Michael A Province
Biographic Data
| ID | 3862424 |
|---|---|
| NAME | Michael A Province |
| GIVEN NAMES | Michael A |
| FAMILY NAME | Province |
| SIGNATURE | PROVINCE M A |
| AFFILIATIONS | Washington University in St. Louis |
| ORCID | 0000-0001-6102-774X |
| VERIFIED | Yes |
| TOTAL WORKS | 11 |
| TOTAL CITATIONS | 24 |
| WORKS AS AUTHOR | 11 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 1990 |
| LATEST PUBLICATION YEAR | 2022 |
| H-INDEX | 1 |
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half th…
Combined Effect of Lead Exposure and Allostatic Load on Cardiovascular Disease Mortality—A Preliminary Study
This study explores the combined effect of lead (Pb) exposure and an index of chronic physiological stress on cardiovascular disease mortality using data from the National Health and Nutrition Examination Survey (NHANES) 1999-2008 linked to 1999-2014 National Death Index data. Chronic physiological stress was measured using the allostatic load (AL) index, which was formed by analyzing markers from the cardiovascular, inflammatory, and metabolic s…
Genetic evidence of assortative mating in humans
Genome-wide association study identifies 74 loci associated with educational attainment
Genetic Structure, Self-Identified Race/Ethnicity, and Confounding in Case-Control Association Studies
Familial resemblance in fatness and fat distribution
The purpose of the study was to estimate the degree of familial resemblance in anthropometric indicators of fatness and fat distribution. The sample consisted of 327 Caucasian participants from 102 nuclear families. Indicators of fatness included the body mass index (BMI), the sum of six skinfolds (SF6: triceps + biceps + medial calf + subscapular + suprailiac + abdominal), and waist circumference (WAIST), while indicators of fat distribution inc…
Familial Resemblance for Hostility
OBJECTIVE: The purpose of this study was to examine whether several aspects of hostility as measured by the Cook-Medley Hostility Scale (ie, aggressive responding, hostile affect, cynicism, and overall hostility score) were determined in part by family factors (ie, genes and/or familial environments). METHODS: Analyses were based on 680 European-American families (2525 individuals) from the NHLBI Family Heart Study (FHS), a population-based study…
Selected antepartum medical complications and very-low-birthweight infants among black and white women
This study estimated the risk of very-low-birthweight delivery among Black and White women with selected treatable antepartum medical conditions. A logistic regression model was applied to a retrospective, population-based data set identified by computerized, linked birth certificate and maternal hospital discharge records. For Black mothers, the adjusted odds ratio for very-low-birthweight delivery was statistically significant for essential hyp…
Heterogeneity among populations for familial aggregation of blood pressure
A simple model of familial aggregation was applied to age–sex corrected systolic (SBP) and diastolic (DBP) blood pressure data from two separate studies: The Québec Family Study and the Tecumseh Community Health Study. Examination of the familial correlations suggested heterogeneity across studies in all DBP correlations, but for SBP only spouse correlations were higher in Québec. Fitting the path model to the data revealed that the only source o…
A commingling analysis of obesity in the Tecumseh community health study
A commingling analysis of the distributions of obesity as quantified by Quetelet's index, triceps skinfold, suprailiac skinfold, umbilical skinfold, subscapular skinfold, a trunk‐extremity ratio of skinfold measurements and Quetelet‐adjusted trunk‐extremity ratio was performed in a population of 9,226 individuals living in Tecumseh, Michigan, during 1962–1965. For all but the (non‐Quetelet‐adjusted) trunk‐extremity ratio, two or three distributio…
Commingling analysis of blood pressure in the Tecumseh community health study
A commingling analysis of the distribution of systolic and diastolic blood pressure was performed on measurements from 9,226 individuals living in Tecumseh, Michigan during 1962–1965. Even after correcting for skewness in the distributions, multiple normal distributions fit the data significantly better than a single normal one, suggesting some level of commingling. The exact nature of the components differed depending on the phenotype, and the n…
Genetic evidence of assortative mating in humans
Selected antepartum medical complications and very-low-birthweight infants among black and white women
