Lewis H Kuller
Biographic Data
| ID | 4231900 |
|---|---|
| NAME | Lewis H Kuller |
| GIVEN NAMES | Lewis H |
| FAMILY NAME | Kuller |
| SIGNATURE | KULLER L H |
| AFFILIATIONS | University of Pittsburgh |
| ORCID | 0000-0002-7148-8416 |
| VERIFIED | Yes |
| TOTAL WORKS | 34 |
| TOTAL CITATIONS | 21 |
| AUTHOR COUNT | 34 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1967 |
| LATEST PUBLICATION YEAR | 2018 |
| H-INDEX | 3 |
Risk thresholds for alcohol consumption: Combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies
BACKGROUND: Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. METHODS: We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-inco…
Association of Cardiometabolic Multimorbidity With Mortality
IMPORTANCE The prevalence of cardiometabolic multimorbidity is increasing. OBJECTIVE To estimate reductions in life expectancy associated with cardiometabolic multimorbidity. DESIGN, SETTING, AND PARTICIPANTS Age-and sex-adjusted mortality rates and hazard ratios (HRs) were calculated using individual participant data from the Emerging Risk Factors Collaboration (689 300 participants; 91 cohorts; years of baseline surveys: 1960-2007; latest morta…
Association Between 6-Minute Walk Test and All-Cause Mortality, Coronary Heart Disease–Specific Mortality, and Incident Coronary Heart Disease
Performance on the 6 MWT is independently associated with all-cause mortality and is of prognostic utility in community-dwelling older adults
Long-Term Survival in Adults 65 Years and Older With White Matter Hyperintensity: Association With Performance on the Digit Symbol Substitution Test
OBJECTIVE: White matter hyperintensity (WMH) confers increased mortality risk in patients with cardiovascular diseases. However, little is known about differences in survival times among adults 65 years and older who have WMH and live in the community. To characterize the factors that may reduce mortality risk in the presence of WMH, measures of race, sex, apolipoprotein E4, neuroimaging, and cardiometabolic, physiological, and psychosocial chara…
Influence of cigarette smoking on coronary artery and aortic calcium among random samples from populations of middle-aged Japanese and Korean men
BACKGROUND: Cigarette smoking is a risk factor of coronary heart disease. Vascular calcification such as coronary artery calcium (CAC) and aortic calcium (AC) is associated with coronary heart disease. The authors hypothesised that cigarette smoking is associated with coronary artery and aortic calcifications in Japanese and Koreans with high smoking prevalence. METHODS: Random samples from populations of 313 Japanese and 302 Korean men aged 40-4…
Psychosocial Predictors of Coronary Artery Calcification Progression in Postmenopausal Women
OBJECTIVE: Coronary artery calcification (CAC) has been associated with psychosocial factors in some but not all cross-sectional analyses. The goal of this study was to determine whether positive and negative psychosocial factors prospectively predict CAC progression in postmenopausal women. METHODS: Participants from the Healthy Women Study who also participated in the Pittsburgh Mind-Body Center protocol (n = 149) completed self-report psychoso…
The Key to Life Nutrition Program: Results from a community-based dietary sodium reduction trial
Objective Evaluation of a dietary Na reduction trial in a community setting. Design Community-based randomized trial. Ten-week nutrition intervention activities focused on lifestyle modification to decrease dietary Na intake, under the supervision of a registered dietitian. Twenty-four hour urine specimens were collected at baseline and follow-up visits to determine 24 h urinary Na excretion. Setting The University of Pittsburgh Center for Health…
The 10 Keys to Healthy Aging: Findings From an Innovative Prevention Program in the Community
This comprehensive prevention program had short-term benefits for improving adherence to established prevention guidelines in older adults. This low-cost effective program could be disseminated nationwide
Gain in Adiposity Across 15 Years is Associated With Reduced Gray Matter Volume in Healthy Women
OBJECTIVE: To test whether current gray matter volume (GMV) covaried with previously obtained longitudinal measures of weight gain-as assessed by increases in body mass index (BMI)-among otherwise healthy postmenopausal women. Cross-sectional results indicate that reduced GMV may be associated with excess body weight. METHODS: Demographic, biometric, and behavioral measures were obtained from 48 women as part of the Pittsburgh Healthy Women Study…
