Ronald Glaser
Biographic Data
| ID | 3657486 |
|---|---|
| NAME | Ronald Glaser |
| GIVEN NAMES | Ronald |
| FAMILY NAME | Glaser |
| SIGNATURE | GLASER R |
| AFFILIATIONS | The Ohio State University |
| VERIFIED | No |
| TOTAL WORKS | 38 |
| TOTAL CITATIONS | 58 |
| AUTHOR COUNT | 38 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1984 |
| LATEST PUBLICATION YEAR | 2013 |
| H-INDEX | 5 |
Stress-Induced Inflammatory Responses in Women: Effects of Race and Pregnancy
OBJECTIVE: African Americans experience preterm birth at nearly twice the rate of whites. Chronic stress associated with minority status is implicated in this disparity. Inflammation is a key biological pathway by which stress may affect birth outcomes. This study examined the effects of race and pregnancy on stress-induced inflammatory responses. METHODS: Thirty-nine women in the second trimester of pregnancy (19 African American, 20 white) and …
Childhood Adversity Heightens the Impact of Later-Life Caregiving Stress on Telomere Length and Inflammation
OBJECTIVE: To address the question of whether childhood abuse and other adversities have lasting, detectable consequences for inflammation and cell aging late in life, and whether the effects are large enough to be discernible beyond that of a major chronic stressor, dementia family caregiving. Previous research on the physical health consequences of childhood abuse and other adversities has been based on data from young or middle-aged adults. ME…
Stress, Inflammation, and Yoga Practice
OBJECTIVE: To address the mechanisms underlying hatha yoga's potential stress-reduction benefits, we compared inflammatory and endocrine responses of novice and expert yoga practitioners before, during, and after a restorative hatha yoga session, as well as in two control conditions. Stressors before each of the three conditions provided data on the extent to which yoga speeded an individual's physiological recovery. METHODS: A total of 50 health…
Depressive Symptoms, omega-6: Omega-3 Fatty Acids, and Inflammation in Older Adults
OBJECTIVE: To address how interactions between polyunsaturated fatty acid (PUFA) levels and depressive symptoms were related to proinflammatory cytokine synthesis. Depression and stress promote proinflammatory cytokine production. Dietary intakes of omega-3 (n-3) and omega-6 (n-6) PUFAs also influence inflammation; high n-6:n-3 ratios enhance proinflammatory cytokine production, although n-3 has anti-inflammatory properties. METHODS: Blood sample…
Hostile Marital Interactions, Proinflammatory Cytokine Production, and Wound Healing
CONTEXT: A growing epidemiological literature has suggested that marital discord is a risk factor for morbidity and mortality. In addition, depression and stress are associated with enhanced production of proinflammatory cytokines that influence a spectrum of conditions associated with aging. OBJECTIVE: To assess how hostile marital behaviors modulate wound healing, as well as local and systemic proinflammatory cytokine production. DESIGN AND SET…
Stress-induced immune dysfunction: Implications for health
Stress Hormone Changes and Marital Conflict: Spouses' Relative Power Makes a Difference
We investigated the impact of relative marital power on 72 newlywed couples' endocrinological responses to marital conflict. Marital power was determined by comparing spouses' reports of dependent love for one another. Less powerful spouses displayed elevated adrenocorticotropic hormone (ACTH) responses to a conflict discussion. Shared power appeared to have a beneficial effect on wives' but not husbands' ACTH responses. Spouses' cortisol levels …
Chronic stress and age-related increases in the proinflammatory cytokine IL-6
Overproduction of IL-6, a proinflammatory cytokine, is associated with a spectrum of age-related conditions including cardiovascular disease, osteoporosis, arthritis, type 2 diabetes, certain cancers, periodontal disease, frailty, and functional decline. To describe the pattern of change in IL-6 over 6 years among older adults undergoing a chronic stressor, this longitudinal community study assessed the relationship between chronic stress and IL-…
Psychoneuroimmunology: Psychological influences on immune function and health.
