Timothy B Gage
Biographic Data
| ID | 3581052 |
|---|---|
| NAME | Timothy B Gage |
| GIVEN NAMES | Timothy B |
| FAMILY NAME | Gage |
| SIGNATURE | GAGE T B |
| AFFILIATIONS | University at Albany, State University of New York |
| VERIFIED | No |
| TOTAL WORKS | 47 |
| TOTAL CITATIONS | 261 |
| AUTHOR COUNT | 47 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1979 |
| LATEST PUBLICATION YEAR | 2016 |
| H-INDEX | 10 |
Heterogeneity identified at birth and blood pressure in adulthood
OBJECTIVE: In the developmental programming literature, the association of birth weight and blood pressure later in life is modest at best. This article reexamines this issue using Covariate Density Defined mixture of regressions (CDDmr) to determine if a latent variable, based on birth weight, and known to influence infant mortality, provides a stronger indicator of developmental programming. METHODS: CDDmr identifies two latent components in th…
Social Networks and the Heritability of Migratory Behavior
A small but growing body of literature examines the relationship between genetics and human migration. These studies suggest that some DRD4 alleles, particularly 7R+, are related to migration. This is surprising from a sociological perspective, which views migration largely as a product of social and economic forces. However, social relationships with migrants, which have been theorized to influence migration by providing access to migration-spec…
The effect of intra‐uterine growth restriction on blood lipids and response to exercise training
An 8-week exercise program corrected some, but not all, of the differences in blood lipid values between the LOWPI and HIGHPI group. The persistent group difference in blood lipid ratios suggests a higher long-term risk of chronic disease in the LOWPI group independent of lifestyle intervention
Maternal Education, Birth Weight, and Infant Mortality in the United States
This research determines whether the observed decline in infant mortality with socioeconomic level, operationalized as maternal education (dichotomized as college or more, versus high school or less), is due to its “indirect” effect (operating through birth weight) and/or to its “direct” effect (independent of birth weight). The data used are the 2001 U.S. national African American, Mexican American, and European American birth cohorts by sex. Th…
Demography Part 1: Mortality and Migration
This chapter contains sections titled: Introduction Demographic Rates and their Estimation Mortality Migration Chapter Summary Acknowledgments References Cited Recommended Readings
Birth-Weight-Specific Infant and Neonatal Mortality: Effects of Heterogeneity in the Birth Cohort
Birth-weight-specific infant mortality is examined using a novel statistical procedure, parametric mixtures of logistic regressions. The results indicate that birth cohorts are composed of two or more subpopulations that are heterogeneous with respect to infant mortality. One subpopulation appears to account for the “normal” process of fetal development, while the other, which accounts for the majority of births at both low and high birth weights…
Birth-Weight-Specific Infant and Neonatal Mortality: Effects of Heterogeneity in the Birth Cohort
Birth-weight-specific infant mortality is examined using a novel statistical procedure, parametric mixtures of logistic regressions. The results indicate that birth cohorts are composed of two or more subpopulations that are heterogeneous with respect to infant mortality. One subpopulation appears to account for the "normal" process of fetal development, while the other, which accounts for the majority of births at both low and high birth weights…
Update to Gage and O'Connor's “Nutrition and the Variation in Level and Age Patterns of Mortality” (1994)
It is widely assumed that nutrition influences the level of mortality. However, the association of nutrition and mortality is not linear; improved nutrition is associated with lower mortality when infectious causes of death dominate, but overnutrition, particularly with respect to the consumption of carbohydrates and fats, is often associated with increased chronic disease mortality. It is also possible that nutrition influences the age patterns …
Update to Gage and O'Connor's "Nutrition and the Variation in Level and Age Patterns of Mortality" (1994)
Update to Gage and O'Connor's "Nutrition and the Variation in Level and Age Patterns of Mortality" (1994) Timothy B. Gage and Kathleen O'Connor Keywords Nutrition, Mortality, Dietary Components, Age Patterns of Mortality. It is widely assumed that nutrition influences the level of mortality. However, the association of nutrition and mortality is not linear; improved nutrition is associated with lower mortality when infectious causes of death domi…
Nutrition and the Variation in Level and Age Patterns of Mortality
