Henrik Larsson
Dados Biográficos
| ID | 3862834 |
|---|---|
| NOME | Henrik Larsson |
| PRENOMES | Henrik |
| SOBRENOME | Larsson |
| ASSINATURA | LARSSON H |
| AFILIAÇÕES | Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden |
| ORCID | 0000-0002-6851-3297 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 45 |
| TOTAL DE CITAÇÕES | 14 |
| TOTAL COMO AUTOR | 45 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 2016 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2026 |
| ÍNDICE H | 2 |
Neighborhood social structure, criminal convictions, and substance use disorders in Sweden
PURPOSE: We investigated how multidimensional neighborhood types, capturing the complexity of neighborhood social structure, related to criminal convictions and substance use disorders (SUDs) in Sweden while accounting for residential mobility and shared familial influences. METHODS: Using nationwide Swedish register data (1991-2020), we followed 1.82 million individuals born 1985-2002 across five neighborhood types previously identified using la…
Parental incarceration and psychiatric disorders, suicidal behavior, risk‐taking, and substance misuse events in offspring
BACKGROUND: Parental incarceration (PI) is associated with mental and behavioral problems in offspring, but causality remains unclear. We conducted a quasi-experimental within-individual study on the associations of PI with offspring psychiatric disorders, suicidal behavior, risk-taking, and substance misuse events, aiming to test the effect of PI on offspring. METHODS: The study included 43,011 and 5,912 individuals born in Sweden 1973-2010 and …
Subclinical hypomania, psychiatric and neurodevelopmental diagnoses
BACKGROUND: Subclinical hypomanic symptoms are fairly common in the general population but are linked to psychiatric and neurodevelopmental conditions. However, the genetic and environmental origins of these associations are unclear. This twin study examined the phenotypic and aetiological associations between subclinical hypomania and psychiatric and neurodevelopmental diagnoses. METHODS: Participants were 4,932 twin pairs from the Child and Ado…
Does the family situation impact academic achievement differently in students with versus without neurodevelopmental disorders
BACKGROUND: Youth with neurodevelopmental disorders are at risk for school failure, but little is known about the contextual factors influencing academic achievement. AIMS: Drawing on a bioecological system framework, we examined how ADHD and autism, parental educational attainment and aspects of the parent-child relationship influence educational achievement at the end of primary school, and to what extent these factors have independent as oppos…
Mortality in offspring with parental criminal convictions
Background: Parental offending behavior is associated with poorer child mental and physical health, but less in known about its association with child mortality. Further, research is focused on the United States, which is unique in its societal structure and mass incarceration. Methods: Using population-based register data on all births in Sweden in 1973-2013 (N = 4.2 million) and Cox regressions, we examined the associations of mother's and fath…
Neurodevelopmental and psychiatric conditions in 600 Swedish children with the avoidant/restrictive food intake disorder phenotype
BACKGROUND: Avoidant restrictive food intake disorder (ARFID) is a feeding and eating disorder characterized by extremely restricted dietary variety and/or quantity resulting in serious consequences for physical health and psychosocial functioning. ARFID often co-occurs with neurodevelopmental conditions (NDCs) and psychiatric conditions, but previous data are mostly limited to small clinical samples examining a narrow range of conditions. Here, …
Predictors of preschool attention‐deficit/hyperactivity disorder diagnosis
BACKGROUND: The diagnosis of attention-deficit/hyperactivity disorder (ADHD) in preschool years (before age 6 years) is a marker of severity and poor prognosis. This study investigated a broad range of predictors of ADHD diagnosis during preschool age. METHODS: Population-based cohort study using Swedish registers. The final sample consisted of all children born in Sweden between 2001 and 2007 who could be linked to both of their biological paren…
Sex differences in psychiatric diagnoses preceding autism diagnosis and their stability post autism diagnosis
Background Autistic individuals often receive psychiatric diagnoses prior to their autism diagnosis. It remains unclear to what extent autistic females and males differ in their likelihood of receiving psychiatric diagnoses prior to their autism diagnosis and continue seeking care for them after an autism diagnosis. Methods In a nationwide cohort of all individuals born in Sweden 1990–2015 with a clinical autism diagnosis ( N = 72,331, n females …
Brain reserve in memory regions is associated with the preservation of autobiographical memories after electroconvulsive therapy
These early findings suggest that a pre-ECT neural reserve in the brain regions subserving memory might act protectively against the development of autobiographical memory loss after ECT. If replicated in larger samples, our findings may have promising clinical implications as a structural MRI scan prior to ECT might contribute to determining the individual risk of autobiographical memory loss following ECT
