Sara Green
Datos Biográficos
| ID | 3581643 |
|---|---|
| NOMBRE | Sara Green |
| NOMBRES | Sara |
| APELLIDO | Green |
| FIRMA | GREEN S |
| AFILIACIONES | University of Copenhagen |
| ORCID | 0000-0001-7011-7202 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 41 |
| TOTAL DE CITAS | 158 |
| TOTAL COMO AUTOR | 41 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 1985 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2026 |
| ÍNDICE H | 7 |
Precision prevention and the temporal disruption of evidence
Precision prevention refers to the use of data-intensive technologies to detect early indicators of disease and risk factors at the individual level. Precision prevention is not just a policy vision for a distant future but a development currently gaining momentum through wearables and self-tests marketed directly to consumers. We critically analyze one of the applications already on the market, namely detection of asymptomatic atrial fibrillatio…
Towards functional precision medicine? Evidence standards of organoids as patient-specific models
Evidence-based medicine (EBM), with meta-analysis of randomized clinical trials as its gold standard, has been criticized for failing to represent the individuality and variability of disease. Precision medicine (PM) has been proposed as an alternative to EBM's "averaging approach", leveraging genomic and other biological information at the individual level. However, PM is still an emerging and changing concept. It is unclear what constitutes acc…
The right standard for the job? On the limits of standard setting as a tool for governing commercial actors
Data standards play a key role in the governance of commercial actors on the market for health data. This commentary explores expectations for standard-setting in the European Health Data Space (EHDS), a pivotal legal initiative for facilitation of cross-border health data exchange. While EHDS aims to establish shared standards for interoperability and innovation in the European Union (EU) and affiliated countries, the analysis reveals some of th…
The Gatekeeper's Dilemma
Low-value care (LVC) is increasingly the focus of debates on how to reduce the use of healthcare resources while maintaining quality care. General practitioners (GPs) are often considered central to this aim. Although GPs facilitate early disease detection, disease prevention and coordinated medical care, they must do so while aiming to protect both patients and the healthcare system from the harmful effects of medical overactivity. Public health…
Constraint-based reasoning in cell biology
Health in data space
Healthcare is increasingly datafied, and a wide range of actors-patients, clinicians, administrators, policymakers, and industry lobbyists-want to be able to exchange and access health data internationally and use them for an increasing number of purposes. Therefore, competing initiatives aimed at fostering international data integration proliferate, with the proposed European Health Data Space as one of the most prominent examples. But how do le…
Precision medicine in primary care
Visions of precision or personalized medicine (PM) are gaining currency around the globe. While the potential of PM in specialist medicine has been in focus, primary care is also considered to be a fruitful area for the application of PM. "Low-tech" forms of personalization and attention to individual patients are already central features of primary care practice, and primary care thus constitutes an area in which "old" and "new" forms of persona…
The practical ethics of repurposing health data
Throughout the Global North, policymakers invest in large-scale integration of health-data infrastructures to facilitate the reuse of clinical data for administration, research, and innovation. Debates about the ethical implications of data repurposing have focused extensively on issues of patient autonomy and privacy. We suggest that it is time to scrutinize also how the everyday work of healthcare staff is affected by political ambitions of dat…
Precision medicine and the problem of structural injustice
Many countries currently invest in technologies and data infrastructures to foster precision medicine (PM), which is hoped to better tailor disease treatment and prevention to individual patients. But who can expect to benefit from PM? The answer depends not only on scientific developments but also on the willingness to address the problem of structural injustice. One important step is to confront the problem of underrepresentation of certain pop…
Building an HIV Learning Health Care Community for Youth in Florida
Slowing down decay
This article discusses so-called biological clocks. These technologies, based on aging biomarkers, trace and measure molecular changes in order to monitor individuals' "true" biological age against their chronological age. Drawing on the concept of decay, and building on ethnographic fieldwork in an academic laboratory and a commercial firm, we analyze the implications of the development and commercialization of biological clocks that can identif…
Caring for Organoids
This article explores the daily practices in a Danish cancer laboratory, where researchers use "personal organoids" as new translational models in the development of personalized medicine. Grown from metastatic cancer tissue of life-threateningly ill patients, personal organoids enable patient-specific drug screenings that may directly shape clinical decision-making and individual patient lives. Hereby, laboratory researchers are confronted with …
Plastic diagnostics
Politically authorized reports on personalized and precision medicine stress an urgent need for finer-grained disease categories and faster taxonomic revision, through integration of genomic and phenotypic data. Developing a data-driven taxonomy is, however, not as simple as it sounds. It is often assumed that an integrated data infrastructure is relatively easy to implement in countries that already have highly centralized and digitalized health…
Precision patients
This paper addresses selection practices in a Danish phase 1 unit specialised in precision medicine in the field of oncology. Where precision medicine holds the ambition of selecting genetically fit medicine for the patient, we find that precision medicine in the early trial setting is oriented towards selecting clinically and genetically fit patients for available treatment protocols. Investigating how phase 1 oncologists experience and respond …
