Danuta Z Loesch
Dados Biográficos
| ID | 4091164 |
|---|---|
| NOME | Danuta Z Loesch |
| PRENOMES | Danuta Z |
| SOBRENOME | Loesch |
| ASSINATURA | LOESCH D Z |
| AFILIAÇÕES | La Trobe University |
| ORCID | 0000-0002-2180-2606 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 24 |
| TOTAL DE CITAÇÕES | 11 |
| TOTAL COMO AUTOR | 24 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 1975 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2021 |
| ÍNDICE H | 2 |
Delineating the Relationships Between Motor, Cognitive-Executive and Psychiatric Symptoms in Female FMR1 Premutation Carriers
Introduction: Premutation expansions (55-200 CGG repeats) of the Fragile X Mental Retardation 1 (FMR1) gene on the X chromosome are associated with a range of clinical features. Apart from the most severe - Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS) - where the most typical white matter changes affect cerebellar peduncles, more subtle changes may include impairment of executive functioning, affective disorders and/or subtle motor changes…
Cellular Bioenergetics and AMPK and Torc1 Signalling in Blood Lymphoblasts Are Biomarkers of Clinical Status in FMR1 Premutation Carriers
Fragile X Associated Tremor/Ataxia Syndrome (FXTAS) is a neurodegenerative disorder affecting carriers of premutation alleles (PM) of the X-linked FMR1 gene, which contain CGG repeat expansions of 55-200 range in a non-coding region. This late-onset disorder is characterised by the presence of tremor/ataxia and cognitive decline, associated with the white matter lesions throughout the brain, especially involving the middle cerebellar peduncles. N…
A review of physical growth in children and adolescents with Autism Spectrum Disorder
Ridgecounter
Finger ridge count is a valuable quantitative phenotype used in a wide range of biological and anthropological research. However, the scoring of the phenotype is both labour intensive and error prone. This paper describe a freely available software program, RIDGECOUNTER, that can be used to obtain ridge counts from digitized prints (either collected using a digital fingerprint scanner or scanned from an inked print). The program yields semi-autom…
Haplotype Study of Intermediate-Length Alleles at the Fragile X (FMR1) Gene
The CGG repeat within the X-chromosome-linked FMR1 gene, which in hyperexpansion (> 200 copies) results in fragile X syndrome, is highly polymorphic. The mechanism of expansion is not well understood, but CGG repeats called intermediate-length or gray zone alleles (approximately equal 35-60 repeats) are thought to make up the FMR1 alleles showing initial steps in this expansion process. It has been hypothesized that the background haplotype of th…
Secular trend in body height and weight of Australian children and adolescents
Secular changes in growth and maturation have been well documented in various world populations, with secular increase especially noticeable in the developed countries. To assess the trend in both adult size and tempo of growth we compared the data on stature and body weight obtained in 1992-1993 from 1,804 Melbourne school students aged 5 to 17 with historical data collected from white Australians during the last 100 years. We illustrate the age…
Relationship of birth weight and length with growth in height and body diameters from 5 years of age to maturity
Birth weight and birth length were compared with several growth measures, including body height and weight, linear measures of limbs, body diameters, and head circumference, in 726 Melbourne schoolchildren of both sexes age 5-18 years. The analysis of relationships between three categories of birth length, weight, and growth measures were based on z-scores and performed by using analysis of variance and partial correlation. The data showed that b…
Relationship of birth weight and length with growth in height and body diameters from 5 years of age to maturity
Birth weight and birth length were compared with several growth measures, including body height and weight, linear measures of limbs, body diameters, and head circumference, in 726 Melbourne schoolchildren of both sexes age 5–18 years. The analysis of relationships between three categories of birth length, weight, and growth measures were based on z-scores and performed by using analysis of variance and partial correlation. The data showed that b…
Genetic correlates of menarcheal age
Multivariate genetic models were fitted to data from 44 pairs of MZ and 42 pairs of DZ twin girls on weight, height, and skeletal maturation at the age of menarche, in order to obtain information on genetic relationships of those measures with the age of menarche. The relationships of all three physical measures with this age were largely genetically controlled, but a genetic system controlling skeletal maturity was identified as the only genetic…
A new anthropometric scale for discrimination between sexes
Sexual dimorphism with respect to body size and shape has been analysed by means of discriminant function. An anthropometric score has been derived from 111 adult normal males and 108 females, based on 11 anthropometric and three dermatoglyphic variables. The score represents the range of quantified physical phenotypes of 'maleness' and 'femaleness'. Complete separation between the distributions of this score in either sex has been achieved. Pred…