High resting heart rate reduces risk of white-collar criminality
Neighborhood social structure in Sweden
Background Neighborhoods shape daily life through physical and social structures, such as socioeconomic conditions, population density, and resident turnover. Decades of research link neighborhood characteristics to health and behavioral outcomes. However, these factors are often studied independently, neglecting their interrelated nature. Methods Using Swedish population registry data, we employed latent class analyses to identify neighborhood t…
Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes
Individual sensitivity to environmental exposures may be genetically influenced. This genotype-by-environment interplay implies differences in phenotypic variance across genotypes, but these variants have proven challenging to detect. Genome-wide association studies of monozygotic twin differences are conducted through family-based variance analyses, which are more robust to the systemic biases that impact population-based methods. We combined da…
Childhood and adolescence outcomes in offspring to parents with bipolar disorder
BACKGROUND: Offspring of parents with bipolar disorder have increased risks of their own psychopathology. However, a large-scale survey of psychiatric, somatic, and adverse social outcomes up to adulthood, which could aid in prioritizing and tailoring prevention, is lacking. It also remains to clarify how risks are modified by other parental factors. METHODS: Swedish population registers were linked to compare offspring having (N = 24,788) and no…
Age effects on autism heritability and etiological stability of autistic traits
BACKGROUND: Autism and autistic traits onset in childhood but persist into adulthood. Little is known about how genetic and environmental factors influence autism and autistic traits into adulthood. We aimed to determine age effects on the heritability of clinically diagnosed autism and the etiological stability of autistic traits from childhood to adulthood using twin methods. METHODS: From 23,849 twin pairs in the Swedish Twin Register born bet…
The association between depression and crime outcomes
Research on the association between depression and crime is limited regarding different types of crime and severity of crime. Using Swedish national register data, we explored the association between depression and various crime outcomes and the severity of crime. We identified 72,057 individuals with an outpatient depression diagnosis between 2001 and 2013. Individuals with depression were age-, sex-, and socioeconomic status (SES)-matched to un…
Resting heart rate as a risk and protective factor for intrapersonal violence
Low resting heart rate (RHR) is a well-replicated biological correlate of interpersonal violence (i.e., violence against others). However, there is limited research examining the relationship between RHR and intrapersonal violence (i.e., violence against oneself). Using Swedish population-based data, this study examined the relationship between RHR and suicide, an extreme form of intrapersonal violence, among individuals with no convictions ( n =…
Evidence for intergenerational transmission of biological risk for antisocial behavior
A twin study of genetic and environmental contributions to attention‐deficit/hyperactivity disorder over time
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is an increasingly commonly diagnosed neurodevelopmental condition. One possibility is that this reflects a genuine increase in the prevalence of ADHD due to secular environmental changes, yet this hypothesis remains untested. We therefore investigated whether the genetic and environmental variance underlying ADHD, and traits of ADHD, has changed over time. METHODS: We identified twins b…
Melatonin use and the risk of self‐harm and unintentional injuries in youths with and without psychiatric disorders
BACKGROUND: Sleep disorders in youth have been associated with increased risks of injury, including suicidal behavior. This study investigated whether melatonin, which is the most common medication for sleep disturbances in youth in Sweden, is associated with a decreased risk of injury. METHODS: This population-based cohort study included 25,575 youths who initiated melatonin treatment between ages 6 and 18. Poisson regression was used to estimat…
A population-based study of unintentional injury and premature death among non-imprisoned and imprisoned youth offenders
Our study shows there are robust modifiable childhood risk factors for injury and mortality among youth offenders. However, the importance of them to assess risk may differ between non-imprisoned and imprisoned youth offenders
Psychiatric diagnoses and criminal convictions in youth
Psychiatric diagnoses are important risk factors for criminal convictions, but few longitudinal studies have examined comorbidity patterns in relation to youth criminal convictions. To explore associations between specific psychiatric diagnoses (substance use disorder (SUD), ADHD, depression, PTSD, intellectual disabilities (ID), and autism spectrum disorders (ASD)) and comorbidities of internalizing, externalizing, or neurodevelopmental diagnose…
Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs
