Lora Sabin
Biographic Data
| ID | 313051 |
|---|---|
| NAME | Lora Sabin |
| GIVEN NAMES | Lora |
| FAMILY NAME | Sabin |
| SIGNATURE | SABIN L |
| AFFILIATIONS | Boston University |
| ORCID | 0000-0002-2782-542X |
| VERIFIED | Yes |
| TOTAL WORKS | 25 |
| TOTAL CITATIONS | 2 |
| AUTHOR COUNT | 25 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1999 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 1 |
Costs and cost-effectiveness of an infection prevention bundle to reduce neonatal sepsis and mortality in Zambia
The Sepsis Prevention in Neonates in Zambia (SPINZ) trial was a prospective observational cohort study conducted in the neonatal intensive care unit of the University Teaching Hospital in Lusaka, Zambia. Introduction of an infection prevention and control (IPC) bundle reduced hospital-associated mortality, total mortality, suspected sepsis, and confirmed bloodstream infections. This companion analysis was undertaken to analyze intervention costs …
Cost of diabetes and hypertension care among patients in rural Bangladesh
Hypertension and diabetes impose significant health and economic burdens in low-and middle-income countries like Bangladesh. This study aimed to estimate both direct and indirect costs associated with hypertension and diabetes care in Dinajpur, a rural district of Bangladesh, and identify factors influencing these costs. This cross-sectional study used baseline data from a community survey conducted as part of an ongoing implementation research p…
Food insecurity in South Indian households with TB during Covid-19 lockdowns and the impact of nutritional interventions
Tuberculosis (TB) mortality rose during the COVID-19 pandemic, as did food insecurity worldwide. Undernourished individuals are at increased risk for incident TB disease and TB mortality. This study examines the impact of COVID lockdowns on the food security of households with TB in Southern India. In-depth interviews and focus group discussions were conducted with household contacts enrolled in a nutritional intervention study, conducted in Pudu…
TB stigma in India
In India, persons with tuberculosis (PWTB) and their households experience significant disease-related stigma. The objective of this narrative review was to conduct a review of existing literature related to the types of stigma experienced by PWTB and their household members, with a focus on the effects of stigma, possible interventions, and gender differences. A literature search was conducted on PubMed, EMBASE, and Web of Science using key sear…
Tuberculosis- learning about experience with nutritional supplementation (TB Lens)
Undernutrition is a major driver of the tuberculosis (TB) epidemic, with one in five TB cases worldwide attributable to undernutrition. Nutritional interventions may reduce TB incidence and mortality for those at increased risk of developing TB. The TB LION (Tuberculosis - Learning the Impact Of Nutrition) study provides nutritional supplementation to household contacts (HHC) of TB index cases ( n = 60) to examine the impact of supplementation on…
Stakeholder priorities for ART initiation and early retention strategies in Malawi
New or returning antiretroviral therapy (ART) clients are largely ineligible for differentiated service delivery (DSD) models. These clients are at increased risk of treatment interruption and may benefit from flexible care models, but stakeholder buy-in may limit progress on interventions for this population. We qualitatively explored stakeholder perceptions and decision-making criteria for scaling DSD models for new or returning ART clients in …
Complexity of Adherence Challenges
How Mobile Health Can Change the Contexts of Living With HIV and Engaging With Treatment and Care in Iran
Mobile health (mHealth) interventions are increasingly used to address the challenges of living with HIV and engaging with antiretroviral therapy. A wealth of evidence supports the efficacy of mHealth in supporting living with HIV. Yet, there is a dearth of evidence on how mHealth improves outcomes, which features are effective, and why these work in a particular setting. This study uses stakeholder views, including patients, providers, peer supp…
Negative clinic experiences as a barrier to care for people with HIV and their impact on patient preferences for intervention support
We conducted qualitative research among people with HIV (PWH) and care providers in Cape Town, South Africa to understand the impact of negative clinic experiences on adherence and support preferences. In-depth interviews were conducted with 41 patients with an unsuppressed viral load or a treatment gap, and focus group discussions with physicians, nurses, counselors, and community health workers. Questions addressed treatment history and adheren…
