Kingman P Strohl
Dados Biográficos
| ID | 4285782 |
|---|---|
| NOME | Kingman P Strohl |
| PRENOMES | Kingman P |
| SOBRENOME | Strohl |
| ASSINATURA | STROHL K P |
| AFILIAÇÕES | Case Western Reserve University |
| ORCID | 0000-0001-7740-9013 |
| VERIFICADO | Sim |
| TOTAL DE OBRAS | 15 |
| TOTAL DE CITAÇÕES | 0 |
| TOTAL COMO AUTOR | 15 |
| TOTAL COMO EDITOR | 0 |
| PRIMEIRO ANO DE PUBLICAÇÃO | 1992 |
| ANO MAIS RECENTE DE PUBLICAÇÃO | 2022 |
| ÍNDICE H | 0 |
Repeatability of adaptive traits among ethnic Tibetan highlanders
OBJECTIVES: Connecting traits to biological pathways and genes relies on stable observations. Researchers typically determine traits once, expecting careful study protocols to yield measurements free of noise. This report examines that expectation with test-retest repeatability analyses for traits used regularly in research on adaptation to high-altitude hypoxia, often in settings without climate control. METHODS: Two hundred ninety-one ethnic Ti…
Adaptations to High-Altitude Hypoxia
Biological anthropologists aim to explain the hows and whys of human biological variation using the concepts of evolution and adaptation. High-altitude environments provide informative natural laboratories with the unique stress of hypobaric hypoxia, which is less than usual oxygen in the ambient air arising from lower barometric pressure. Indigenous populations have adapted biologically to their extreme environment with acclimatization, developm…
Elevated pulmonary artery pressure among Amhara highlanders in Ethiopia
OBJECTIVE: Pulmonary arterioles respond to hypoxia with constriction that raises vascular resistance and pulmonary artery blood pressure. The response is sustained indefinitely by the chronic hypoxia of high-altitude residence among highlanders of European and Andean descent, but not Tibetans. The objective of this study was to identify the consequences of lifelong hypoxia exposure for the pulmonary vasculature among Amhara high-altitude natives …
Keeping Sleepy People off the Road
Automobile crashes are the third leading cause of death and injury in the United States, with nearly 43,000 people killed in approximately 6 million accidents in 2006, according to National Highway Traffic Safety Administration statistics Over the years the ratio of the number of crashes and severity of injury to miles driven is consistently highest in younger drivers (15 to 25 years) and in those over the age of 65 The most frequent contributors…
Exhaled nitric oxide decreases upon acute exposure to high-altitude hypoxia
Nitric oxide (NO) is a vasodilator that plays a role in blood flow and oxygen delivery. Acute hypoxia down regulates NO synthesis, a response that may exacerbate hypoxic stress by decreasing blood flow. This study was designed to test the hypotheses that pulmonary NO decreases upon acute exposure to high-altitude hypoxia and that relatively low levels of NO at altitude are associated with greater stress as reflected in more symptoms of acute moun…
Strategies Resident-Physicians Use to Manage Sleep Loss and Fatigue
Our purpose is to examine strategies or countermeasures resident-physicians used in dealing with the effects of sleep loss and fatigue during residency training. A total of 149 residents across five sites and six specialty areas were recruited for the study. Focus groups consisted of an average of 7 individuals in the same year of training and residency program, and included 60 interns and 89 senior residents. Trained moderators conducted focus g…
Percent of oxygen saturation of arterial hemoglobin among Bolivian Aymara at 3,900-4,000 m
A range of variation in percent of oxygen saturation of arterial hemoglobin (SaO2) among healthy individuals at a given high altitude indicates differences in physiological hypoxemia despite uniform ambient hypoxic stress. In populations native to the Tibetan plateau, a significant portion of the variance is attributable to additive genetic factors, and there is a major gene influencing SaO2. To determine whether there is genetic variance in othe…
Percent of oxygen saturation of arterial hemoglobin among Bolivian Aymara at 3,900–4,000 m
A range of variation in percent of oxygen saturation of arterial hemoglobin (SaO2) among healthy individuals at a given high altitude indicates differences in physiological hypoxemia despite uniform ambient hypoxic stress. In populations native to the Tibetan plateau, a significant portion of the variance is attributable to additive genetic factors, and there is a major gene influencing SaO2. To determine whether there is genetic variance in othe…
Breathlessness, Anxiety, and Respiratory Physiology
Department of Medicine; Case Western Reserve University and the Department of Veteran's Affairs Medical Center; Cleveland, OH 44106
Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara
