Leonardo Trasande
Biographic Data
| ID | 3043292 |
|---|---|
| NAME | Leonardo Trasande |
| GIVEN NAMES | Leonardo |
| FAMILY NAME | Trasande |
| SIGNATURE | TRASANDE L |
| AFFILIATIONS | Icahn School of Medicine at Mount Sinai |
| ORCID | 0000-0002-1928-597X |
| VERIFIED | Yes |
| TOTAL WORKS | 23 |
| TOTAL CITATIONS | 8 |
| AUTHOR COUNT | 23 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2006 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 2 |
Environmental Risk and Adverse Perinatal Health Indicators in New York City
Environmental exposures can have adverse associations with perinatal health and birth outcomes. This study aimed to identify the overlap and association between urban areas of environmental risk and adverse perinatal health indicator hotspots in New York City. We examined 2101 census tracts representing 575,257 births from 2016 to 2020 recorded by the New York City Bureau of Vital Statistics looking at preterm birth, adolescent pregnancy, and pre…
Prepandemic levels of cytokines and immunoglobulins and risk of Sars-CoV-2 infection and Covid-19 in the general population of Barcelona
Background From a public health perspective it is remarkable that there are yet no longitudinal studies in the general population investigating the influence of the basal immune state, measured before the pandemic, on the risk of SARS-CoV-2 infection and COVID-19. Objective To investigate the specific and combined effects of personal levels of cytokines and immunoglobulins—measured in individuals’ blood 4 years before the pandemic—on the risk of …
Stability of cytokine and immunoglobulin concentrations in the general population
Background: While there is wide evidence on concentrations of cytokines in patients attending health care facilities, evidence is scant on physiological, basal concentrations of cytokines in the general population and across sociodemographic groups, as well as on their potential stability over time. Furthermore, from a public health perspective it is remarkable that no studies have analyzed intraindividual changes in such concentrations from befo…
Redlining in New York City
Background Evidence suggests historical redlining shaped the built environment and health outcomes in urban areas. Only a handful of studies have examined redlining’s association with air pollution and adverse birth outcomes in New York City (NYC). Additionally, no NYC-specific studies have examined the impact of redlining on birth weight. Methods This longitudinal cohort study analysed data from the National Institute of Health Environmental Inf…
Association of Gestational Diabetes Mellitus and Perinatal Maternal Depression with Early Childhood Behavioral Problems
This study examined the association of gestational diabetes mellitus (GDM), prenatal, and postnatal maternal depressive symptoms with externalizing, internalizing, and autism spectrum problems on the Preschool Child Behavior Checklist in 2379 children aged 4.12 ± 0.60 (48% female; 47% White, 32% Black, 15% Mixed Race, 4% Asian, <2% American Indian/Alaskan Native, <2% Native Hawaiian; 23% Hispanic). Data were collected from the NIH Environmental i…
Understanding the Role of Persistent Organic Pollutants and Stress in the Association between Proximity to the World Trade Center Disaster and Birth Outcomes
Fetal growth is affected by exposure to both prenatal stress and environmental contaminants. The attacks on the World Trade Center (WTC) resulted in exposure to chemicals and psychological stress amongst New York City residents. We measured prenatal maternal stress and exposure to persistent organic pollutants (polybrominated diphenyl ethers, polychlorinated biphenyls, and polychlorinated dibenzo-p-dioxins (PCDDs)) in 108 participants from a Colu…
The Prenatal Neighborhood Environment and Geographic Hotspots of Infants with At-risk Birthweights in New York City
Covid-19 Symptoms and Diagnoses among a Sociodemographically Diverse Cohort of Children from New York City
Early in the pandemic, in the North American epicenter, we investigated associations between sociodemographic factors and rates of pediatric COVID-19 diagnoses in a non-clinical setting and whether symptoms varied by child age. From 20 April-31 August 2020, COVID-19-related data were collected on 2694 children aged ≤ 18 years living in households participating in the New York University Children's Health and Environment Study. We examined differe…
Urinary Pesticide Levels in Children and Adolescents Residing in Two Agricultural Communities in Mexico
The use of pesticides in agricultural activities has increased significantly during the last decades. Several studies have reported the health damage that results from exposure to pesticides. In Mexico, hundreds of communities depend economically on agricultural activities. The participation of minors in this type of activity and their exposure to pesticides represents a potential public health problem. A cross-sectional study was conducted, in w…
Neighborhood walk score and selected Cardiometabolic factors in the French Record cohort study
In this large population-based study, we found that, even in a European context, living in a highly walkable neighborhood was associated with improved cardiometabolic health. Designing walkable neighborhoods may be a viable strategy in reducing cardiovascular disease prevalence at the population level
