Harold Snieder
Datos Biográficos
| ID | 352777 |
|---|---|
| NOMBRE | Harold Snieder |
| NOMBRES | Harold |
| APELLIDO | Snieder |
| FIRMA | SNIEDER H |
| AFILIACIONES | University Medical Center Groningen |
| ORCID | 0000-0003-1949-2298 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 26 |
| TOTAL DE CITAS | 64 |
| TOTAL COMO AUTOR | 26 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 2005 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2025 |
| ÍNDICE H | 4 |
Associations between common genetic variants and income provide insights about the socio-economic health gradient
We conducted a genome-wide association study on income among individuals of European descent ( N = 668,288) to investigate the relationship between socio-economic status and health disparities. We identified 162 genomic loci associated with a common genetic factor underlying various income measures, all with small effect sizes (the Income Factor). Our polygenic index captures 1–5% of income variance, with only one fourth due to direct genetic eff…
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the Fads locus
Diurnal Cortisol Slope and Nighttime Blood Pressure
This study confirms ethnic differences in DCS and nighttime BP and further demonstrates that the ethnic differences in DCS can, at least partially, explain the ethnic differences found in nighttime BP
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
Three facets of planning and postponement of parenthood in the Netherlands
The age at parenthood has risen by about five years in the last decades in the Netherlands. Previous studies typically focused on the age at which people have their first child, but little is known about desired timing of parenthood and how this desire cha
Using Polygenic Scores in Social Science Research
Biological, genetic, and socio-demographic factors are all important in explaining reproductive behavior, yet these factors are typically studied in isolation. In this study, we explore an innovative sociogenomic approach, which entails including key socio-demographic (marriage, education, occupation, religion, cohort) and genetic factors related to both behavioral [age at first birth (AFB), number of children ever born (NEB)] and biological fecu…
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a meta-analysis of genome-wide association studies (GWAS) of gram/day (g/d) alcohol consumption in UK-Biobank, AlcGen and CHARGE+ consortia accumulating 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigate…
Heart Rate Variability and Its Relation to Chronic Kidney Disease
OBJECTIVE: In the general population, reduced heart rate variability (HRV) has been associated with cardiovascular disease. However, its relation to chronic kidney disease (CKD) is debated. We therefore investigated the relation between low HRV and renal outcomes. METHODS: In the population-based Prevention of REnal and Vascular ENdstage Disease study, renal outcomes (CKD, estimated glomerular filtration rate [eGFR], urinary albumin) were measure…
The Interaction of Genetic Predisposition and Socioeconomic Position With Type 2 Diabetes Mellitus
OBJECTIVE: A strong genetic predisposition for type 2 diabetes mellitus (T2DM) may aggravate the negative effects of low socioeconomic position (SEP) in the etiology of the disorder. This study aimed to examine cross-sectional and longitudinal associations and interactions of a genetic risk score (GRS) and SEP with T2DM and to investigate whether clinical and behavioral risk factors can explain these associations and interactions. METHODS: We use…
Bivariate Genome-Wide Association Study of Depressive Symptoms With Type 2 Diabetes and Quantitative Glycemic Traits
OBJECTIVE: Shared genetic background may explain phenotypic associations between depression and Type 2 diabetes (T2D). We aimed to study, on a genome-wide level, if genetic correlation and pleiotropic loci exist between depressive symptoms and T2D or glycemic traits. METHODS: We estimated single-nucleotide polymorphism (SNP)-based heritability and analyzed genetic correlation between depressive symptoms and T2D and glycemic traits with the linkag…
SNP‐Based Heritability Estimates of Common and Specific Variance in Self‐ and Informant‐Reported Neuroticism Scales
OBJECTIVE: Our study aims to estimate the proportion of the phenotypic variance of Neuroticism and its facet scales that can be attributed to common single-nucleotide polymorphisms (SNPs) in two adult populations from Estonia (EGCUT; N = 3,292) and the Netherlands (Lifelines; N = 13,383). METHOD: Genomic-relatedness-matrix restricted maximum likelihood (GREML) using genome-wide complex trait analysis (GCTA) software was employed. To build upon pr…
