Lorna G Moore
Biographic Data
| ID | 4040209 |
|---|---|
| NAME | Lorna G Moore |
| GIVEN NAMES | Lorna G |
| FAMILY NAME | Moore |
| SIGNATURE | MOORE L G |
| AFFILIATIONS | Department of Obstetrics and Gynecology School of Medicine University of Colorado Denver Aurora Colorado |
| VERIFIED | No |
| TOTAL WORKS | 18 |
| TOTAL CITATIONS | 53 |
| WORKS AS AUTHOR | 18 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 1991 |
| LATEST PUBLICATION YEAR | 2019 |
| H-INDEX | 3 |
High Altitude Continues to Reduce Birth Weights in Colorado
Human genetic adaptation to high altitudes
Surname‐Inferred andean ancestry is associated with child stature and limb lengths at high altitude in P eru, but not at sea level
OBJECTIVES: Native Andean ancestry gives partial protection from reduced birthweight at high altitude in the Andes compared with European ancestry. Whether Andean ancestry is also associated with body proportions and greater postnatal body size at altitude is unknown. Therefore, we tested whether a greater proportion of Andean ancestry is associated with stature and body proportions among Peruvian children at high and low altitude. METHODS: Heigh…
Andean and Tibetan patterns of adaptation to high altitude
OBJECTIVES: High-altitude hypoxia, or decreased oxygen levels caused by low barometric pressure, challenges the ability of humans to live and reproduce. Despite these challenges, human populations have lived on the Andean Altiplano and the Tibetan Plateau for millennia and exhibit unique circulatory, respiratory, and hematological adaptations to life at high altitude. We and others have identified natural selection candidate genes and gene region…
Little Effect of Gestation at 3,100 m on Fetal Fat Accretion or the Fetal Circulation
OBJECTIVE: While chronic hypoxia has been recognized as the principal causative factor for decreasing birth weight at high altitude, unknown is whether fetal fat accretion and vascular function are affected. METHODS: Colorado women with normal singleton pregnancies (18 Denver residents, 1,600 m; 24 Leadville residents, 3,100 m) were studied longitudinally from 20 to 36 weeks gestation. Fetal biometry was used to obtain axial images for assessing …
Lowland origin women raised at high altitude are not protected against lower uteroplacental O 2 delivery during pregnancy or reduced birth weight
OBJECTIVE: Maternal physiologic responses to pregnancy promoting fetal oxygen and nutrient delivery are important determinants of reproductive success. Incomplete physiologic compensation for reduced oxygen availability at high altitude (≥2,500 m) compromises fetal growth. Populations of highland (e.g., Andeans, Tibetans) compared with lowland origin groups (e.g., Europeans, Han Chinese) are protected from this altitude-associated decrease in bir…
Evolutionary adaptation to high altitude
A primary focus within biological anthropology has been to elucidate the processes of evolutionary adaptation. Frisancho helped to move anthropology towards more mechanistic explanations of human adaptation by drawing attention to the importance of the functional relevance of human variation. Using the natural laboratory of high altitude, he and others asked whether the unique physiology of indigenous high‐altitude residents was the result of acc…
Evidence that parent‐of‐origin affects birth‐weight reductions at high altitude
Hypoxia exerts a profound depressant effect on fetal growth, lowering birth weight, and raising mortality risk. Multigenerational high‐altitude populations are relatively protected from this birth‐weight decline, leading us to hypothesize that genetic factors were involved. We asked if the amount of high‐ versus low‐altitude ancestry influenced birth weight at high altitude and, specifically, whether such influences were affected by parent‐of‐ori…
Human physiological adaptation to pregnancy
Reproductive success requires successful maternal physiological adaptation to pregnancy. An interspecific perspective reveals that the human species has modified features of our haplorhine heritage affecting the uteroplacental circulation. We speculate that such modifications — including early implantation and deep, widespread invasion of fetal (trophoblast cells) into and resultant remodeling of maternal uterine vessels — are responses to or com…
Introduction
Tibetan protection from intrauterine growth restriction (Iugr) and reproductive loss at high altitude
