Abigail Fraser
Biographic Data
| ID | 3863792 |
|---|---|
| NAME | Abigail Fraser |
| GIVEN NAMES | Abigail |
| FAMILY NAME | Fraser |
| SIGNATURE | FRASER A |
| AFFILIATIONS | University of Bristol |
| ORCID | 0000-0001-6117-3472 |
| VERIFIED | Yes |
| TOTAL WORKS | 18 |
| TOTAL CITATIONS | 3 |
| WORKS AS AUTHOR | 18 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 2002 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 1 |
Violence Exposure and Cognitive Outcomes Among Children in Low- and Middle-Income Countries (LMICs)
This article examines how exposure to violence in childhood is linked to impaired cognitive functioning and academic performance. Children who reside in low- and middle-income countries (LMICs) are more likely to be exposed to violence yet their representation in published studies is often limited. Here, we conducted a systematic review to examine the evidence regarding the association between childhood violence exposure and cognitive outcomes as…
What Do Antenatal Women Want From Their Antenatal Education? A National Survey
NHS antenatal classes are a trusted source of ANE, forming a core element of many women's antenatal journey. However, inconsistent provision highlights the need for a standardised, comprehensive curriculum. Flexible delivery models and tailored content are crucial to address diverse needs, particularly for multiparous women and underrepresented groups. Enhanced accessibility could reduce inequalities in ANE provision and improve maternal outcomes
Cross Sectional Survey of Antenatal Educators’ Views About Current Antenatal Education Provision
Antenatal educators believe current NHS ANE does not adequately prepare women for labour and birth, leading to disparities in birth preparedness for those who cannot access non-NHS classes. To reduce this healthcare inequality, NHS classes need to be standardised, with training for midwives in delivering ANE enhanced
Changes in preterm birth and stillbirth during Covid-19 lockdowns in 26 countries
Preterm birth (PTB) is the leading cause of infant mortality worldwide. Changes in PTB rates, ranging from −90% to +30%, were reported in many countries following early COVID-19 pandemic response measures ('lockdowns'). It is unclear whether this variation reflects real differences in lockdown impacts, or perhaps differences in stillbirth rates and/or study designs. Here we present interrupted time series and meta-analyses using harmonized data f…
Being silenced, loneliness and being heard
It is likely that negative labelling and loneliness mediate pathways to IPVA, especially among more disadvantaged young women. The impact of early maltreatment on young people's wellbeing and own relationships is compounded by disadvantage, disability and ethnicity. Participants' resilience was enabled by support in the community
The evolutionary ecology of age at natural menopause
Childhood psychosocial adversity and female reproductive timing
BACKGROUND: Previous studies of childhood psychosocial adversity and age at menarche mostly evaluated single or a few measures of adversity, and therefore could not quantify total psychosocial adversity. Limited knowledge is currently available regarding childhood psychosocial adversity in relation to age at menopause and reproductive lifespan. METHODS: We examined the associations of total and specific components of childhood psychosocial advers…
Prospective associations of psychosocial adversity in childhood with risk factors for cardiovascular disease in adulthood
We found no evidence that exposure to greater psychosocial adversity, or specific forms of psychosocial adversity during childhood is associated with adult CVD risk factors. Further large population studies are needed to clarify whether parental death is associated with higher systolic and diastolic blood pressure
Cohort Profile
The Avon Longitudinal Study of Parents and Children (ALSPAC) is a transgenerational prospective observational study investigating influences on health and development across the life course. It considers multiple genetic, epigenetic, biological, psychological, social and other environmental exposures in relation to a similarly diverse range of health, social and developmental outcomes. Recruitment sought to enroll pregnant women in the Bristol ar…
Cohort Profile
The Avon Longitudinal Study of Children and Parents (ALSPAC) was established to understand how genetic and environmental characteristics influence health and development in parents and children. All pregnant women resident in a defined area in the South West of England, with an expected date of delivery between 1st April 1991 and 31st December 1992, were eligible and 13761 women (contributing 13867 pregnancies) were recruited. These women have be…
