M J Mosher
Biographic Data
| ID | 4090201 |
|---|---|
| NAME | M J Mosher |
| GIVEN NAMES | M J |
| FAMILY NAME | Mosher |
| SIGNATURE | MOSHER M J |
| AFFILIATIONS | Western Washington University |
| ORCID | 0000-0002-2497-5369 |
| VERIFIED | Yes |
| TOTAL WORKS | 9 |
| TOTAL CITATIONS | 13 |
| WORKS AS AUTHOR | 9 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 2002 |
| LATEST PUBLICATION YEAR | 2015 |
| H-INDEX | 1 |
Genomic evidence for the Pleistocene and recent population history of Native Americans
Genetic history of Native Americans Several theories have been put forth as to the origin and timing of when Native American ancestors entered the Americas. To clarify this controversy, Raghavan et al. examined the genomic variation among ancient and modern individuals from Asia and the Americas. There is no evidence for multiple waves of entry or recurrent gene flow with Asians in northern populations. The earliest migrations occurred no earlier…
Epigenetic mechanisms as an archive of ancestral dietary history of populations
Mitochondrial DNA Diversity in Mennonite Communities from the Midwestern United States
We examined mitochondrial DNA (mtDNA) variation in six Mennonite communities from Kansas (Goessel, Lone Tree, Garden View, Meridian, and Garden City) and Nebraska (Henderson) to determine their genetic structure and its relationship to population history. Mitochondrial DNA haplogroup and haplotype information were obtained from blood samples from 118 individuals. Molecular genetic variation was analyzed using diversity measures, neutrality test s…
Reduced fat oxidation and obesity risks among the Buryat of Southern Siberia
Over the last 20 years, obesity and associated metabolic diseases have emerged as major global health problems. Among urbanizing populations of developing regions of the world, childhood undernutrition often coexists with adult overnutrition, a phenomenon known as the “dual nutritional burden”. A recent work (Frisancho 2003 : Am J Hum Biol 15:522–532) suggests that linear growth stunting in early childhood may contribute to adult obesity by reduc…
The influence of basal metabolic rate on blood pressure among indigenous Siberians
Hypertension is an important global health issue and is currently increasing at a rapid pace in most industrializing nations. Although a number of risk factors have been linked with the development of hypertension, including obesity, high dietary sodium, and chronic psychosocial stress, these factors cannot fully explain the variation in blood pressure and hypertension rates that occurs within and between populations. The present study uses data …
Apolipoproteins (apoproteins) and LPL variation in Mennonite populations of Kansas and Nebraska
Apoproteins (also known as apolipoproteins) have been studied extensively because of their role in lipid transport, association between specific genotypes and elevated serum lipid levels, and increased risk of heart disease. There is considerable genetic variation in the geographic distributions of these markers, with a north-south cline of the APOE*4 allele observed in Europe by Lucotte et al. ([1997] Hum Biol 69:253-262). This study compares th…
Applications of Pooled DNA Samples to the Assessment of Population Affinities
Pooled DNA samples have been used in association studies of Mendelian disease genes. This method involves combining equal quantities of DNA from patients and control subjects into separate pools and comparing the pools for distributions of genetic markers. In this study identical quantities of DNA from 300 individuals representing 6 populations were pooled and amplified for 296 loci using the touchdown polymerase chain reaction (PCR) method. The …
Genotype-by-Sex Interaction in the Regulation of High-Density Lipoprotein
Low levels of high-density lipoprotein (HDL) are widely documented as a risk factor for cardiovascular disease (CVD). Furthermore, there is marked sexual dimorphism in both HDL levels and the prevalence of CVD. However, the extent to which genetic factors contribute to such dimorphism has been largely unexplored. We examined the evidence for genotype-by-sex effects on HDL in a longitudinal sample of 1,562 participants from 330 families in the Fra…
Climatic influences on basal metabolic rates among circumpolar populations
This article examines evidence for elevations in basal metabolic rate (BMR) among indigenous Northern (circumpolar) populations and considers potential mechanisms and the adaptive basis for such elevations. Data on BMR among indigenous (n = 109 males; 122 females) and nonindigenous (n = 15 males; 22 females) circumpolar groups of North America and Siberia are compiled and compared to predicted BMRs based on three different references: body surfac…
The influence of basal metabolic rate on blood pressure among indigenous Siberians