Hidden heritability due to heterogeneity across seven populations
Meta-analyses of genome-wide association studies, which dominate genetic discovery, are based on data from diverse historical time periods and populations. Genetic scores derived from genome-wide association studies explain only a fraction of the heritability estimates obtained from whole-genome studies on single populations, known as the ‘hidden heritability’ puzzle. Using seven sampling populations (n = 35,062), we test whether hidden heritabil…
Genetic evidence of assortative mating in humans
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Genetic studies of body mass index yield new insights for obesity biology
Ethnic Differences in Resting Heart Rate Variability
BACKGROUND: Ethnic disparities in cardiovascular morbidity and mortality are widely documented in the literature. Recently, research has shown that decreased parasympathetic cardiac modulation is associated with the established and emerging risk factors for cardiovascular disease (CVD) and stroke. In consideration of the disproportionate CVD risk and disease profile of African Americans (AAs), it is plausible that decreased cardiac parasympatheti…
Genetic influence on age at first birth of female twins born in the UK, 1919-68
Using a sample of monozygotic (945, 42 per cent) and dizygotic (1,329, 58 per cent) twin pairs born 1919-68 in the UK, we applied innovative tobit models to investigate genetic and environmental influences on age at first birth (AFB). We found that a substantial part (40 per cent) of the variation in AFB is caused by latent family characteristics. Genetic dispositions (26 per cent) play a more important role than the shared environment of sibling…
Association Between Methylation of the SLC6A4 Promoter Region in Peripheral Blood Leukocytes and Methylation in Amygdala Tissue
Objective The aim of this study was to examine the association of depressive symptoms with asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). Patients with chronic hepatitis C infection were examined during interferon- (IFN-) treatment, which is often associated with treatment-induced depression. The associations between IFN--induced depressive symptoms with ADMA and SDMA levels were prospectively investigated until 3 month…
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Genetic College Many genomic elements in humans are associated with behavior, including educational attainment. In a genome-wide association study including more than 100,000 samples, Rietveld et al. (p. 1467 , published online 30 May; see the Perspective by Flint and Munafò ) looked for genes related to educational attainment in Caucasians. Small genetic effects at three loci appeared to impact educational attainment.
Genetic Influence on Blood Pressure and Underlying Hemodynamics Measured at Rest and During Stress
OBJECTIVE: This study examined the genetic and environmental contributions to the individual differences in blood pressure (BP) levels and underlying hemodynamic characteristics at rest and during mental challenge tasks in a large twin cohort of youth. Including both European American and African American twins further allowed examination of potential ethnic differences. METHODS: We studied cardiovascular reactivity to two stressors (car-driving …
Common Genetic Contributions to Depressive Symptoms and Inflammatory Markers in Middle-Aged Men
Objective: To examine the extent to which a common genetic pathway is also involved in the relationship between depressive symptoms, in the absence of major depressive disorder (MDD), and inflammation. Recent data suggested that MDD and inflammation share common genes. Methods: We recruited 188 male twins from the Vietnam Era Twin Registry who were free of symptomatic coronary artery disease and MDD, with mean ± standard deviation (SD) age of 55 …
Neuroticism and Morning Cortisol Secretion
Neuroticism is widely used as an explanatory concept in etiological research of psychopathology. To clarify what neuroticism actually represents, we investigated the phenotypic and genetic relationship between neuroticism and the morning cortisol secretion. In the current classic twin study, 125 female twin pairs (74 monozygotic and 51 dizygotic pairs) participated. For each participant, 4 different neuroticism scores were available to calculate …
Bivariate Genetic Modeling of Cardiovascular Stress Reactivity
