Richard B Lipton
Biographic Data
| ID | 4233617 |
|---|---|
| NAME | Richard B Lipton |
| GIVEN NAMES | Richard B |
| FAMILY NAME | Lipton |
| SIGNATURE | LIPTON R B |
| AFFILIATIONS | Albert Einstein College of Medicine |
| ORCID | 0000-0003-2652-2897 |
| VERIFIED | Yes |
| TOTAL WORKS | 17 |
| TOTAL CITATIONS | 34 |
| WORKS AS AUTHOR | 17 |
| WORKS AS EDITOR | 0 |
| FIRST PUBLICATION YEAR | 1996 |
| LATEST PUBLICATION YEAR | 2026 |
| H-INDEX | 3 |
From Static to Person-Specific Neighborhood Contexts
A Taxonomy of Data Synthesis
As efforts to improve the credibility of psychological and other social sciences continue, researchers aim to conduct multi-study or multi-sample research and synthesize findings using different parameterizations of individual participant meta-analysis. No overarching organizational framework exists, and only a few simulation-based or empirical examples comparing these parameterizations. This article has two goals. First, we provide an overview o…
Neighborhood Bonding and Bridging Social Capital, Social Activity Participation, and Short-term Cognitive Variability in Later Life
Objectives Investigating social determinants of health and related outcomes may help identify effective and sustainable intervention targets. This study examined whether contextual-level social capital (bonding and bridging capital) and individual-level social participation were associated with short-term cognitive variability, an early indicator of normal and pathological cognitive aging. Methods The sample consisted of urban community-dwelling …
Associations of personality trait level and change with mortality risk in 11 longitudinal studies
People who are higher in conscientiousness, extraversion, and agreeableness and lower in neuroticism tend to live longer. The present research tested the hypothesis that personality trait change in middle and older adulthood would also be associated with mortality risk, above and beyond personality trait level. Personality trait change may causally influence mortality risk through corresponding changes in health behaviors, social processes, and s…
Computational Phenotyping of Cognitive Decline With Retest Learning
Objectives Cognitive change is a complex phenomenon encompassing both retest-related performance gains and potential cognitive decline. Disentangling these dynamics is necessary for effective tracking of subtle cognitive change and risk factors for Alzheimer’s Disease and Related Dementias (ADRD). Method We applied a computational cognitive model of learning and forgetting to data from Einstein Aging Study (EAS; n = 316). EAS participants complet…
Development of Simple Risk Scores for Prediction of Brain β-Amyloid and Tau Status in Older Adults With Mild Cognitive Impairment
Objectives The aim of this work is to use a machine learning framework to develop simple risk scores for predicting β-amyloid (Aβ) and tau positivity among individuals with mild cognitive impairment (MCI). Methods Data for 657 individuals with MCI from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) data set were used. A modified version of AutoScore, a machine learning-based software tool, was used to develop risk scores based on hierarch…
A Coordinated Multi-study Analysis of the Longitudinal Association Between Handgrip Strength and Cognitive Function in Older Adults
OBJECTIVE: Handgrip strength, an indicator of overall muscle strength, has been found to be associated with slower rate of cognitive decline and decreased risk for cognitive impairment and dementia. However, evaluating the replicability of associations between aging-related changes in physical and cognitive functioning is challenging due to differences in study designs and analytical models. A multiple-study coordinated analysis approach was used…
A coordinated analysis of the associations among personality traits, cognitive decline, and dementia in older adulthood
Reliability and validity of the 6-item Headache Impact Test in chronic migraine from the PROMISE-2 study
The HIT-6 was successfully calibrated using IRT with data from PROMISE-2. Results from these analyses were generally consistent with previous literature and provided supportive evidence that the HIT-6 is well suited for measuring the impact of headache and migraine in the CM population
Mentally Challenging Occupations Are Associated With More Rapid Cognitive Decline at Later Stages of Cognitive Aging
The result suggests that protective factors for cognitive health may be associated with delayed onset but more rapid cognitive decline afterwards at later stages of cognitive aging
Stress Is Associated With Neurocognitive Function in Hispanic/Latino Adults
Our results suggest that mental and physical health may help explain some cross-sectional associations between stress and cognition and highlight the need to examine culture-specific psychosocial stressors to better understand the context of psychosocial risk factors for neurocognitive performance
Increases in Neuroticism May Be an Early Indicator of Dementia
Replication of our previous work in 2 additional datasets provides compelling evidence that increases in neuroticism may be early indication of dementia, which can facilitate development of screening assessments
Personality predicts mortality risk
Nativity differences in allostatic load by age, sex, and Hispanic background from the Hispanic Community Health Study/Study of Latinos
