Mario Maj
Biographic Data
| ID | 3931786 |
|---|---|
| NAME | Mario Maj |
| GIVEN NAMES | Mario |
| FAMILY NAME | Maj |
| SIGNATURE | MAJ M |
| AFFILIATIONS | Department of Psychiatry University of Naples SUN Naples Italy |
| VERIFIED | No |
| TOTAL WORKS | 22 |
| TOTAL CITATIONS | 16 |
| WORKS AS AUTHOR | 21 |
| WORKS AS EDITOR | 1 |
| FIRST PUBLICATION YEAR | 1989 |
| LATEST PUBLICATION YEAR | 2024 |
| H-INDEX | 2 |
Illness-related variables and abnormalities of resting-state brain activity in schizophrenia
Neurocognitive deficits and the two negative symptom domains are associated with different neural markers. Replications of these findings could foster the identification of clinically actionable biomarkers of poor functional outcomes
The mediating effect of mood spectrum on the relationship between autistic traits and catatonia spectrum
The present study highlights the presence of a mediating role of the mood disorder spectrum in the relationship between autistic traits and the catatonia spectrum
Investigating suicidality across the autistic-catatonic continuum in a clinical sample of subjects with major depressive disorder and borderline personality disorder
In both disorders, higher catatonic traits are linked to higher suicidal tendencies, confirming the high risk of suicide for this population. However, different patterns of association between catatonic symptoms and suicidality were highlighted in the two disorders
Time for united action on depression
Tracing Links Between Early Auditory Information Processing and Negative Symptoms in Schizophrenia
Background: Negative symptoms represent a heterogeneous dimension with a strong impact on functioning of subjects with schizophrenia (SCZ). Five constructs are included in this dimension: anhedonia, asociality, avolition, blunted affect, and alogia. Factor analyses revealed that these symptoms cluster in two domains: experiential domain (avolition, asociality, and anhedonia) and the expressive deficit (alogia and blunted affect), that might be li…
The Lancet Psychiatry Commission
Insecure Attachment and Hypothalamus-Pituitary-Adrenal Axis Functioning in People With Eating Disorders
OBJECTIVE: Childhood attachment experiences affect adult emotion regulation and ability to cope with stressors. Therefore, insecure attachment may influence the functioning of the hypothalamic-pituitary-adrenal (HPA) axis and a dysregulation of HPA axis has been found in insecure attached healthy individuals. The effects of attachment on HPA axis activity have never been investigated in eating disorders (EDs). Therefore, we assessed the relations…
A Randomized Controlled Trial on the Efficacy of a Psychosocial Behavioral Intervention to Improve the Lifestyle of Patients With Severe Mental Disorders
2015C7374S
Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder
Bipolar disorder (BD) is a common, highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. Lithium is the best-established long-term treatment for BD, even though individual response is highly variable. Evidence suggests that some of this variability has a genetic basis. This is supported by the largest genome-wide association study (GWAS) of lithium response to date conducted by the International Co…
Excess mortality in persons with severe mental disorders
Excess mortality in persons with severe mental disorders (SMD) is a major public health challenge that warrants action. The number and scope of truly tested interventions in this area remain limited, and strategies for implementation and scaling up of programmes with a strong evidence base are scarce. Furthermore, the majority of available interventions focus on a single or an otherwise limited number of risk factors. Here we present a multilevel…
Depression and Diabetes
Development and Validation of a Self-Reported Questionnaire On Users’ Opinions About Schizophrenia
Background: Although users’ involvement in mental health research has repeatedly been acknowledged as having a positive influence on research quality, this rarely happens. Aims: To develop and validate a Questionnaire on Users’ Opinions (QOU) about schizophrenia, in close collaboration with 279 persons affected by this disorder. Methods: A preliminary list of items concerning the opinions of users with schizophrenia regarding causes, treatments a…
No health without mental health
Investigation of the Serotonin Transporter Regulatory Region Polymorphism in Bulimia Nervosa
Objective: Genes involved in 5HT transmission have been supposed to contribute to the biologic vulnerability for bulimia nervosa (BN). Because a long (L) and a short (S) variant of the promoter region of the 5HT transporter gene have been identified, we tested whether the 5HTT gene-linked polymorphic region (5HTTLPR) could represent a susceptibility factor for BN and/or could be related to nutritional parameters, harm avoidance personality dimens…
Social network in long-term diseases
Family burden in long-term diseases
Opposite Changes in the Serum Brain-Derived Neurotrophic Factor in Anorexia Nervosa and Obesity
Objective: A role for the brain-derived neurotrophic factor (BDNF) in the regulation of eating behavior has been recently demonstrated. Therefore, the possibility exists that alterations in BDNF production and/or activity are involved in the pathophysiology of anorexia nervosa (AN) and obesity. Methods: We measured morning serum levels of BDNF in 22 women with AN, 24 women with obesity (body mass index [BMI] > 30 kg/m2), and 27 nonobese healthy w…
