Sophie E Moore
Biographic Data
| ID | 3774066 |
|---|---|
| NAME | Sophie E Moore |
| GIVEN NAMES | Sophie E |
| FAMILY NAME | Moore |
| SIGNATURE | MOORE S E |
| AFFILIATIONS | King's College London |
| ORCID | 0000-0003-1650-3238 |
| VERIFIED | Yes |
| TOTAL WORKS | 26 |
| TOTAL CITATIONS | 7 |
| AUTHOR COUNT | 26 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1986 |
| LATEST PUBLICATION YEAR | 2025 |
| H-INDEX | 2 |
Community perspectives on maternal dietary diversity in rural Kenya, Mozambique and The Gambia
Pregnant and lactating women in sub-Saharan Africa are vulnerable to micronutrient inadequacies, with risk of adverse pregnancy outcomes. Adequate intakes of diverse foods are associated with better micronutrient status and recommended by the World Health Organization as part of healthy eating counselling during antenatal care. However, our understanding of community knowledge of dietary diversity within the context of maternal diets is limited. …
A Contextual Approach to Characterizing Caregiver Responsiveness in a Rural Area of The Gambia
Interactions with caregivers play a crucial role in early development. While most of the world's children live in Majority World countries, research on caregiving predominantly uses measures developed in the Minority World (particularly North America and Europe), potentially biasing characterizations of parenting in understudied populations. This study describes the development of the “Demba Yaal Interaction Scale (DYIS)”, a behavioral micro‐codi…
Cognitive control in infancy
Cognitive control is a predictor of later‐life outcomes and may underpin higher order executive processes. The present study examines the development of early cognitive control during the first 24‐month. We evaluated a tablet‐based assessment of cognitive control among infants aged 18‐ and 24‐month. We also examined concurrent and longitudinal associations between attentional disengagement, general cognitive skills and cognitive control. Particip…
Iron status in early infancy is associated with trajectories of cognitive development up to pre-school age in rural Gambia
Introduction Iron deficiency is among the leading risk factors for poor cognitive development. However, interventions targeting iron deficiency have had mixed results on cognitive outcomes. This may be due to previous interventions focusing on the correction of iron deficiency anaemia in late infancy and early childhood, at which point long lasting neural impacts may already be established. We hypothesise that the relationship between iron status…
Human milk immune factors, maternal nutritional status, and infant sex
OBJECTIVES: Breastfeeding is an energetically costly and intense form of human parental investment, providing sole-source nutrition in early infancy and bioactive components, including immune factors. Given the energetic cost of lactation, milk factors may be subject to tradeoffs, and variation in concentrations have been explored utilizing the Trivers-Willard hypothesis. As human milk immune factors are critical to developing immune system and p…
Caregiver perceptions of nutrition interventions in infants and children under 24 months of age
Objective: Efficacy studies show early nutrition interventions improving infant nutrition status, but understanding caregiver acceptability is required for implementation of such interventions. This systematic review examines caregivers’ perceptions of nutrition interventions in young children. Design: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, CINAHL and PsychINFO from date of online journal inception throug…
Neural Marker of Habituation at 5 Months of Age Associated with Deferred Imitation Performance at 12 Months
Across cultures, imitation provides a crucial route to learning during infancy. However, neural predictors which would enable early identification of infants at risk of suboptimal developmental outcomes are still rare. In this paper, we examine associations between ERP markers of habituation and novelty detection measured at 1 and 5 months of infant age in the UK ( n = 61) and rural Gambia ( n = 214) and infants' responses on a deferred imitation…
Seasonal modulation of antibody response to diphtheria-tetanus-pertussis vaccination in infants
Infant antibody response to the primary dose of the DTP vaccine was influenced by both season of pregnancy and infancy, although effects were diminished following three doses. Environmental exposures, including nutrition, to both the mother and infant are hypothesised as likely drivers of these seasonal effects
The missing focus on women’s health in the First 1,000 days approach to nutrition
The First 1,000 Days approach highlights the time between conception and a child’s second birthday as a critical period where adequate nutrition is essential for adequate development and growth throughout the child’s life and potentially onto their own offspring. Based on a review of relevant literature, this commentary explores the First 1,000 Days approach with a maternal lens. While the primary objective of the First 1,000 Days approach to nut…