Aging biomarkers and the measurement of health and risk
Mouse avatars of human cancers
Steel and bone
Digital phenotyping and data inheritance
Proponents of precision medicine envision that digital phenotyping can enable more individualized strategies to manage current and future health conditions. We problematize the interpretation of digital phenotypes as straightforward representations of individuals through examples of what we call data inheritance. Rather than being a digital copy of a presumed original, digital phenotypes are shaped by larger data collectives that precede and cont…
Book Forum
How to choose your research organism
Despite August Krogh's famous admonition that a 'convenient' organism exists for every biological problem, we argue that appeals to 'convenience' are not sufficient to capture reasoning about organism choice. Instead, we offer a detailed analysis based on empirical data and philosophical arguments for a working set of twenty criteria that interact with each other in the highly contextualized judgements that biologists make about organism choice. …
Science and common sense
Extreme’ organisms and the problem of generalization
Many biologists appeal to the so-called Krogh principle when justifying their choice of experimental organisms. The principle states that "for a large number of problems there will be some animal of choice, or a few such animals, on which it can be most conveniently studied". Despite its popularity, the principle is often critiqued for implying unwarranted generalizations from optimal models. We argue that the Krogh principle should be interprete…
Network analyses in systems biology
What is the ‘post’ in postgenomics
Pocketable philosophy of biology
Living Stigma
In this study, we examine the direct and vicarious impact of the social processes of felt and enacted stigma and their impact on the lives of individuals with disabilities and their families. Specifically, findings of interactive interviews with eight adults with disabilities and seven mothers of children with disabilities were analyzed for themes related to components of stigma described by Link and Phelan (2001): labeling, stereotyping, separat…
Biology meets physics
Plastic diagnostics
Politically authorized reports on personalized and precision medicine stress an urgent need for finer-grained disease categories and faster taxonomic revision, through integration of genomic and phenotypic data. Developing a data-driven taxonomy is, however, not as simple as it sounds. It is often assumed that an integrated data infrastructure is relatively easy to implement in countries that already have highly centralized and digitalized health…
When one model is not enough
Aging biomarkers and the measurement of health and risk
Steel and bone
Is defining life pointless? Operational definitions at the frontiers of biology
Precision patients
This paper addresses selection practices in a Danish phase 1 unit specialised in precision medicine in the field of oncology. Where precision medicine holds the ambition of selecting genetically fit medicine for the patient, we find that precision medicine in the early trial setting is oriented towards selecting clinically and genetically fit patients for available treatment protocols. Investigating how phase 1 oncologists experience and respond …
How to choose your research organism
Despite August Krogh's famous admonition that a 'convenient' organism exists for every biological problem, we argue that appeals to 'convenience' are not sufficient to capture reasoning about organism choice. Instead, we offer a detailed analysis based on empirical data and philosophical arguments for a working set of twenty criteria that interact with each other in the highly contextualized judgements that biologists make about organism choice. …
Network analyses in systems biology
Spouse Psychological Well-Being
Understanding predictors of military spouse psychosocial vulnerability informs efforts to assess, identify, and support at-risk spouses and families. In this analysis we test the effects of family stress and strain on military spouse psychological health, using a sample of female civilian spouses (n=161). Regression findings confirm expectations of the significant contribution of family stressors, strain, and resources in explaining variation in …
Beyond Individual Literacy
Literacy has long been considered an important prerequisite to the improvement of living conditions in the developing world. It has generally been proposed that a literate individual is more likely to accept and adopt new modes of behavior (such as agricultural and nutritional practices) designed to improve his quality of life. Consistent empirical evidence of the proposed relationship, however, is lacking. Several authors have suggested that thi…
Health in data space
Healthcare is increasingly datafied, and a wide range of actors-patients, clinicians, administrators, policymakers, and industry lobbyists-want to be able to exchange and access health data internationally and use them for an increasing number of purposes. Therefore, competing initiatives aimed at fostering international data integration proliferate, with the proposed European Health Data Space as one of the most prominent examples. But how do le…
Mouse avatars of human cancers
Extreme’ organisms and the problem of generalization
Many biologists appeal to the so-called Krogh principle when justifying their choice of experimental organisms. The principle states that "for a large number of problems there will be some animal of choice, or a few such animals, on which it can be most conveniently studied". Despite its popularity, the principle is often critiqued for implying unwarranted generalizations from optimal models. We argue that the Krogh principle should be interprete…
Digital phenotyping and data inheritance
Proponents of precision medicine envision that digital phenotyping can enable more individualized strategies to manage current and future health conditions. We problematize the interpretation of digital phenotypes as straightforward representations of individuals through examples of what we call data inheritance. Rather than being a digital copy of a presumed original, digital phenotypes are shaped by larger data collectives that precede and cont…
Can biological complexity be reverse engineered
Precision medicine in primary care