Population attributable risks and costs of diabetogenic chemical exposures in the elderly
BACKGROUND: A previous analysis examined the contribution of endocrine disruptor exposures (endocrine-disrupting chemicals, EDCs) to adult diabetes, but was limited to effects of phthalates in middle-aged women and did not simultaneously examine multiple EDCs which are known to coexist in the environment. We therefore endeavoured to quantify potential reductions in diabetes and disease costs that could result from reducing synthetic chemical diab…
Dismissing manufactured uncertainties, limitations and competing interpretations about chemical exposures and diabetes
A chemical industry consultant with a competing interest (Bond) and his collaborator (Dietrich) dismiss over 20 cross-sectional studies and at least 7 prospective studies that have found links between persistent organic pollutants and diabetes. In this comment, they also ask for experimental studies supporting the view that environmental contaminants could affect glucose tolerance, neglecting more than a dozen of experimental in vivo and in vitro…
Walk Score, Transportation Mode Choice, and Walking Among French Adults
Walkable neighborhoods were associated with increases in walking among adults in Paris, as documented at the trip level. Creating walkable neighborhoods (through neighborhood design increased commercial activity) may increase walking trips and, therefore, could be a relevant health promotion strategy to increase physical activity
Peer-reviewed and unbiased research, rather than ‘sound science’, should be used to evaluate endocrine-disrupting chemicals
Evidence increasingly confirms that synthetic chemicals disrupt the endocrine system and contribute to disease and disability across the lifespan. Despite a United Nations Environment Programme/WHO report affirmed by over 100 countries at the Fourth International Conference on Chemicals Management, ‘manufactured doubt’ continues to be cast as a cloud over rigorous, peer-reviewed and independently funded scientific data. This study describes the s…
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013
Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013
Improving Knowledge about Children’s Environmental Health in Northwest China
The main purpose of this study was to identify policy maker opinions and attitudes towards children's environmental health (CEH), potential barriers to child-specific protective legislation and implementation in northwest China, and evaluate knowledge and attitudes about CEH before and after an educational conference. We conducted seventy-two interviews with regional officials, researchers and non-governmental organization representatives from fi…
Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013
The Effects of Outdoor Air Pollutants on the Costs of Pediatric Asthma Hospitalizations in the United States, 1999 to 2007
BACKGROUND: Acute exposure to outdoor air pollutants has been associated with increased pediatric asthma morbidity. However, the impact of subchronic exposures is largely unknown. OBJECTIVE: To examine the association between subchronic exposure to 6 outdoor air pollutants (PM2.5, PM10, ozone, nitrogen oxides, sulfur oxides, carbon monoxide) and pediatric asthma hospitalization length of stay, charges, and costs. METHODS: We linked pediatric asth…
Environment and Obesity in the National Children's Study
We describe the approach taken by the National Children's Study (NCS) to understanding the role of environmental factors in the development of obesity. We review the literature with regard to the two core hypotheses in the NCS that relate to environmental origins of obesity and describe strategies that will be used to test each hypothesis. Although it is clear that obesity in an individual results from an imbalance between energy intake and expen…
Incremental Charges, Costs, and Length of Stay Associated With Obesity as a Secondary Diagnosis Among Pregnant Women
BACKGROUND: Elevation in prepregnancy body mass index (BMI) has been linked to a host of perinatal complications, but increases in charges or costs associated with obesity during pregnancy have not been quantified. METHODS: To evaluate the economic impact of obesity as a diagnosis on hospitalizations of pregnant women, we performed descriptive, univariate, and multivariable analysis of the 1999 to 2005 Nationwide Inpatient Sample, a nationally re…
Clinical Awareness of Occupation-Related Toxic Exposure
Case Mr. Juarez went to a local community clinic in south central California as a new patient because he was experiencing a slight but persistent cough, shortness of breath, headache, fatigue, muscle weakness and eye irritation. He was not febrile and reported occasional nausea during the preceding two weeks, although not at the time of the visit. He was seeing the physician as a self-pay patient
The Environment in Pediatric Practice
Peer-reviewed and unbiased research, rather than ‘sound science’, should be used to evaluate endocrine-disrupting chemicals
Evidence increasingly confirms that synthetic chemicals disrupt the endocrine system and contribute to disease and disability across the lifespan. Despite a United Nations Environment Programme/WHO report affirmed by over 100 countries at the Fourth International Conference on Chemicals Management, ‘manufactured doubt’ continues to be cast as a cloud over rigorous, peer-reviewed and independently funded scientific data. This study describes the s…
