Miguel A Alfonso-Sánchez
Biographic Data
| ID | 4089980 |
|---|---|
| NAME | Miguel A Alfonso-Sánchez |
| GIVEN NAMES | Miguel A |
| FAMILY NAME | Alfonso-Sánchez |
| SIGNATURE | ALFONSO-SÁNCHEZ M A |
| AFFILIATIONS | Departamento de Genética, Antropología Física y Fisiología Animal, Facultad de Ciencia y Tecnología, Universidad del País Vasco (UPV/EHU), Bilbao, Spain |
| VERIFIED | No |
| TOTAL WORKS | 9 |
| TOTAL CITATIONS | 15 |
| AUTHOR COUNT | 9 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 2003 |
| LATEST PUBLICATION YEAR | 2025 |
| H-INDEX | 3 |
Genetic Ancestry Strongly Impacts Mapt (17q21.31) Haplotype Frequencies of South American Populations
Genetic and archaeological studies indicate that the American continent has undergone multiple waves of human migration, shaping a complex population genetic structure comprising three major ethnic groups—Native American, European, and African—unevenly distributed across the continent. In this study, we examined MAPT (17q21.31) haplotype and subhaplotype frequencies by analyzing two single nucleotide polymorphism markers (rs10514879 and rs199451)…
Tau (Mapt) haplotypes in Jordan: New evidence on the Middle East as a melting-pot predating Neolithic migration
Frequencies of H1 and H2 haplotypes of the microtubule-associated protein tau (MAPT) gene were examined in two Jordanian samples. The criterion for haplotype assignment was the presence/absence of the intronic 238-bp deletion, located between exons 9 and 10 of the MAPT genomic region. We further compiled MAPT haplotype frequencies in Middle Eastern, South Asian, and European populations to widen the scope of analyses. Jordan MAPT*H2 haplotype fre…
STR Markers Unveil Microgeographic Differentiation over the Steep Mountainous Landscape of Jujuy Province, Northwest Argentina
This study explores potential signals of microdifferentiation in the gene pool of three high-altitude populations from Jujuy province in northwest Argentina using highly polymorphic markers. These human communities are characterized by extreme living conditions and very low population densities owing to considerable height above sea level and steep orography. A set of autosomal short tandem repeats (STRs) located at chromosome 6 (6p21.3) was type…
Genetic admixture estimates by Alu elements in Afro-Colombian and Mestizo populations from Antioquia, Colombia
The peculiarity of the Afro-Colombian gene pool seems to be associated with intense genetic drift episodes that occurred in isolated communities founded by small groups of runaway slaves. ACE, APO, FXIIIB, PV92 and TPA25 could be efficiently utilized in studies dealing with demographic history and biogeographical ancestry in human populations
Genetic polymorphisms in autochthonous Basques from Northern Navarre
This survey reports primary results of classical allele frequencies on ten protein loci in a Basque population sample from northern Navarre, the less known from an anthropological and genetic point of view than the populations of the other Basque territories of Spain. Since ancient times this has been a zone of Basque population settlement, and the Basque language (Euskera) still remains deeply rooted among its autochthonous population. A total o…
Effects of consanguinity on pre-reproductive mortality: Does demographic transition matter
The aim of this study was to investigate whether there is an increase on premature deaths due to genetically determined factors at the beginning of a demographic transition. We also analyzed the effects of parental consanguinity on offspring mortality from an epidemiological viewpoint, using parish records for family reconstitution in a Basque population (1800-1990). Among the offspring of unrelated parents, 13.1% died before their first year of …
Inbreeding levels and consanguinity structure in the Basque province of Guipúzcoa (1862-1980)
This work analyzes the spatial heterogeneity of consanguinity in the Basque province of Guipúzcoa (Spain), using data provided by Catholic dispensations (1862-1980). Secular trends in consanguinity rates (%M(C)) and mean inbreeding coefficient (F) were similar in the seven Guipúzcoan regions considered, with peaks between 1881-1920 and subsequently a gradual decline. Substantial differences in consanguinity characteristics emerged when the region…
Opportunity for Natural Selection in a Basque Population and Its Secular Trend: Evolutionary Implications of Epidemic Mortality
Analysis of the interaction between mortality patterns and opportunity for natural selection could help to elucidate potential evolutionary implications of epidemic mortality. In this paper secular trends are studied in relation to Crow's index (It) and its components of mortality (Im) and fertility (If), using parish records for family reconstitution in a Basque population. A principal components analysis (91% of the variance accounted for) show…
Time Trends and Determinants of Completed Family Size in a Rural Community From the Basque Area of Spain (1800–1969)
The focus of this work is the analysis of changes in completed family size and possible determinants of that size over time, in an attempt to characterize the evolution of reproductive patterns during the demographic transition. With this purpose in mind, time trends are studied in relation to the mean number of live births per family (as an indirect measure of fertility), using family reconstitution techniques to trace the reproductive history o…
Opportunity for Natural Selection in a Basque Population and Its Secular Trend: Evolutionary Implications of Epidemic Mortality
Analysis of the interaction between mortality patterns and opportunity for natural selection could help to elucidate potential evolutionary implications of epidemic mortality. In this paper secular trends are studied in relation to Crow's index (It) and its components of mortality (Im) and fertility (If), using parish records for family reconstitution in a Basque population. A principal components analysis (91% of the variance accounted for) show…
STR Markers Unveil Microgeographic Differentiation over the Steep Mountainous Landscape of Jujuy Province, Northwest Argentina
