Alfredo Santovito
Biographic Data
| ID | 4091037 |
|---|---|
| NAME | Alfredo Santovito |
| GIVEN NAMES | Alfredo |
| FAMILY NAME | Santovito |
| SIGNATURE | SANTOVITO A |
| AFFILIATIONS | University of Turin |
| ORCID | 0000-0001-5292-5206 |
| VERIFIED | Yes |
| TOTAL WORKS | 8 |
| TOTAL CITATIONS | 0 |
| WORKS AS AUTHOR | 8 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 2007 |
| LATEST PUBLICATION YEAR | 2021 |
| H-INDEX | 0 |
Association of TGFβ1 codon 10 (T>C) and IL ‐10 (G>C) cytokine gene polymorphisms with longevity in a cohort of Italian population
Longevity is a complex process controlled by both environmental and genetic factors. We evaluated the association of four cytokine gene polymorphisms with longevity in an Italian cohort. A sample of 1019 subjects aged 10 to 100 and belonging to the North‐Italian population was genotyped for IL‐6 (G>C, rs1800796), IL‐10 ‐1082 (G>A, rs1800896), TNF‐α ‐308 (G>A, rs1800629), and TGFβ1 codon 10 (T>C, rs1800471) gene polymorphisms. The association betw…
GSTT1 , GSTP1 and XPC genes are associated with longevity in an Italian cohort
Longevity is a complex process controlled by environmental and genetic factors. We evaluated the association of seven drug metabolising and DNA-repair gene polymorphisms with longevity in an Italian cohort. A sample of 756 subjects aged 18-98 was genotyped for CYP1A1 (rs1048943, A>G), GSTM1 (rs 1183423000, presence/absence), GSTT1 (rs1601993659, presence/absence), GSTP1 (rs1695, A>G), XRCC1 (rs1799782, C>T), XRCC1 (rs25489, A>G) and XPC (rs222800…
Micronuclei frequency in peripheral blood lymphocytes of healthy subjects living in Turin (North-Italy)
Background: Increased micronuclei (MNi) frequencies in human lymphocytes are an indicator of chromosome instability and could be influenced by different exogenous and endogenous factors. The increased exposure to environmental pollutants has led to the awareness of the necessity for constant monitoring of urban human populations. Aim: We evaluated the MNi frequency in a sample belonging to the non-occupationally exposed population of Turin (North…
Evaluation of baseline frequency of sister chromatid exchanges in an Italian population according to age, sex, smoking habits, and gene polymorphisms
Baseline frequency of chromosomal aberrations and sister chromatid exchanges in peripheral blood lymphocytes of healthy individuals living in Turin (North-Western Italy)
The CAs background frequency observed in this study is one of the highest reported among European populations. Turin is one of the most polluted cities in Europe in terms of air fine PM10 and ozone and the clastogenic potential of these pollutants may explain the high frequencies of chromosomal rearrangements reported here
Alu insertion polymorphisms in four ethnic groups from northern Ivory Coast
Patterns of genetic variation among geographically and ethnically diverse African populations have been under-represented in human genetics studies despite their importance for describing the evolutionary history of modern human populations. We conducted a study on 133 individuals, belonging to four northern Ivorian ethnic groups, based on the allele distribution of 11 Alu insertion loci, and compared the results with other African populations. A…
Polymorphic Alu insertions in five North‐West Italian populations
We analyzed the frequencies of eight human polymorphic Alu insertion loci in population samples from five towns in North‐West Italy: Postua, Cavaglià, Biella, Torino, and Genova. All loci under scrutiny were found to be polymorphic in all samples, with the two exceptions of locus A25 in Postua, which was fixed for the absence of the Alu element, and APO in Genova, where the Alu insertion was fixed. Heterozigosity values were highly variable in al…
Allelic frequencies at the ACE and LRPAP1 loci suggest age-related relationships in a Northern Italian population
The present work attempts to determine the distribution of ACE and LRPAP1 genotypes and allele frequencies in a sample of the population of north-western Italy and to examine the age-related association of these polymorphisms. ACE D allele frequency found in this work further confirms data obtained in previous studies of Northern Italian populations. Regarding the LRPAP1 gene, high frequencies of the deleted allele in European populations were al…