Relationships of epidermal ridge patterns with body measurements and their possible evolutionary significance
It is commonly believed that in humans epidermal ridge patterns are in regression relative to nonhuman primates, and they play no role in adaptive processes. In contrast with this we have found relationships between anthropometric and dermatoglyphic measurements in a sample of 61 normal males. Anthropometric variables included limb, trunk, head, and face measures. Dermatoglyphic variables included finger ridge counts and pattern intensities and r…
Principal component analysis of shape variables in adult individuals
Human body shape variables were obtained by adjusting 34 distances between trunk/limbs, and head/face, landmarks, for an overall appropriate body size measurement. The adjustment was based on regression analysis. Principal component analysis was applied to thus defined shape variables to obtain shape dimensions in 99 normal adult males and 103 females. The first principal component either for trunk/limbs shape variables, or for head/face variable…
Dermatoglyphic variation and weight and length at birth
Relationships between dermatoglyphic variables, including finger ridge counts and finger, palmar, and plantar pattern intensities, and weight and length at birth, were tested in a sample of 184 boys and 202 girls from Warsaw schools. No convincing evidence for such relationships has been obtained from the results of correlations and one‐way analysis of variance, although there are indications that some palmar traits may be related to length at bi…
Bivariate and multivariate analysis of the skin ridge pattern intensities
Bivariate correlations and multivariate (factor) analysis of pattern intensities on individual fingers and all specified areas of palms and soles were performed in a large sample of 834 individuals from two rural districts of Poland, and in a sample of 383 school children from the city of Warsaw, with males and females considered separately. Eleven factors were extracted in all samples, including two for finger pattern intensities, and the remain…
Dermal ridge patterns and fertility in a Polish rural sample
The relationship between ridge counts and pattern intensities on fingers, palms and soles, and number of pregnancies, number of surviving children, maternal age at birth of first child, and miscarriages was investigated in a rural Polish sample of 273 females. All subjects had completed their reproduction by the time of investigation and the use of contraceptives was negligible. Results show that females with a history of miscarriage have lower m…
Relationships between minute characteristics of finger ridges and pattern size and shape
We present results of a multivariate analysis of several characteristics of the ridge pattern on the tip of fingers III and IV of the right hand, with special consideration of the minute properties of ridges. The analysis is based on a sample of 38 females and 63 males of European origin. Results of factor analysis for the male sample reveal that pattern type and size load on one factor. Furthermore, there are separate factors for the two types o…
Finger ridge patterns and tactile sensitivity
Tactile sensitivity has been measured in 101 normal individuals (38 females and 63 males) of European origin, and compared with ridge pattern characteristics of the fourth fingertip of the right hand. There is a relationship of tactile sensitivity performance with the type of pattern, particularly in females, and also with the number of junctions within the pattern, particularly in males. The possible origin of sex differences in tactile sensitiv…
Some dermatoglyphic features of Australian aboriginals from Mornington Island
Topologically significant dermatoglyphic patterns on palms and fingers have been analyzed in a sample of 118 Lardiil and 37 Kaiadilt males and females living on Mornington Island. The purpose of this analysis has been to demonstrate the applications of the topological classification in comparative studies and to point out some general developmental problems which have emerged from dermatoglyphic study of distant populations. The results are prese…
Evidence for directional non-additivity in the genetics of finger ridge counts
A genetical analysis of variation in finger ridge counts of 221 pairs of twins and 80 pairs of opposite sex siblings has been carried out. Negative regression of DZ and sibling pair variances on pair means suggests the action of non-additive genes or unequal gene frequencies tending to increase finger ridge counts. Negative skewness of the distributions supports this view. While models including dominance or epistasis are not a significant improv…
A genetical analysis of covariation between finger ridge counts
1. The genetical and environmental structure of covariation between finger ridge counts in twin and sibling data has been analysed using the method of Martin and Eaves (1977) adapted from Jöreskog. 2. The model for environmental covariance contains a single factor loading on all ten digits but most environmental variance is specific to each finger. 3. For additive genetic variance there is one common factor loading on all digits. There are also f…
Classification of dermal patterns on the proximal sole