Background Although polygenic risk scores (PRS) predict psychiatric problems, these associations might be attributable to indirect pathways including population stratification, assortative mating, or dynastic effects (mediation via parental environments). The goal of this study was to examine whether PRS‐psychiatric symptom associations were attributable to indirect versus direct pathways. Methods The sample consisted of 3,907 dizygotic (DZ) twin…
Perceived child impairment and the ‘autism epidemic’
BACKGROUND: The prevalence of diagnosed Autism Spectrum Disorder (ASD) has increased substantially across the world. Much - or even most - prevalence increase seems to reflect changes in diagnostic practice and ascertainment. A key part of ASD assessment is to document that the relevant symptoms are associated with clinical impairment. The aim of the present study is to capitalize on a nationwide longitudinal study spanning 15 consecutive birth y…
Shared familial risk factors between autism spectrum disorder and obesity – a register‐based familial coaggregation cohort study
BACKGROUND: Meta-analyses suggest an association between autism spectrum disorder (ASD) and obesity, but the factors underlying this association remain unclear. This study investigated the association between ASD and obesity stratified on intellectual disability (ID). In addition, in order to gain insight into possible shared etiological factors, the potential role of shared familial liability was examined. METHOD: We studied a cohort of 3,141,69…
How interactions between ADHD and schools affect educational achievement
BACKGROUND: Children with ADHD tend to achieve less than their peers in school. It is unknown whether schools moderate this association. Nonrandom selection of children into schools related to variations in their ADHD risk poses a methodological problem. METHODS: We linked data on ADHD symptoms of inattention and hyperactivity and parent-child ADHD polygenic scores (PGS) from the Norwegian Mother, Father, and Child Cohort Study (MoBa) to achievem…
Body dissatisfaction in adolescent boys
Body dissatisfaction is a significant mental health symptom present in adolescent girls and boys. However, it is often either disregarded in adolescent boys or examined using assessments that may not resonate with males. The present study addresses these issues, examining the manifestation, etiology, and correlates of 3 facets of body dissatisfaction in adolescent boys. Adolescent male twins aged 16- to 17-years-old from the Swedish Twin Study of…
Adverse perinatal events and offspring criminal convictions in men and women
We examined associations of adverse perinatal events with offspring violent and non-violent criminal convictions in men and women. All singleton births between 1973 and 1995 (n = 1,146,570 men, n = 1,085,217 women) were identified through Swedish population-based registers. Information about adverse perinatal events was retrieved from the Medical Birth Register. Outcomes were criminal convictions collected from the National Crime Register. We est…
Prediction of reoffending risk in men convicted of sexual offences
Scalable evidence-based risk assessment tools for sexual offenders in the criminal justice system and forensic mental health could assist decision-making and treatment allocation by identifying those at higher risk, and screening out low risk persons
A genetically informed Registered Report on adverse childhood experiences and mental health
Children who experience adversities have an elevated risk of mental health problems. However, the extent to which adverse childhood experiences (ACEs) cause mental health problems remains unclear, as previous associations may partly reflect genetic confounding. In this Registered Report, we used DNA from 11,407 children from the United Kingdom and the United States to investigate gene–environment correlations and genetic confounding of the associ…
Psychiatric diagnoses and criminal convictions in youth
Psychiatric diagnoses are important risk factors for criminal convictions, but few longitudinal studies have examined comorbidity patterns in relation to youth criminal convictions. To explore associations between specific psychiatric diagnoses (substance use disorder (SUD), ADHD, depression, PTSD, intellectual disabilities (ID), and autism spectrum disorders (ASD)) and comorbidities of internalizing, externalizing, or neurodevelopmental diagnose…
Premature mortality in autism spectrum disorder
BACKGROUND: Mortality has been suggested to be increased in autism spectrum disorder (ASD). AIMS: To examine both all-cause and cause-specific mortality in ASD, as well as investigate moderating role of gender and intellectual ability. METHOD: Odds ratios (ORs) were calculated for a population-based cohort of ASD probands (n = 27,122, diagnosed between 1987 and 2009) compared with gender-, age- and county of residence-matched controls (n = 2,672,…
Live fast, die young? A review on the developmental trajectories of ADHD across the lifespan
Attention-deficit/hyperactivity disorder (ADHD) is highly heritable and the most common neurodevelopmental disorder in childhood. In recent decades, it has been appreciated that in a substantial number of cases the disorder does not remit in puberty, but persists into adulthood. Both in childhood and adulthood, ADHD is characterised by substantial comorbidity including substance use, depression, anxiety, and accidents. However, course and symptom…
Genetics of attention deficit hyperactivity disorder