This review focuses on human psychoneuroimmunology studies published in the past decade. Issues discussed include the routes through which psychological factors influence immune function, how a stressor's duration may influence the changes observed, individual difference variables, the ability of interventions to modulate immune function, and the health consequences of psychosocially mediated immune dysregulation. The importance of negative affec…
Emotions, Morbidity, and Mortality: New Perspectives from Psychoneuroimmunology
Negative emotions can intensify a variety of health threats. We provide a broad framework relating negative emotions to a range of diseases whose onset and course may be influenced by the immune system; inflammation has been linked to a spectrum of conditions associated with aging, including cardiovascular disease, osteoporosis, arthritis, type 2 diabetes, certain cancers, Alzheimer's disease, frailty and functional decline, and periodontal disea…
Psychoneuroimmunology and Psychosomatic Medicine: Back to the Future
OBJECTIVE: Although psychological modulation of immune function is now a well-established phenomenon, much of the relevant literature has been published within the last decade. This article speculates on future directions for psychoneuroimmunology research, after reviewing the history of the field. METHODS: This review focuses on human psychoneuroimmunology studies published since 1939, particularly those that have appeared in Psychosomatic Medic…
Epstein-Barr Virus Antibodies in Whole Blood Spots: A Minimally Invasive Method for Assessing an Aspect of Cell-Mediated Immunity
OBJECTIVE: Study 1: Introduce and validate a method for measuring EBV p18-VCA antibodies in whole blood spots to provide a minimally invasive marker of cell-mediated immune function. Study 2: Apply this method to a large community-based study of psychopathology in children and adolescents. METHODS: The EBV antibody method was evaluated through analysis of precision, reliability, stability, and comparisons with plasma and indirect immunofluorescen…
Chronic Stress Modulates the Immune Response to a Pneumococcal Pneumonia Vaccine
OBJECTIVE: Influenza and pneumonia account for significant morbidity and mortality, particularly in older individuals. Previous studies have shown that spousal caregivers of patients with dementia have poorer antibody and virus specific T cell responses to an influenza virus vaccine relative to noncaregiving control subjects. This study tested the hypothesis that stress can also significantly inhibit the IgG antibody response to a pneumococcal ba…
Psychoneuroimmunology and Immunotoxicology: Implications for Carcinogenesis
From the Department of Psychiatry (J.K.K.-G.), Department of Medical Microbiology and Immunology (R.G.), the Ohio State Institute for Behavioral Medicine Research (J.K.K.-G., R.G.), and the Ohio State University Comprehensive Cancer Center (J.K.K.-G., R.G.); the Ohio State University College of Medicine, Columbus, Ohio. Address reprint requests to: Janice K. Kiecolt-Glaser, PhD, Department of Psychiatry, Ohio State University College of Medicine,…
Cardiovascular and Immune Responses to Acute Psychological Stress in Young and Old Women: A Meta-Analysis
OBJECTIVE: To describe the relationships between cardiovascular and natural killer (NK) cell number changes on acute psychological stress in women. METHOD: Data from eight different studies were analyzed. A total of 128 healthy female subjects, 85 younger (18-45 years) and 43 older (49-87 years), had been subjected to a speech stressor (N = 80) or a mental effort stressor (N = 48), mental arithmetic, or the Stroop test. Correlations between chang…
Postmenopausal Hormone Replacement: Effects on Autonomic, Neuroendocrine, and Immune Reactivity to Brief Psychological Stressors
OBJECTIVE: Postmenopausal status increases some aspects of women's physiological responses to psychological stress; however, the influences of chronic hormone replacement with estrogen and progestogen on these responses are not known. We investigated possible effects of long-term estrogen replacement therapy (ERT), both with and without progestogen, on physiological reactivity to brief laboratory stressors. METHOD: We studied three groups of post…
Psychological influences on surgical recovery: Perspectives from psychoneuroimmunology
Greater fear or distress prior to surgery is associated with a slower and more complicated postoperative recovery. Although anxiety presumably interferes with recuperation through both behavioral and physiological mechanisms, the pathways have been unclear. Recent work in psychoneuroimmunology (PNI) has demonstrated that stress delays wound healing. In addition, a second line of research has illustrated the adverse effects of pain on endocrine an…
Marital Conflict in Older Adults: Endocrinological and Immunological Correlates
OBJECTIVE: To assess endocrinological and immunological correlates of marital conflict and marital satisfaction, 31 older couples (mean age 67 years) who had been married an average of 42 years were studied. METHOD: Couples were admitted to the Clinical Research Center and a catheter was placed in each subject's arm. Blood was drawn on entry for immunological assays; for hormone analyses, five blood samples were drawn during a 30-minute conflict …
Chronic stress alters the immune response to influenza virus vaccine in older adults.