The Environment in Pediatric Practice
Population attributable risks and costs of diabetogenic chemical exposures in the elderly
BACKGROUND: A previous analysis examined the contribution of endocrine disruptor exposures (endocrine-disrupting chemicals, EDCs) to adult diabetes, but was limited to effects of phthalates in middle-aged women and did not simultaneously examine multiple EDCs which are known to coexist in the environment. We therefore endeavoured to quantify potential reductions in diabetes and disease costs that could result from reducing synthetic chemical diab…
Clinical Awareness of Occupation-Related Toxic Exposure
Case Mr. Juarez went to a local community clinic in south central California as a new patient because he was experiencing a slight but persistent cough, shortness of breath, headache, fatigue, muscle weakness and eye irritation. He was not febrile and reported occasional nausea during the preceding two weeks, although not at the time of the visit. He was seeing the physician as a self-pay patient
The Environment in Pediatric Practice
Incremental Charges, Costs, and Length of Stay Associated With Obesity as a Secondary Diagnosis Among Pregnant Women
BACKGROUND: Elevation in prepregnancy body mass index (BMI) has been linked to a host of perinatal complications, but increases in charges or costs associated with obesity during pregnancy have not been quantified. METHODS: To evaluate the economic impact of obesity as a diagnosis on hospitalizations of pregnant women, we performed descriptive, univariate, and multivariable analysis of the 1999 to 2005 Nationwide Inpatient Sample, a nationally re…
Environment and Obesity in the National Children's Study
We describe the approach taken by the National Children's Study (NCS) to understanding the role of environmental factors in the development of obesity. We review the literature with regard to the two core hypotheses in the NCS that relate to environmental origins of obesity and describe strategies that will be used to test each hypothesis. Although it is clear that obesity in an individual results from an imbalance between energy intake and expen…
The Effects of Outdoor Air Pollutants on the Costs of Pediatric Asthma Hospitalizations in the United States, 1999 to 2007
BACKGROUND: Acute exposure to outdoor air pollutants has been associated with increased pediatric asthma morbidity. However, the impact of subchronic exposures is largely unknown. OBJECTIVE: To examine the association between subchronic exposure to 6 outdoor air pollutants (PM2.5, PM10, ozone, nitrogen oxides, sulfur oxides, carbon monoxide) and pediatric asthma hospitalization length of stay, charges, and costs. METHODS: We linked pediatric asth…
Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013
Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013
Improving Knowledge about Children’s Environmental Health in Northwest China
The main purpose of this study was to identify policy maker opinions and attitudes towards children's environmental health (CEH), potential barriers to child-specific protective legislation and implementation in northwest China, and evaluate knowledge and attitudes about CEH before and after an educational conference. We conducted seventy-two interviews with regional officials, researchers and non-governmental organization representatives from fi…
Walk Score, Transportation Mode Choice, and Walking Among French Adults
Walkable neighborhoods were associated with increases in walking among adults in Paris, as documented at the trip level. Creating walkable neighborhoods (through neighborhood design increased commercial activity) may increase walking trips and, therefore, could be a relevant health promotion strategy to increase physical activity
Peer-reviewed and unbiased research, rather than ‘sound science’, should be used to evaluate endocrine-disrupting chemicals
Evidence increasingly confirms that synthetic chemicals disrupt the endocrine system and contribute to disease and disability across the lifespan. Despite a United Nations Environment Programme/WHO report affirmed by over 100 countries at the Fourth International Conference on Chemicals Management, ‘manufactured doubt’ continues to be cast as a cloud over rigorous, peer-reviewed and independently funded scientific data. This study describes the s…
Neighborhood walk score and selected Cardiometabolic factors in the French Record cohort study
In this large population-based study, we found that, even in a European context, living in a highly walkable neighborhood was associated with improved cardiometabolic health. Designing walkable neighborhoods may be a viable strategy in reducing cardiovascular disease prevalence at the population level
Population attributable risks and costs of diabetogenic chemical exposures in the elderly
BACKGROUND: A previous analysis examined the contribution of endocrine disruptor exposures (endocrine-disrupting chemicals, EDCs) to adult diabetes, but was limited to effects of phthalates in middle-aged women and did not simultaneously examine multiple EDCs which are known to coexist in the environment. We therefore endeavoured to quantify potential reductions in diabetes and disease costs that could result from reducing synthetic chemical diab…