How do we improve adolescent diet and physical activity in India and sub-Saharan Africa? Findings from the Transforming Adolescent Lives through Nutrition (Talent) consortium
Objective: Adolescent diet, physical activity and nutritional status are generally known to be sub-optimal. This is an introduction to a special issue of papers devoted to exploring factors affecting diet and physical activity in adolescents, including food insecure and vulnerable groups. Setting Eight settings including urban, peri-urban and rural across sites from five different low- and middle-income countries. Design: Focus groups with adoles…
Exploring influences on adolescent diet and physical activity in rural Gambia, West Africa
Objective: To explore, from the perspectives of adolescents and caregivers, and using qualitative methods, influences on adolescent diet and physical activity in rural Gambia. Design: Six focus group discussions (FGD) with adolescents and caregivers were conducted. Thematic analysis was employed across the data set. Setting: Rural region of The Gambia, West Africa. Participants: Participants were selected using purposive sampling. Four FGD, condu…
A Novel method for the identification and quantification of weight faltering
OBJECTIVE: We describe a new method for identifying and quantifying the magnitude and rate of short-term weight faltering episodes, and assess how (a) these episodes relate to broader growth outcomes, and (b) different data collection intervals influence the quantification of weight faltering. MATERIALS AND METHODS: We apply this method to longitudinal growth data collected every other day across the first year of life in Gambian infants (n = 124…
Interactions between the Physical and Social Environments with Adverse Pregnancy Events Related to Placental Disorders—A Scoping Review
More evidence is needed to determine the relationships between the environment and placental function in Africa. The results show that understanding the nature of the relationship between social determinants of health (SDH) and placental health outcomes plays a pivotal role in understanding the risk in the heterogenous communities in Africa
Using longitudinal data to understand nutrition and health interactions in rural Gambia
Context: Population-based cohort studies have been pivotal in establishing a number of nutrition-health interactions, especially in high-income settings. Less research is available from low- and middle-income countries due to the lack of detailed longitudinal data.Objective: To describe the use of prospectively collected longitudinal data from the rural West Kiang region of The Gambia to explore nutrition-health interactions in a rural sub-Sahara…
Behind the cloak of competence
Purpose Brain Injury Case Managers (BICMs) work closely with individuals with Acquired Brain Injury (ABI), assessing needs, structuring rehabilitation interventions and providing support, and have significant experience of clients with impairments to decision making. The purpose of this paper is to explore the application of the Mental Capacity Act (MCA) and its guidance when applied to ABI survivors. This research aimed to: first, highlight pote…
Household composition and the infant fecal microbiome
OBJECTIVES: Establishment and development of the infant gastrointestinal microbiome (GIM) varies cross-culturally and is thought to be influenced by factors such as gestational age, birth mode, diet, and antibiotic exposure. However, there is little data as to how the composition of infants' households may play a role, particularly from a cross-cultural perspective. Here, we examined relationships between infant fecal microbiome (IFM) diversity/c…
Impaired growth in rural Gambian infants exposed to aflatoxin
This study found a small but significant effect of aflatoxin exposure on the growth of Gambian infants. This relationship is not apparently explained by aflatoxin induced changes in the IGF-axis
The influence of maternal psychosocial circumstances and physical environment on the risk of severe wasting in rural Gambian infants
In rural Gambia, inappropriate infant feeding practices were associated with severe wasting in infants. Additionally, adverse psychosocial circumstances and infant feeding difficulties constrain mothers from practising the recommended child care practices. Interventions that promote maternal resilience through gender empowerment, prioritising maternal psychosocial support and encouraging the involvement of fathers in infant and child care promoti…
Consequences of bullying victimization in childhood and adolescence
Understanding and acting on the developmental origins of health and disease in Africa would improve health across generations
Data from many high- and low- or middle-income countries have linked exposures during key developmental periods (in particular pregnancy and infancy) to later health and disease. Africa faces substantial challenges with persisting infectious disease and now burgeoning non-communicable disease.This paper opens the debate to the value of strengthening the developmental origins of health and disease (DOHaD) research focus in Africa to tackle critica…
