Research in Learning Health Care: Against a Minimal Risk Limit,” Robert Steel offers an argument in favor of compelling individuals to participate in some research that poses more than minimal risk. In his view, the ethics of compulsory research turns on questions of fair distribution of benefits and burdens, within a paradigm analogous to health care resource rationing. We do not dispute that it may theoretically be permissible to…
Sharing precision medicine data with private industry
Precision medicine is an emerging approach to treatment and disease prevention that relies on linkages between very large datasets of health information that is shared amongst researchers and health professionals. While studies suggest broad support for sharing precision medicine data with researchers at publicly funded institutions, there is reluctance to share health information with private industry for research and development. As the private…
Ethical and policy considerations for Covid-19 vaccination modalities
Background To investigate whether neonatal hyperglycaemia in the first postnatal week is associated with treatment-demanding retinopathy of prematurity (ROP). Methods This is a Danish national, retrospective, case–control study of premature infants (birth period 2003–2006). Three national registers were searched, and data were linked through a unique civil registration number. The study sample consisted of 106 cases each matched with two comparis…
In defence of a broad approach to public interest in health data research
In their response to ‘Public interest in health data research: laying out the conceptual groundwork’, Grewal and Newson critique us for inattention to the law and putting forward an impracticably broad conceptual understanding of public interest. While we agree more work is needed to generate a workable framework for Institutional Review Boards/Research Ethics Committees (IRBs/RECs), we would contend that this should be grounded on a broad concep…
On the Ethics of Vaccine Nationalism
COVID-19 vaccines are likely to be scarce for years to come. Many countries, from India to the U.K., have demonstrated vaccine nationalism. What are the ethical limits to this vaccine nationalism? Neither extreme nationalism nor extreme cosmopolitanism is ethically justifiable. Instead, we propose the fair priority for residents (FPR) framework, in which governments can retain COVID-19 vaccine doses for their residents only to the extent that the…
Enhancing the WHO’s Proposed Framework for Distributing Covid-19 Vaccines Among Countries
An ethical framework for global vaccine allocation
The Fair Priority Model offers a practical way to fulfill pledges to distribute vaccines fairly and equitably
Can reproductive genetic manipulation save lives
Public interest in health data research
The future of health research will be characterised by three continuing trends: rising demand for health data; increasing impracticability of obtaining specific consent for secondary research; and decreasing capacity to effectively anonymise data. In this context, governments, clinicians and the research community must demonstrate that they can be responsible stewards of health data. IRBs and RECs sit at heart of this process because in many juri…
On the Ethics of Vaccine Nationalism
COVID-19 vaccines are likely to be scarce for years to come. Many countries, from India to the U.K., have demonstrated vaccine nationalism. What are the ethical limits to this vaccine nationalism? Neither extreme nationalism nor extreme cosmopolitanism is ethically justifiable. Instead, we propose the fair priority for residents (FPR) framework, in which governments can retain COVID-19 vaccine doses for their residents only to the extent that the…
Enhancing the WHO’s Proposed Framework for Distributing Covid-19 Vaccines Among Countries
Sharing precision medicine data with private industry
Precision medicine is an emerging approach to treatment and disease prevention that relies on linkages between very large datasets of health information that is shared amongst researchers and health professionals. While studies suggest broad support for sharing precision medicine data with researchers at publicly funded institutions, there is reluctance to share health information with private industry for research and development. As the private…
The Importance of Rationality
One of three commentaries on “Scholarly Discussion of Infanticide?” by Mirko D. Garasic, and “Reflections from a Troubled Stream: Giubilini and Minerva on ‘After‐Birth Abortion,’” by Michael Hauskeller, from the July‐August 2012 issue
Better Minds, Better Morals
Making more moral decisions - an uncontroversial goal, if ever there was one. But how to go about it? In this article, we offer a practical guide on ways to promote good judgment in our personal and professional lives. We will do this not by outlining what the good life consists in or which values we should accept.Rather, we offer a theory of procedural reliability : a set of dimensions of thought that are generally conducive to good moral reason…
The Right to Know
During the course of biomedical research, researchers sometimes obtain information on participants that is outside the aim of the study but may nonetheless be relevant to the participants. These incidental findings, as they are known, have been the focus of a substantial amount of discussion in the bioethics literature, and a consensus has begun to emerge about what researchers should do in light of the possibility of incidental findings. A conse…
An ethical framework for global vaccine allocation
The Fair Priority Model offers a practical way to fulfill pledges to distribute vaccines fairly and equitably
Can reproductive genetic manipulation save lives
Public interest in health data research
The future of health research will be characterised by three continuing trends: rising demand for health data; increasing impracticability of obtaining specific consent for secondary research; and decreasing capacity to effectively anonymise data. In this context, governments, clinicians and the research community must demonstrate that they can be responsible stewards of health data. IRBs and RECs sit at heart of this process because in many juri…
Navigating conflicts of justice in the use of race and ethnicity in precision medicine
Given the sordid history of injustices linking genetics to race and ethnicity, considerations of justice are central to ensuring the responsible development of precision medicine programmes around the world. While considerations of justice may be in tension with other areas of concern, such as scientific value or privacy, there are also tensions between different aspects of justice. This paper focuses on three particular aspects of justice releva…