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Polymorphic Alu insertions in five North‐West Italian populations
We analyzed the frequencies of eight human polymorphic Alu insertion loci in population samples from five towns in North‐West Italy: Postua, Cavaglià, Biella, Torino, and Genova. All loci under scrutiny were found to be polymorphic in all samples, with the two exceptions of locus A25 in Postua, which was fixed for the absence of the Alu element, and APO in Genova, where the Alu insertion was fixed. Heterozigosity values were highly variable in al…
Allelic frequencies at the ACE and LRPAP1 loci suggest age-related relationships in a Northern Italian population
The present work attempts to determine the distribution of ACE and LRPAP1 genotypes and allele frequencies in a sample of the population of north-western Italy and to examine the age-related association of these polymorphisms. ACE D allele frequency found in this work further confirms data obtained in previous studies of Northern Italian populations. Regarding the LRPAP1 gene, high frequencies of the deleted allele in European populations were al…
Alu insertion polymorphisms in four ethnic groups from northern Ivory Coast
Patterns of genetic variation among geographically and ethnically diverse African populations have been under-represented in human genetics studies despite their importance for describing the evolutionary history of modern human populations. We conducted a study on 133 individuals, belonging to four northern Ivorian ethnic groups, based on the allele distribution of 11 Alu insertion loci, and compared the results with other African populations. A…
Baseline frequency of chromosomal aberrations and sister chromatid exchanges in peripheral blood lymphocytes of healthy individuals living in Turin (North-Western Italy)
The CAs background frequency observed in this study is one of the highest reported among European populations. Turin is one of the most polluted cities in Europe in terms of air fine PM10 and ozone and the clastogenic potential of these pollutants may explain the high frequencies of chromosomal rearrangements reported here
Evaluation of baseline frequency of sister chromatid exchanges in an Italian population according to age, sex, smoking habits, and gene polymorphisms
Micronuclei frequency in peripheral blood lymphocytes of healthy subjects living in Turin (North-Italy)
Background: Increased micronuclei (MNi) frequencies in human lymphocytes are an indicator of chromosome instability and could be influenced by different exogenous and endogenous factors. The increased exposure to environmental pollutants has led to the awareness of the necessity for constant monitoring of urban human populations. Aim: We evaluated the MNi frequency in a sample belonging to the non-occupationally exposed population of Turin (North…
Association of TGFβ1 codon 10 (T>C) and IL ‐10 (G>C) cytokine gene polymorphisms with longevity in a cohort of Italian population
Longevity is a complex process controlled by both environmental and genetic factors. We evaluated the association of four cytokine gene polymorphisms with longevity in an Italian cohort. A sample of 1019 subjects aged 10 to 100 and belonging to the North‐Italian population was genotyped for IL‐6 (G>C, rs1800796), IL‐10 ‐1082 (G>A, rs1800896), TNF‐α ‐308 (G>A, rs1800629), and TGFβ1 codon 10 (T>C, rs1800471) gene polymorphisms. The association betw…
GSTT1 , GSTP1 and XPC genes are associated with longevity in an Italian cohort
Longevity is a complex process controlled by environmental and genetic factors. We evaluated the association of seven drug metabolising and DNA-repair gene polymorphisms with longevity in an Italian cohort. A sample of 756 subjects aged 18-98 was genotyped for CYP1A1 (rs1048943, A>G), GSTM1 (rs 1183423000, presence/absence), GSTT1 (rs1601993659, presence/absence), GSTP1 (rs1695, A>G), XRCC1 (rs1799782, C>T), XRCC1 (rs25489, A>G) and XPC (rs222800…
Biology (7 works) · Demography (6 works) · Gene (6 works) · Genetics (6 works) · Population (6 works) · Allele (4 works) · Demography (4 works) · Genotype (4 works) · Allele frequency (3 works) · Carcinogens and Genotoxicity Assessment (3 works)