Association of prenatal lipid‐based nutritional supplementation with fetal growth in rural Gambia
Prenatal supplementation with protein-energy (PE) and/or multiple-micronutrients (MMNs) may improve fetal growth, but trials of lipid-based nutritional supplements (LNSs) have reported inconsistent results. We conducted a post-hoc analysis of non-primary outcomes in a trial in Gambia, with the aim to test the associations of LNS with fetal growth and explore how efficacy varies depending on nutritional status. The sample comprised 620 pregnant wo…
Endocrine responses, weight change, and energy sparing mechanisms during Ramadan among Gambian adolescent women
Even using energy sparing behaviors, adolescent women enter negative energy balance when Ramadan and the agricultural season co-occur. Metabolic physiology shows a transient response to high glycemic index foods consumed at night. Older and larger individuals sustain greater losses during Ramadan
Nutritional status and childhood wheezing in rural Bangladesh
Objective To investigate the association between current childhood nutritional status and current wheezing among pre-school children in rural Bangladesh. Design Cross-sectional study. Setting Matlab region, rural Bangladesh. Subjects Children ( n 912) aged 4·5 years. Anthropometric measurements of the mothers and their children were taken during a 1-year period from December 2007 to November 2008. Current wheezing was identified using the Interna…
Critical windows for nutritional interventions against stunting
Birth weight, season of birth and postnatal growth do not predict levels of systemic inflammation in gambian adults
OBJECTIVES: Studies testing whether systemic inflammation might lie on the causal pathway between aberrant fetal and post-natal growth patterns and later cardiovascular disease have been inconclusive, possibly due to the use of single markers of unknown predictive value. We used repeated measures of a comprehensive set of inflammatory markers to investigate the relationship between early life measures and systemic inflammation in an African popul…
Household composition and the infant fecal microbiome
OBJECTIVES: Establishment and development of the infant gastrointestinal microbiome (GIM) varies cross-culturally and is thought to be influenced by factors such as gestational age, birth mode, diet, and antibiotic exposure. However, there is little data as to how the composition of infants' households may play a role, particularly from a cross-cultural perspective. Here, we examined relationships between infant fecal microbiome (IFM) diversity/c…
Behind the cloak of competence
Purpose Brain Injury Case Managers (BICMs) work closely with individuals with Acquired Brain Injury (ABI), assessing needs, structuring rehabilitation interventions and providing support, and have significant experience of clients with impairments to decision making. The purpose of this paper is to explore the application of the Mental Capacity Act (MCA) and its guidance when applied to ABI survivors. This research aimed to: first, highlight pote…
The impact of 'Bottle Bill' legislation on the incidence of lacerations in childhood
We studied the effect of legislation requiring deposits for beverage containers on the incidence of lacerations in urban children. Records of emergency room visits for lacerations and fractures were reviewed for three years pre-legislation (1980-82) and the immediate post-legislation period (1983). The incidence of total sutured lacerations did not change substantially after the legislation, but glass-related lacerations fell by 60 per cent, due …
Critical windows for nutritional interventions against stunting
Birth weight, season of birth and postnatal growth do not predict levels of systemic inflammation in gambian adults
OBJECTIVES: Studies testing whether systemic inflammation might lie on the causal pathway between aberrant fetal and post-natal growth patterns and later cardiovascular disease have been inconclusive, possibly due to the use of single markers of unknown predictive value. We used repeated measures of a comprehensive set of inflammatory markers to investigate the relationship between early life measures and systemic inflammation in an African popul…
Endocrine responses, weight change, and energy sparing mechanisms during Ramadan among Gambian adolescent women
Even using energy sparing behaviors, adolescent women enter negative energy balance when Ramadan and the agricultural season co-occur. Metabolic physiology shows a transient response to high glycemic index foods consumed at night. Older and larger individuals sustain greater losses during Ramadan
Nutritional status and childhood wheezing in rural Bangladesh
Objective To investigate the association between current childhood nutritional status and current wheezing among pre-school children in rural Bangladesh. Design Cross-sectional study. Setting Matlab region, rural Bangladesh. Subjects Children ( n 912) aged 4·5 years. Anthropometric measurements of the mothers and their children were taken during a 1-year period from December 2007 to November 2008. Current wheezing was identified using the Interna…