Associations of mortality with own height using son's height as an instrumental variable
Height is associated with mortality from many diseases, but it remains unclear whether the association is causal or due to confounding by social factors, genetic pleiotropy,(1) or existing ill-health. The authors investigated whether the association of height with mortality is causal by using a son's height as an instrumental variable (IV) for parents' height among the parents of a cohort of 1,036,963 Swedish men born between 1951 and 1980 who ha…
P1-427 Associations of maternal weight gain in pregnancy with offspring cognition throughout childhood and adolescence
Introduction Basic science evidence suggests that gestational weight gain (GWG) may influence offspring cognitive development. However, this relationship has not been investigated in human population studies. Methods Data from the ALSPAC, a UK prospective pregnancy cohort were used. GWG was expressed using 2009 IOM categories of GWG and estimates from random effect linear spline models (median number of measures per woman: 10 IQR: 8–11). Outcomes…
P2-330 Associations of 25-hydroxyvitamin D2 and D3 with cardiovascular risk factors in childhood
Introduction Some observational studies have associated low vitamin D status with increased cardiovascular disease (CVD) and risk factors in adults, but results from randomised controlled trials suggest these associations may not be causal. Trials have largely used supplementation with vitamin D2 and the availability of D3 supplements has led to the suggestion that this is more potent and null effects in previous trials may be because of inadequa…
O1-2.4 Hypertensive disorders of pregnancy and offspring vascular, inflammatory and lipid outcomes in childhood
Introduction Offspring of hypertensive pregnancies have higher blood pressure (BP) in later life. Whether this is accompanied by impaired vascular function and worse cardiovascular risk profiles suggesting mediation by intrauterine exposure to vascular toxins and long term programming, or is restricted to hypertension consistent with a genetic predisposition, is unknown. Specificity of association would be a useful test of these alternatives. Met…
P2-166 Relationships of risk factors for pre-eclampsia with blood pressure changes during normal term pregnancy
Objective It is unclear whether established risk factors for pre-eclampsia are related to blood pressure (BP) changes across pregnancy in women who do not develop pre-eclampsia. We investigated these associations. Methods We studied routine antenatal BP measurements for 11 789 women (median 14 per woman) in ALSPAC who had a live term birth without pre-eclampsia or previous hypertension. Linear spline random effects models with knots at 18, 30 and…
Associations of mortality rates with height using son's height as an instrumental variable
Objectives Height has been negatively associated with mortality from circulatory disease, but positively associated with mortality from most forms of cancer. These results are vulnerable to confounding, including the confounding effect of early stages of disease causing shrinkage and later death. To avoid these problems, we used the height of subjects' sons as an instrument for subjects' own height. Design A record linkage cohort study of over 2 …
The associations between height components (leg and trunk length) and adult levels of liver enzymes
STUDY OBJECTIVE: To examine the separate associations of leg length, a biomarker of prepubertal exposures and growth, and trunk length with adult levels of liver enzymes: alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), aspartate transaminase (AST) and alkaline phosphatase (ALP). METHODS: A cross-sectional analysis of baseline data from the British Women's Health and Heart Study, a random sample of British women aged 60-79 years. …
Between Nationalism and Liberalism
Changes in preterm birth and stillbirth during Covid-19 lockdowns in 26 countries
Preterm birth (PTB) is the leading cause of infant mortality worldwide. Changes in PTB rates, ranging from −90% to +30%, were reported in many countries following early COVID-19 pandemic response measures ('lockdowns'). It is unclear whether this variation reflects real differences in lockdown impacts, or perhaps differences in stillbirth rates and/or study designs. Here we present interrupted time series and meta-analyses using harmonized data f…
Childhood psychosocial adversity and female reproductive timing