We examine the associations between nutrition and mortality at the national level. Altogether four aspects of this association are explored: (1) total calories with expectation of life, (2) dietary composition with expectation of life, (3) total calories with the age patterns of mortality, and (4) dietary composition with the age patterns of mortality. The data consist of life tables and national food balance sheets for 341 populations from 96 co…
Update to Gage's “Birth-Weight-Specific Infant and Neonatal Mortality” (2002)
Update to Gage's "Birth-Weight-Specific Infant and Neonatal Mortality" (2002)
Update to Gage's "Birth-Weight-Specific Infant and Neonatal Mortality" (2002) Timothy B. Gage Keywords Birth Weight, Infant Mortality, Gestational Age, pediatric paradox, maternal age Fryer et al. (1984), Gage and Therriault (1998), and Gage (2000) show that a two-component Gaussian mixture model describes the birth-weight distribution very well and gestational age distribution reasonably well. This finding led to the hypothesis that one of the s…
What Do We Know about the Agricultural Demographic Transition
The Agricultural Revolution accompanied, either as a cause or as an effect, important changes in human demographic systems. The consensus model is that fertility and mortality increased and health declined with the adoption of agriculture, compared to those for hunter-gatherers. Analysis of the agricultural transition relies primarily on archaeological and paleodemographic data and is thus subject to the errors associated with such data. The assu…
Modeling the pediatric paradox: Birth weight by gestational age
The "pediatric paradox" of African versus European American infant mortality is often observed with respect to birth weight, but rarely to gestational age, even though the two measures are biologically related. This paper models the pediatric paradox by birth weight and gestational age simultaneously, using Covariate Density Defined mixture of logistic regressions (CDDmlr) fitted to 1985-1988 New York State births. The model controls for unobserv…
Multiple mortality optima due to heterogeneity in the birth cohort: A continuous model of birth weight by gestational age‐specific infant mortality
Birth weight and gestational age are both important predictors of infant survival. Covariate Density Defined mixture of logistic regressions (CDDmlr), a method that accounts for unobserved heterogeneity, has been applied to birth outcomes using birth weight alone. This paper investigates a CDDmlr model of birth outcomes that includes birth weight and gestational age. Applications to four birth cohorts, composed of all non‐Hispanic singleton Afric…
Are Modern Environments Really Bad for Us: Revisiting the Demographic and Epidemiologic Transitions
It is a common assumption that agriculture and modernization have been detrimental for human health. The theoretical argument is that humans are adapted to hunter-gatherer lifestyles, and that the agricultural and "modern" environments are novel and hence likely to be detrimental. In particular, changes in nutrition, and population size and distribution with the adoption of agriculture, are considered to increase the risk of infectious disease mo…
Has the transition to agriculture reshaped the demographic structure of prehistoric populations? New evidence from the Levant
This paper presents the demographic changes that followed the transition from a hunting‐gathering way of life (Natufian) to an agricultural, food‐producing economy (Neolithic) in the southern Levant. The study is based on 217 Natufian (10,500–8,300 BC) skeletons and 262 Neolithic (8,300–5,500 BC) skeletons. Age and sex identification were carried out, and life tables were constructed. A five‐parameter competing hazard model developed by Siler ([ …
Pediatric Paradox: Heterogeneity in the Birth Cohort
Comparisons of birth-weight-specific infant mortality indicate that low-birth-weight African American infants have lower mortality than low-birth-weight European American infants despite higher infant mortality overall-the "pediatric paradox." One explanation is heterogeneity in birth weight. Analyses of African American and European American births suggest that birth cohorts consist of two heterogeneous subpopulations. One appears to account for…
Classification of births by birth weight and gestational age: An application of multivariate mixture models
Multivariate Gaussian mixture models provide a method of identifying compromised births that is not dependent upon arbitrary standards
The Evolution of Human Phenotypic Plasticity: Age and Nutritional Status at Maturity
Several evolutionary optimal models of human plasticity in age and nutritional status at reproductive maturation are proposed and their dynamics examined. These models differ from previously published models because fertility is not assumed to be a function of body size or nutritional status. Further, the models are based on explicitly human demographic patterns, that is, model human life-tables, model human fertility tables, and, a nutrient flow…