Association of prenatal lipid‐based nutritional supplementation with fetal growth in rural Gambia
Prenatal supplementation with protein-energy (PE) and/or multiple-micronutrients (MMNs) may improve fetal growth, but trials of lipid-based nutritional supplements (LNSs) have reported inconsistent results. We conducted a post-hoc analysis of non-primary outcomes in a trial in Gambia, with the aim to test the associations of LNS with fetal growth and explore how efficacy varies depending on nutritional status. The sample comprised 620 pregnant wo…
Consequences of bullying victimization in childhood and adolescence
Understanding and acting on the developmental origins of health and disease in Africa would improve health across generations
Data from many high- and low- or middle-income countries have linked exposures during key developmental periods (in particular pregnancy and infancy) to later health and disease. Africa faces substantial challenges with persisting infectious disease and now burgeoning non-communicable disease.This paper opens the debate to the value of strengthening the developmental origins of health and disease (DOHaD) research focus in Africa to tackle critica…
Impaired growth in rural Gambian infants exposed to aflatoxin
This study found a small but significant effect of aflatoxin exposure on the growth of Gambian infants. This relationship is not apparently explained by aflatoxin induced changes in the IGF-axis
The influence of maternal psychosocial circumstances and physical environment on the risk of severe wasting in rural Gambian infants
In rural Gambia, inappropriate infant feeding practices were associated with severe wasting in infants. Additionally, adverse psychosocial circumstances and infant feeding difficulties constrain mothers from practising the recommended child care practices. Interventions that promote maternal resilience through gender empowerment, prioritising maternal psychosocial support and encouraging the involvement of fathers in infant and child care promoti…
Behind the cloak of competence
Purpose Brain Injury Case Managers (BICMs) work closely with individuals with Acquired Brain Injury (ABI), assessing needs, structuring rehabilitation interventions and providing support, and have significant experience of clients with impairments to decision making. The purpose of this paper is to explore the application of the Mental Capacity Act (MCA) and its guidance when applied to ABI survivors. This research aimed to: first, highlight pote…
Household composition and the infant fecal microbiome
OBJECTIVES: Establishment and development of the infant gastrointestinal microbiome (GIM) varies cross-culturally and is thought to be influenced by factors such as gestational age, birth mode, diet, and antibiotic exposure. However, there is little data as to how the composition of infants' households may play a role, particularly from a cross-cultural perspective. Here, we examined relationships between infant fecal microbiome (IFM) diversity/c…
Interactions between the Physical and Social Environments with Adverse Pregnancy Events Related to Placental Disorders—A Scoping Review
More evidence is needed to determine the relationships between the environment and placental function in Africa. The results show that understanding the nature of the relationship between social determinants of health (SDH) and placental health outcomes plays a pivotal role in understanding the risk in the heterogenous communities in Africa
Using longitudinal data to understand nutrition and health interactions in rural Gambia
Context: Population-based cohort studies have been pivotal in establishing a number of nutrition-health interactions, especially in high-income settings. Less research is available from low- and middle-income countries due to the lack of detailed longitudinal data.Objective: To describe the use of prospectively collected longitudinal data from the rural West Kiang region of The Gambia to explore nutrition-health interactions in a rural sub-Sahara…
Seasonal modulation of antibody response to diphtheria-tetanus-pertussis vaccination in infants
Infant antibody response to the primary dose of the DTP vaccine was influenced by both season of pregnancy and infancy, although effects were diminished following three doses. Environmental exposures, including nutrition, to both the mother and infant are hypothesised as likely drivers of these seasonal effects
The missing focus on women’s health in the First 1,000 days approach to nutrition
The First 1,000 Days approach highlights the time between conception and a child’s second birthday as a critical period where adequate nutrition is essential for adequate development and growth throughout the child’s life and potentially onto their own offspring. Based on a review of relevant literature, this commentary explores the First 1,000 Days approach with a maternal lens. While the primary objective of the First 1,000 Days approach to nut…