Positive and Negative Attributes and Risk for Coronary and Aortic Calcification in Healthy Women
OBJECTIVE: Negative emotions predict the development of clinical coronary events, and some evidence suggests that negative emotions relate to subclinical atherosclerosis. Low levels of positive emotions and cognitions are relatively unexplored as predictors of cardiovascular risk. We tested the hypothesis that low positive and high negative affect and cognitions would be related to risk for coronary and aortic calcification in healthy women. METH…
A Greater Reduction in High-Frequency Heart Rate Variability to a Psychological Stressor is Associated With Subclinical Coronary and Aortic Calcification in Postmenopausal Women
OBJECTIVE: Reduced cardiac parasympathetic activity, as indicated by a reduced level of clinic or ambulatory high-frequency heart rate variability (HF-HRV), is associated with an increased risk for atherosclerosis and coronary artery disease. We tested whether the reduction in HF-HRV to a psychological stressor relative to a baseline level is also associated with subclinical coronary or aortic atherosclerosis, as assessed by calcification in thes…
Optimistic Attitudes Protect Against Progression of Carotid Atherosclerosis in Healthy Middle-Aged Women
OBJECTIVE: Optimistic people report a higher quality of life, engage in more active coping and adopt more health-promoting behaviors than people low in optimism, ie, pessimism. We evaluated whether pessimists are more likely to show progression in carotid disease than optimists. METHODS: A total of 209 middle-aged healthy premenopausal women enrolled in an epidemiological study of cardiovascular risk factors and had carotid scans 10.4 years and 1…
Trait Anger and the Metabolic Syndrome Predict Progression of Carotid Atherosclerosis in Healthy Middle-Aged Women
OBJECTIVE: Hostility may predict coronary heart disease morbidity and mortality, as well as the metabolic syndrome. We tested to see if high levels of the attitudinal and emotional aspects of hostility lead to progression of carotid atherosclerosis in women and if the metabolic syndrome is a mediator of the association. METHODS: Two hundred nine healthy women were followed during the perimenopausal and postmenopausal periods. Carotid artery ultra…
Associations Between Psychological Traits and Endothelial Function in Postmenopausal Women
OBJECTIVE: The objective of this study was to determine whether psychosocial risk factors for cardiovascular disease (CVD) are associated with impairments in endothelial function and to determine whether use of hormone replacement therapy (HRT) can moderate observed associations among women without prior CVD. METHODS: Flow-mediated dilation was assessed by brachial ultrasound after reactive hyperemia in 193 postmenopausal women enrolled in the pr…
Marital Status, Marital Quality, and Atherosclerotic Burden in Postmenopausal Women
UNLABELLED: Marriage confers health benefits for men, but the evidence for women is less consistent. Inconsistent findings may be attributed, in part, to the confounding of marital status and marital quality. OBJECTIVES: The authors examined whether women in satisfying marriages evidence lesser atherosclerosis relative to women in low-satisfying marriages and relative to unmarried women. MATERIALS AND METHODS: Three hundred ninety-three women fro…
On Reconsidering Community-Based Health Promotion
Merzel and D’Afflitti are to be commended for their excellent overview of community-based health promotion studies.1 The human immunodeficiency virus (HIV) prevention studies are a model for possible successful community intervention programs. These “successful” community intervention programs to change HIV risk behavior are not unique. They represent the classic “shoe leather” epidemiological prevention approach for control of sexually transmitt…
Educational Attainment and Coronary and Aortic Calcification in Postmenopausal Women
OBJECTIVE: Low socioeconomic status is a risk factor for clinical coronary heart disease, a relatively crude outcome associated with important biases. By avoiding these biases, subclinical assessments could facilitate efforts to understand the association between socioeconomic status and coronary disease. The current study 1) evaluated the nature of the associations between educational attainment and subclinical atherosclerosis and 2) examined if…