BACKGROUND: Previous studies of childhood psychosocial adversity and age at menarche mostly evaluated single or a few measures of adversity, and therefore could not quantify total psychosocial adversity. Limited knowledge is currently available regarding childhood psychosocial adversity in relation to age at menopause and reproductive lifespan. METHODS: We examined the associations of total and specific components of childhood psychosocial advers…
The associations between height components (leg and trunk length) and adult levels of liver enzymes
STUDY OBJECTIVE: To examine the separate associations of leg length, a biomarker of prepubertal exposures and growth, and trunk length with adult levels of liver enzymes: alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), aspartate transaminase (AST) and alkaline phosphatase (ALP). METHODS: A cross-sectional analysis of baseline data from the British Women's Health and Heart Study, a random sample of British women aged 60-79 years. …
Between Nationalism and Liberalism
The associations between height components (leg and trunk length) and adult levels of liver enzymes
STUDY OBJECTIVE: To examine the separate associations of leg length, a biomarker of prepubertal exposures and growth, and trunk length with adult levels of liver enzymes: alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), aspartate transaminase (AST) and alkaline phosphatase (ALP). METHODS: A cross-sectional analysis of baseline data from the British Women's Health and Heart Study, a random sample of British women aged 60-79 years. …
P1-427 Associations of maternal weight gain in pregnancy with offspring cognition throughout childhood and adolescence
Introduction Basic science evidence suggests that gestational weight gain (GWG) may influence offspring cognitive development. However, this relationship has not been investigated in human population studies. Methods Data from the ALSPAC, a UK prospective pregnancy cohort were used. GWG was expressed using 2009 IOM categories of GWG and estimates from random effect linear spline models (median number of measures per woman: 10 IQR: 8–11). Outcomes…
P2-330 Associations of 25-hydroxyvitamin D2 and D3 with cardiovascular risk factors in childhood
Introduction Some observational studies have associated low vitamin D status with increased cardiovascular disease (CVD) and risk factors in adults, but results from randomised controlled trials suggest these associations may not be causal. Trials have largely used supplementation with vitamin D2 and the availability of D3 supplements has led to the suggestion that this is more potent and null effects in previous trials may be because of inadequa…
O1-2.4 Hypertensive disorders of pregnancy and offspring vascular, inflammatory and lipid outcomes in childhood
Introduction Offspring of hypertensive pregnancies have higher blood pressure (BP) in later life. Whether this is accompanied by impaired vascular function and worse cardiovascular risk profiles suggesting mediation by intrauterine exposure to vascular toxins and long term programming, or is restricted to hypertension consistent with a genetic predisposition, is unknown. Specificity of association would be a useful test of these alternatives. Met…
P2-166 Relationships of risk factors for pre-eclampsia with blood pressure changes during normal term pregnancy
Objective It is unclear whether established risk factors for pre-eclampsia are related to blood pressure (BP) changes across pregnancy in women who do not develop pre-eclampsia. We investigated these associations. Methods We studied routine antenatal BP measurements for 11 789 women (median 14 per woman) in ALSPAC who had a live term birth without pre-eclampsia or previous hypertension. Linear spline random effects models with knots at 18, 30 and…
Associations of mortality rates with height using son's height as an instrumental variable
Objectives Height has been negatively associated with mortality from circulatory disease, but positively associated with mortality from most forms of cancer. These results are vulnerable to confounding, including the confounding effect of early stages of disease causing shrinkage and later death. To avoid these problems, we used the height of subjects' sons as an instrument for subjects' own height. Design A record linkage cohort study of over 2 …
Associations of mortality with own height using son's height as an instrumental variable
Height is associated with mortality from many diseases, but it remains unclear whether the association is causal or due to confounding by social factors, genetic pleiotropy,(1) or existing ill-health. The authors investigated whether the association of height with mortality is causal by using a son's height as an instrumental variable (IV) for parents' height among the parents of a cohort of 1,036,963 Swedish men born between 1951 and 1980 who ha…