Allostatic load (AL), an index of biological "wear and tear" on the body from cumulative exposure to stress, has been little studied in US Hispanics/Latinos. We investigated AL accumulation patterns by age, sex, and nativity in the Hispanic Community Health Study/Study of Latinos. We studied 15,830 Hispanic/Latinos of Mexican, Cuban, Dominican, Puerto Rican, Central and South American descent aged 18-74 years, 77% of whom were foreign-born. Consi…
Leisure Activities and the Risk of Dementia in the Elderly
BACKGROUND: Participation in leisure activities has been associated with a lower risk of dementia. It is unclear whether increased participation in leisure activities lowers the risk of dementia or participation in leisure activities declines during the preclinical phase of dementia. METHODS: We examined the relation between leisure activities and the risk of dementia in a prospective cohort of 469 subjects older than 75 years of age who resided …
The migraine work and productivity loss questionnaire
The Effects of Preclinical Dementia on Estimates of Normal Cognitive Functioning in Aging
Individuals with preclinical dementia have begun to decline cognitively, but still perform within normal limits on cognitive testing. As a group, subjects with preclinical dementia have lower scores on neuropsychological tests than their dementia-free counterparts. This study examines the effects of preclinical dementia on estimates of normal cognitive function in the aged using data from a longitudinal study. Individuals with preclinical dementi…
Personality predicts mortality risk
The Effects of Preclinical Dementia on Estimates of Normal Cognitive Functioning in Aging
Individuals with preclinical dementia have begun to decline cognitively, but still perform within normal limits on cognitive testing. As a group, subjects with preclinical dementia have lower scores on neuropsychological tests than their dementia-free counterparts. This study examines the effects of preclinical dementia on estimates of normal cognitive function in the aged using data from a longitudinal study. Individuals with preclinical dementi…
Stress Is Associated With Neurocognitive Function in Hispanic/Latino Adults
Our results suggest that mental and physical health may help explain some cross-sectional associations between stress and cognition and highlight the need to examine culture-specific psychosocial stressors to better understand the context of psychosocial risk factors for neurocognitive performance
Increases in Neuroticism May Be an Early Indicator of Dementia
Replication of our previous work in 2 additional datasets provides compelling evidence that increases in neuroticism may be early indication of dementia, which can facilitate development of screening assessments
Neighborhood Bonding and Bridging Social Capital, Social Activity Participation, and Short-term Cognitive Variability in Later Life
Objectives Investigating social determinants of health and related outcomes may help identify effective and sustainable intervention targets. This study examined whether contextual-level social capital (bonding and bridging capital) and individual-level social participation were associated with short-term cognitive variability, an early indicator of normal and pathological cognitive aging. Methods The sample consisted of urban community-dwelling …
Computational Phenotyping of Cognitive Decline With Retest Learning
Objectives Cognitive change is a complex phenomenon encompassing both retest-related performance gains and potential cognitive decline. Disentangling these dynamics is necessary for effective tracking of subtle cognitive change and risk factors for Alzheimer’s Disease and Related Dementias (ADRD). Method We applied a computational cognitive model of learning and forgetting to data from Einstein Aging Study (EAS; n = 316). EAS participants complet…
Development of Simple Risk Scores for Prediction of Brain β-Amyloid and Tau Status in Older Adults With Mild Cognitive Impairment
Objectives The aim of this work is to use a machine learning framework to develop simple risk scores for predicting β-amyloid (Aβ) and tau positivity among individuals with mild cognitive impairment (MCI). Methods Data for 657 individuals with MCI from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) data set were used. A modified version of AutoScore, a machine learning-based software tool, was used to develop risk scores based on hierarch…
The Effects of Preclinical Dementia on Estimates of Normal Cognitive Functioning in Aging
Individuals with preclinical dementia have begun to decline cognitively, but still perform within normal limits on cognitive testing. As a group, subjects with preclinical dementia have lower scores on neuropsychological tests than their dementia-free counterparts. This study examines the effects of preclinical dementia on estimates of normal cognitive function in the aged using data from a longitudinal study. Individuals with preclinical dementi…
The migraine work and productivity loss questionnaire
Leisure Activities and the Risk of Dementia in the Elderly
BACKGROUND: Participation in leisure activities has been associated with a lower risk of dementia. It is unclear whether increased participation in leisure activities lowers the risk of dementia or participation in leisure activities declines during the preclinical phase of dementia. METHODS: We examined the relation between leisure activities and the risk of dementia in a prospective cohort of 469 subjects older than 75 years of age who resided …
Nativity differences in allostatic load by age, sex, and Hispanic background from the Hispanic Community Health Study/Study of Latinos