Anger, Hostility, and Visceral Adipose Tissue: A 13-Year Follow-Up in Healthy Postmenopausal Women
s of Papers for 1999 Annual Meeting: Symposium: Stress, Abdominal Fat Distribution, and the Metabolic Syndrome
Are Hostility and Anxiety Associated With Carotid Atherosclerosis in Healthy Postmenopausal Women
OBJECTIVE: In this article, we evaluated the prospective association between measures of trait anger, hostility, and anxiety and indices of carotid atherosclerosis in 200 healthy middle-aged postmenopausal women. METHODS: Starting in 1983, 541 premenopausal women were evaluated for their levels of standard cardiovascular risk factors and psychosocial attributes, including their scores on Spielberger Trait Anger, Anxiety, and Anger-in, and Public …
Cardiovascular Responses to Stress Predict Carotid Atherosclerosis in Healthy Postmenopausal Women
Matthews, Karen A.; Owens, Jane F.; Kuller, Lewis H.; Sutton-Tyrrell, Kim; Lassila, Holly C.; Wolfson, Sidney K. Author Information
John Henryism and blood pressure among Nigerian civil servants
STUDY OBJECTIVE: Among urban Nigerian civil servants, higher socioeconomic status is related to increased blood pressure. In the United States, the relation between increased blood pressure and low socioeconomic status or low level of education has been found to be potentiated by high effort active coping (John Henryism) among African-Americans. Thus, the potentiating effect of high effort active coping as measured by the John Henryism Active Cop…
Smoking cessation, weight gain, and changes in cardiovascular risk factors during menopause: The Healthy Women Study
OBJECTIVES: The relationship between smoking cessation, subsequent weight gain, and cardiovascular disease risk factors from premenopause to postmenopause was studied. METHODS: Healthy Women Study participants were assessed for changes in coronary heart disease risk factors from a premenopausal baseline assessment to first- and second-year postmenopausal assessments. RESULTS: Although ex-smokers gained substantially more weight than nonsmokers an…
Are Life Stress and Social Support Related to Parity in Women
Although an increased risk of coronary heart disease has been demonstrated among women with high gravidity/parity, the mechanism by which this association may be mediated is unclear. One possible pathway that has been suggested is that pregnancy and child rearing may result in changes in factors such as stress or lifestyle. This hypothesis was tested in a sample of 541 middle-aged women who participated in a prospective study of the effects of me…
Lipoprotein (a) distribution in a Nigerian population
Lp(a) concentrations are high in Nigerians, particularly among women, and the association between the Lp(a) concentrations and other lipoproteins is stronger than in white populations
Association News: In Memoriam: Nemat Borhani
Association News: In Memoriam: Nemat Borhani Manning Feinleib, and Lewis H. Kuller CopyRight https://doi.org/10.2105/AJPH.87.7.1247 Published Online: October 07, 2011
Determinants of decisions to seek medical treatment by patients with acute myocardial infarction symptoms
The present study examined the type A behavior, symptom experience, and decisions to seek treatment of patients with acute myocardial infarction (MI) symptoms. Subjects were 43 patients admitted to the coronary care units of one of two hospitals for a suspected infarct. They were interviewed in the hospital, usually within 5 days of their arrival. The interview included questions about the patients' prehospital symptom experience, demographic cha…
John Henryism and blood pressure among Nigerian civil servants
STUDY OBJECTIVE: Among urban Nigerian civil servants, higher socioeconomic status is related to increased blood pressure. In the United States, the relation between increased blood pressure and low socioeconomic status or low level of education has been found to be potentiated by high effort active coping (John Henryism) among African-Americans. Thus, the potentiating effect of high effort active coping as measured by the John Henryism Active Cop…
The relationship of smoking cessation to coronary heart disease and lung cancer in the Multiple Risk Factor Intervention Trial (MRFIT)
