Claudio Franceschi
Datos Biográficos
| ID | 4197489 |
|---|---|
| NOMBRE | Claudio Franceschi |
| NOMBRES | Claudio |
| APELLIDO | Franceschi |
| FIRMA | FRANCESCHI C |
| AFILIACIONES | University of Bologna |
| ORCID | 0000-0001-9841-6386 |
| VERIFICADO | Sí |
| TOTAL DE OBRAS | 9 |
| TOTAL DE CITAS | 3 |
| TOTAL COMO AUTOR | 9 |
| TOTAL COMO EDITOR | 0 |
| PRIMER AÑO DE PUBLICACIÓN | 2013 |
| AÑO MÁS RECIENTE DE PUBLICACIÓN | 2019 |
| ÍNDICE H | 1 |
Chronic inflammation in the etiology of disease across the life span
Inferring chronological age from DNA methylation patterns of human teeth
We propose for the first time the evaluation of DNA methylation at ELOVL2, FHL2, and PENK genes as a powerful tool to predict age in modern teeth for anthropological applications. Future studies are needed to apply this method also to historical and relatively ancient human teeth
The epigenetic side of human adaptation
CONTEXT: Epigenetics represents a still unexplored research field in the understanding of micro- and macro-evolutionary mechanisms, as epigenetic changes create phenotypic diversity within both individuals and populations. OBJECTIVE: The purpose of this review is to dissect the landscape of studies focused on DNA methylation, one of the most described epigenetic mechanisms, emphasizing the aspects that could be relevant in human adaptations. METH…
Inferring the genetic history of lactase persistence along the Italian peninsula from a large genomic interval surrounding the LCT gene
OBJECTIVE: Although genetic variants related to lactase persistence in European populations were supposed to have firstly undergone positive selection in farmers from the Balkans and Central Europe, demographic and evolutionary dynamics that subsequently shaped the distribution of this adaptive trait across the continent have still to be elucidated. To deepen the knowledge about potential routes of diffusion of lactase persistence to Western Euro…
Demographic characteristics of Sardinian centenarian genealogies
This article provides an overview of the AKeA2 study, with a particular focus on data collection concerning family genealogies of the Sardinian centenarians and controls, and on the quality of these data. A first analysis of the main characteristics of the
Geroscience
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Human aging is characterized by a chronic, low-grade inflammation, and this phenomenon has been termed as "inflammaging." Inflammaging is a highly significant risk factor for both morbidity and mortality in the elderly people, as most if not all age-related diseases share an inflammatory pathogenesis. Nevertheless, the precise etiology of inflammaging and its potential causal role in contributing to adverse health outcomes remain largely unknown.…
Maternal longevity is associated with lower infant mortality
Referring to the multidisciplinary and multipurpose survey AKeA2, and focusing on family genealogy data on centenarian women and controls, this paper aims to verify the hypothesis that maternal longevity is associated with lower infant mortality in offspri
Analysis of Population Substructure in Two Sympatric Populations of Gran Chaco, Argentina
Sub-population structure and intricate kinship dynamics might introduce biases in molecular anthropology studies and could invalidate the efforts to understand diseases in highly admixed populations. In order to clarify the previously observed distribution pattern and morbidity of Chagas disease in Gran Chaco, Argentina, we studied two populations (Wichí and Criollos) recruited following an innovative bio-cultural model considering their complex …
Inferring chronological age from DNA methylation patterns of human teeth
We propose for the first time the evaluation of DNA methylation at ELOVL2, FHL2, and PENK genes as a powerful tool to predict age in modern teeth for anthropological applications. Future studies are needed to apply this method also to historical and relatively ancient human teeth
Inferring the genetic history of lactase persistence along the Italian peninsula from a large genomic interval surrounding the LCT gene
OBJECTIVE: Although genetic variants related to lactase persistence in European populations were supposed to have firstly undergone positive selection in farmers from the Balkans and Central Europe, demographic and evolutionary dynamics that subsequently shaped the distribution of this adaptive trait across the continent have still to be elucidated. To deepen the knowledge about potential routes of diffusion of lactase persistence to Western Euro…
Analysis of Population Substructure in Two Sympatric Populations of Gran Chaco, Argentina
Sub-population structure and intricate kinship dynamics might introduce biases in molecular anthropology studies and could invalidate the efforts to understand diseases in highly admixed populations. In order to clarify the previously observed distribution pattern and morbidity of Chagas disease in Gran Chaco, Argentina, we studied two populations (Wichí and Criollos) recruited following an innovative bio-cultural model considering their complex …
Geroscience
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Human aging is characterized by a chronic, low-grade inflammation, and this phenomenon has been termed as "inflammaging." Inflammaging is a highly significant risk factor for both morbidity and mortality in the elderly people, as most if not all age-related diseases share an inflammatory pathogenesis. Nevertheless, the precise etiology of inflammaging and its potential causal role in contributing to adverse health outcomes remain largely unknown.…
Maternal longevity is associated with lower infant mortality
Referring to the multidisciplinary and multipurpose survey AKeA2, and focusing on family genealogy data on centenarian women and controls, this paper aims to verify the hypothesis that maternal longevity is associated with lower infant mortality in offspri
The epigenetic side of human adaptation
CONTEXT: Epigenetics represents a still unexplored research field in the understanding of micro- and macro-evolutionary mechanisms, as epigenetic changes create phenotypic diversity within both individuals and populations. OBJECTIVE: The purpose of this review is to dissect the landscape of studies focused on DNA methylation, one of the most described epigenetic mechanisms, emphasizing the aspects that could be relevant in human adaptations. METH…
Inferring the genetic history of lactase persistence along the Italian peninsula from a large genomic interval surrounding the LCT gene
OBJECTIVE: Although genetic variants related to lactase persistence in European populations were supposed to have firstly undergone positive selection in farmers from the Balkans and Central Europe, demographic and evolutionary dynamics that subsequently shaped the distribution of this adaptive trait across the continent have still to be elucidated. To deepen the knowledge about potential routes of diffusion of lactase persistence to Western Euro…
Demographic characteristics of Sardinian centenarian genealogies
This article provides an overview of the AKeA2 study, with a particular focus on data collection concerning family genealogies of the Sardinian centenarians and controls, and on the quality of these data. A first analysis of the main characteristics of the
Inferring chronological age from DNA methylation patterns of human teeth
We propose for the first time the evaluation of DNA methylation at ELOVL2, FHL2, and PENK genes as a powerful tool to predict age in modern teeth for anthropological applications. Future studies are needed to apply this method also to historical and relatively ancient human teeth
Chronic inflammation in the etiology of disease across the life span
Biology (5 obras) · Demography (4 obras) · Medicine (4 obras) · Population (4 obras) · Evolutionary biology (3 obras) · Geography (3 obras) · Intensive care medicine (3 obras) · Sociology (3 obras) · Adipokines, Inflammation, and Metabolic Diseases (2 obras) · Bioinformatics (2 obras)