Cohort Profile
The Avon Longitudinal Study of Parents and Children (ALSPAC) is a transgenerational prospective observational study investigating influences on health and development across the life course. It considers multiple genetic, epigenetic, biological, psychological, social and other environmental exposures in relation to a similarly diverse range of health, social and developmental outcomes. Recruitment sought to enroll pregnant women in the Bristol ar…
Cohort Profile
The Avon Longitudinal Study of Children and Parents (ALSPAC) was established to understand how genetic and environmental characteristics influence health and development in parents and children. All pregnant women resident in a defined area in the South West of England, with an expected date of delivery between 1st April 1991 and 31st December 1992, were eligible and 13761 women (contributing 13867 pregnancies) were recruited. These women have be…
Prospective associations of psychosocial adversity in childhood with risk factors for cardiovascular disease in adulthood
We found no evidence that exposure to greater psychosocial adversity, or specific forms of psychosocial adversity during childhood is associated with adult CVD risk factors. Further large population studies are needed to clarify whether parental death is associated with higher systolic and diastolic blood pressure
Childhood psychosocial adversity and female reproductive timing
BACKGROUND: Previous studies of childhood psychosocial adversity and age at menarche mostly evaluated single or a few measures of adversity, and therefore could not quantify total psychosocial adversity. Limited knowledge is currently available regarding childhood psychosocial adversity in relation to age at menopause and reproductive lifespan. METHODS: We examined the associations of total and specific components of childhood psychosocial advers…
The evolutionary ecology of age at natural menopause
Being silenced, loneliness and being heard
It is likely that negative labelling and loneliness mediate pathways to IPVA, especially among more disadvantaged young women. The impact of early maltreatment on young people's wellbeing and own relationships is compounded by disadvantage, disability and ethnicity. Participants' resilience was enabled by support in the community
Changes in preterm birth and stillbirth during Covid-19 lockdowns in 26 countries
Preterm birth (PTB) is the leading cause of infant mortality worldwide. Changes in PTB rates, ranging from −90% to +30%, were reported in many countries following early COVID-19 pandemic response measures ('lockdowns'). It is unclear whether this variation reflects real differences in lockdown impacts, or perhaps differences in stillbirth rates and/or study designs. Here we present interrupted time series and meta-analyses using harmonized data f…
Cross Sectional Survey of Antenatal Educators’ Views About Current Antenatal Education Provision
Antenatal educators believe current NHS ANE does not adequately prepare women for labour and birth, leading to disparities in birth preparedness for those who cannot access non-NHS classes. To reduce this healthcare inequality, NHS classes need to be standardised, with training for midwives in delivering ANE enhanced
What Do Antenatal Women Want From Their Antenatal Education? A National Survey
NHS antenatal classes are a trusted source of ANE, forming a core element of many women's antenatal journey. However, inconsistent provision highlights the need for a standardised, comprehensive curriculum. Flexible delivery models and tailored content are crucial to address diverse needs, particularly for multiparous women and underrepresented groups. Enhanced accessibility could reduce inequalities in ANE provision and improve maternal outcomes
Violence Exposure and Cognitive Outcomes Among Children in Low- and Middle-Income Countries (LMICs)
This article examines how exposure to violence in childhood is linked to impaired cognitive functioning and academic performance. Children who reside in low- and middle-income countries (LMICs) are more likely to be exposed to violence yet their representation in published studies is often limited. Here, we conducted a systematic review to examine the evidence regarding the association between childhood violence exposure and cognitive outcomes as…
Medicine (16 works) · Internal Medicine (9 works) · Internal Medicine (8 works) · Birth, Development, and Health (7 works) · Environmental health (6 works) · Longitudinal study (6 works) · Population (6 works) · Pregnancy (6 works) · Cohort (5 works) · Demography (5 works)