The impact of smoking cessation on coronary heart disease (CHD) and lung cancer was assessed after 10.5 years of follow-up in the 12,866 men in the Multiple Risk Factor Intervention Trial (MRFIT). Those men who died of lung cancer (n = 119) were either cigarette smokers at entry or ex-smokers; no lung cancer deaths occurred among the 1,859 men who reported never smoking cigarettes. The risk of lung cancer for smokers, adjusted for selected baseli…
Relationship of hypertension to socioeconomic status in a West African population
Even in this very lean population, the higher risk for hypertension in males of higher SES was confirmed. This was explained, in part, by higher BMI
The 10 Keys to Healthy Aging: Findings From an Innovative Prevention Program in the Community
This comprehensive prevention program had short-term benefits for improving adherence to established prevention guidelines in older adults. This low-cost effective program could be disseminated nationwide
Smoking cessation, weight gain, and changes in cardiovascular risk factors during menopause: The Healthy Women Study
OBJECTIVES: The relationship between smoking cessation, subsequent weight gain, and cardiovascular disease risk factors from premenopause to postmenopause was studied. METHODS: Healthy Women Study participants were assessed for changes in coronary heart disease risk factors from a premenopausal baseline assessment to first- and second-year postmenopausal assessments. RESULTS: Although ex-smokers gained substantially more weight than nonsmokers an…
Blood lead levels among high-risk children, Detroit, Michigan
Since 1972, a federally funded lead screening program has been operational in Detroit, Michigan. Blood lead screening data (27,430 initial tests on Black children less than or equal to 6 years) were assigned by census tract of child's residence to one of the 15 socioeconomically similar areas in geographic proximity to one another. Higher blood lead levels were associated with lower education, lower income, and increased proportion of single pare…
Cerebrovascular disease mortality among Baltimore residents aged 20-64
Cerebrovascular disease mortality among Baltimore residents aged 20-64. L KullerCopyRight https://doi.org/10.2105/AJPH.57.12.2089 Published Online: August 29, 2011
Changing trends in cirrhosis and fatty liver mortality
Changing trends in cirrhosis and fatty liver mortality. L H Kuller, K Kramer, and R FisherCopyRight https://doi.org/10.2105/AJPH.59.7.1124 Published Online: August 29, 2011
Environmental Events Preceding Sudden Death in Women
The present case-control study examined if sudden cardiac death in women is preceded by death of a significant other, change in residence, or change in work. The sample included 81 Caucasian women ages 25-64 years in Allegheny County, Pennsylvania, who died suddenly from arteriosclerotic heart disease (ASHD) within a 11/2 year interval. Each case was matched to a neighborhood control on the basis of race, age, and sex. Results revealed that relat…
Health costs of air pollution'; second challenge
'Health costs of air pollution'; second challenge. L H Kuller, and G Weinberg Ben H. Carpenter CopyRight https://doi.org/10.2105/AJPH.70.7.744-a Published Online: October 07, 2011
Blood lead levels among high-risk children, Detroit, Michigan
Since 1972, a federally funded lead screening program has been operational in Detroit, Michigan. Blood lead screening data (27,430 initial tests on Black children less than or equal to 6 years) were assigned by census tract of child's residence to one of the 15 socioeconomically similar areas in geographic proximity to one another. Higher blood lead levels were associated with lower education, lower income, and increased proportion of single pare…
Determinants of decisions to seek medical treatment by patients with acute myocardial infarction symptoms
The present study examined the type A behavior, symptom experience, and decisions to seek treatment of patients with acute myocardial infarction (MI) symptoms. Subjects were 43 patients admitted to the coronary care units of one of two hospitals for a suspected infarct. They were interviewed in the hospital, usually within 5 days of their arrival. The interview included questions about the patients' prehospital symptom experience, demographic cha…
Occupational stress, suppressed anger, and hypertension
