Le Shi

Biographic Data

ID	4227349
NAME	Le Shi
FAMILY NAME	Le Shi
SIGNATURE	LE SHI
AFFILIATIONS	Peking University
ORCID	0000-0003-3611-7801
VERIFIED	Yes
TOTAL WORKS	21
TOTAL CITATIONS	0
AUTHOR COUNT	21
EDITOR COUNT	0
FIRST PUBLICATION YEAR	2013
LATEST PUBLICATION YEAR	2024
H-INDEX	0

Modified Simiaowan prevents and treats gouty arthritis via the Nrf2/NLRP3 inflammasome signaling pathway
Open AccessDong-er Qin, Wei Liang et al.ARTICLEJournal of Ethnopharmacology2024
Association of Systemic Family Dynamics and Well-Being During the Covid-19 Outbreak
Open AccessJia Xu, Jingli Yue et al.ARTICLEJournal of Family Issues2024References: 28
This cross-sectional survey evaluated well-being and family dynamics before and during the COVID-19 pandemic in 1287 (16 + years of age, 68.3% female) Chinese participants. Structural equation modeling was used to test the association of well-being and systemic family dynamics, and related moderating factors. Results indicated some subscales of well-being and systemic family dynamics significantly worsened during the pandemic. A modified model fi…
The neural correlation of emotion recognition ability and depressive symptoms–evidence from the HCP database
Open AccessZe Yuan, Lin Xiao et al.ARTICLEFrontiers in Psychiatry2023
The core brain regions centered on the inferior orbitofrontal cortex such as middle temporal gyrus, precuneus lobe, frontal pole, insula and cingulate gyrus are the potential neuroimaging basis for the interaction between depressive symptoms and emotional recognition
Connectivity-Based Brain Network Supports Restricted and Repetitive Behaviors in Autism Spectrum Disorder Across Development
Open AccessAnyi Zhang, Lin Liu et al.ARTICLEFrontiers in Psychiatry2022
We identified improvements in RRBIs with age in ASD patients, especially stereotyped behaviors, ritualistic behaviors, and restricted behaviors. The decrease in FC between left superior occipital lobe and right angular and between left insula and left caudate might contribute to these improvements. Our findings improve our understanding of the pathogenesis of RRBIs and suggest potential intervention targets to improve prognosis in adulthood
Accessibility to Digital Mental Health Services among the General Public throughout Covid-19
Open AccessZheng-An Lu, Le Shi et al.ARTICLEInternational Journal of…2022
Digital mental health services (DMHSs) have great potential for mitigating the mental health burden related to COVID-19, but public accessibility (ease of acquiring services when needed) to DMHSs during the pandemic is largely unknown. Accessibility to DMHSs was tracked longitudinally among a nationwide sample of 18,804 adults in China from before to one year after COVID-19 outbreak. Unconditional and conditional latent growth curve models and la…
Anti-tumor effect of Yanggan Huayu granule by inducing AKT-mediated apoptosis in hepatocellular carcinoma
Open AccessYang Shen, Fan Yang et al.ARTICLEJournal of Ethnopharmacology2022
The impact of quarantine on mental health status among general population in China during the Covid-19 pandemic
Open AccessYunhe Wang, Le Shi et al.ARTICLEMolecular Psychiatry2021
Mental Health Status of Late-Middle-Aged Adults in China During the Coronavirus Disease 2019 Pandemic
Open AccessYongbo Zheng, Bayram Kodaman et al.ARTICLEFrontiers in Public Health2021
Background: The novel coronavirus 2019 (COVID-19) pandemic and related compulsory measures have triggered a wide range of psychological issues. However, the effect of COVID-19 on mental health in late-middle-aged adults remains unclear. Methods: This cross-sectional, web-based survey recruited 3,730 participants (≥ 50 years old) between February 28 and March 11 of 2020. The Patient Health Questionnaire-9, Generalized Anxiety Disorder-7, Insomnia …
Mental Health in Children in the Context of Covid-19
Open AccessAnyi Zhang, Le Shi et al.ARTICLEFrontiers in Psychiatry2021
Introduction: To date, the mental health consequences of children hospitalized with COVID-19 remain unclear. We aimed to assess mental health status in children in the context of COVID-19, with a focus on discharged children. Methods: We recruited discharged children who recovered from COVID-19 and healthy controls between July and September 2020 in Wuhan Children's Hospital. Post-traumatic stress disorder (PTSD), anxiety, depression, and sleep p…
Covid-19 Vaccine-Related Psychological Stress Among General Public in China
Open AccessYongbo Zheng, Jie Sun et al.ARTICLEFrontiers in Psychiatry2021
Background: The COVID-19 pandemic is our generation's greatest global challenge to our public health system. Vaccines are considered one of the most effective tools available for preventing COVID-19 infection and its complications and sequelae. Understanding and addressing the psychological stress related to COVID-19 vaccination may promote acceptance of these vaccines. Methods: We conducted an online survey from January 29 to April 26, 2021 to e…