This study explores potential signals of microdifferentiation in the gene pool of three high-altitude populations from Jujuy province in northwest Argentina using highly polymorphic markers. These human communities are characterized by extreme living conditions and very low population densities owing to considerable height above sea level and steep orography. A set of autosomal short tandem repeats (STRs) located at chromosome 6 (6p21.3) was type…
Inbreeding levels and consanguinity structure in the Basque province of Guipúzcoa (1862-1980)
This work analyzes the spatial heterogeneity of consanguinity in the Basque province of Guipúzcoa (Spain), using data provided by Catholic dispensations (1862-1980). Secular trends in consanguinity rates (%M(C)) and mean inbreeding coefficient (F) were similar in the seven Guipúzcoan regions considered, with peaks between 1881-1920 and subsequently a gradual decline. Substantial differences in consanguinity characteristics emerged when the region…
Time Trends and Determinants of Completed Family Size in a Rural Community From the Basque Area of Spain (1800–1969)
The focus of this work is the analysis of changes in completed family size and possible determinants of that size over time, in an attempt to characterize the evolution of reproductive patterns during the demographic transition. With this purpose in mind, time trends are studied in relation to the mean number of live births per family (as an indirect measure of fertility), using family reconstitution techniques to trace the reproductive history o…
Opportunity for Natural Selection in a Basque Population and Its Secular Trend: Evolutionary Implications of Epidemic Mortality
Analysis of the interaction between mortality patterns and opportunity for natural selection could help to elucidate potential evolutionary implications of epidemic mortality. In this paper secular trends are studied in relation to Crow's index (It) and its components of mortality (Im) and fertility (If), using parish records for family reconstitution in a Basque population. A principal components analysis (91% of the variance accounted for) show…
Effects of consanguinity on pre-reproductive mortality: Does demographic transition matter
The aim of this study was to investigate whether there is an increase on premature deaths due to genetically determined factors at the beginning of a demographic transition. We also analyzed the effects of parental consanguinity on offspring mortality from an epidemiological viewpoint, using parish records for family reconstitution in a Basque population (1800-1990). Among the offspring of unrelated parents, 13.1% died before their first year of …
Inbreeding levels and consanguinity structure in the Basque province of Guipúzcoa (1862-1980)
This work analyzes the spatial heterogeneity of consanguinity in the Basque province of Guipúzcoa (Spain), using data provided by Catholic dispensations (1862-1980). Secular trends in consanguinity rates (%M(C)) and mean inbreeding coefficient (F) were similar in the seven Guipúzcoan regions considered, with peaks between 1881-1920 and subsequently a gradual decline. Substantial differences in consanguinity characteristics emerged when the region…
Genetic polymorphisms in autochthonous Basques from Northern Navarre
This survey reports primary results of classical allele frequencies on ten protein loci in a Basque population sample from northern Navarre, the less known from an anthropological and genetic point of view than the populations of the other Basque territories of Spain. Since ancient times this has been a zone of Basque population settlement, and the Basque language (Euskera) still remains deeply rooted among its autochthonous population. A total o…
Genetic admixture estimates by Alu elements in Afro-Colombian and Mestizo populations from Antioquia, Colombia
The peculiarity of the Afro-Colombian gene pool seems to be associated with intense genetic drift episodes that occurred in isolated communities founded by small groups of runaway slaves. ACE, APO, FXIIIB, PV92 and TPA25 could be efficiently utilized in studies dealing with demographic history and biogeographical ancestry in human populations
STR Markers Unveil Microgeographic Differentiation over the Steep Mountainous Landscape of Jujuy Province, Northwest Argentina
This study explores potential signals of microdifferentiation in the gene pool of three high-altitude populations from Jujuy province in northwest Argentina using highly polymorphic markers. These human communities are characterized by extreme living conditions and very low population densities owing to considerable height above sea level and steep orography. A set of autosomal short tandem repeats (STRs) located at chromosome 6 (6p21.3) was type…
Tau (Mapt) haplotypes in Jordan: New evidence on the Middle East as a melting-pot predating Neolithic migration
Frequencies of H1 and H2 haplotypes of the microtubule-associated protein tau (MAPT) gene were examined in two Jordanian samples. The criterion for haplotype assignment was the presence/absence of the intronic 238-bp deletion, located between exons 9 and 10 of the MAPT genomic region. We further compiled MAPT haplotype frequencies in Middle Eastern, South Asian, and European populations to widen the scope of analyses. Jordan MAPT*H2 haplotype fre…
Genetic Ancestry Strongly Impacts Mapt (17q21.31) Haplotype Frequencies of South American Populations
Genetic and archaeological studies indicate that the American continent has undergone multiple waves of human migration, shaping a complex population genetic structure comprising three major ethnic groups—Native American, European, and African—unevenly distributed across the continent. In this study, we examined MAPT (17q21.31) haplotype and subhaplotype frequencies by analyzing two single nucleotide polymorphism markers (rs10514879 and rs199451)…
Demography (8 works) · Population (8 works) · Geography (7 works) · Biology (6 works) · Forensic and Genetic Research (5 works) · Sociology (5 works) · Demography (4 works) · Evolutionary biology (4 works) · Gene (4 works) · Allele (3 works)