Disruptions to the social determinants of health and mental health indicators during the pandemic in eight countries
The social determinants of health (SDoH) shape both the risk of mental disorders and access to treatment. There is ample evidence detailing the decline in mental health during the Covid-19 pandemic. However, there is a gap in our understanding of the association between disruptions to SDoH and adverse psychological indicators in different contexts. Data were collected through a multi-country, random, anonymous, opt-in, cross-sectional online surv…
What matters for health? Public views from eight countries
Introduction Despite growing scholarship on the social determinants of health (SDoH), wider action remains in its early stages. Broad public understanding of SDoH can help catalyse such action. This paper aimed to document public perception of what matters for health from countries with broad geographic, cultural, linguistic, population composition, language and income level variation. Methods We conducted an online survey in Brazil, China, Germa…
Adherence to and enforcement of non-pharmaceutical interventions (NPIs) for Covid-19 prevention in Nigeria, Rwanda, and Zambia
Introduction In the early parts of the COVID-19 pandemic, non-pharmaceutical interventions (NPIs) were implemented worldwide, including in sub-Saharan Africa, to prevent and control SARS-CoV-2 transmission. This mixed-methods study examines adherence to and enforcement of NPIs implemented to curb COVID-19 in Nigeria, Rwanda, and Zambia, leading up to the 10,000 th case of laboratory-confirmed COVID-19 in each country. Additionally, we aim to eval…
Patients’ and Providers’ Views on Optimal Evidence-Based and Scalable Interventions for Individuals at High Risk of HIV Treatment Failure
Real-time Feedback to Improve HIV Treatment Adherence in Pregnant and Postpartum Women in Uganda
We assessed an intervention aimed at improving adherence to antiretroviral therapy (ART) among pregnant and postpartum women living with HIV (PPWLH). We randomized 133 pregnant women initiating ART in Uganda to receive text reminders generated by real time-enabled electronic monitors and data-informed counseling through 3 months postpartum (PPM3) or standard care. Intention-to-treat analyses found low adherence levels and no intervention impact. …
‘You just prefer to die early!’
INTRODUCTION: Despite the low prevalence of HIV and broad provision of antiretroviral therapy, the Middle East and North Africa (MENA) remains the only region where new HIV infections and AIDS-related deaths are not declining. There is a dearth of evidence from MENA on antiretroviral therapy engagement. In this qualitative study, we sought to identify the ways in which successful treatment is hindered in Iran, which is home to 24% of HIV infectio…
People listen more to what actors say’
India has made substantial advancements in reducing the burden of tuberculosis (TB), but persons living with active TB (PLWATB) still face myriad challenges in seeking and receiving care, including TB-related stigma. To meet the END TB targets, it is critical that PLWATB engage in care and are able to adhere to treatment. This qualitative study aimed to understand TB-related stigma (perceived, enacted, and internalised) and possible interventions…
Retention in HIV Care Among HIV-Seropositive Pregnant and Postpartum Women in Uganda
Effectiveness of community outreach HIV prevention programs in Vietnam
Outreach programs appear to have reduced risky sexual behaviors and increased use of HIV testing services among high-risk populations in Vietnam. These programs can play a key role in reducing gaps in the HIV care cascade, achieving the global 90-90-90 goals, and creating an AIDS-free generation
The role of motivation in predicting antiretroviral therapy adherence in China
Patient motivation is important in managing medication regimens such as antiretroviral treatment for HIV/AIDS. We tested whether self-determination theory could predict adherence behavior among 115 HIV-positive patients in the China Adherence through Technology Study, a randomized controlled trial of an intervention using text reminders and supportive counseling to increase adherence. Being in the treatment group had a significant effect on impro…
Novel Approaches for Visualizing and Analyzing Dose-Timing Data from Electronic Drug Monitors, or “How the ‘Broken Window’ Theory Pertains to ART Adherence”
Women living with HIV in Vietnam
In Vietnam, despite the possibility of living healthy sexual lives and bearing children due to the increasing availability of antiretroviral therapy and prevention of mother-to-child transmission services, HIV programming has given little attention to the sexual and reproductive health of people living with HIV. Our study explored factors influencing sexual and reproductive health decision-making, needs, rights and access to services for women li…