Elevated hemoglobin concentrations have been reported for high-altitude sojourners and Andean high-altitude natives since early in the 20th century. Thus, reports that have appeared since the 1970s describing relatively low hemoglobin concentration among Tibetan high-altitude natives were unexpected. These suggested a hypothesis of population differences in hematological response to high-altitude hypoxia. A case of quantitatively different respon…
Hemoglobin concentration of high‐altitude Tibetans and Bolivian Aymara
Elevated hemoglobin concentrations have been reported for high-altitude sojourners and Andean high-altitude natives since early in the 20th century. Thus, reports that have appeared since the 1970s describing relatively low hemoglobin concentration among Tibetan high-altitude natives were unexpected. These suggested a hypothesis of population differences in hematological response to high-altitude hypoxia. A case of quantitatively different respon…
Ventilation and hypoxic ventilatory response of Tibetan and Aymara high altitude natives
Ventilation and hypoxic ventilatory response of Tibetan and Aymara high altitude natives
Newcomers acclimatizing to high altitude and adult male Tibetan high altitude natives have increased ventilation relative to sea level natives at sea level. However, Andean and Rocky Mountain high altitude natives have an intermediate level of ventilation lower than that of newcomers and Tibetan high altitude natives although generally higher than that of sea level natives at sea level. Because the reason for the relative hypoventilation of some …
Respiratory and hematological adaptations of young and older Aymara men native to 3600M
This paper reports the results of a study designed to test the hypothesis that an inevitable concomitant of aging at high altitudes is chronic mountain sickness resulting from excess erythrocytosis secondary to exaggerated hypoxemia caused by aging processes in the respiratory system. It compares age differences in respiratory system function in oxygenating the blood measured as percent O 2 saturation of arterial hemoglobin during wakefulness and…
Salivary testosterone concentration of Aymara men native to 3600 m
This paper explores the possibility that variation in the normal physiological range of testosterone concentration modulates men's adaptation to hypobaric high-altitude hypoxia through stimulating haemoglobin production and/or causing respiratory disturbances and exacerbated hypoxaemia during sleep. These effects of testosterone are observed clinically at sea level and have potentially opposing consequences at high altitude, the former perhaps en…
Sem obras proeminentes nesta página.
Respiratory and hematological adaptations of young and older Aymara men native to 3600M
This paper reports the results of a study designed to test the hypothesis that an inevitable concomitant of aging at high altitudes is chronic mountain sickness resulting from excess erythrocytosis secondary to exaggerated hypoxemia caused by aging processes in the respiratory system. It compares age differences in respiratory system function in oxygenating the blood measured as percent O 2 saturation of arterial hemoglobin during wakefulness and…
Salivary testosterone concentration of Aymara men native to 3600 m
This paper explores the possibility that variation in the normal physiological range of testosterone concentration modulates men's adaptation to hypobaric high-altitude hypoxia through stimulating haemoglobin production and/or causing respiratory disturbances and exacerbated hypoxaemia during sleep. These effects of testosterone are observed clinically at sea level and have potentially opposing consequences at high altitude, the former perhaps en…
Ventilation and hypoxic ventilatory response of Tibetan and Aymara high altitude natives
Ventilation and hypoxic ventilatory response of Tibetan and Aymara high altitude natives
Newcomers acclimatizing to high altitude and adult male Tibetan high altitude natives have increased ventilation relative to sea level natives at sea level. However, Andean and Rocky Mountain high altitude natives have an intermediate level of ventilation lower than that of newcomers and Tibetan high altitude natives although generally higher than that of sea level natives at sea level. Because the reason for the relative hypoventilation of some …
Breathlessness, Anxiety, and Respiratory Physiology
Department of Medicine; Case Western Reserve University and the Department of Veteran's Affairs Medical Center; Cleveland, OH 44106
Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara
Elevated hemoglobin concentrations have been reported for high-altitude sojourners and Andean high-altitude natives since early in the 20th century. Thus, reports that have appeared since the 1970s describing relatively low hemoglobin concentration among Tibetan high-altitude natives were unexpected. These suggested a hypothesis of population differences in hematological response to high-altitude hypoxia. A case of quantitatively different respon…