The present study examined the modifying effect of suppressed anger on the relationship between job stress and hypertension. The study population consisted of a random sample of male hourly workers, aged 40-63 years, employed at one of two plants in the metropolitan Pittsburgh, Pennsylvania area. Those men currently taking antihypertensive medication were excluded from the analyses. With both plants combined, stratified analyses indicated that, c…
The relationship of smoking cessation to coronary heart disease and lung cancer in the Multiple Risk Factor Intervention Trial (MRFIT)
The impact of smoking cessation on coronary heart disease (CHD) and lung cancer was assessed after 10.5 years of follow-up in the 12,866 men in the Multiple Risk Factor Intervention Trial (MRFIT). Those men who died of lung cancer (n = 119) were either cigarette smokers at entry or ex-smokers; no lung cancer deaths occurred among the 1,859 men who reported never smoking cigarettes. The risk of lung cancer for smokers, adjusted for selected baseli…
Relationship of hypertension to socioeconomic status in a West African population
Even in this very lean population, the higher risk for hypertension in males of higher SES was confirmed. This was explained, in part, by higher BMI
Are Life Stress and Social Support Related to Parity in Women
Although an increased risk of coronary heart disease has been demonstrated among women with high gravidity/parity, the mechanism by which this association may be mediated is unclear. One possible pathway that has been suggested is that pregnancy and child rearing may result in changes in factors such as stress or lifestyle. This hypothesis was tested in a sample of 541 middle-aged women who participated in a prospective study of the effects of me…
Lipoprotein (a) distribution in a Nigerian population
Lp(a) concentrations are high in Nigerians, particularly among women, and the association between the Lp(a) concentrations and other lipoproteins is stronger than in white populations
Association News: In Memoriam: Nemat Borhani
Association News: In Memoriam: Nemat Borhani Manning Feinleib, and Lewis H. Kuller CopyRight https://doi.org/10.2105/AJPH.87.7.1247 Published Online: October 07, 2011
Are Hostility and Anxiety Associated With Carotid Atherosclerosis in Healthy Postmenopausal Women
OBJECTIVE: In this article, we evaluated the prospective association between measures of trait anger, hostility, and anxiety and indices of carotid atherosclerosis in 200 healthy middle-aged postmenopausal women. METHODS: Starting in 1983, 541 premenopausal women were evaluated for their levels of standard cardiovascular risk factors and psychosocial attributes, including their scores on Spielberger Trait Anger, Anxiety, and Anger-in, and Public …
Cardiovascular Responses to Stress Predict Carotid Atherosclerosis in Healthy Postmenopausal Women
Matthews, Karen A.; Owens, Jane F.; Kuller, Lewis H.; Sutton-Tyrrell, Kim; Lassila, Holly C.; Wolfson, Sidney K. Author Information
John Henryism and blood pressure among Nigerian civil servants
STUDY OBJECTIVE: Among urban Nigerian civil servants, higher socioeconomic status is related to increased blood pressure. In the United States, the relation between increased blood pressure and low socioeconomic status or low level of education has been found to be potentiated by high effort active coping (John Henryism) among African-Americans. Thus, the potentiating effect of high effort active coping as measured by the John Henryism Active Cop…
Smoking cessation, weight gain, and changes in cardiovascular risk factors during menopause: The Healthy Women Study
OBJECTIVES: The relationship between smoking cessation, subsequent weight gain, and cardiovascular disease risk factors from premenopause to postmenopause was studied. METHODS: Healthy Women Study participants were assessed for changes in coronary heart disease risk factors from a premenopausal baseline assessment to first- and second-year postmenopausal assessments. RESULTS: Although ex-smokers gained substantially more weight than nonsmokers an…
Anger, Hostility, and Visceral Adipose Tissue: A 13-Year Follow-Up in Healthy Postmenopausal Women
s of Papers for 1999 Annual Meeting: Symposium: Stress, Abdominal Fat Distribution, and the Metabolic Syndrome
Educational Attainment and Coronary and Aortic Calcification in Postmenopausal Women