Visions of precision or personalized medicine (PM) are gaining currency around the globe. While the potential of PM in specialist medicine has been in focus, primary care is also considered to be a fruitful area for the application of PM. "Low-tech" forms of personalization and attention to individual patients are already central features of primary care practice, and primary care thus constitutes an area in which "old" and "new" forms of persona…
Scale Dependency and Downward Causation in Biology
This article argues that scale dependence of physical and biological processes offers resistance to reductionism and has implications that support a specific kind of downward causation. I demonstrate how insights from multiscale modeling can provide a concrete mathematical interpretation of downward causation as boundary conditions for models used to represent processes at lower scales. The autonomy and role of macroscale parameters and higher-le…
The right standard for the job? On the limits of standard setting as a tool for governing commercial actors
Data standards play a key role in the governance of commercial actors on the market for health data. This commentary explores expectations for standard-setting in the European Health Data Space (EHDS), a pivotal legal initiative for facilitation of cross-border health data exchange. While EHDS aims to establish shared standards for interoperability and innovation in the European Union (EU) and affiliated countries, the analysis reveals some of th…
Science and common sense
Beyond Individual Literacy
Literacy has long been considered an important prerequisite to the improvement of living conditions in the developing world. It has generally been proposed that a literate individual is more likely to accept and adopt new modes of behavior (such as agricultural and nutritional practices) designed to improve his quality of life. Consistent empirical evidence of the proposed relationship, however, is lacking. Several authors have suggested that thi…
Living Stigma
In this study, we examine the direct and vicarious impact of the social processes of felt and enacted stigma and their impact on the lives of individuals with disabilities and their families. Specifically, findings of interactive interviews with eight adults with disabilities and seven mothers of children with disabilities were analyzed for themes related to components of stigma described by Link and Phelan (2001): labeling, stereotyping, separat…
Lessons Learned from “Integrating” Intensive Family-based Interventions into Medical Care Settings for Mothers Living with HIV/Aids and their Adolescent Children
A Lifetime of Low-Risk Behaviors Among HIV-Positive Latinas in Los Angeles
Differential Disclosure Across Social Network Ties Among Women Living with HIV
Women's disclosure of their HIV serostatus across social network ties was examined in a sample of women living in Los Angeles (n = 234), using multivariate random intercept logistic regressions. Women with disclosure-averse attitudes were less likely to disclose, while women with higher CD4+ counts were significantly more likely to disclose, regardless of relationship type. Relative to all other types of relationships, spouses/romantic partners w…
Intervention Outcomes Among HIV-Affected Families Over 18 Months
When one model is not enough
Spouse Psychological Well-Being
Understanding predictors of military spouse psychosocial vulnerability informs efforts to assess, identify, and support at-risk spouses and families. In this analysis we test the effects of family stress and strain on military spouse psychological health, using a sample of female civilian spouses (n=161). Regression findings confirm expectations of the significant contribution of family stressors, strain, and resources in explaining variation in …
Life course pathways of adverse childhood experiences toward adult psychological well-being
Can biological complexity be reverse engineered
Sociology Looking at Disability
Explanatory pluralism in biology
Biology meets physics
Why the Small Things in Life Matter
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Extreme’ organisms and the problem of generalization
Many biologists appeal to the so-called Krogh principle when justifying their choice of experimental organisms. The principle states that "for a large number of problems there will be some animal of choice, or a few such animals, on which it can be most conveniently studied". Despite its popularity, the principle is often critiqued for implying unwarranted generalizations from optimal models. We argue that the Krogh principle should be interprete…
Network analyses in systems biology
Is defining life pointless? Operational definitions at the frontiers of biology
Scale Dependency and Downward Causation in Biology
This article argues that scale dependence of physical and biological processes offers resistance to reductionism and has implications that support a specific kind of downward causation. I demonstrate how insights from multiscale modeling can provide a concrete mathematical interpretation of downward causation as boundary conditions for models used to represent processes at lower scales. The autonomy and role of macroscale parameters and higher-le…
How to choose your research organism
Despite August Krogh's famous admonition that a 'convenient' organism exists for every biological problem, we argue that appeals to 'convenience' are not sufficient to capture reasoning about organism choice. Instead, we offer a detailed analysis based on empirical data and philosophical arguments for a working set of twenty criteria that interact with each other in the highly contextualized judgements that biologists make about organism choice. …
Science and common sense
Book Forum
Aging biomarkers and the measurement of health and risk
Mouse avatars of human cancers
Steel and bone
Digital phenotyping and data inheritance
Proponents of precision medicine envision that digital phenotyping can enable more individualized strategies to manage current and future health conditions. We problematize the interpretation of digital phenotypes as straightforward representations of individuals through examples of what we call data inheritance. Rather than being a digital copy of a presumed original, digital phenotypes are shaped by larger data collectives that precede and cont…
Epistemology (19 obras) · Psychology (19 obras) · Philosophy (17 obras) · Computer Science (16 obras) · Medicine (13 obras) · Biology (12 obras) · Sociology (11 obras) · Philosophy (9 obras) · Philosophy of science (8 obras) · Political science (8 obras)