Availability and utilization of malaria prevention strategies in pregnancy in eastern India
A disconnect remains between routine antenatal practices in India and known strategies to prevent and treat malaria in pregnancy. Prevention strategies, in particular the use of insecticide-treated bednets, are underutilized. Gaps highlighted by this study combined with recent estimates of the prevalence of malaria during pregnancy in these areas should be used to revise governmental policy and target increased educational efforts among health ca…
Using Electronic Drug Monitor Feedback to Improve Adherence to Antiretroviral Therapy Among HIV-Positive Patients in China
Effective antiretroviral therapy (ART) requires excellent adherence. Little is known about how to improve ART adherence in many HIV/AIDS-affected countries, including China. We therefore assessed an adherence intervention among HIV-positive patients in southwestern China. Eighty subjects were enrolled and monitored for 6 months. Sixty-eight remaining subjects were randomized to intervention/control arms. In months 7-12, intervention subjects were…
Barriers to adherence to antiretroviral medications among patients living with HIV in southern China
Although China's government is rapidly expanding access to antiretroviral therapy, little is known about barriers to adherence among Chinese HIV-infected patients, particularly among injection drug users. To better understand barriers to antiretroviral treatment adherence, we conducted a qualitative research study, using both focus group and key informant methods, among 36 HIV-positive men and women in Dali, in southwestern China. All interviews …
The development of urban labour markets
This study explores the effect of China's economic reforms and growth on a critical outcome of labour market interactions: wage levels. Provincial data from 1980 to 1992 are used to analyse changes in interregional wage differentiation, and the relationship between average and real wages and a variety of economic variables. The results illuminate the increasing role of market forces, particularly labour demand variables such as economic growth an…
The role of motivation in predicting antiretroviral therapy adherence in China
Patient motivation is important in managing medication regimens such as antiretroviral treatment for HIV/AIDS. We tested whether self-determination theory could predict adherence behavior among 115 HIV-positive patients in the China Adherence through Technology Study, a randomized controlled trial of an intervention using text reminders and supportive counseling to increase adherence. Being in the treatment group had a significant effect on impro…
The development of urban labour markets
This study explores the effect of China's economic reforms and growth on a critical outcome of labour market interactions: wage levels. Provincial data from 1980 to 1992 are used to analyse changes in interregional wage differentiation, and the relationship between average and real wages and a variety of economic variables. The results illuminate the increasing role of market forces, particularly labour demand variables such as economic growth an…
Barriers to adherence to antiretroviral medications among patients living with HIV in southern China
Although China's government is rapidly expanding access to antiretroviral therapy, little is known about barriers to adherence among Chinese HIV-infected patients, particularly among injection drug users. To better understand barriers to antiretroviral treatment adherence, we conducted a qualitative research study, using both focus group and key informant methods, among 36 HIV-positive men and women in Dali, in southwestern China. All interviews …
Using Electronic Drug Monitor Feedback to Improve Adherence to Antiretroviral Therapy Among HIV-Positive Patients in China
Effective antiretroviral therapy (ART) requires excellent adherence. Little is known about how to improve ART adherence in many HIV/AIDS-affected countries, including China. We therefore assessed an adherence intervention among HIV-positive patients in southwestern China. Eighty subjects were enrolled and monitored for 6 months. Sixty-eight remaining subjects were randomized to intervention/control arms. In months 7-12, intervention subjects were…
Availability and utilization of malaria prevention strategies in pregnancy in eastern India
A disconnect remains between routine antenatal practices in India and known strategies to prevent and treat malaria in pregnancy. Prevention strategies, in particular the use of insecticide-treated bednets, are underutilized. Gaps highlighted by this study combined with recent estimates of the prevalence of malaria during pregnancy in these areas should be used to revise governmental policy and target increased educational efforts among health ca…