Beliefs of Psychiatric Nurses about Schizophrenia
Background: What patients’ relatives and health professionals think about causes, treatments and psychosocial consequences of schizophrenia can influence its detection and outcome. Aims: To compare the beliefs about schizophrenia in 190 nurses, 110 psychiatrists and 709 relatives of patients with this mental disorder, recruited in 30 randomly selected mental health centres. Methods: In each centre, the key-relatives of the first consecutive 25 su…
The effect of social network on burden and pessimism in relatives of patients with schizophrenia
The authors explored the social network of caregivers of patients with schizophrenia in relation to relatives' sociodemographic characteristics, patients' clinical variables, family burden, and pessimism about the consequences of the disease. They evaluated 709 key relatives of patients with schizophrenia concerning the above-mentioned variables by means of well-validated questionnaires. A more supportive social network was found in relatives who…
Leptin Secretion Is Related to Chronicity and Severity of the Illness in Bulimia Nervosa
Objective A reduction in circulating leptin has been reported in some patients with BN, but not in others. The reasons for such diversity have not been explained. Therefore, we measured plasma levels of leptin and other hormones in a large sample of patients with eating disorders and in healthy controls and explored differences between bulimics with low plasma leptin levels and those with normal concentrations of the hormone. Method One hundred a…
Plasma Levels of Neuroactive Steroids Are Increased in Untreated Women With Anorexia Nervosa or Bulimia Nervosa
OBJECTIVE: Animal data suggest that neuroactive steroids, such as 3alpha,5alpha-tetrahydroprogesterone (3a,5a-THP), dehydroepiandrosterone (DHEA), and its sulfated metabolite (DHEA-S), are involved in the modulation of eating behavior, aggressiveness, mood, and anxiety. Anorexia nervosa (AN) and bulimia nervosa (BN) are eating disorders characterized by abnormal eating patterns, depressive and anxious symptoms, enhanced aggressiveness, and endocr…
Implementing Psychiatric Reform in Southern Italy
The implementation of the 1978 psychiatric reform in Campania, the most populated region of Southern Italy, is surveyed, by referring to currently available empirical data. Emphasis is laid on the incomplete development of psychiatric wards within general hospitals and of mental health services, on the lack of residential structures, on the failure to implement comprehensive departments for mental health care, on the increase in the number of adm…
Implementing Psychiatric Reform in Southern Italy
The implementation of the 1978 psychiatric reform in Campania, the most populated region of Southern Italy, is surveyed, by referring to currently available empirical data. Emphasis is laid on the incomplete development of psychiatric wards within general hospitals and of mental health services, on the lack of residential structures, on the failure to implement comprehensive departments for mental health care, on the increase in the number of adm…
Plasma Levels of Neuroactive Steroids Are Increased in Untreated Women With Anorexia Nervosa or Bulimia Nervosa
OBJECTIVE: Animal data suggest that neuroactive steroids, such as 3alpha,5alpha-tetrahydroprogesterone (3a,5a-THP), dehydroepiandrosterone (DHEA), and its sulfated metabolite (DHEA-S), are involved in the modulation of eating behavior, aggressiveness, mood, and anxiety. Anorexia nervosa (AN) and bulimia nervosa (BN) are eating disorders characterized by abnormal eating patterns, depressive and anxious symptoms, enhanced aggressiveness, and endocr…
Leptin Secretion Is Related to Chronicity and Severity of the Illness in Bulimia Nervosa
Objective A reduction in circulating leptin has been reported in some patients with BN, but not in others. The reasons for such diversity have not been explained. Therefore, we measured plasma levels of leptin and other hormones in a large sample of patients with eating disorders and in healthy controls and explored differences between bulimics with low plasma leptin levels and those with normal concentrations of the hormone. Method One hundred a…
The effect of social network on burden and pessimism in relatives of patients with schizophrenia
The authors explored the social network of caregivers of patients with schizophrenia in relation to relatives' sociodemographic characteristics, patients' clinical variables, family burden, and pessimism about the consequences of the disease. They evaluated 709 key relatives of patients with schizophrenia concerning the above-mentioned variables by means of well-validated questionnaires. A more supportive social network was found in relatives who…
Opposite Changes in the Serum Brain-Derived Neurotrophic Factor in Anorexia Nervosa and Obesity
Objective: A role for the brain-derived neurotrophic factor (BDNF) in the regulation of eating behavior has been recently demonstrated. Therefore, the possibility exists that alterations in BDNF production and/or activity are involved in the pathophysiology of anorexia nervosa (AN) and obesity. Methods: We measured morning serum levels of BDNF in 22 women with AN, 24 women with obesity (body mass index [BMI] > 30 kg/m2), and 27 nonobese healthy w…