Modeling birthweight and gestational age distributions: Additive vs. multiplicative processes
Researchers have traditionally employed Gaussian distributions to model quantitative biological traits. Recently, mixtures of Gaussian distributions have begun to be used as well. However, there are many alternatives to the Gaussian distribution. From a theoretical perspective, the lognormal distribution is as applicable as the Gaussian (both are justified on the basis of the Central Limit Theorem). Here, the utility of mixtures of Gaussians and …
Genetic and environmental correlations between various anthropometric and blood pressure traits among adult Samoans
Shared polygenic effects (i.e., pleiotropy) are assumed to exist for such obesity‐related phenotypes as blood pressure and adiposity. It is possible to identify these shared genetic effects through bivariate genetic analyses. This analysis of 1,342 adult Samoans, across 801 pedigrees, indicates that significant heritable components ( P
Variability of gestational age distributions by sex and ethnicity: An analysis using mixture models
Variability of gestational age distributions by sex and ethnicity: An analysis using mixture models
As an antecedent of birthweight and in its own right, gestational age is an important proximate determinant of infant mortality. Recent analyses using mixture models of birthweight distributions suggest that substantial heterogeneity occurs within a birth cohort even when controlling for sex and ethnicity. This article extends the mixture model analysis to gestational age. The results indicate that, like birthweight, human gestational age distrib…
Biodemography in Anthropological Studies, volume dedicated to Gabriel W. Lasker
Mathematical hazard models of mortality: An alternative to model life tables
A five‐parameter competing hazard model of the age pattern of mortality is described, and methods of fitting it to survivorship, death rate, and age structure data are developed and presented. The methods are then applied to published life table and census data to construct life tables for a Late Woodland population, a Christian period Nubian population, and the Yanomama. The advantage of this approach over the use of model life tables is that th…
What Do We Know about the Agricultural Demographic Transition
The Agricultural Revolution accompanied, either as a cause or as an effect, important changes in human demographic systems. The consensus model is that fertility and mortality increased and health declined with the adoption of agriculture, compared to those for hunter-gatherers. Analysis of the agricultural transition relies primarily on archaeological and paleodemographic data and is thus subject to the errors associated with such data. The assu…
Has the transition to agriculture reshaped the demographic structure of prehistoric populations? New evidence from the Levant
This paper presents the demographic changes that followed the transition from a hunting‐gathering way of life (Natufian) to an agricultural, food‐producing economy (Neolithic) in the southern Levant. The study is based on 217 Natufian (10,500–8,300 BC) skeletons and 262 Neolithic (8,300–5,500 BC) skeletons. Age and sex identification were carried out, and life tables were constructed. A five‐parameter competing hazard model developed by Siler ([ …
The Comparative Demography of Primates: With Some Comments on the Evolution of Life Histories
This chapter reviews the current state of knowledge concerning the demography of primates. It compiles demographic systems (mortality and fertility estimates) for four broad grades of primates: New World monkeys, Old World monkeys, chimpanzees, and humans. The characteristics of each system, including its demographic stability, are presented and discussed. The environmentally induced variation in human and nonhuman primate vital rates are explore…
Bio-mathematical approaches to the study of human variation in mortality
The recent development of a number of biologically interpretable mathematical models of human mortality has facilitated the study of human variation in mortality patterns. This paper reviews the biological basis of these models, describes the models themselves, and presents the results of four anthropological applications of these models to the study of human variation in mortality. The models examined include a multi-stage model of carcinogenesi…
Are Modern Environments Really Bad for Us: Revisiting the Demographic and Epidemiologic Transitions