Women living with HIV in Vietnam
In Vietnam, despite the possibility of living healthy sexual lives and bearing children due to the increasing availability of antiretroviral therapy and prevention of mother-to-child transmission services, HIV programming has given little attention to the sexual and reproductive health of people living with HIV. Our study explored factors influencing sexual and reproductive health decision-making, needs, rights and access to services for women li…
Novel Approaches for Visualizing and Analyzing Dose-Timing Data from Electronic Drug Monitors, or “How the ‘Broken Window’ Theory Pertains to ART Adherence”
The role of motivation in predicting antiretroviral therapy adherence in China
Patient motivation is important in managing medication regimens such as antiretroviral treatment for HIV/AIDS. We tested whether self-determination theory could predict adherence behavior among 115 HIV-positive patients in the China Adherence through Technology Study, a randomized controlled trial of an intervention using text reminders and supportive counseling to increase adherence. Being in the treatment group had a significant effect on impro…
Effectiveness of community outreach HIV prevention programs in Vietnam
Outreach programs appear to have reduced risky sexual behaviors and increased use of HIV testing services among high-risk populations in Vietnam. These programs can play a key role in reducing gaps in the HIV care cascade, achieving the global 90-90-90 goals, and creating an AIDS-free generation
Retention in HIV Care Among HIV-Seropositive Pregnant and Postpartum Women in Uganda
‘You just prefer to die early!’
INTRODUCTION: Despite the low prevalence of HIV and broad provision of antiretroviral therapy, the Middle East and North Africa (MENA) remains the only region where new HIV infections and AIDS-related deaths are not declining. There is a dearth of evidence from MENA on antiretroviral therapy engagement. In this qualitative study, we sought to identify the ways in which successful treatment is hindered in Iran, which is home to 24% of HIV infectio…
People listen more to what actors say’
India has made substantial advancements in reducing the burden of tuberculosis (TB), but persons living with active TB (PLWATB) still face myriad challenges in seeking and receiving care, including TB-related stigma. To meet the END TB targets, it is critical that PLWATB engage in care and are able to adhere to treatment. This qualitative study aimed to understand TB-related stigma (perceived, enacted, and internalised) and possible interventions…
What matters for health? Public views from eight countries
Introduction Despite growing scholarship on the social determinants of health (SDoH), wider action remains in its early stages. Broad public understanding of SDoH can help catalyse such action. This paper aimed to document public perception of what matters for health from countries with broad geographic, cultural, linguistic, population composition, language and income level variation. Methods We conducted an online survey in Brazil, China, Germa…
Adherence to and enforcement of non-pharmaceutical interventions (NPIs) for Covid-19 prevention in Nigeria, Rwanda, and Zambia
Introduction In the early parts of the COVID-19 pandemic, non-pharmaceutical interventions (NPIs) were implemented worldwide, including in sub-Saharan Africa, to prevent and control SARS-CoV-2 transmission. This mixed-methods study examines adherence to and enforcement of NPIs implemented to curb COVID-19 in Nigeria, Rwanda, and Zambia, leading up to the 10,000 th case of laboratory-confirmed COVID-19 in each country. Additionally, we aim to eval…
Patients’ and Providers’ Views on Optimal Evidence-Based and Scalable Interventions for Individuals at High Risk of HIV Treatment Failure
Real-time Feedback to Improve HIV Treatment Adherence in Pregnant and Postpartum Women in Uganda
We assessed an intervention aimed at improving adherence to antiretroviral therapy (ART) among pregnant and postpartum women living with HIV (PPWLH). We randomized 133 pregnant women initiating ART in Uganda to receive text reminders generated by real time-enabled electronic monitors and data-informed counseling through 3 months postpartum (PPM3) or standard care. Intention-to-treat analyses found low adherence levels and no intervention impact. …
Disruptions to the social determinants of health and mental health indicators during the pandemic in eight countries
The social determinants of health (SDoH) shape both the risk of mental disorders and access to treatment. There is ample evidence detailing the decline in mental health during the Covid-19 pandemic. However, there is a gap in our understanding of the association between disruptions to SDoH and adverse psychological indicators in different contexts. Data were collected through a multi-country, random, anonymous, opt-in, cross-sectional online surv…