This study estimated the risk of very-low-birthweight delivery among Black and White women with selected treatable antepartum medical conditions. A logistic regression model was applied to a retrospective, population-based data set identified by computerized, linked birth certificate and maternal hospital discharge records. For Black mothers, the adjusted odds ratio for very-low-birthweight delivery was statistically significant for essential hyp…
Commingling analysis of blood pressure in the Tecumseh community health study
A commingling analysis of the distribution of systolic and diastolic blood pressure was performed on measurements from 9,226 individuals living in Tecumseh, Michigan during 1962–1965. Even after correcting for skewness in the distributions, multiple normal distributions fit the data significantly better than a single normal one, suggesting some level of commingling. The exact nature of the components differed depending on the phenotype, and the n…
Heterogeneity among populations for familial aggregation of blood pressure
A simple model of familial aggregation was applied to age–sex corrected systolic (SBP) and diastolic (DBP) blood pressure data from two separate studies: The Québec Family Study and the Tecumseh Community Health Study. Examination of the familial correlations suggested heterogeneity across studies in all DBP correlations, but for SBP only spouse correlations were higher in Québec. Fitting the path model to the data revealed that the only source o…
A commingling analysis of obesity in the Tecumseh community health study
A commingling analysis of the distributions of obesity as quantified by Quetelet's index, triceps skinfold, suprailiac skinfold, umbilical skinfold, subscapular skinfold, a trunk‐extremity ratio of skinfold measurements and Quetelet‐adjusted trunk‐extremity ratio was performed in a population of 9,226 individuals living in Tecumseh, Michigan, during 1962–1965. For all but the (non‐Quetelet‐adjusted) trunk‐extremity ratio, two or three distributio…
Selected antepartum medical complications and very-low-birthweight infants among black and white women
This study estimated the risk of very-low-birthweight delivery among Black and White women with selected treatable antepartum medical conditions. A logistic regression model was applied to a retrospective, population-based data set identified by computerized, linked birth certificate and maternal hospital discharge records. For Black mothers, the adjusted odds ratio for very-low-birthweight delivery was statistically significant for essential hyp…
Familial resemblance in fatness and fat distribution
The purpose of the study was to estimate the degree of familial resemblance in anthropometric indicators of fatness and fat distribution. The sample consisted of 327 Caucasian participants from 102 nuclear families. Indicators of fatness included the body mass index (BMI), the sum of six skinfolds (SF6: triceps + biceps + medial calf + subscapular + suprailiac + abdominal), and waist circumference (WAIST), while indicators of fat distribution inc…
Familial Resemblance for Hostility
OBJECTIVE: The purpose of this study was to examine whether several aspects of hostility as measured by the Cook-Medley Hostility Scale (ie, aggressive responding, hostile affect, cynicism, and overall hostility score) were determined in part by family factors (ie, genes and/or familial environments). METHODS: Analyses were based on 680 European-American families (2525 individuals) from the NHLBI Family Heart Study (FHS), a population-based study…
Genetic Structure, Self-Identified Race/Ethnicity, and Confounding in Case-Control Association Studies
Genome-wide association study identifies 74 loci associated with educational attainment
Genetic evidence of assortative mating in humans
Combined Effect of Lead Exposure and Allostatic Load on Cardiovascular Disease Mortality—A Preliminary Study
This study explores the combined effect of lead (Pb) exposure and an index of chronic physiological stress on cardiovascular disease mortality using data from the National Health and Nutrition Examination Survey (NHANES) 1999-2008 linked to 1999-2014 National Death Index data. Chronic physiological stress was measured using the allostatic load (AL) index, which was formed by analyzing markers from the cardiovascular, inflammatory, and metabolic s…
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12–16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half th…
Biology (8 works) · Medicine (7 works) · Demography (6 works) · Genetic Associations and Epidemiology (6 works) · Population (6 works) · Genetics (4 works) · Internal Medicine (4 works) · Birth, Development, and Health (3 works) · Environmental health (3 works) · Gene (3 works)