Janine D Flory
Biographic Data
| ID | 4234967 |
|---|---|
| NAME | Janine D Flory |
| GIVEN NAMES | Janine D |
| FAMILY NAME | Flory |
| SIGNATURE | FLORY J D |
| AFFILIATIONS | Icahn School of Medicine at Mount Sinai |
| VERIFIED | No |
| TOTAL WORKS | 12 |
| TOTAL CITATIONS | 12 |
| AUTHOR COUNT | 12 |
| EDITOR COUNT | 0 |
| FIRST PUBLICATION YEAR | 1999 |
| LATEST PUBLICATION YEAR | 2016 |
| H-INDEX | 1 |
Personality Correlates of Midlife Cardiometabolic Risk
Varying associations are reported between Five‐Factor Model (FFM) personality traits and cardiovascular disease risk. Here, we further examine dispositional correlates of cardiometabolic risk within a hierarchical model of personality that proposes higher‐order traits of Stability (shared variance of Agreeableness, Conscientiousness, inverse Neuroticism) and Plasticity (Extraversion, Openness), and we test hypothesized mediation via biological an…
Epigenetic Biomarkers as Predictors and Correlates of Symptom Improvement Following Psychotherapy in Combat Veterans with PTSD
Epigenetic alterations offer promise as diagnostic or prognostic markers, but it is not known whether these measures associate with, or predict, clinical state. These questions were addressed in a pilot study with combat veterans with PTSD to determine whether cytosine methylation in promoter regions of the glucocorticoid related NR3C1 and FKBP51 genes would predict or associate with treatment outcome. Veterans with PTSD received prolonged exposu…
Subjective Socioeconomic Status and Presence of the Metabolic Syndrome in Midlife Community Volunteers
OBJECTIVE: Objective indices of socioeconomic status (SES) predict diverse sources of morbidity and mortality as well as numerous biological and behavioral risk factors for disease. Here we examine whether subjective measures of SES may be similarly associated with measured risk factors including the metabolic syndrome and its components of elevated blood pressure, high fasting glucose, dyslipidemia, and central adiposity. METHODS: Observations w…
Impulsiveness and Cigarette Smoking
OBJECTIVE: Varying aspects of impulsive personality have been associated with tobacco use in cross-sectional and prospective studies, including novelty seeking and (low) constraint but most studies have not examined more than one tobacco use phenotype (e.g., any tobacco use versus dependence) or considered more than one variety of impulsiveness simultaneously. METHODS: The current study was conducted to evaluate the association of impulsive perso…
Trait Negative Affect
Objective: To assess depression, anxiety, and anger as well as the variance that these emotions share (conceptualized as negative affect) in relationship to high-frequency heart rate variability (HF-HRV), a specific indicator of parasympathetic cardiac autonomic function related to premature cardiovascular morbidity and mortality. Although individual trait negative emotions have been studied in relation to risk for coronary heart disease (CHD) as…
Community Socioeconomic Status is Associated With Circulating Interleukin-6 and C-Reactive Protein
OBJECTIVE: To examine the association of both individual and community socioeconomic status (SES) with inflammatory mediators relevant to cardiovascular pathophysiology, i.e., interleukin (IL)-6 and C-reactive protein (CRP), in a midlife community sample. Growing evidence suggests that socioeconomic attributes of both individuals and communities confer risk for cardiovascular morbidity and mortality. METHODS: Subjects were 851 men and women, 30 t…
High ω-6 and Low ω-3 Fatty Acids are Associated With Depressive Symptoms and Neuroticism
OBJECTIVE: To examine the concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum obtained from nonpatient community volunteers not selected for hypercholesterolemia. Previously we reported that the relative concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum covary with depressive symptomatology and neuroticism in hypercholesterolemic adults. METHODS: A total of 116 adults without current Axis I psychopa…
Interleukin-6 Covaries Inversely With Cognitive Performance Among Middle-Aged Community Volunteers
OBJECTIVE: Recent evidence suggests that higher peripheral levels of interleukin 6 (IL-6) are associated with poorer cognitive function and predict future cognitive decline among the elderly. The current investigation extends the study of relationships between plasma IL-6 and cognitive performance to healthy middle-aged adults and to an examination of more specific cognitive domains. METHODS: Five hundred relatively healthy community volunteers a…
Neural basis of individual differences in impulsivity