Chronic hypoxia at high altitude restricts fetal growth, reducing birth weight and increasing infant mortality. We asked whether Tibetans, a long‐resident high‐altitude population, exhibit less altitude‐associated intrauterine growth restriction (IUGR) and prenatal or postnatal reproductive loss than Han (ethnic Chinese), a group that has lived there for a shorter period of time. A population sample was obtained, comprising 485 deliveries to Tibe…
Tibetan protection from intrauterine growth restriction (Iugr) and reproductive loss at high altitude
Oxygen transport in Tibetan women during pregnancy at 3,658 m
High-altitude reduces infant birth weight as a result of intrauterine growth restriction (IUGR) and is associated with increased neonatal mortality. We hypothesized that babies born to Tibetan compared to Han (Chinese) high-altitude residents were protected from IUGR as the result of increased maternal O(2) transport due, in turn, to increased uterine artery (UA) blood flow. We studied 68 nonpregnant or pregnant Tibetan or Han residents of Lhasa,…
Superior exercise performance in lifelong Tibetan residents of 4,400 m compared with Tibetan residents of 3,658 m
Few environments challenge human populations more than high altitude, since the accompanying low oxygen pressures (hypoxia) are pervasive and impervious to cultural modification. Work capacity is an important factor in a population's ability to thrive in such an environment. The performance of work or exercise is a measure of the integrated functioning of the O2 transport system, with maximal O2 uptake (.VO2max) a convenient index of that functio…
Human adaptation to high altitude
Studies of the ways in which persons respond to the adaptive challenges of life at high altitude have occupied an important place in anthropology. There are three major regions of the world where high-altitude studies have recently been performed: the Himalayas of Asia, the Andes of South America, and the Rocky Mountains of North America. Of these, the Himalayan region is larger, more geographically remote, and likely to have been occupied by hum…
Mitochondrial DNA analysis in Tibet
Mitochondrial DNAs (mtDNAs) of 54 Tibetans residing at altitudes ranging from 3,000–4,500 m were amplified by polymerase chain reaction (PCR), examined by high‐resolution restriction endonuclease analysis, and compared with those previously described in 10 other Asian and Siberian populations. This comparison revealed that more than 50% of Asian mtDNAs belong to a unique mtDNA lineage which is found only among Mongoloids, suggesting that this lin…
Protection from intrauterine growth retardation in Tibetans at high altitude
Intrauterine growth retardation has long been recognized at high altitude. Since growth‐retarded babies have a decreased chance of survival, intrauterine growth retardation would be expected to have been selected against in populations long resident at high altitude. We have previously reported that Tibetan babies born at 3,658 m weighed more than their North or South American altitude counterparts. This study sought to determine whether Tibetans…
Increased vital and total lung capacities in Tibetan compared to Han residents of Lhasa (3,658 m)
Larger chest dimensions and lung volumes have been reported for Andean high‐altitude natives compared with sea‐level residents and implicated in raising lung diffusing capacity. Studies conducted in Nepal suggested that lifelong Himalayan residents did not have enlarged chest dimensions. To determine if high‐altitude Himalayans (Tibetans) had larger lung volumes than acclimatized newcomers (Han “Chinese”), we studied 38 Tibetan and 43 Han residen…
Protection from intrauterine growth retardation in Tibetans at high altitude
Intrauterine growth retardation has long been recognized at high altitude. Since growth‐retarded babies have a decreased chance of survival, intrauterine growth retardation would be expected to have been selected against in populations long resident at high altitude. We have previously reported that Tibetan babies born at 3,658 m weighed more than their North or South American altitude counterparts. This study sought to determine whether Tibetans…
Increased vital and total lung capacities in Tibetan compared to Han residents of Lhasa (3,658 m)