It is a common assumption that agriculture and modernization have been detrimental for human health. The theoretical argument is that humans are adapted to hunter-gatherer lifestyles, and that the agricultural and "modern" environments are novel and hence likely to be detrimental. In particular, changes in nutrition, and population size and distribution with the adoption of agriculture, are considered to increase the risk of infectious disease mo…
Population Variation in Cause of Death: Level, Gender, and Period Effects
The trends in 13 cause of death categories are examined with respect to expectation of life, sex differences, and period effects while misclassification of cause of death is controlled. The results suggest that as mortality declines, 1) the increasingly U-shaped age pattern of mortality is a period effect associated with the infectious diseases, 2) the risks of both overall infectious and degenerative causes of death decline, and 3) infectious di…
Did more than one species of hominid coexist before 3·0 Ma: Evidence from blood and teeth
Maternal Education, Birth Weight, and Infant Mortality in the United States
This research determines whether the observed decline in infant mortality with socioeconomic level, operationalized as maternal education (dichotomized as college or more, versus high school or less), is due to its “indirect” effect (operating through birth weight) and/or to its “direct” effect (independent of birth weight). The data used are the 2001 U.S. national African American, Mexican American, and European American birth cohorts by sex. Th…
Demographic Estimation From Anthropological Data: New Methods
The Decline of Mortality in England and Wales 1861 to 1964: Decomposition by Cause of Death and Component of Mortality
The decline in mortality in England and Wales, between 1861 and 1964 is analysed, using competing-hazard models. These methods provide greater specificity concerning the potential biases due to misdiagnosis, and facilitate the examination of temporal shifts in the age-patterns of mortality. The results provide a number of insights into the historical decline of mortality that were not previously available. First, misclassification of causes of de…
Genetic and environmental correlations between various anthropometric and blood pressure traits among adult Samoans
Shared polygenic effects (i.e., pleiotropy) are assumed to exist for such obesity‐related phenotypes as blood pressure and adiposity. It is possible to identify these shared genetic effects through bivariate genetic analyses. This analysis of 1,342 adult Samoans, across 801 pedigrees, indicates that significant heritable components ( P
Pediatric Paradox: Heterogeneity in the Birth Cohort
Comparisons of birth-weight-specific infant mortality indicate that low-birth-weight African American infants have lower mortality than low-birth-weight European American infants despite higher infant mortality overall-the "pediatric paradox." One explanation is heterogeneity in birth weight. Analyses of African American and European American births suggest that birth cohorts consist of two heterogeneous subpopulations. One appears to account for…
The Evolution of Human Phenotypic Plasticity: Age and Nutritional Status at Maturity
Several evolutionary optimal models of human plasticity in age and nutritional status at reproductive maturation are proposed and their dynamics examined. These models differ from previously published models because fertility is not assumed to be a function of body size or nutritional status. Further, the models are based on explicitly human demographic patterns, that is, model human life-tables, model human fertility tables, and, a nutrient flow…
Flushing the radiator? A reply to Braga & Boesch
Reproductive factors affecting survivorship in captive callitrichidae
Efforts to breed Callitrichidae in captivity have resulted in high fertility accompanied by high infant mortality. This paper investigates the relationship between reproductive characteristics and survivorship in the Oak Ridge and Associated Universities (ORAU) callitrichid colony. Records of 2,834 individuals were analyzed using Cox Proportional Hazards regression to investigate factors affecting infant survivorship. Species and birth cohort wer…
Estimating Mortality Level for Small Populations: An Evaluation of a Pair of Two-Census Methods
A pair of two-census methods of estimating mortality levels are tested with simulated census data. The populations considered range in size from 250 to 1500 individuals of each sex; censuses were taken at intervals of five and ten years. In general, the methods are resistant to bias, and yield variances similar in magnitude to those obtained using vital registration data and life table techniques for censored data. The two-census methods represen…
Radiators are cool: A response to Braga & Boeschrsquo;s published paper and reply
Effects of age and gender on the location and orientation of the foramen magnum in rhesus macaques (Macaca mulatta)