Hemoglobin concentration of high‐altitude Tibetans and Bolivian Aymara
Elevated hemoglobin concentrations have been reported for high-altitude sojourners and Andean high-altitude natives since early in the 20th century. Thus, reports that have appeared since the 1970s describing relatively low hemoglobin concentration among Tibetan high-altitude natives were unexpected. These suggested a hypothesis of population differences in hematological response to high-altitude hypoxia. A case of quantitatively different respon…
Percent of oxygen saturation of arterial hemoglobin among Bolivian Aymara at 3,900-4,000 m
A range of variation in percent of oxygen saturation of arterial hemoglobin (SaO2) among healthy individuals at a given high altitude indicates differences in physiological hypoxemia despite uniform ambient hypoxic stress. In populations native to the Tibetan plateau, a significant portion of the variance is attributable to additive genetic factors, and there is a major gene influencing SaO2. To determine whether there is genetic variance in othe…
Percent of oxygen saturation of arterial hemoglobin among Bolivian Aymara at 3,900–4,000 m
A range of variation in percent of oxygen saturation of arterial hemoglobin (SaO2) among healthy individuals at a given high altitude indicates differences in physiological hypoxemia despite uniform ambient hypoxic stress. In populations native to the Tibetan plateau, a significant portion of the variance is attributable to additive genetic factors, and there is a major gene influencing SaO2. To determine whether there is genetic variance in othe…
Strategies Resident-Physicians Use to Manage Sleep Loss and Fatigue
Our purpose is to examine strategies or countermeasures resident-physicians used in dealing with the effects of sleep loss and fatigue during residency training. A total of 149 residents across five sites and six specialty areas were recruited for the study. Focus groups consisted of an average of 7 individuals in the same year of training and residency program, and included 60 interns and 89 senior residents. Trained moderators conducted focus g…
Exhaled nitric oxide decreases upon acute exposure to high-altitude hypoxia
Nitric oxide (NO) is a vasodilator that plays a role in blood flow and oxygen delivery. Acute hypoxia down regulates NO synthesis, a response that may exacerbate hypoxic stress by decreasing blood flow. This study was designed to test the hypotheses that pulmonary NO decreases upon acute exposure to high-altitude hypoxia and that relatively low levels of NO at altitude are associated with greater stress as reflected in more symptoms of acute moun…
Keeping Sleepy People off the Road
Automobile crashes are the third leading cause of death and injury in the United States, with nearly 43,000 people killed in approximately 6 million accidents in 2006, according to National Highway Traffic Safety Administration statistics Over the years the ratio of the number of crashes and severity of injury to miles driven is consistently highest in younger drivers (15 to 25 years) and in those over the age of 65 The most frequent contributors…
Elevated pulmonary artery pressure among Amhara highlanders in Ethiopia
OBJECTIVE: Pulmonary arterioles respond to hypoxia with constriction that raises vascular resistance and pulmonary artery blood pressure. The response is sustained indefinitely by the chronic hypoxia of high-altitude residence among highlanders of European and Andean descent, but not Tibetans. The objective of this study was to identify the consequences of lifelong hypoxia exposure for the pulmonary vasculature among Amhara high-altitude natives …
Adaptations to High-Altitude Hypoxia
Biological anthropologists aim to explain the hows and whys of human biological variation using the concepts of evolution and adaptation. High-altitude environments provide informative natural laboratories with the unique stress of hypobaric hypoxia, which is less than usual oxygen in the ambient air arising from lower barometric pressure. Indigenous populations have adapted biologically to their extreme environment with acclimatization, developm…
Repeatability of adaptive traits among ethnic Tibetan highlanders
OBJECTIVES: Connecting traits to biological pathways and genes relies on stable observations. Researchers typically determine traits once, expecting careful study protocols to yield measurements free of noise. This report examines that expectation with test-retest repeatability analyses for traits used regularly in research on adaptation to high-altitude hypoxia, often in settings without climate control. METHODS: Two hundred ninety-one ethnic Ti…
High Altitude and Hypoxia (12 obras) · Medicine (11 obras) · Neuroscience of respiration and sleep (11 obras) · Effects of high altitude on humans (9 obras) · Internal Medicine (7 obras) · Oxygen (6 obras) · Altitude (triangle) (5 obras) · Biology (5 obras) · Chemistry (5 obras) · Demography (5 obras)