Objective: To test the existence of gene-by-stress interaction by assessing cardiovascular stress reactivity in monozygotic and dizygotic twins. Methods: We studied 160 adolescent (mean age 16.7 ± 2.0 years; range 13–22 years) and 212 middle-aged twin pairs (mean age 44.2 ± 6.7 years; range 34–63 years). Systolic (SBP) and diastolic (DBP) blood pressure, heart rate (HR), pre-ejection period (PEP), and respiratory sinus arrhythmia (RSA) were measu…
Genetics in Psychosomatic Medicine
It has become increasingly clear that genetic factors influence many of the behaviors and disease endpoints of interest to psychosomatic medicine researchers. There has been increasing interest in incorporating genetic variation markers into psychosomatic research. In this Statistical Corner article, we build on the valuable experiences gained during two workshops for “starters in the field” at the American Psychosomatic Society and the Society f…
Anger Suppression and Adiposity Modulate Association Between ADRB2 Haplotype and Cardiovascular Stress Reactivity
OBJECTIVES: The purpose of this study was to examine how variation in the beta-2 adrenergic receptor gene (ADRB2), in combination with the moderating influences of race, body mass index (BMI), and anger expression style (anger-in, anger-out), affects blood pressure (BP) at rest and in response to acute laboratory stress. METHODS: Four hundred fifty adolescents (mean age = 18.5 +/- 2.7 years; 228 [124 males] whites and 222 [110 males] blacks compl…
Genetic evidence of assortative mating in humans
Hidden heritability due to heterogeneity across seven populations
Meta-analyses of genome-wide association studies, which dominate genetic discovery, are based on data from diverse historical time periods and populations. Genetic scores derived from genome-wide association studies explain only a fraction of the heritability estimates obtained from whole-genome studies on single populations, known as the ‘hidden heritability’ puzzle. Using seven sampling populations (n = 35,062), we test whether hidden heritabil…
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
Genetic influence on age at first birth of female twins born in the UK, 1919-68
Using a sample of monozygotic (945, 42 per cent) and dizygotic (1,329, 58 per cent) twin pairs born 1919-68 in the UK, we applied innovative tobit models to investigate genetic and environmental influences on age at first birth (AFB). We found that a substantial part (40 per cent) of the variation in AFB is caused by latent family characteristics. Genetic dispositions (26 per cent) play a more important role than the shared environment of sibling…
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the Fads locus
Associations between common genetic variants and income provide insights about the socio-economic health gradient
We conducted a genome-wide association study on income among individuals of European descent ( N = 668,288) to investigate the relationship between socio-economic status and health disparities. We identified 162 genomic loci associated with a common genetic factor underlying various income measures, all with small effect sizes (the Income Factor). Our polygenic index captures 1–5% of income variance, with only one fourth due to direct genetic eff…
Three facets of planning and postponement of parenthood in the Netherlands
The age at parenthood has risen by about five years in the last decades in the Netherlands. Previous studies typically focused on the age at which people have their first child, but little is known about desired timing of parenthood and how this desire cha
Genetic and Environmental Influences on Anger Expression, John Henryism, and Stressful Life Events
Objective: To examine the genetic and/or environmental origin of variation and covariation of perceived stressful life events and two stress-related coping styles, anger expression and John Henryism. Methods: Data were available from 306 European American (EA) and 213 African American (AA) twin pairs, including monozygotic and dizygotic of same as well as opposite sex (mean age, 14.8 ± 3.1 years; range, 10.0–25.9 years). Anger expression, John He…
Anger Suppression and Adiposity Modulate Association Between ADRB2 Haplotype and Cardiovascular Stress Reactivity
OBJECTIVES: The purpose of this study was to examine how variation in the beta-2 adrenergic receptor gene (ADRB2), in combination with the moderating influences of race, body mass index (BMI), and anger expression style (anger-in, anger-out), affects blood pressure (BP) at rest and in response to acute laboratory stress. METHODS: Four hundred fifty adolescents (mean age = 18.5 +/- 2.7 years; 228 [124 males] whites and 222 [110 males] blacks compl…