Larger chest dimensions and lung volumes have been reported for Andean high‐altitude natives compared with sea‐level residents and implicated in raising lung diffusing capacity. Studies conducted in Nepal suggested that lifelong Himalayan residents did not have enlarged chest dimensions. To determine if high‐altitude Himalayans (Tibetans) had larger lung volumes than acclimatized newcomers (Han “Chinese”), we studied 38 Tibetan and 43 Han residen…
Mitochondrial DNA analysis in Tibet
Mitochondrial DNAs (mtDNAs) of 54 Tibetans residing at altitudes ranging from 3,000–4,500 m were amplified by polymerase chain reaction (PCR), examined by high‐resolution restriction endonuclease analysis, and compared with those previously described in 10 other Asian and Siberian populations. This comparison revealed that more than 50% of Asian mtDNAs belong to a unique mtDNA lineage which is found only among Mongoloids, suggesting that this lin…
Increased vital and total lung capacities in Tibetan compared to Han residents of Lhasa (3,658 m)
Larger chest dimensions and lung volumes have been reported for Andean high‐altitude natives compared with sea‐level residents and implicated in raising lung diffusing capacity. Studies conducted in Nepal suggested that lifelong Himalayan residents did not have enlarged chest dimensions. To determine if high‐altitude Himalayans (Tibetans) had larger lung volumes than acclimatized newcomers (Han “Chinese”), we studied 38 Tibetan and 43 Han residen…
Protection from intrauterine growth retardation in Tibetans at high altitude
Intrauterine growth retardation has long been recognized at high altitude. Since growth‐retarded babies have a decreased chance of survival, intrauterine growth retardation would be expected to have been selected against in populations long resident at high altitude. We have previously reported that Tibetan babies born at 3,658 m weighed more than their North or South American altitude counterparts. This study sought to determine whether Tibetans…
Mitochondrial DNA analysis in Tibet
Mitochondrial DNAs (mtDNAs) of 54 Tibetans residing at altitudes ranging from 3,000–4,500 m were amplified by polymerase chain reaction (PCR), examined by high‐resolution restriction endonuclease analysis, and compared with those previously described in 10 other Asian and Siberian populations. This comparison revealed that more than 50% of Asian mtDNAs belong to a unique mtDNA lineage which is found only among Mongoloids, suggesting that this lin…
Superior exercise performance in lifelong Tibetan residents of 4,400 m compared with Tibetan residents of 3,658 m
Few environments challenge human populations more than high altitude, since the accompanying low oxygen pressures (hypoxia) are pervasive and impervious to cultural modification. Work capacity is an important factor in a population's ability to thrive in such an environment. The performance of work or exercise is a measure of the integrated functioning of the O2 transport system, with maximal O2 uptake (.VO2max) a convenient index of that functio…
Human adaptation to high altitude
Studies of the ways in which persons respond to the adaptive challenges of life at high altitude have occupied an important place in anthropology. There are three major regions of the world where high-altitude studies have recently been performed: the Himalayas of Asia, the Andes of South America, and the Rocky Mountains of North America. Of these, the Himalayan region is larger, more geographically remote, and likely to have been occupied by hum…
Tibetan protection from intrauterine growth restriction (Iugr) and reproductive loss at high altitude
Chronic hypoxia at high altitude restricts fetal growth, reducing birth weight and increasing infant mortality. We asked whether Tibetans, a long‐resident high‐altitude population, exhibit less altitude‐associated intrauterine growth restriction (IUGR) and prenatal or postnatal reproductive loss than Han (ethnic Chinese), a group that has lived there for a shorter period of time. A population sample was obtained, comprising 485 deliveries to Tibe…
Tibetan protection from intrauterine growth restriction (Iugr) and reproductive loss at high altitude
Oxygen transport in Tibetan women during pregnancy at 3,658 m