How do we improve adolescent diet and physical activity in India and sub-Saharan Africa? Findings from the Transforming Adolescent Lives through Nutrition (Talent) consortium
Objective: Adolescent diet, physical activity and nutritional status are generally known to be sub-optimal. This is an introduction to a special issue of papers devoted to exploring factors affecting diet and physical activity in adolescents, including food insecure and vulnerable groups. Setting Eight settings including urban, peri-urban and rural across sites from five different low- and middle-income countries. Design: Focus groups with adoles…
Exploring influences on adolescent diet and physical activity in rural Gambia, West Africa
Objective: To explore, from the perspectives of adolescents and caregivers, and using qualitative methods, influences on adolescent diet and physical activity in rural Gambia. Design: Six focus group discussions (FGD) with adolescents and caregivers were conducted. Thematic analysis was employed across the data set. Setting: Rural region of The Gambia, West Africa. Participants: Participants were selected using purposive sampling. Four FGD, condu…
A Novel method for the identification and quantification of weight faltering
OBJECTIVE: We describe a new method for identifying and quantifying the magnitude and rate of short-term weight faltering episodes, and assess how (a) these episodes relate to broader growth outcomes, and (b) different data collection intervals influence the quantification of weight faltering. MATERIALS AND METHODS: We apply this method to longitudinal growth data collected every other day across the first year of life in Gambian infants (n = 124…
Neural Marker of Habituation at 5 Months of Age Associated with Deferred Imitation Performance at 12 Months
Across cultures, imitation provides a crucial route to learning during infancy. However, neural predictors which would enable early identification of infants at risk of suboptimal developmental outcomes are still rare. In this paper, we examine associations between ERP markers of habituation and novelty detection measured at 1 and 5 months of infant age in the UK ( n = 61) and rural Gambia ( n = 214) and infants' responses on a deferred imitation…
Iron status in early infancy is associated with trajectories of cognitive development up to pre-school age in rural Gambia
Introduction Iron deficiency is among the leading risk factors for poor cognitive development. However, interventions targeting iron deficiency have had mixed results on cognitive outcomes. This may be due to previous interventions focusing on the correction of iron deficiency anaemia in late infancy and early childhood, at which point long lasting neural impacts may already be established. We hypothesise that the relationship between iron status…
Human milk immune factors, maternal nutritional status, and infant sex
OBJECTIVES: Breastfeeding is an energetically costly and intense form of human parental investment, providing sole-source nutrition in early infancy and bioactive components, including immune factors. Given the energetic cost of lactation, milk factors may be subject to tradeoffs, and variation in concentrations have been explored utilizing the Trivers-Willard hypothesis. As human milk immune factors are critical to developing immune system and p…
Caregiver perceptions of nutrition interventions in infants and children under 24 months of age
Objective: Efficacy studies show early nutrition interventions improving infant nutrition status, but understanding caregiver acceptability is required for implementation of such interventions. This systematic review examines caregivers’ perceptions of nutrition interventions in young children. Design: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, CINAHL and PsychINFO from date of online journal inception throug…
Cognitive control in infancy
Cognitive control is a predictor of later‐life outcomes and may underpin higher order executive processes. The present study examines the development of early cognitive control during the first 24‐month. We evaluated a tablet‐based assessment of cognitive control among infants aged 18‐ and 24‐month. We also examined concurrent and longitudinal associations between attentional disengagement, general cognitive skills and cognitive control. Particip…
Community perspectives on maternal dietary diversity in rural Kenya, Mozambique and The Gambia
Pregnant and lactating women in sub-Saharan Africa are vulnerable to micronutrient inadequacies, with risk of adverse pregnancy outcomes. Adequate intakes of diverse foods are associated with better micronutrient status and recommended by the World Health Organization as part of healthy eating counselling during antenatal care. However, our understanding of community knowledge of dietary diversity within the context of maternal diets is limited. …
Medicine (21 works) · Child Nutrition and Water Access (14 works) · Environmental health (11 works) · Pediatrics (9 works) · Psychology (9 works) · Internal Medicine (7 works) · Psychological intervention (7 works) · Gerontology (6 works) · Population (6 works) · Pregnancy (6 works)