Decades of research show that genes play an vital role in the etiology of attention deficit hyperactivity disorder (ADHD) and its comorbidity with other disorders. Family, twin, and adoption studies show that ADHD runs in families. ADHD’s high heritability of 74% motivated the search for ADHD susceptibility genes. Genetic linkage studies show that the effects of DNA risk variants on ADHD must, individually, be very small. Genome-wide association …
Low stress resilience in late adolescence and risk of smoking, high alcohol consumption and drug use later in life
Low stress resilience in late adolescence appears to be associated with an increased risk of disadvantageous and addictive health behaviours in adulthood
Body dissatisfaction in adolescent boys
Body dissatisfaction is a significant mental health symptom present in adolescent girls and boys. However, it is often either disregarded in adolescent boys or examined using assessments that may not resonate with males. The present study addresses these issues, examining the manifestation, etiology, and correlates of 3 facets of body dissatisfaction in adolescent boys. Adolescent male twins aged 16- to 17-years-old from the Swedish Twin Study of…
Research Review
Trajectories of healthcare utilization and costs of psychiatric and somatic multimorbidity in adults with childhood ADHD
BACKGROUND: A better understanding of the trajectories and economic burden of psychiatric and somatic disorders (multimorbidity) in ADHD from childhood to adulthood is important for guiding more targeted areas for treatment of ADHD and prevention of multimorbidity, and for forecasting demands on the medical infrastructure. This study aimed to investigate patterns of healthcare utilization and costs of multimorbidity across young adulthood in indi…
Machine‐Learning prediction of comorbid substance use disorders in ADHD youth using Swedish registry data
BACKGROUND: Children with attention-deficit/hyperactivity disorder (ADHD) have a high risk for substance use disorders (SUDs). Early identification of at-risk youth would help allocate scarce resources for prevention programs. METHODS: Psychiatric and somatic diagnoses, family history of these disorders, measures of socioeconomic distress, and information about birth complications were obtained from the national registers in Sweden for 19,787 chi…
Clinical Characteristics and Pharmacological Treatment of Individuals With and Without Intellectual Disability in Pre-trial Assessment—A Population-Based Study
Background: The current lack of knowledge about intellectual disability (ID) in forensic psychiatric contexts can compromise the legal certainty of these individuals during the medico-legal process. To address ambiguous results in previous literature, the aim of the current study was to estimate the prevalence of ID in a pre-trial forensic psychiatric settings. Moreover, as little is known about the characteristics of offenders with ID, we conduc…
The World Federation of ADHD International Consensus Statement
BACKGROUND: Misconceptions about ADHD stigmatize affected people, reduce credibility of providers, and prevent/delay treatment. To challenge misconceptions, we curated findings with strong evidence base. METHODS: We reviewed studies with more than 2000 participants or meta-analyses from five or more studies or 2000 or more participants. We excluded meta-analyses that did not assess publication bias, except for meta-analyses of prevalence. For net…
Familial and genetic associations between autism spectrum disorder and other neurodevelopmental and psychiatric disorders
Background Familial and genetic associations between autism spectrum disorder (ASD) and other neurodevelopmental and psychiatric disorders have been reported, sometimes with conflicting results. We estimated familial and genetic associations between ASD and nine disorder groups, and explored differences in these associations for ASD in the context of intellectual disability, epilepsy, chromosomal abnormalities, and congenital malformations. Metho…
Sexual orientation and adolescent suicide attempt and self‐harm
Identifying as a sexual minority was associated with approximately 50% increased odds of SA/SH in adolescence after adjusting for unmeasured genetic and environmental factors shared by twins and for childhood psychopathology. The results support that environmental factors specifically associated with identifying as a sexual minority likely increase risk for SA/SH. Our findings highlight the need to monitor suicidality risk among this group
Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs
Background Although polygenic risk scores (PRS) predict psychiatric problems, these associations might be attributable to indirect pathways including population stratification, assortative mating, or dynastic effects (mediation via parental environments). The goal of this study was to examine whether PRS‐psychiatric symptom associations were attributable to indirect versus direct pathways. Methods The sample consisted of 3,907 dizygotic (DZ) twin…
Perceived child impairment and the ‘autism epidemic’
BACKGROUND: The prevalence of diagnosed Autism Spectrum Disorder (ASD) has increased substantially across the world. Much - or even most - prevalence increase seems to reflect changes in diagnostic practice and ascertainment. A key part of ASD assessment is to document that the relevant symptoms are associated with clinical impairment. The aim of the present study is to capitalize on a nationwide longitudinal study spanning 15 consecutive birth y…