Bivariate Genetic Modeling of Cardiovascular Stress Reactivity
Objective: To test the existence of gene-by-stress interaction by assessing cardiovascular stress reactivity in monozygotic and dizygotic twins. Methods: We studied 160 adolescent (mean age 16.7 ± 2.0 years; range 13–22 years) and 212 middle-aged twin pairs (mean age 44.2 ± 6.7 years; range 34–63 years). Systolic (SBP) and diastolic (DBP) blood pressure, heart rate (HR), pre-ejection period (PEP), and respiratory sinus arrhythmia (RSA) were measu…
Genetics in Psychosomatic Medicine
It has become increasingly clear that genetic factors influence many of the behaviors and disease endpoints of interest to psychosomatic medicine researchers. There has been increasing interest in incorporating genetic variation markers into psychosomatic research. In this Statistical Corner article, we build on the valuable experiences gained during two workshops for “starters in the field” at the American Psychosomatic Society and the Society f…
Common Genetic Contributions to Depressive Symptoms and Inflammatory Markers in Middle-Aged Men
Objective: To examine the extent to which a common genetic pathway is also involved in the relationship between depressive symptoms, in the absence of major depressive disorder (MDD), and inflammation. Recent data suggested that MDD and inflammation share common genes. Methods: We recruited 188 male twins from the Vietnam Era Twin Registry who were free of symptomatic coronary artery disease and MDD, with mean ± standard deviation (SD) age of 55 …
Neuroticism and Morning Cortisol Secretion
Neuroticism is widely used as an explanatory concept in etiological research of psychopathology. To clarify what neuroticism actually represents, we investigated the phenotypic and genetic relationship between neuroticism and the morning cortisol secretion. In the current classic twin study, 125 female twin pairs (74 monozygotic and 51 dizygotic pairs) participated. For each participant, 4 different neuroticism scores were available to calculate …
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Genetic College Many genomic elements in humans are associated with behavior, including educational attainment. In a genome-wide association study including more than 100,000 samples, Rietveld et al. (p. 1467 , published online 30 May; see the Perspective by Flint and Munafò ) looked for genes related to educational attainment in Caucasians. Small genetic effects at three loci appeared to impact educational attainment.
Genetic Influence on Blood Pressure and Underlying Hemodynamics Measured at Rest and During Stress
OBJECTIVE: This study examined the genetic and environmental contributions to the individual differences in blood pressure (BP) levels and underlying hemodynamic characteristics at rest and during mental challenge tasks in a large twin cohort of youth. Including both European American and African American twins further allowed examination of potential ethnic differences. METHODS: We studied cardiovascular reactivity to two stressors (car-driving …
Association Between Methylation of the SLC6A4 Promoter Region in Peripheral Blood Leukocytes and Methylation in Amygdala Tissue
Objective The aim of this study was to examine the association of depressive symptoms with asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). Patients with chronic hepatitis C infection were examined during interferon- (IFN-) treatment, which is often associated with treatment-induced depression. The associations between IFN--induced depressive symptoms with ADMA and SDMA levels were prospectively investigated until 3 month…
Genetic studies of body mass index yield new insights for obesity biology
Ethnic Differences in Resting Heart Rate Variability
BACKGROUND: Ethnic disparities in cardiovascular morbidity and mortality are widely documented in the literature. Recently, research has shown that decreased parasympathetic cardiac modulation is associated with the established and emerging risk factors for cardiovascular disease (CVD) and stroke. In consideration of the disproportionate CVD risk and disease profile of African Americans (AAs), it is plausible that decreased cardiac parasympatheti…
Genetic influence on age at first birth of female twins born in the UK, 1919-68
Using a sample of monozygotic (945, 42 per cent) and dizygotic (1,329, 58 per cent) twin pairs born 1919-68 in the UK, we applied innovative tobit models to investigate genetic and environmental influences on age at first birth (AFB). We found that a substantial part (40 per cent) of the variation in AFB is caused by latent family characteristics. Genetic dispositions (26 per cent) play a more important role than the shared environment of sibling…