Negative clinic experiences as a barrier to care for people with HIV and their impact on patient preferences for intervention support
We conducted qualitative research among people with HIV (PWH) and care providers in Cape Town, South Africa to understand the impact of negative clinic experiences on adherence and support preferences. In-depth interviews were conducted with 41 patients with an unsuppressed viral load or a treatment gap, and focus group discussions with physicians, nurses, counselors, and community health workers. Questions addressed treatment history and adheren…
Food insecurity in South Indian households with TB during Covid-19 lockdowns and the impact of nutritional interventions
Tuberculosis (TB) mortality rose during the COVID-19 pandemic, as did food insecurity worldwide. Undernourished individuals are at increased risk for incident TB disease and TB mortality. This study examines the impact of COVID lockdowns on the food security of households with TB in Southern India. In-depth interviews and focus group discussions were conducted with household contacts enrolled in a nutritional intervention study, conducted in Pudu…
TB stigma in India
In India, persons with tuberculosis (PWTB) and their households experience significant disease-related stigma. The objective of this narrative review was to conduct a review of existing literature related to the types of stigma experienced by PWTB and their household members, with a focus on the effects of stigma, possible interventions, and gender differences. A literature search was conducted on PubMed, EMBASE, and Web of Science using key sear…
Tuberculosis- learning about experience with nutritional supplementation (TB Lens)
Undernutrition is a major driver of the tuberculosis (TB) epidemic, with one in five TB cases worldwide attributable to undernutrition. Nutritional interventions may reduce TB incidence and mortality for those at increased risk of developing TB. The TB LION (Tuberculosis - Learning the Impact Of Nutrition) study provides nutritional supplementation to household contacts (HHC) of TB index cases ( n = 60) to examine the impact of supplementation on…
Stakeholder priorities for ART initiation and early retention strategies in Malawi
New or returning antiretroviral therapy (ART) clients are largely ineligible for differentiated service delivery (DSD) models. These clients are at increased risk of treatment interruption and may benefit from flexible care models, but stakeholder buy-in may limit progress on interventions for this population. We qualitatively explored stakeholder perceptions and decision-making criteria for scaling DSD models for new or returning ART clients in …
Complexity of Adherence Challenges
How Mobile Health Can Change the Contexts of Living With HIV and Engaging With Treatment and Care in Iran
Mobile health (mHealth) interventions are increasingly used to address the challenges of living with HIV and engaging with antiretroviral therapy. A wealth of evidence supports the efficacy of mHealth in supporting living with HIV. Yet, there is a dearth of evidence on how mHealth improves outcomes, which features are effective, and why these work in a particular setting. This study uses stakeholder views, including patients, providers, peer supp…
Costs and cost-effectiveness of an infection prevention bundle to reduce neonatal sepsis and mortality in Zambia
The Sepsis Prevention in Neonates in Zambia (SPINZ) trial was a prospective observational cohort study conducted in the neonatal intensive care unit of the University Teaching Hospital in Lusaka, Zambia. Introduction of an infection prevention and control (IPC) bundle reduced hospital-associated mortality, total mortality, suspected sepsis, and confirmed bloodstream infections. This companion analysis was undertaken to analyze intervention costs …
Cost of diabetes and hypertension care among patients in rural Bangladesh
Hypertension and diabetes impose significant health and economic burdens in low-and middle-income countries like Bangladesh. This study aimed to estimate both direct and indirect costs associated with hypertension and diabetes care in Dinajpur, a rural district of Bangladesh, and identify factors influencing these costs. This cross-sectional study used baseline data from a community survey conducted as part of an ongoing implementation research p…
Medicine (19 works) · HIV/AIDS Research and Interventions (13 works) · Nursing (12 works) · Public health (11 works) · Environmental health (10 works) · Family medicine (9 works) · Psychological intervention (9 works) · Qualitative research (9 works) · HIV, Drug Use, Sexual Risk (8 works) · Focus group (7 works)