Endocasts from 378 rhesus macaque skulls from the Cayo Santiago skeletal collection were measured to determine the effects of age and gender on the position and orientation of the foramen magnum. The foramen magnum migrates from a rostral to a caudal position and its angle changes during postnatal development. The angles and relative positions of the foramen magnum are similar for both genders of infants and for both genders of adults. However, a…
The competitive interactions of man and deer in prehistoric California
Demographic Estimation From Anthropological Data: New Methods
A demographic analysis of the Wisconsin Regional Primate Center rhesus colony, 1962–1982
A detailed demographic analysis was made of the Wisconsin Regional Primate Research Center rhesus colony from vital statistics recorded over a 20‐year period. Techniques used were based on demographic and epidemiological methods developed for human populations, which provide the potential for making standardized measurements within captive primate colonies. A life table based on 1,086 deaths showed an abnormally high survivorship at the older age…
Estimating Mortality Level for Small Populations: An Evaluation of a Pair of Two-Census Methods
A pair of two-census methods of estimating mortality levels are tested with simulated census data. The populations considered range in size from 250 to 1500 individuals of each sex; censuses were taken at intervals of five and ten years. In general, the methods are resistant to bias, and yield variances similar in magnitude to those obtained using vital registration data and life table techniques for censored data. The two-census methods represen…
Model life tables for the larger old world monkeys
Mortality statistics for 25 populations of the larger Old World monkeys (members of the subfamily Cercopithecinae ) were evaluated with a competing hazard model of mortality. The best eight of these life tables were combined to generate a standard model life table representative of the mortality patterns of these primates. Two applications of the standard model to smooth, graduate, and compare life tables based on limited and defective data are p…
Mathematical hazard models of mortality: An alternative to model life tables
A five‐parameter competing hazard model of the age pattern of mortality is described, and methods of fitting it to survivorship, death rate, and age structure data are developed and presented. The methods are then applied to published life table and census data to construct life tables for a Late Woodland population, a Christian period Nubian population, and the Yanomama. The advantage of this approach over the use of model life tables is that th…
Bio-mathematical approaches to the study of human variation in mortality
The recent development of a number of biologically interpretable mathematical models of human mortality has facilitated the study of human variation in mortality patterns. This paper reviews the biological basis of these models, describes the models themselves, and presents the results of four anthropological applications of these models to the study of human variation in mortality. The models examined include a multi-stage model of carcinogenesi…
Causes of death and the components of mortality: Testing the biological interpretations of a competing hazards model
Biological interpretations of a competing hazards model intended to express the age pattern of mortality throughout the life span are evaluated using cause of death data. The model examined is the Siler model, which consists of three competing hazards, immature, residual, and senescent. The data employed are the worldwide sample of life tables and decremented life tables, that is, life tables with a cause of death eliminated, assembled by Preston…
Reproductive factors affecting survivorship in captive callitrichidae
Efforts to breed Callitrichidae in captivity have resulted in high fertility accompanied by high infant mortality. This paper investigates the relationship between reproductive characteristics and survivorship in the Oak Ridge and Associated Universities (ORAU) callitrichid colony. Records of 2,834 individuals were analyzed using Cox Proportional Hazards regression to investigate factors affecting infant survivorship. Species and birth cohort wer…
Effects of age and gender on the location and orientation of the foramen magnum in rhesus macaques (Macaca mulatta)
Endocasts from 378 rhesus macaque skulls from the Cayo Santiago skeletal collection were measured to determine the effects of age and gender on the position and orientation of the foramen magnum. The foramen magnum migrates from a rostral to a caudal position and its angle changes during postnatal development. The angles and relative positions of the foramen magnum are similar for both genders of infants and for both genders of adults. However, a…
Height, Health and History: Nutritional Status in the United Kingdom, 1750- 1980