The objective of the current study was to analyze the neural correlates of behavioral arousal and inhibitory control as they relate to individual differences in impulsivity via well-established functional MRI amygdala reactivity and prefrontal inhibitory control paradigms in healthy adult subjects. Impulsivity correlated positively with activity of the bilateral ventral amygdala, parahippocampal gyrus, dorsal anterior cingulate gyrus (BA 32), and…
Does Socioeconomic Status Relate to Central Serotonergic Responsivity in Healthy Adults
OBJECTIVE: We tested whether low SES was associated with reduced central serotonergic responsivity in a community sample of adult men and women and the extent to which standardized measures of aggression and impulsivity mediate the association. METHODS: A total of 270 adults who were enrolled in a clinical trial on the neurobehavioral effects of lipid lowering were given a neuropharmacologic challenge (plasma prolactin response to orally administ…
Do the Daily Experiences of Healthy Men and Women Vary According to Occupational Prestige and Work Strain
OBJECTIVE: This study evaluated the influence of occupational prestige and work strain on mood, the occurrence of interpersonal conflict, and ambulatory blood pressure and heart rate. METHODS: Participants were 50 men and 50 women matched for occupational prestige who were healthy and middle-aged and who completed measures of mood and conflict simultaneously with measures of ambulatory blood pressure and heart rate recorded every 30 minutes durin…
Effects of optimism, pessimism, and trait anxiety on ambulatory blood pressure and mood during everyday life
This study tested whether dispositional measures of optimism, pessimism, and anxiety affected ambulatory blood pressure (BP) and mood and whether any cardiovascular effects of dispositions were moderated by mood. Pessimistic and anxious adults had higher BP levels and felt more negative and less positive than did optimists or low anxious adults throughout the monitoring. The few times that optimists did feel negative were associated with levels o…
Effects of optimism, pessimism, and trait anxiety on ambulatory blood pressure and mood during everyday life
This study tested whether dispositional measures of optimism, pessimism, and anxiety affected ambulatory blood pressure (BP) and mood and whether any cardiovascular effects of dispositions were moderated by mood. Pessimistic and anxious adults had higher BP levels and felt more negative and less positive than did optimists or low anxious adults throughout the monitoring. The few times that optimists did feel negative were associated with levels o…
Effects of optimism, pessimism, and trait anxiety on ambulatory blood pressure and mood during everyday life
This study tested whether dispositional measures of optimism, pessimism, and anxiety affected ambulatory blood pressure (BP) and mood and whether any cardiovascular effects of dispositions were moderated by mood. Pessimistic and anxious adults had higher BP levels and felt more negative and less positive than did optimists or low anxious adults throughout the monitoring. The few times that optimists did feel negative were associated with levels o…
Does Socioeconomic Status Relate to Central Serotonergic Responsivity in Healthy Adults
OBJECTIVE: We tested whether low SES was associated with reduced central serotonergic responsivity in a community sample of adult men and women and the extent to which standardized measures of aggression and impulsivity mediate the association. METHODS: A total of 270 adults who were enrolled in a clinical trial on the neurobehavioral effects of lipid lowering were given a neuropharmacologic challenge (plasma prolactin response to orally administ…
Do the Daily Experiences of Healthy Men and Women Vary According to Occupational Prestige and Work Strain
OBJECTIVE: This study evaluated the influence of occupational prestige and work strain on mood, the occurrence of interpersonal conflict, and ambulatory blood pressure and heart rate. METHODS: Participants were 50 men and 50 women matched for occupational prestige who were healthy and middle-aged and who completed measures of mood and conflict simultaneously with measures of ambulatory blood pressure and heart rate recorded every 30 minutes durin…
Interleukin-6 Covaries Inversely With Cognitive Performance Among Middle-Aged Community Volunteers
OBJECTIVE: Recent evidence suggests that higher peripheral levels of interleukin 6 (IL-6) are associated with poorer cognitive function and predict future cognitive decline among the elderly. The current investigation extends the study of relationships between plasma IL-6 and cognitive performance to healthy middle-aged adults and to an examination of more specific cognitive domains. METHODS: Five hundred relatively healthy community volunteers a…