OBJECTIVE: Low socioeconomic status is a risk factor for clinical coronary heart disease, a relatively crude outcome associated with important biases. By avoiding these biases, subclinical assessments could facilitate efforts to understand the association between socioeconomic status and coronary disease. The current study 1) evaluated the nature of the associations between educational attainment and subclinical atherosclerosis and 2) examined if…
Associations Between Psychological Traits and Endothelial Function in Postmenopausal Women
OBJECTIVE: The objective of this study was to determine whether psychosocial risk factors for cardiovascular disease (CVD) are associated with impairments in endothelial function and to determine whether use of hormone replacement therapy (HRT) can moderate observed associations among women without prior CVD. METHODS: Flow-mediated dilation was assessed by brachial ultrasound after reactive hyperemia in 193 postmenopausal women enrolled in the pr…
Marital Status, Marital Quality, and Atherosclerotic Burden in Postmenopausal Women
UNLABELLED: Marriage confers health benefits for men, but the evidence for women is less consistent. Inconsistent findings may be attributed, in part, to the confounding of marital status and marital quality. OBJECTIVES: The authors examined whether women in satisfying marriages evidence lesser atherosclerosis relative to women in low-satisfying marriages and relative to unmarried women. MATERIALS AND METHODS: Three hundred ninety-three women fro…
On Reconsidering Community-Based Health Promotion
Merzel and D’Afflitti are to be commended for their excellent overview of community-based health promotion studies.1 The human immunodeficiency virus (HIV) prevention studies are a model for possible successful community intervention programs. These “successful” community intervention programs to change HIV risk behavior are not unique. They represent the classic “shoe leather” epidemiological prevention approach for control of sexually transmitt…
Optimistic Attitudes Protect Against Progression of Carotid Atherosclerosis in Healthy Middle-Aged Women
OBJECTIVE: Optimistic people report a higher quality of life, engage in more active coping and adopt more health-promoting behaviors than people low in optimism, ie, pessimism. We evaluated whether pessimists are more likely to show progression in carotid disease than optimists. METHODS: A total of 209 middle-aged healthy premenopausal women enrolled in an epidemiological study of cardiovascular risk factors and had carotid scans 10.4 years and 1…
Trait Anger and the Metabolic Syndrome Predict Progression of Carotid Atherosclerosis in Healthy Middle-Aged Women
OBJECTIVE: Hostility may predict coronary heart disease morbidity and mortality, as well as the metabolic syndrome. We tested to see if high levels of the attitudinal and emotional aspects of hostility lead to progression of carotid atherosclerosis in women and if the metabolic syndrome is a mediator of the association. METHODS: Two hundred nine healthy women were followed during the perimenopausal and postmenopausal periods. Carotid artery ultra…
A Greater Reduction in High-Frequency Heart Rate Variability to a Psychological Stressor is Associated With Subclinical Coronary and Aortic Calcification in Postmenopausal Women
OBJECTIVE: Reduced cardiac parasympathetic activity, as indicated by a reduced level of clinic or ambulatory high-frequency heart rate variability (HF-HRV), is associated with an increased risk for atherosclerosis and coronary artery disease. We tested whether the reduction in HF-HRV to a psychological stressor relative to a baseline level is also associated with subclinical coronary or aortic atherosclerosis, as assessed by calcification in thes…
Positive and Negative Attributes and Risk for Coronary and Aortic Calcification in Healthy Women
OBJECTIVE: Negative emotions predict the development of clinical coronary events, and some evidence suggests that negative emotions relate to subclinical atherosclerosis. Low levels of positive emotions and cognitions are relatively unexplored as predictors of cardiovascular risk. We tested the hypothesis that low positive and high negative affect and cognitions would be related to risk for coronary and aortic calcification in healthy women. METH…
Medicine (33 works) · Internal Medicine (27 works) · Internal Medicine (21 works) · Psychology (12 works) · Clinical Psychology (11 works) · Demography (10 works) · Gerontology (10 works) · Cardiac Health and Mental Health (8 works) · Cardiology (8 works) · Environmental health (8 works)