Dismissing manufactured uncertainties, limitations and competing interpretations about chemical exposures and diabetes
A chemical industry consultant with a competing interest (Bond) and his collaborator (Dietrich) dismiss over 20 cross-sectional studies and at least 7 prospective studies that have found links between persistent organic pollutants and diabetes. In this comment, they also ask for experimental studies supporting the view that environmental contaminants could affect glucose tolerance, neglecting more than a dozen of experimental in vivo and in vitro…
Urinary Pesticide Levels in Children and Adolescents Residing in Two Agricultural Communities in Mexico
The use of pesticides in agricultural activities has increased significantly during the last decades. Several studies have reported the health damage that results from exposure to pesticides. In Mexico, hundreds of communities depend economically on agricultural activities. The participation of minors in this type of activity and their exposure to pesticides represents a potential public health problem. A cross-sectional study was conducted, in w…
Covid-19 Symptoms and Diagnoses among a Sociodemographically Diverse Cohort of Children from New York City
Early in the pandemic, in the North American epicenter, we investigated associations between sociodemographic factors and rates of pediatric COVID-19 diagnoses in a non-clinical setting and whether symptoms varied by child age. From 20 April-31 August 2020, COVID-19-related data were collected on 2694 children aged ≤ 18 years living in households participating in the New York University Children's Health and Environment Study. We examined differe…
Understanding the Role of Persistent Organic Pollutants and Stress in the Association between Proximity to the World Trade Center Disaster and Birth Outcomes
Fetal growth is affected by exposure to both prenatal stress and environmental contaminants. The attacks on the World Trade Center (WTC) resulted in exposure to chemicals and psychological stress amongst New York City residents. We measured prenatal maternal stress and exposure to persistent organic pollutants (polybrominated diphenyl ethers, polychlorinated biphenyls, and polychlorinated dibenzo-p-dioxins (PCDDs)) in 108 participants from a Colu…
The Prenatal Neighborhood Environment and Geographic Hotspots of Infants with At-risk Birthweights in New York City
Association of Gestational Diabetes Mellitus and Perinatal Maternal Depression with Early Childhood Behavioral Problems
This study examined the association of gestational diabetes mellitus (GDM), prenatal, and postnatal maternal depressive symptoms with externalizing, internalizing, and autism spectrum problems on the Preschool Child Behavior Checklist in 2379 children aged 4.12 ± 0.60 (48% female; 47% White, 32% Black, 15% Mixed Race, 4% Asian, <2% American Indian/Alaskan Native, <2% Native Hawaiian; 23% Hispanic). Data were collected from the NIH Environmental i…
Prepandemic levels of cytokines and immunoglobulins and risk of Sars-CoV-2 infection and Covid-19 in the general population of Barcelona
Background From a public health perspective it is remarkable that there are yet no longitudinal studies in the general population investigating the influence of the basal immune state, measured before the pandemic, on the risk of SARS-CoV-2 infection and COVID-19. Objective To investigate the specific and combined effects of personal levels of cytokines and immunoglobulins—measured in individuals’ blood 4 years before the pandemic—on the risk of …
Stability of cytokine and immunoglobulin concentrations in the general population
Background: While there is wide evidence on concentrations of cytokines in patients attending health care facilities, evidence is scant on physiological, basal concentrations of cytokines in the general population and across sociodemographic groups, as well as on their potential stability over time. Furthermore, from a public health perspective it is remarkable that no studies have analyzed intraindividual changes in such concentrations from befo…
Redlining in New York City
Background Evidence suggests historical redlining shaped the built environment and health outcomes in urban areas. Only a handful of studies have examined redlining’s association with air pollution and adverse birth outcomes in New York City (NYC). Additionally, no NYC-specific studies have examined the impact of redlining on birth weight. Methods This longitudinal cohort study analysed data from the National Institute of Health Environmental Inf…
Environmental Risk and Adverse Perinatal Health Indicators in New York City
Environmental exposures can have adverse associations with perinatal health and birth outcomes. This study aimed to identify the overlap and association between urban areas of environmental risk and adverse perinatal health indicator hotspots in New York City. We examined 2101 census tracts representing 575,257 births from 2016 to 2020 recorded by the New York City Bureau of Vital Statistics looking at preterm birth, adolescent pregnancy, and pre…
Medicine (21 works) · Environmental health (14 works) · Demography (7 works) · Population (7 works) · Internal Medicine (6 works) · Air Quality and Health Impacts (5 works) · Demography (5 works) · Gerontology (5 works) · Pregnancy (5 works) · Psychology (5 works)