High-altitude reduces infant birth weight as a result of intrauterine growth restriction (IUGR) and is associated with increased neonatal mortality. We hypothesized that babies born to Tibetan compared to Han (Chinese) high-altitude residents were protected from IUGR as the result of increased maternal O(2) transport due, in turn, to increased uterine artery (UA) blood flow. We studied 68 nonpregnant or pregnant Tibetan or Han residents of Lhasa,…
Human physiological adaptation to pregnancy
Reproductive success requires successful maternal physiological adaptation to pregnancy. An interspecific perspective reveals that the human species has modified features of our haplorhine heritage affecting the uteroplacental circulation. We speculate that such modifications — including early implantation and deep, widespread invasion of fetal (trophoblast cells) into and resultant remodeling of maternal uterine vessels — are responses to or com…
Introduction
Evidence that parent‐of‐origin affects birth‐weight reductions at high altitude
Hypoxia exerts a profound depressant effect on fetal growth, lowering birth weight, and raising mortality risk. Multigenerational high‐altitude populations are relatively protected from this birth‐weight decline, leading us to hypothesize that genetic factors were involved. We asked if the amount of high‐ versus low‐altitude ancestry influenced birth weight at high altitude and, specifically, whether such influences were affected by parent‐of‐ori…
Evolutionary adaptation to high altitude
A primary focus within biological anthropology has been to elucidate the processes of evolutionary adaptation. Frisancho helped to move anthropology towards more mechanistic explanations of human adaptation by drawing attention to the importance of the functional relevance of human variation. Using the natural laboratory of high altitude, he and others asked whether the unique physiology of indigenous high‐altitude residents was the result of acc…
Lowland origin women raised at high altitude are not protected against lower uteroplacental O 2 delivery during pregnancy or reduced birth weight
OBJECTIVE: Maternal physiologic responses to pregnancy promoting fetal oxygen and nutrient delivery are important determinants of reproductive success. Incomplete physiologic compensation for reduced oxygen availability at high altitude (≥2,500 m) compromises fetal growth. Populations of highland (e.g., Andeans, Tibetans) compared with lowland origin groups (e.g., Europeans, Han Chinese) are protected from this altitude-associated decrease in bir…
Andean and Tibetan patterns of adaptation to high altitude
OBJECTIVES: High-altitude hypoxia, or decreased oxygen levels caused by low barometric pressure, challenges the ability of humans to live and reproduce. Despite these challenges, human populations have lived on the Andean Altiplano and the Tibetan Plateau for millennia and exhibit unique circulatory, respiratory, and hematological adaptations to life at high altitude. We and others have identified natural selection candidate genes and gene region…
Little Effect of Gestation at 3,100 m on Fetal Fat Accretion or the Fetal Circulation
OBJECTIVE: While chronic hypoxia has been recognized as the principal causative factor for decreasing birth weight at high altitude, unknown is whether fetal fat accretion and vascular function are affected. METHODS: Colorado women with normal singleton pregnancies (18 Denver residents, 1,600 m; 24 Leadville residents, 3,100 m) were studied longitudinally from 20 to 36 weeks gestation. Fetal biometry was used to obtain axial images for assessing …
Surname‐Inferred andean ancestry is associated with child stature and limb lengths at high altitude in P eru, but not at sea level
OBJECTIVES: Native Andean ancestry gives partial protection from reduced birthweight at high altitude in the Andes compared with European ancestry. Whether Andean ancestry is also associated with body proportions and greater postnatal body size at altitude is unknown. Therefore, we tested whether a greater proportion of Andean ancestry is associated with stature and body proportions among Peruvian children at high and low altitude. METHODS: Heigh…
Human genetic adaptation to high altitudes
High Altitude Continues to Reduce Birth Weights in Colorado
Biology (17 works) · Effects of high altitude on humans (14 works) · Medicine (10 works) · Pregnancy and preeclampsia studies (10 works) · Demography (9 works) · High Altitude and Hypoxia (9 works) · Pregnancy (9 works) · Birth, Development, and Health (8 works) · Genetics (8 works) · Fetus (7 works)