To determine whether a chronic stressor (caregiving for a spouse with a progressive dementia) is associated with an impaired immune response to influenza virus vaccination, we compared 32 caregivers' vaccine responses with those of 32 sex-, age-, and socioeconomically matched control subjects. Caregivers showed a poorer antibody response following vaccination relative to control subjects as assessed by two independent methods, ELISA and hemagglut…
Psychosocial Modulation of Cytokine-Induced Natural Killer Cell Activity in Older Adults
The objective of this study was to address the cellular and psychological mechanisms underlying previously observed changes in natural killer (NK) cell cytotoxicity associated with chronic stress. We compared 28 current and former spousal caregivers of patients with Alzheimer's disease (AD) and 29 control subjects. NK cells were enriched (E-NK) using a 4-step procedure that resulted in a cell preparation consisting of 88.2% NK cells. These cells …
Heterogeneity in Neuroendocrine and Immune Responses to Brief PsychologicalStressors as a Function of Autonomic Cardiac Activation
Human responses to brief psychological stressors are characterized by changes and large individual differences in autonomic, neuroendocrine, and immune function. The authors examined the effects of brief psychological stressors on cardiovascular, neuroendocrine, and cellular immune response in 22 older women to investigate the common effects of stress across systems. They also used interindividual variation in heart rate reactivity, cardiac sympa…
Psychoneuroimmunology and Health Consequences: Data and Shared Mechanisms
There is evidence linking psychosocially mediated immunological alterations with cancer, infectious illness, and HIV progression. The data reviewed suggest that immune modulation by psychosocial stressors and/or interventions may importantly influence health status. The research literature also suggests that the impact of chronic stressors and psychosocial factors on sympathetic nervous system and endocrine function influences the immune system, …
The view from here: Rejoinder to Temoshok
The view from here: Rejoinder to Temoshok
Individual differences in cardiac sympathetic control predict endocrine and immune responses to acute psychological stress
Potential mechanisms coordinating individual differences in cardiovascular reactivity and endocrine and immune responses to acute psychological stress were examined. Twenty-three young, healthy women performed a mental arithmetic challenge while measures of cardiovascular, endocrine, and immune function were assessed. Results revealed that the acute stressor was associated with changes in the cardiovascular, endocrine, and immune systems. More im…
A biobehavioral model of cancer stress and disease course
Psychological influences on immunity: Implications for Aids
Stress Hormone Changes and Marital Conflict: Spouses' Relative Power Makes a Difference
We investigated the impact of relative marital power on 72 newlywed couples' endocrinological responses to marital conflict. Marital power was determined by comparing spouses' reports of dependent love for one another. Less powerful spouses displayed elevated adrenocorticotropic hormone (ACTH) responses to a conflict discussion. Shared power appeared to have a beneficial effect on wives' but not husbands' ACTH responses. Spouses' cortisol levels …
Psychological influences on surgical recovery: Perspectives from psychoneuroimmunology
Greater fear or distress prior to surgery is associated with a slower and more complicated postoperative recovery. Although anxiety presumably interferes with recuperation through both behavioral and physiological mechanisms, the pathways have been unclear. Recent work in psychoneuroimmunology (PNI) has demonstrated that stress delays wound healing. In addition, a second line of research has illustrated the adverse effects of pain on endocrine an…
Individual differences in cardiac sympathetic control predict endocrine and immune responses to acute psychological stress
Potential mechanisms coordinating individual differences in cardiovascular reactivity and endocrine and immune responses to acute psychological stress were examined. Twenty-three young, healthy women performed a mental arithmetic challenge while measures of cardiovascular, endocrine, and immune function were assessed. Results revealed that the acute stressor was associated with changes in the cardiovascular, endocrine, and immune systems. More im…
Psychosocial Modifiers of Immunocompetence in Medical Students
This study addressed the effects of a naturally occurring stressor on components of the immune response. Blood was drawn twice from 75 first-year medical students, with a baseline sample taken one month before their final examinations and a stress sample drawn on the first day of final examinations. Median splits on scores from the Holmes--Rahe Social Readjustment Rating Scale and the UCLA Loneliness Scale produced a 2 X 2 X 2 repeated measures A…
Urinary Cortisol Levels, Cellular Immunocompetency, and Loneliness in Psychiatric Inpatients
This study examined the associations among loneliness, stressful life events, urinary cortisol levels, and immunocompetency. Blood and urine were obtained from 33 psychiatric inpatients on the day after admission, at which time the patients completed the UCLA Loneliness Scale, the Psychiatric Epidemiology Research Interview Life Events Scale (PERI), and the MMPI. Patients who scored above the median on loneliness had significantly higher urinary …
Marital quality, marital disruption, and immune function
Marital disruption is associated with significant increases in a variety of psychologic and physical disorders. In order to examine psychologic and physiologic mediators, self-report data and blood samples were obtained from 38 married women and 38 separated/divorced women. Among married subjects, poorer marital quality was associated with greater depression and a poorer response on three qualitative measures of immune function. Women who had bee…
Chronic stress and immunity in family caregivers of Alzheimerʼs disease victims
Although acute stress has been associated with transient immunosuppression, little is known about the immunologic consequences of chronic stress in humans. In order to investigate possible health-related consequences of a long-term stressor, we obtained blood samples for immunologic and nutritional analyses and psychologic data from 34 family caregivers of Alzheimer's disease (AD) victims and 34 sociodemographically matched comparison subjects. F…
Disclosure of traumas and immune function: Health implications for psychotherapy.