Prevalence and Risk Factors of Mental Health Symptoms and Suicidal Behavior Among University Students in Wuhan, China During the Covid-19 Pandemic
Open AccessYingying Xu, Sizhen Su et al.ARTICLEFrontiers in Psychiatry2021
Background: University students who are exposed to coronavirus disease 2019 (COVID-19) could be mentally distressed. We aimed to evaluate the pattern and risk factors of mental health and suicidal behavior among students who experienced long-term school closure due to the COVID-19 pandemic. Methods: This large-sample, cross-sectional, online survey was conducted from June 29, 2020, to July 18, 2020. Eleven thousand two hundred fifty four particip…
Long-Term Impact of Covid-19 on Mental Health among the General Public
Open AccessLe Shi, Zheng-An Lu et al.ARTICLEInternational Journal of…2021
COVID-19 might have long-term mental health impacts. We aim to investigate the longitudinal changes in mental problems from initial COVID-19 peak to its aftermath among general public in China. Depression, anxiety and insomnia were assessed among a large-sample nationwide cohort of 10,492 adults during the initial COVID-19 peak (28 February 2020 to 11 March 2020) and its aftermath (8 July 2020 to 8 August 2020) using the Patient Health Questionna…
Effects of Covid-19 on career and specialty choices among Chinese medical students
Open AccessJiahui Deng, Jianyu Que et al.ARTICLEMedical Education Online2021
Coronavirus disease 2019 (COVID-19) pandemic has brought unprecedented challenges to medical education systems and medical students. The aim of this study was to investigate the effects of COVID-19 pandemic on medical career and specialty choices among medical students. An online cross-sectional survey of Chinese medical students was conducted during the COVID-19 pandemic from February to April 2020. The students' willingness to be a doctor befor…
Modified Simiaowan prevents articular cartilage injury in experimental gouty arthritis by negative regulation of STAT3 pathway
Open AccessLe Shi, Ziqiao Yuan et al.ARTICLEJournal of Ethnopharmacology2021
Prevalence of and Risk Factors Associated With Mental Health Symptoms Among the General Population in China During the Coronavirus Disease 2019 Pandemic
Open AccessLe Shi, Zheng-An Lu et al.ARTICLEJAMA Network Open2020
Importance: People exposed to coronavirus disease 2019 (COVID-19) and a series of imperative containment measures could be psychologically stressed, yet the burden of and factors associated with mental health symptoms remain unclear. Objective: To investigate the prevalence of and risk factors associated with mental health symptoms in the general population in China during the COVID-19 pandemic. Design, Setting, and Participants: This large-sampl…
Psychological impact of the Covid‐19 pandemic on healthcare workers
Open AccessJianyu Que, Le Shi et al.ARTICLEGeneral Psychiatry2020
BACKGROUND: Healthcare workers fighting against the coronavirus disease 2019 (COVID-19) pandemic are under tremendous pressure, which puts them at an increased risk of developing psychological problems. AIMS: This study aimed to investigate the prevalence of psychological problems in different healthcare workers (ie, physicians, medical residents, nurses, technicians and public health professionals) during the COVID-19 pandemic in China and explo…
Public awareness and knowledge of factors associated with dementia in China
Open AccessYongbo Zheng, Yong-Bo Zheng et al.ARTICLEBMC Public Health2020
Background Dementia is a global public health priority. Many modifiable factors have been shown to influence the development of dementia, but these factors are not adequately known by the general public. This study aimed to assess public awareness of the factors that are associated with dementia in China. Methods A cross-sectional study was conducted from May to October 2019 using an Internet-based questionnaire. Data on basic sociodemographic ch…
Traditional Chinese Medicine Formula “Xiaofeng granules” suppressed gouty arthritis animal models and inhibited the proteoglycan degradation on chondrocytes induced by monosodium urate
Open AccessLe Shi, Fangli Zhao et al.ARTICLEJournal of Ethnopharmacology2016
A network pharmacology approach to determine active ingredients and rationality of herb combinations of Modified-Simiaowan for treatment of gout
Open AccessFangli Zhao, Guochun Li et al.ARTICLEJournal of Ethnopharmacology2015
Study on the correlation between constituents detected in serum from Rhizoma Smilacis Glabrae and the reduction of uric acid levels in hyperuricemia
Open AccessWen-Ai Xu, Lian Yin et al.ARTICLEJournal of Ethnopharmacology2013
Suppressive effect of modified Simiaowan on experimental gouty arthritis
Le Shi, Li Xu et al.ARTICLEJournal of Ethnopharmacology2013