A classification formula which includes all true patterns on the proximal sole and is based on topological principles is presented. The frequencies of all respective pattern elements were obtained from a sample of 219 healthy individuals of Croatian origin (116 males and 103 females) and all the formulae (total patterns) encountered in this sample are listed in a dictionary form. Examples of the whole configurations are also given and the applica…
Dermatoglyphic total patterns on palms, finger-tips and soles in twins
110 palms of MZ twins and 111 like-sexed pairs of DZ twins have been compared in respect of a concordance rate of the palmar, sole and finger-tip total pattern types. Dermatoglyphic patterns have been classified according to the topological method, and the distributions of the numbers of discordant pattern elements from homolateral, heterolateral and bilateral comparisons in MZ and DZ twins, respectively, are presented. The highest concordance oc…
Topological classification and genetical studies of dermatoglyphic patterns
Badania właściwości genetycznych układów linii papilarnych dłoni i stóp
The paper presents the results of genetical analysis of dermatoglyphic characters, as classified by the new topological method, introduced by Penrose and Loesch. Firstly, the difficulties in genetical analysis of non-metrical dermatoglyphic characters and the limitations of the traditional classification methods in this respect, concerning particularly sole patterns, are pointed out. Then, the principles of the alternative method of classificatio…
Topological classification and genetical studies of dermatoglyphic patterns
Haplotype Study of Intermediate-Length Alleles at the Fragile X (FMR1) Gene
The CGG repeat within the X-chromosome-linked FMR1 gene, which in hyperexpansion (> 200 copies) results in fragile X syndrome, is highly polymorphic. The mechanism of expansion is not well understood, but CGG repeats called intermediate-length or gray zone alleles (approximately equal 35-60 repeats) are thought to make up the FMR1 alleles showing initial steps in this expansion process. It has been hypothesized that the background haplotype of th…
Bivariate and multivariate analysis of the skin ridge pattern intensities
Bivariate correlations and multivariate (factor) analysis of pattern intensities on individual fingers and all specified areas of palms and soles were performed in a large sample of 834 individuals from two rural districts of Poland, and in a sample of 383 school children from the city of Warsaw, with males and females considered separately. Eleven factors were extracted in all samples, including two for finger pattern intensities, and the remain…
Some dermatoglyphic features of Australian aboriginals from Mornington Island
Topologically significant dermatoglyphic patterns on palms and fingers have been analyzed in a sample of 118 Lardiil and 37 Kaiadilt males and females living on Mornington Island. The purpose of this analysis has been to demonstrate the applications of the topological classification in comparative studies and to point out some general developmental problems which have emerged from dermatoglyphic study of distant populations. The results are prese…
Relationships of epidermal ridge patterns with body measurements and their possible evolutionary significance
It is commonly believed that in humans epidermal ridge patterns are in regression relative to nonhuman primates, and they play no role in adaptive processes. In contrast with this we have found relationships between anthropometric and dermatoglyphic measurements in a sample of 61 normal males. Anthropometric variables included limb, trunk, head, and face measures. Dermatoglyphic variables included finger ridge counts and pattern intensities and r…
Dermatoglyphic variation and weight and length at birth
Relationships between dermatoglyphic variables, including finger ridge counts and finger, palmar, and plantar pattern intensities, and weight and length at birth, were tested in a sample of 184 boys and 202 girls from Warsaw schools. No convincing evidence for such relationships has been obtained from the results of correlations and one‐way analysis of variance, although there are indications that some palmar traits may be related to length at bi…
Badania właściwości genetycznych układów linii papilarnych dłoni i stóp
The paper presents the results of genetical analysis of dermatoglyphic characters, as classified by the new topological method, introduced by Penrose and Loesch. Firstly, the difficulties in genetical analysis of non-metrical dermatoglyphic characters and the limitations of the traditional classification methods in this respect, concerning particularly sole patterns, are pointed out. Then, the principles of the alternative method of classificatio…
Dermatoglyphic total patterns on palms, finger-tips and soles in twins
110 palms of MZ twins and 111 like-sexed pairs of DZ twins have been compared in respect of a concordance rate of the palmar, sole and finger-tip total pattern types. Dermatoglyphic patterns have been classified according to the topological method, and the distributions of the numbers of discordant pattern elements from homolateral, heterolateral and bilateral comparisons in MZ and DZ twins, respectively, are presented. The highest concordance oc…
Topological classification and genetical studies of dermatoglyphic patterns
Classification of dermal patterns on the proximal sole