Marital discord and immunity in males
While limited data suggest significant gender differences in mental and physical health risks following marital disruption, men have not been studied as intensively as women. In this study, self-report data and blood samples were obtained from 32 separated or divorced men and 32 sociodemographically matched married men. Separated/divorced men were more distressed and lonelier, and reported significantly more recent illness than did married men; t…
Psychological influences on immunity: Implications for Aids
Spousal caregivers of dementia victims: Longitudinal changes in immunity and health
Providing long-term care for a demented relative profoundly affects caregivers' lives. We assessed changes in depression, immune function, and health in 69 spousal caregivers who had already been caregiving for an average of five years and 69 sociodemographically matched control subjects. Between the initial sample ("intake") and the follow-up data collected an average of 13 months later, caregivers showed decrements relative to controls on three…
Stress-induced modulation of the immune response to recombinant hepatitis B vaccine
Each of a series of three hepatitis B (Hep B) inoculations was given to 48 second-year medical students on the 3rd day of a 3-day examination series to study the effect of academic stress on the ability to generate an immune response to a primary antigen. Those students who seroconverted after the first injection (25%) were significantly less stressed and anxious than those who did not seroconvert at that time. In addition, students who reported …
Acute psychological stressors and short-term immune changes: What, why, for whom, and to what extent
Negative behavior during marital conflict is associated with immunological down-regulation
Although increased morbidity and mortality have been reliably associated with social isolation and less satisfying personal relationships, relatively little is known about the underlying biopsychosocial mechanisms. We assessed problem-solving behaviors and changes in immune function in 90 newlywed couples who were admitted to a hospital research unit for 24 hours. Subjects who exhibited more negative or hostile behaviors during a 30-minute discus…
Hostile behavior during marital conflict alters pituitary and adrenal hormones
We evaluated hormonal changes and problem-solving behaviors in 90 newlywed couples who were admitted to a hospital research unit for 24 hours. The subjects were selected on the basis of stringent mental and physical health criteria, and admissions were scheduled during the follicular phase of the woman's menstrual cycle. For frequent, unobtrusive endocrine sampling during the interaction tasks, a long polyethylene tube was attached to a heparin w…
A biobehavioral model of cancer stress and disease course
Heterogeneity in Neuroendocrine and Immune Responses to Brief PsychologicalStressors as a Function of Autonomic Cardiac Activation
Human responses to brief psychological stressors are characterized by changes and large individual differences in autonomic, neuroendocrine, and immune function. The authors examined the effects of brief psychological stressors on cardiovascular, neuroendocrine, and cellular immune response in 22 older women to investigate the common effects of stress across systems. They also used interindividual variation in heart rate reactivity, cardiac sympa…
Psychoneuroimmunology and Health Consequences: Data and Shared Mechanisms
There is evidence linking psychosocially mediated immunological alterations with cancer, infectious illness, and HIV progression. The data reviewed suggest that immune modulation by psychosocial stressors and/or interventions may importantly influence health status. The research literature also suggests that the impact of chronic stressors and psychosocial factors on sympathetic nervous system and endocrine function influences the immune system, …
The view from here: Rejoinder to Temoshok
The view from here: Rejoinder to Temoshok
Individual differences in cardiac sympathetic control predict endocrine and immune responses to acute psychological stress
Potential mechanisms coordinating individual differences in cardiovascular reactivity and endocrine and immune responses to acute psychological stress were examined. Twenty-three young, healthy women performed a mental arithmetic challenge while measures of cardiovascular, endocrine, and immune function were assessed. Results revealed that the acute stressor was associated with changes in the cardiovascular, endocrine, and immune systems. More im…
Chronic stress alters the immune response to influenza virus vaccine in older adults.