Beliefs of Psychiatric Nurses about Schizophrenia
Background: What patients’ relatives and health professionals think about causes, treatments and psychosocial consequences of schizophrenia can influence its detection and outcome. Aims: To compare the beliefs about schizophrenia in 190 nurses, 110 psychiatrists and 709 relatives of patients with this mental disorder, recruited in 30 randomly selected mental health centres. Methods: In each centre, the key-relatives of the first consecutive 25 su…
Family burden in long-term diseases
Investigation of the Serotonin Transporter Regulatory Region Polymorphism in Bulimia Nervosa
Objective: Genes involved in 5HT transmission have been supposed to contribute to the biologic vulnerability for bulimia nervosa (BN). Because a long (L) and a short (S) variant of the promoter region of the 5HT transporter gene have been identified, we tested whether the 5HTT gene-linked polymorphic region (5HTTLPR) could represent a susceptibility factor for BN and/or could be related to nutritional parameters, harm avoidance personality dimens…
Social network in long-term diseases
No health without mental health
Development and Validation of a Self-Reported Questionnaire On Users’ Opinions About Schizophrenia
Background: Although users’ involvement in mental health research has repeatedly been acknowledged as having a positive influence on research quality, this rarely happens. Aims: To develop and validate a Questionnaire on Users’ Opinions (QOU) about schizophrenia, in close collaboration with 279 persons affected by this disorder. Methods: A preliminary list of items concerning the opinions of users with schizophrenia regarding causes, treatments a…
Depression and Diabetes
Excess mortality in persons with severe mental disorders
Excess mortality in persons with severe mental disorders (SMD) is a major public health challenge that warrants action. The number and scope of truly tested interventions in this area remain limited, and strategies for implementation and scaling up of programmes with a strong evidence base are scarce. Furthermore, the majority of available interventions focus on a single or an otherwise limited number of risk factors. Here we present a multilevel…
Insecure Attachment and Hypothalamus-Pituitary-Adrenal Axis Functioning in People With Eating Disorders
OBJECTIVE: Childhood attachment experiences affect adult emotion regulation and ability to cope with stressors. Therefore, insecure attachment may influence the functioning of the hypothalamic-pituitary-adrenal (HPA) axis and a dysregulation of HPA axis has been found in insecure attached healthy individuals. The effects of attachment on HPA axis activity have never been investigated in eating disorders (EDs). Therefore, we assessed the relations…
A Randomized Controlled Trial on the Efficacy of a Psychosocial Behavioral Intervention to Improve the Lifestyle of Patients With Severe Mental Disorders
2015C7374S
Analysis of the Influence of microRNAs in Lithium Response in Bipolar Disorder
Bipolar disorder (BD) is a common, highly heritable neuropsychiatric disease characterized by recurrent episodes of mania and depression. Lithium is the best-established long-term treatment for BD, even though individual response is highly variable. Evidence suggests that some of this variability has a genetic basis. This is supported by the largest genome-wide association study (GWAS) of lithium response to date conducted by the International Co…
The Lancet Psychiatry Commission
Tracing Links Between Early Auditory Information Processing and Negative Symptoms in Schizophrenia
Background: Negative symptoms represent a heterogeneous dimension with a strong impact on functioning of subjects with schizophrenia (SCZ). Five constructs are included in this dimension: anhedonia, asociality, avolition, blunted affect, and alogia. Factor analyses revealed that these symptoms cluster in two domains: experiential domain (avolition, asociality, and anhedonia) and the expressive deficit (alogia and blunted affect), that might be li…
Time for united action on depression
The mediating effect of mood spectrum on the relationship between autistic traits and catatonia spectrum
The present study highlights the presence of a mediating role of the mood disorder spectrum in the relationship between autistic traits and the catatonia spectrum
Investigating suicidality across the autistic-catatonic continuum in a clinical sample of subjects with major depressive disorder and borderline personality disorder
In both disorders, higher catatonic traits are linked to higher suicidal tendencies, confirming the high risk of suicide for this population. However, different patterns of association between catatonic symptoms and suicidality were highlighted in the two disorders
Illness-related variables and abnormalities of resting-state brain activity in schizophrenia
Neurocognitive deficits and the two negative symptom domains are associated with different neural markers. Replications of these findings could foster the identification of clinically actionable biomarkers of poor functional outcomes
Medicine (18 works) · Psychiatry (18 works) · Psychology (16 works) · Clinical Psychology (10 works) · Schizophrenia research and treatment (10 works) · Eating Disorders and Behaviors (6 works) · Mental health (6 works) · Psychological intervention (6 works) · Schizophrenia (object-oriented programming (6 works) · Clinical Psychology (5 works)