A classification formula which includes all true patterns on the proximal sole and is based on topological principles is presented. The frequencies of all respective pattern elements were obtained from a sample of 219 healthy individuals of Croatian origin (116 males and 103 females) and all the formulae (total patterns) encountered in this sample are listed in a dictionary form. Examples of the whole configurations are also given and the applica…
Evidence for directional non-additivity in the genetics of finger ridge counts
A genetical analysis of variation in finger ridge counts of 221 pairs of twins and 80 pairs of opposite sex siblings has been carried out. Negative regression of DZ and sibling pair variances on pair means suggests the action of non-additive genes or unequal gene frequencies tending to increase finger ridge counts. Negative skewness of the distributions supports this view. While models including dominance or epistasis are not a significant improv…
A genetical analysis of covariation between finger ridge counts
1. The genetical and environmental structure of covariation between finger ridge counts in twin and sibling data has been analysed using the method of Martin and Eaves (1977) adapted from Jöreskog. 2. The model for environmental covariance contains a single factor loading on all ten digits but most environmental variance is specific to each finger. 3. For additive genetic variance there is one common factor loading on all digits. There are also f…
Some dermatoglyphic features of Australian aboriginals from Mornington Island
Topologically significant dermatoglyphic patterns on palms and fingers have been analyzed in a sample of 118 Lardiil and 37 Kaiadilt males and females living on Mornington Island. The purpose of this analysis has been to demonstrate the applications of the topological classification in comparative studies and to point out some general developmental problems which have emerged from dermatoglyphic study of distant populations. The results are prese…
Relationships between minute characteristics of finger ridges and pattern size and shape
We present results of a multivariate analysis of several characteristics of the ridge pattern on the tip of fingers III and IV of the right hand, with special consideration of the minute properties of ridges. The analysis is based on a sample of 38 females and 63 males of European origin. Results of factor analysis for the male sample reveal that pattern type and size load on one factor. Furthermore, there are separate factors for the two types o…
Finger ridge patterns and tactile sensitivity
Tactile sensitivity has been measured in 101 normal individuals (38 females and 63 males) of European origin, and compared with ridge pattern characteristics of the fourth fingertip of the right hand. There is a relationship of tactile sensitivity performance with the type of pattern, particularly in females, and also with the number of junctions within the pattern, particularly in males. The possible origin of sex differences in tactile sensitiv…
Dermal ridge patterns and fertility in a Polish rural sample
The relationship between ridge counts and pattern intensities on fingers, palms and soles, and number of pregnancies, number of surviving children, maternal age at birth of first child, and miscarriages was investigated in a rural Polish sample of 273 females. All subjects had completed their reproduction by the time of investigation and the use of contraceptives was negligible. Results show that females with a history of miscarriage have lower m…
Bivariate and multivariate analysis of the skin ridge pattern intensities
Bivariate correlations and multivariate (factor) analysis of pattern intensities on individual fingers and all specified areas of palms and soles were performed in a large sample of 834 individuals from two rural districts of Poland, and in a sample of 383 school children from the city of Warsaw, with males and females considered separately. Eleven factors were extracted in all samples, including two for finger pattern intensities, and the remain…
Dermatoglyphic variation and weight and length at birth
Relationships between dermatoglyphic variables, including finger ridge counts and finger, palmar, and plantar pattern intensities, and weight and length at birth, were tested in a sample of 184 boys and 202 girls from Warsaw schools. No convincing evidence for such relationships has been obtained from the results of correlations and one‐way analysis of variance, although there are indications that some palmar traits may be related to length at bi…
Principal component analysis of shape variables in adult individuals
Human body shape variables were obtained by adjusting 34 distances between trunk/limbs, and head/face, landmarks, for an overall appropriate body size measurement. The adjustment was based on regression analysis. Principal component analysis was applied to thus defined shape variables to obtain shape dimensions in 99 normal adult males and 103 females. The first principal component either for trunk/limbs shape variables, or for head/face variable…
Relationships of epidermal ridge patterns with body measurements and their possible evolutionary significance