Hypertension is an important global health issue and is currently increasing at a rapid pace in most industrializing nations. Although a number of risk factors have been linked with the development of hypertension, including obesity, high dietary sodium, and chronic psychosocial stress, these factors cannot fully explain the variation in blood pressure and hypertension rates that occurs within and between populations. The present study uses data …
Climatic influences on basal metabolic rates among circumpolar populations
This article examines evidence for elevations in basal metabolic rate (BMR) among indigenous Northern (circumpolar) populations and considers potential mechanisms and the adaptive basis for such elevations. Data on BMR among indigenous (n = 109 males; 122 females) and nonindigenous (n = 15 males; 22 females) circumpolar groups of North America and Siberia are compiled and compared to predicted BMRs based on three different references: body surfac…
Apolipoproteins (apoproteins) and LPL variation in Mennonite populations of Kansas and Nebraska
Apoproteins (also known as apolipoproteins) have been studied extensively because of their role in lipid transport, association between specific genotypes and elevated serum lipid levels, and increased risk of heart disease. There is considerable genetic variation in the geographic distributions of these markers, with a north-south cline of the APOE*4 allele observed in Europe by Lucotte et al. ([1997] Hum Biol 69:253-262). This study compares th…
Applications of Pooled DNA Samples to the Assessment of Population Affinities
Pooled DNA samples have been used in association studies of Mendelian disease genes. This method involves combining equal quantities of DNA from patients and control subjects into separate pools and comparing the pools for distributions of genetic markers. In this study identical quantities of DNA from 300 individuals representing 6 populations were pooled and amplified for 296 loci using the touchdown polymerase chain reaction (PCR) method. The …
Genotype-by-Sex Interaction in the Regulation of High-Density Lipoprotein
Low levels of high-density lipoprotein (HDL) are widely documented as a risk factor for cardiovascular disease (CVD). Furthermore, there is marked sexual dimorphism in both HDL levels and the prevalence of CVD. However, the extent to which genetic factors contribute to such dimorphism has been largely unexplored. We examined the evidence for genotype-by-sex effects on HDL in a longitudinal sample of 1,562 participants from 330 families in the Fra…
The influence of basal metabolic rate on blood pressure among indigenous Siberians
Hypertension is an important global health issue and is currently increasing at a rapid pace in most industrializing nations. Although a number of risk factors have been linked with the development of hypertension, including obesity, high dietary sodium, and chronic psychosocial stress, these factors cannot fully explain the variation in blood pressure and hypertension rates that occurs within and between populations. The present study uses data …
Reduced fat oxidation and obesity risks among the Buryat of Southern Siberia
Over the last 20 years, obesity and associated metabolic diseases have emerged as major global health problems. Among urbanizing populations of developing regions of the world, childhood undernutrition often coexists with adult overnutrition, a phenomenon known as the “dual nutritional burden”. A recent work (Frisancho 2003 : Am J Hum Biol 15:522–532) suggests that linear growth stunting in early childhood may contribute to adult obesity by reduc…
Mitochondrial DNA Diversity in Mennonite Communities from the Midwestern United States
We examined mitochondrial DNA (mtDNA) variation in six Mennonite communities from Kansas (Goessel, Lone Tree, Garden View, Meridian, and Garden City) and Nebraska (Henderson) to determine their genetic structure and its relationship to population history. Mitochondrial DNA haplogroup and haplotype information were obtained from blood samples from 118 individuals. Molecular genetic variation was analyzed using diversity measures, neutrality test s…
Genomic evidence for the Pleistocene and recent population history of Native Americans
Genetic history of Native Americans Several theories have been put forth as to the origin and timing of when Native American ancestors entered the Americas. To clarify this controversy, Raghavan et al. examined the genomic variation among ancient and modern individuals from Asia and the Americas. There is no evidence for multiple waves of entry or recurrent gene flow with Asians in northern populations. The earliest migrations occurred no earlier…
Epigenetic mechanisms as an archive of ancestral dietary history of populations
Biology (9 works) · Demography (7 works) · Genetics (5 works) · Population (5 works) · Endocrinology (4 works) · Gene (4 works) · Internal Medicine (4 works) · Medicine (4 works) · Allele (3 works) · Birth, Development, and Health (3 works)