Ethical and policy considerations for Covid-19 vaccination modalities
Background To investigate whether neonatal hyperglycaemia in the first postnatal week is associated with treatment-demanding retinopathy of prematurity (ROP). Methods This is a Danish national, retrospective, case–control study of premature infants (birth period 2003–2006). Three national registers were searched, and data were linked through a unique civil registration number. The study sample consisted of 106 cases each matched with two comparis…
In defence of a broad approach to public interest in health data research
In their response to ‘Public interest in health data research: laying out the conceptual groundwork’, Grewal and Newson critique us for inattention to the law and putting forward an impracticably broad conceptual understanding of public interest. While we agree more work is needed to generate a workable framework for Institutional Review Boards/Research Ethics Committees (IRBs/RECs), we would contend that this should be grounded on a broad concep…
On the Ethics of Vaccine Nationalism
COVID-19 vaccines are likely to be scarce for years to come. Many countries, from India to the U.K., have demonstrated vaccine nationalism. What are the ethical limits to this vaccine nationalism? Neither extreme nationalism nor extreme cosmopolitanism is ethically justifiable. Instead, we propose the fair priority for residents (FPR) framework, in which governments can retain COVID-19 vaccine doses for their residents only to the extent that the…
Enhancing the WHO’s Proposed Framework for Distributing Covid-19 Vaccines Among Countries
Risk stratification
10.1136/jme-2022-108527
Ethics of digital contact tracing wearables
The success of digital COVID-19 contact tracing requires a strategy that successfully addresses the digital divide—inequitable access to technology such as smartphones. Lack of access both undermines the degree of social benefit achieved by the use of tracing apps, and exacerbates existing social and health inequities because those who lack access are likely to already be disadvantaged. Recently, Singapore has introduced portable tracing wearable…
Zero Covid and health inequities
Funder priority for vaccines
The development of some COVID‐19 vaccines by private companies like Moderna and Sanofi‐GSK has been substantially funded by various governments. While the Sanofi CEO has previously suggested that countries that fund this development ought to be given some priority, this suggestion has not been taken seriously in the literature. Considerations of nationalism, sustainability, need, and equitability have been more extensively discussed with respect …
Necessity, Rights, and Rationing in Compulsory Research
In “Compulsory Research in Learning Health Care: Against a Minimal Risk Limit,” Robert Steel offers an argument in favor of compelling individuals to participate in some research that poses more than minimal risk. In his view, the ethics of compulsory research turns on questions of fair distribution of benefits and burdens, within a paradigm analogous to health care resource rationing. We do not dispute that it may theoretically be permissible to…
Sharing precision medicine data with private industry
Precision medicine is an emerging approach to treatment and disease prevention that relies on linkages between very large datasets of health information that is shared amongst researchers and health professionals. While studies suggest broad support for sharing precision medicine data with researchers at publicly funded institutions, there is reluctance to share health information with private industry for research and development. As the private…
Institutional Review Boards and Public Justification
Sustainability in the pandemic accord
Careful consideration of ethical principles and their ramifications continues to be central to pandemic prevention, preparedness and response, as reflected in the latest iteration of the pandemic accord
AI and the need for justification (to the patient)
This paper argues that one problem that besets black-box AI is that it lacks algorithmic justifiability. We argue that the norm of shared decision making in medical care presupposes that treatment decisions ought to be justifiable to the patient. Medical decisions are justifiable to the patient only if they are compatible with the patient’s values and preferences and the patient is able to see that this is so. Patient-directed justifiability is t…
If it walks like a duck
Monitored Emergency Use of Unregistered and Experimental Interventions (MEURI) is an ethical framework developed by the WHO for using unproven interventions in public health emergencies outside the context of medical research. It is mainly intended for use when medical research would be impracticable, but there is still a need to systematically gather data about unproven interventions. As such, it is designed as something of a middle ground betwe…
Augmenting research consent
The integration of artificial intelligence (AI), particularly large language models (LLMs) like OpenAI’s ChatGPT, into clinical research could significantly enhance the informed consent process. This paper critically examines the ethical implications of employing LLMs to facilitate consent in clinical research. LLMs could offer considerable benefits, such as improving participant understanding and engagement, broadening participants’ access to th…
Polygenic risk scores and embryonic screening
Polygenic risk scores (PRSs) have recently been used to inform reproductive decision-making in the context of embryonic screening. While this is yet to be widespread, it is contested and raises several challenges. This article provides an overview of some of the ethical considerations that arise with using PRSs for embryo screening and offers a series of regulatory considerations for jurisdictions that may wish to permit this in the future. These…
Why de-identified data sharing for research should be in the public interest
‘Advancing the public interest’ is a criterion for de-identified data use for research via several national data platforms and biobanks. This may be referred to via cognate terms such as public benefit, public good or social value. The criterion is often adopted without it being a legal requirement. It is a legal requirement in some jurisdictions for sharing identifiable data without consent, which does not apply to de-identified data. We argue t…
Justifying emergent personhood
Medicine (18 works) · Political science (17 works) · Computer Science (14 works) · Law (14 works) · Ethics in Clinical Research (12 works) · Biomedical Ethics and Regulation (8 works) · Business (7 works) · Psychology (7 works) · Public relations (7 works) · Economics (6 works)