Model life tables for the larger old world monkeys: A revision
We report a change in the method of averaging parameters of the Siler mortality model fitted to a series of Old World monkey survivorship schedules. Substitution of geometric for arithmetic means of multipliers of exponential terms avoids incorrect weighting of parameters. These changes have minor effects on the composite standard mortality schedule for these animals originally described in 1988. © 1993 Wiley‐Liss, Inc
Model life tables for the smaller new world monkeys
Mortality statistics from five populations of small New World monkeys (includinsg Callithrix jaccus, Leontopithecus rosalia, Saguinus fuscicollis , and Saguinus oedipus ) were combined to generate a standard model life table reflecting the mortality patterns of these primates. The model is applied to three individual populations to illustrate a strategy for smoothing and interpolating mortality statistics of varying completeness and quality. © 19…
The Decline of Mortality in England and Wales 1861 to 1964: Decomposition by Cause of Death and Component of Mortality
The decline in mortality in England and Wales, between 1861 and 1964 is analysed, using competing-hazard models. These methods provide greater specificity concerning the potential biases due to misdiagnosis, and facilitate the examination of temporal shifts in the age-patterns of mortality. The results provide a number of insights into the historical decline of mortality that were not previously available. First, misclassification of causes of de…
Population Variation in Cause of Death: Level, Gender, and Period Effects
The trends in 13 cause of death categories are examined with respect to expectation of life, sex differences, and period effects while misclassification of cause of death is controlled. The results suggest that as mortality declines, 1) the increasingly U-shaped age pattern of mortality is a period effect associated with the infectious diseases, 2) the risks of both overall infectious and degenerative causes of death decline, and 3) infectious di…
Anthropometric indicators of nutritional status and level of mortality
The strength of the relationship between several anthropometric indicators of nutritional status, or more generally, standard of living, with overall mortality at the population level is compared. The anthropometic indicators examined include height, weight, weight‐for‐height, and weight‐for‐height 2 at various ages. The results demonstrate that height is most closely associated with the level of mortality. Weight‐for height 2 , in contrast, has …
Model life table for captive chimpanzees
Mortality statistics from three captive populations of chimpanzees ( Pan troglodytes ) were combined to generate standard model life tables for each sex in this species. The model is compared to an estimate of survivorship of a group of wild animals, and is applied to an incomplete data set to illustrate how the model may be used to extend estimates of mortality statistics to missing older ages. © 1995 Wiley‐Liss, Inc
Did more than one species of hominid coexist before 3·0 Ma: Evidence from blood and teeth
Flushing the radiator? A reply to Braga & Boesch
Radiators are cool: A response to Braga & Boeschrsquo;s published paper and reply
The Comparative Demography of Primates: With Some Comments on the Evolution of Life Histories
This chapter reviews the current state of knowledge concerning the demography of primates. It compiles demographic systems (mortality and fertility estimates) for four broad grades of primates: New World monkeys, Old World monkeys, chimpanzees, and humans. The characteristics of each system, including its demographic stability, are presented and discussed. The environmentally induced variation in human and nonhuman primate vital rates are explore…
Biodemography in Anthropological Studies, volume dedicated to Gabriel W. Lasker
Biodemography in Anthropological Studies, volume dedicated to Gabriel W. Lasker
Variability of gestational age distributions by sex and ethnicity: An analysis using mixture models
Variability of gestational age distributions by sex and ethnicity: An analysis using mixture models
As an antecedent of birthweight and in its own right, gestational age is an important proximate determinant of infant mortality. Recent analyses using mixture models of birthweight distributions suggest that substantial heterogeneity occurs within a birth cohort even when controlling for sex and ethnicity. This article extends the mixture model analysis to gestational age. The results indicate that, like birthweight, human gestational age distrib…
Demography (35 works) · Biology (32 works) · Medicine (24 works) · Population (20 works) · Sociology (18 works) · Birth, Development, and Health (16 works) · Insurance, Mortality, Demography, Risk Management (15 works) · Geography (14 works) · Statistics (14 works) · Mathematics (13 works)