It is commonly believed that in humans epidermal ridge patterns are in regression relative to nonhuman primates, and they play no role in adaptive processes. In contrast with this we have found relationships between anthropometric and dermatoglyphic measurements in a sample of 61 normal males. Anthropometric variables included limb, trunk, head, and face measures. Dermatoglyphic variables included finger ridge counts and pattern intensities and r…
A new anthropometric scale for discrimination between sexes
Sexual dimorphism with respect to body size and shape has been analysed by means of discriminant function. An anthropometric score has been derived from 111 adult normal males and 108 females, based on 11 anthropometric and three dermatoglyphic variables. The score represents the range of quantified physical phenotypes of 'maleness' and 'femaleness'. Complete separation between the distributions of this score in either sex has been achieved. Pred…
Genetic correlates of menarcheal age
Multivariate genetic models were fitted to data from 44 pairs of MZ and 42 pairs of DZ twin girls on weight, height, and skeletal maturation at the age of menarche, in order to obtain information on genetic relationships of those measures with the age of menarche. The relationships of all three physical measures with this age were largely genetically controlled, but a genetic system controlling skeletal maturity was identified as the only genetic…
Relationship of birth weight and length with growth in height and body diameters from 5 years of age to maturity
Birth weight and birth length were compared with several growth measures, including body height and weight, linear measures of limbs, body diameters, and head circumference, in 726 Melbourne schoolchildren of both sexes age 5-18 years. The analysis of relationships between three categories of birth length, weight, and growth measures were based on z-scores and performed by using analysis of variance and partial correlation. The data showed that b…
Relationship of birth weight and length with growth in height and body diameters from 5 years of age to maturity
Birth weight and birth length were compared with several growth measures, including body height and weight, linear measures of limbs, body diameters, and head circumference, in 726 Melbourne schoolchildren of both sexes age 5–18 years. The analysis of relationships between three categories of birth length, weight, and growth measures were based on z-scores and performed by using analysis of variance and partial correlation. The data showed that b…
Secular trend in body height and weight of Australian children and adolescents
Secular changes in growth and maturation have been well documented in various world populations, with secular increase especially noticeable in the developed countries. To assess the trend in both adult size and tempo of growth we compared the data on stature and body weight obtained in 1992-1993 from 1,804 Melbourne school students aged 5 to 17 with historical data collected from white Australians during the last 100 years. We illustrate the age…
Haplotype Study of Intermediate-Length Alleles at the Fragile X (FMR1) Gene
The CGG repeat within the X-chromosome-linked FMR1 gene, which in hyperexpansion (> 200 copies) results in fragile X syndrome, is highly polymorphic. The mechanism of expansion is not well understood, but CGG repeats called intermediate-length or gray zone alleles (approximately equal 35-60 repeats) are thought to make up the FMR1 alleles showing initial steps in this expansion process. It has been hypothesized that the background haplotype of th…
Ridgecounter
Finger ridge count is a valuable quantitative phenotype used in a wide range of biological and anthropological research. However, the scoring of the phenotype is both labour intensive and error prone. This paper describe a freely available software program, RIDGECOUNTER, that can be used to obtain ridge counts from digitized prints (either collected using a digital fingerprint scanner or scanned from an inked print). The program yields semi-autom…
A review of physical growth in children and adolescents with Autism Spectrum Disorder
Delineating the Relationships Between Motor, Cognitive-Executive and Psychiatric Symptoms in Female FMR1 Premutation Carriers
Introduction: Premutation expansions (55-200 CGG repeats) of the Fragile X Mental Retardation 1 (FMR1) gene on the X chromosome are associated with a range of clinical features. Apart from the most severe - Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS) - where the most typical white matter changes affect cerebellar peduncles, more subtle changes may include impairment of executive functioning, affective disorders and/or subtle motor changes…
Cellular Bioenergetics and AMPK and Torc1 Signalling in Blood Lymphoblasts Are Biomarkers of Clinical Status in FMR1 Premutation Carriers
Fragile X Associated Tremor/Ataxia Syndrome (FXTAS) is a neurodegenerative disorder affecting carriers of premutation alleles (PM) of the X-linked FMR1 gene, which contain CGG repeat expansions of 55-200 range in a non-coding region. This late-onset disorder is characterised by the presence of tremor/ataxia and cognitive decline, associated with the white matter lesions throughout the brain, especially involving the middle cerebellar peduncles. N…
Biology (15 obras) · Mathematics (14 obras) · Statistics (11 obras) · Demography (10 obras) · Ridge (10 obras) · Genetics (9 obras) · Medicine (8 obras) · Dermatoglyphics and Human Traits (6 obras) · Geography (6 obras) · Demography (5 obras)