Shared familial risk factors between autism spectrum disorder and obesity – a register‐based familial coaggregation cohort study
BACKGROUND: Meta-analyses suggest an association between autism spectrum disorder (ASD) and obesity, but the factors underlying this association remain unclear. This study investigated the association between ASD and obesity stratified on intellectual disability (ID). In addition, in order to gain insight into possible shared etiological factors, the potential role of shared familial liability was examined. METHOD: We studied a cohort of 3,141,69…
How interactions between ADHD and schools affect educational achievement
BACKGROUND: Children with ADHD tend to achieve less than their peers in school. It is unknown whether schools moderate this association. Nonrandom selection of children into schools related to variations in their ADHD risk poses a methodological problem. METHODS: We linked data on ADHD symptoms of inattention and hyperactivity and parent-child ADHD polygenic scores (PGS) from the Norwegian Mother, Father, and Child Cohort Study (MoBa) to achievem…
Familial risk and heritability of intellectual disability
BACKGROUND: Intellectual disability (ID) aggregates in families, but factors affecting individual risk and heritability estimates remain unknown. METHODS: A population-based family cohort study of 4,165,785 individuals born 1973-2013 in Sweden, including 37,787 ID individuals and their relatives. The relative risks (RR) of ID with 95% confidence intervals (95% CI) were obtained from stratified Cox proportional-hazards models. Relatives of ID indi…
Etiological links between autism and difficulties in initiating and maintaining sleep
BACKGROUND: Difficulties initiating and maintaining sleep (DIMS) are frequent features of autism, yet little is known about why these conditions co-occur. One possibility is that they share etiological factors, yet this hypothesis remains to be tested using quantitative genetic designs. We thus investigated etiological links between autism and DIMS using familial co-aggregation and twin methods. METHODS: Twins, siblings, half-siblings, and cousin…
Criminal recidivism in offenders with and without intellectual disability sentenced to forensic psychiatric care in Sweden—A 17-year follow-up study
A diagnosis of ID was associated with a lower risk of criminal recidivism among male offenders sentenced to forensic psychiatric care. The association between ADHD and recidivism among ID offenders highlights eligible focus areas in the management of offenders with ID
Adverse perinatal events and offspring criminal convictions in men and women
We examined associations of adverse perinatal events with offspring violent and non-violent criminal convictions in men and women. All singleton births between 1973 and 1995 (n = 1,146,570 men, n = 1,085,217 women) were identified through Swedish population-based registers. Information about adverse perinatal events was retrieved from the Medical Birth Register. Outcomes were criminal convictions collected from the National Crime Register. We est…
Parental criminality and children's educational attainment
We examine how parental criminality is associated with offspring education at different educational stages from primary to tertiary education and conduct separate analyses for non-violent and violent crimes and incarceration, and for paternal and maternal criminality. We use Swedish total population register data of 513,886 children and their parents and estimate both population-level linear probability models and cousin fixed-effects models. Par…
Do psychopathic personality traits in childhood predict subsequent criminality and psychiatric outcomes over and above childhood behavioral problems
Prediction of reoffending risk in men convicted of sexual offences
Scalable evidence-based risk assessment tools for sexual offenders in the criminal justice system and forensic mental health could assist decision-making and treatment allocation by identifying those at higher risk, and screening out low risk persons
A genetically informed Registered Report on adverse childhood experiences and mental health
Children who experience adversities have an elevated risk of mental health problems. However, the extent to which adverse childhood experiences (ACEs) cause mental health problems remains unclear, as previous associations may partly reflect genetic confounding. In this Registered Report, we used DNA from 11,407 children from the United Kingdom and the United States to investigate gene–environment correlations and genetic confounding of the associ…
A twin study of genetic and environmental contributions to attention‐deficit/hyperactivity disorder over time
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is an increasingly commonly diagnosed neurodevelopmental condition. One possibility is that this reflects a genuine increase in the prevalence of ADHD due to secular environmental changes, yet this hypothesis remains untested. We therefore investigated whether the genetic and environmental variance underlying ADHD, and traits of ADHD, has changed over time. METHODS: We identified twins b…
Psychology (35 obras) · Psychiatry (29 obras) · Medicine (27 obras) · Clinical Psychology (21 obras) · Population (18 obras) · Attention Deficit Hyperactivity Disorder (10 obras) · Autism (10 obras) · Internal Medicine (10 obras) · Autism Spectrum Disorder Research (9 obras) · Developmental psychology (8 obras)