Allostatic load (AL), an index of biological "wear and tear" on the body from cumulative exposure to stress, has been little studied in US Hispanics/Latinos. We investigated AL accumulation patterns by age, sex, and nativity in the Hispanic Community Health Study/Study of Latinos. We studied 15,830 Hispanic/Latinos of Mexican, Cuban, Dominican, Puerto Rican, Central and South American descent aged 18-74 years, 77% of whom were foreign-born. Consi…
Personality predicts mortality risk
Increases in Neuroticism May Be an Early Indicator of Dementia
Replication of our previous work in 2 additional datasets provides compelling evidence that increases in neuroticism may be early indication of dementia, which can facilitate development of screening assessments
Mentally Challenging Occupations Are Associated With More Rapid Cognitive Decline at Later Stages of Cognitive Aging
The result suggests that protective factors for cognitive health may be associated with delayed onset but more rapid cognitive decline afterwards at later stages of cognitive aging
Stress Is Associated With Neurocognitive Function in Hispanic/Latino Adults
Our results suggest that mental and physical health may help explain some cross-sectional associations between stress and cognition and highlight the need to examine culture-specific psychosocial stressors to better understand the context of psychosocial risk factors for neurocognitive performance
Reliability and validity of the 6-item Headache Impact Test in chronic migraine from the PROMISE-2 study
The HIT-6 was successfully calibrated using IRT with data from PROMISE-2. Results from these analyses were generally consistent with previous literature and provided supportive evidence that the HIT-6 is well suited for measuring the impact of headache and migraine in the CM population
A Coordinated Multi-study Analysis of the Longitudinal Association Between Handgrip Strength and Cognitive Function in Older Adults
OBJECTIVE: Handgrip strength, an indicator of overall muscle strength, has been found to be associated with slower rate of cognitive decline and decreased risk for cognitive impairment and dementia. However, evaluating the replicability of associations between aging-related changes in physical and cognitive functioning is challenging due to differences in study designs and analytical models. A multiple-study coordinated analysis approach was used…
A coordinated analysis of the associations among personality traits, cognitive decline, and dementia in older adulthood
Neighborhood Bonding and Bridging Social Capital, Social Activity Participation, and Short-term Cognitive Variability in Later Life
Objectives Investigating social determinants of health and related outcomes may help identify effective and sustainable intervention targets. This study examined whether contextual-level social capital (bonding and bridging capital) and individual-level social participation were associated with short-term cognitive variability, an early indicator of normal and pathological cognitive aging. Methods The sample consisted of urban community-dwelling …
Associations of personality trait level and change with mortality risk in 11 longitudinal studies
People who are higher in conscientiousness, extraversion, and agreeableness and lower in neuroticism tend to live longer. The present research tested the hypothesis that personality trait change in middle and older adulthood would also be associated with mortality risk, above and beyond personality trait level. Personality trait change may causally influence mortality risk through corresponding changes in health behaviors, social processes, and s…
Computational Phenotyping of Cognitive Decline With Retest Learning
Objectives Cognitive change is a complex phenomenon encompassing both retest-related performance gains and potential cognitive decline. Disentangling these dynamics is necessary for effective tracking of subtle cognitive change and risk factors for Alzheimer’s Disease and Related Dementias (ADRD). Method We applied a computational cognitive model of learning and forgetting to data from Einstein Aging Study (EAS; n = 316). EAS participants complet…
Development of Simple Risk Scores for Prediction of Brain β-Amyloid and Tau Status in Older Adults With Mild Cognitive Impairment
Objectives The aim of this work is to use a machine learning framework to develop simple risk scores for predicting β-amyloid (Aβ) and tau positivity among individuals with mild cognitive impairment (MCI). Methods Data for 657 individuals with MCI from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) data set were used. A modified version of AutoScore, a machine learning-based software tool, was used to develop risk scores based on hierarch…
From Static to Person-Specific Neighborhood Contexts
A Taxonomy of Data Synthesis
As efforts to improve the credibility of psychological and other social sciences continue, researchers aim to conduct multi-study or multi-sample research and synthesize findings using different parameterizations of individual participant meta-analysis. No overarching organizational framework exists, and only a few simulation-based or empirical examples comparing these parameterizations. This article has two goals. First, we provide an overview o…
Psychology (13 works) · Medicine (11 works) · Cognition (8 works) · Dementia and Cognitive Impairment Research (8 works) · Clinical Psychology (7 works) · Dementia (7 works) · Cognitive decline (6 works) · Developmental psychology (6 works) · Psychiatry (6 works) · Big Five personality traits (5 works)