Neural basis of individual differences in impulsivity
The objective of the current study was to analyze the neural correlates of behavioral arousal and inhibitory control as they relate to individual differences in impulsivity via well-established functional MRI amygdala reactivity and prefrontal inhibitory control paradigms in healthy adult subjects. Impulsivity correlated positively with activity of the bilateral ventral amygdala, parahippocampal gyrus, dorsal anterior cingulate gyrus (BA 32), and…
High ω-6 and Low ω-3 Fatty Acids are Associated With Depressive Symptoms and Neuroticism
OBJECTIVE: To examine the concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum obtained from nonpatient community volunteers not selected for hypercholesterolemia. Previously we reported that the relative concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum covary with depressive symptomatology and neuroticism in hypercholesterolemic adults. METHODS: A total of 116 adults without current Axis I psychopa…
Trait Negative Affect
Objective: To assess depression, anxiety, and anger as well as the variance that these emotions share (conceptualized as negative affect) in relationship to high-frequency heart rate variability (HF-HRV), a specific indicator of parasympathetic cardiac autonomic function related to premature cardiovascular morbidity and mortality. Although individual trait negative emotions have been studied in relation to risk for coronary heart disease (CHD) as…
Community Socioeconomic Status is Associated With Circulating Interleukin-6 and C-Reactive Protein
OBJECTIVE: To examine the association of both individual and community socioeconomic status (SES) with inflammatory mediators relevant to cardiovascular pathophysiology, i.e., interleukin (IL)-6 and C-reactive protein (CRP), in a midlife community sample. Growing evidence suggests that socioeconomic attributes of both individuals and communities confer risk for cardiovascular morbidity and mortality. METHODS: Subjects were 851 men and women, 30 t…
Impulsiveness and Cigarette Smoking
OBJECTIVE: Varying aspects of impulsive personality have been associated with tobacco use in cross-sectional and prospective studies, including novelty seeking and (low) constraint but most studies have not examined more than one tobacco use phenotype (e.g., any tobacco use versus dependence) or considered more than one variety of impulsiveness simultaneously. METHODS: The current study was conducted to evaluate the association of impulsive perso…
Subjective Socioeconomic Status and Presence of the Metabolic Syndrome in Midlife Community Volunteers
OBJECTIVE: Objective indices of socioeconomic status (SES) predict diverse sources of morbidity and mortality as well as numerous biological and behavioral risk factors for disease. Here we examine whether subjective measures of SES may be similarly associated with measured risk factors including the metabolic syndrome and its components of elevated blood pressure, high fasting glucose, dyslipidemia, and central adiposity. METHODS: Observations w…
Epigenetic Biomarkers as Predictors and Correlates of Symptom Improvement Following Psychotherapy in Combat Veterans with PTSD
Epigenetic alterations offer promise as diagnostic or prognostic markers, but it is not known whether these measures associate with, or predict, clinical state. These questions were addressed in a pilot study with combat veterans with PTSD to determine whether cytosine methylation in promoter regions of the glucocorticoid related NR3C1 and FKBP51 genes would predict or associate with treatment outcome. Veterans with PTSD received prolonged exposu…
Personality Correlates of Midlife Cardiometabolic Risk
Varying associations are reported between Five‐Factor Model (FFM) personality traits and cardiovascular disease risk. Here, we further examine dispositional correlates of cardiometabolic risk within a hierarchical model of personality that proposes higher‐order traits of Stability (shared variance of Agreeableness, Conscientiousness, inverse Neuroticism) and Plasticity (Extraversion, Openness), and we test hypothesized mediation via biological an…
Psychology (12 works) · Medicine (10 works) · Clinical Psychology (8 works) · Internal Medicine (8 works) · Internal Medicine (8 works) · Psychiatry (7 works) · Cardiac Health and Mental Health (5 works) · Developmental psychology (5 works) · Environmental health (4 works) · Gerontology (4 works)