To determine whether a chronic stressor (caregiving for a spouse with a progressive dementia) is associated with an impaired immune response to influenza virus vaccination, we compared 32 caregivers' vaccine responses with those of 32 sex-, age-, and socioeconomically matched control subjects. Caregivers showed a poorer antibody response following vaccination relative to control subjects as assessed by two independent methods, ELISA and hemagglut…
Psychosocial Modulation of Cytokine-Induced Natural Killer Cell Activity in Older Adults
The objective of this study was to address the cellular and psychological mechanisms underlying previously observed changes in natural killer (NK) cell cytotoxicity associated with chronic stress. We compared 28 current and former spousal caregivers of patients with Alzheimer's disease (AD) and 29 control subjects. NK cells were enriched (E-NK) using a 4-step procedure that resulted in a cell preparation consisting of 88.2% NK cells. These cells …
Marital Conflict in Older Adults: Endocrinological and Immunological Correlates
OBJECTIVE: To assess endocrinological and immunological correlates of marital conflict and marital satisfaction, 31 older couples (mean age 67 years) who had been married an average of 42 years were studied. METHOD: Couples were admitted to the Clinical Research Center and a catheter was placed in each subject's arm. Blood was drawn on entry for immunological assays; for hormone analyses, five blood samples were drawn during a 30-minute conflict …
Cardiovascular and Immune Responses to Acute Psychological Stress in Young and Old Women: A Meta-Analysis
OBJECTIVE: To describe the relationships between cardiovascular and natural killer (NK) cell number changes on acute psychological stress in women. METHOD: Data from eight different studies were analyzed. A total of 128 healthy female subjects, 85 younger (18-45 years) and 43 older (49-87 years), had been subjected to a speech stressor (N = 80) or a mental effort stressor (N = 48), mental arithmetic, or the Stroop test. Correlations between chang…
Postmenopausal Hormone Replacement: Effects on Autonomic, Neuroendocrine, and Immune Reactivity to Brief Psychological Stressors
OBJECTIVE: Postmenopausal status increases some aspects of women's physiological responses to psychological stress; however, the influences of chronic hormone replacement with estrogen and progestogen on these responses are not known. We investigated possible effects of long-term estrogen replacement therapy (ERT), both with and without progestogen, on physiological reactivity to brief laboratory stressors. METHOD: We studied three groups of post…
Psychological influences on surgical recovery: Perspectives from psychoneuroimmunology
Greater fear or distress prior to surgery is associated with a slower and more complicated postoperative recovery. Although anxiety presumably interferes with recuperation through both behavioral and physiological mechanisms, the pathways have been unclear. Recent work in psychoneuroimmunology (PNI) has demonstrated that stress delays wound healing. In addition, a second line of research has illustrated the adverse effects of pain on endocrine an…
Psychoneuroimmunology and Immunotoxicology: Implications for Carcinogenesis
From the Department of Psychiatry (J.K.K.-G.), Department of Medical Microbiology and Immunology (R.G.), the Ohio State Institute for Behavioral Medicine Research (J.K.K.-G., R.G.), and the Ohio State University Comprehensive Cancer Center (J.K.K.-G., R.G.); the Ohio State University College of Medicine, Columbus, Ohio. Address reprint requests to: Janice K. Kiecolt-Glaser, PhD, Department of Psychiatry, Ohio State University College of Medicine,…
Medicine (35 works) · Psychology (30 works) · Immunology (22 works) · Immune system (21 works) · Clinical Psychology (20 works) · Stress Responses and Cortisol (20 works) · Immunology (18 works) · Internal Medicine (18 works) · Internal Medicine (18 works) · Psychoneuroimmunology (15 works)