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
SNP‐Based Heritability Estimates of Common and Specific Variance in Self‐ and Informant‐Reported Neuroticism Scales
OBJECTIVE: Our study aims to estimate the proportion of the phenotypic variance of Neuroticism and its facet scales that can be attributed to common single-nucleotide polymorphisms (SNPs) in two adult populations from Estonia (EGCUT; N = 3,292) and the Netherlands (Lifelines; N = 13,383). METHOD: Genomic-relatedness-matrix restricted maximum likelihood (GREML) using genome-wide complex trait analysis (GCTA) software was employed. To build upon pr…
Hidden heritability due to heterogeneity across seven populations
Meta-analyses of genome-wide association studies, which dominate genetic discovery, are based on data from diverse historical time periods and populations. Genetic scores derived from genome-wide association studies explain only a fraction of the heritability estimates obtained from whole-genome studies on single populations, known as the ‘hidden heritability’ puzzle. Using seven sampling populations (n = 35,062), we test whether hidden heritabil…
Genetic evidence of assortative mating in humans
Heart Rate Variability and Its Relation to Chronic Kidney Disease
OBJECTIVE: In the general population, reduced heart rate variability (HRV) has been associated with cardiovascular disease. However, its relation to chronic kidney disease (CKD) is debated. We therefore investigated the relation between low HRV and renal outcomes. METHODS: In the population-based Prevention of REnal and Vascular ENdstage Disease study, renal outcomes (CKD, estimated glomerular filtration rate [eGFR], urinary albumin) were measure…
The Interaction of Genetic Predisposition and Socioeconomic Position With Type 2 Diabetes Mellitus
OBJECTIVE: A strong genetic predisposition for type 2 diabetes mellitus (T2DM) may aggravate the negative effects of low socioeconomic position (SEP) in the etiology of the disorder. This study aimed to examine cross-sectional and longitudinal associations and interactions of a genetic risk score (GRS) and SEP with T2DM and to investigate whether clinical and behavioral risk factors can explain these associations and interactions. METHODS: We use…
Bivariate Genome-Wide Association Study of Depressive Symptoms With Type 2 Diabetes and Quantitative Glycemic Traits
OBJECTIVE: Shared genetic background may explain phenotypic associations between depression and Type 2 diabetes (T2D). We aimed to study, on a genome-wide level, if genetic correlation and pleiotropic loci exist between depressive symptoms and T2D or glycemic traits. METHODS: We estimated single-nucleotide polymorphism (SNP)-based heritability and analyzed genetic correlation between depressive symptoms and T2D and glycemic traits with the linkag…
Using Polygenic Scores in Social Science Research
Biological, genetic, and socio-demographic factors are all important in explaining reproductive behavior, yet these factors are typically studied in isolation. In this study, we explore an innovative sociogenomic approach, which entails including key socio-demographic (marriage, education, occupation, religion, cohort) and genetic factors related to both behavioral [age at first birth (AFB), number of children ever born (NEB)] and biological fecu…
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. We conducted a meta-analysis of genome-wide association studies (GWAS) of gram/day (g/d) alcohol consumption in UK-Biobank, AlcGen and CHARGE+ consortia accumulating 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 novel, common loci, and investigate…
Three facets of planning and postponement of parenthood in the Netherlands
The age at parenthood has risen by about five years in the last decades in the Netherlands. Previous studies typically focused on the age at which people have their first child, but little is known about desired timing of parenthood and how this desire cha
Diurnal Cortisol Slope and Nighttime Blood Pressure
This study confirms ethnic differences in DCS and nighttime BP and further demonstrates that the ethnic differences in DCS can, at least partially, explain the ethnic differences found in nighttime BP
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the Fads locus
Biology (20 obras) · Genetics (16 obras) · Genetic Associations and Epidemiology (14 obras) · Medicine (14 obras) · Genetics (13 obras) · Psychology (12 obras) · Gene (11 obras) · Internal Medicine (11 obras) · Internal Medicine (10 obras) · Demography (9 obras)